Sin Hang Lee

Summary

Affiliation: Milford Hospital
Location: Milford , USA
Summary:
MD anatomical and clinical pathologist

Publications

  1. pmc Routine human papillomavirus genotyping by DNA sequencing in community hospital laboratories
    Sin Hang Lee
    Department of Pathology, Milford Hospital, Milford, Connecticut, USA
    Infect Agent Cancer 2:11. 2007
  2. doi request reprint DNA sequencing validation of Chlamydia trachomatis and Neisseria gonorrhoeae nucleic acid tests
    Sin Hang Lee
    Department of Pathology, Milford Hospital, Milford, CT
    Am J Clin Pathol 129:852-9. 2008
  3. doi request reprint HPV infection among women in a representative rural and suburban population of the USA
    Sin Hang Lee
    Department of Pathology, Milford Hospital, Milford, Connecticut 06460, USA
    Int J Gynaecol Obstet 105:210-4. 2009
  4. pmc Molecular tests for human papillomavirus (HPV), Chlamydia trachomatis and Neisseria gonorrhoeae in liquid-based cytology specimen
    Sin Hang Lee
    Department of Pathology, Milford Hospital, Milford, Connecticut, USA
    BMC Womens Health 9:8. 2009
  5. pmc Validation of human papillomavirus genotyping by signature DNA sequence analysis
    Sin Hang Lee
    Department of Pathology, Milford Hospital, Milford, Connecticut, USA
    BMC Clin Pathol 9:3. 2009
  6. pmc Signature sequence validation of human papillomavirus type 16 (HPV-16) in clinical specimens
    Sin Hang Lee
    Milford Hospital, Milford, Connecticut 06460, USA
    J Clin Pathol 63:235-9. 2010
  7. doi request reprint Increased sensitivity and specificity of Borrelia burgdorferi 16S ribosomal DNA detection
    Sin Hang Lee
    Department of Pathology, Milford Hospital, CT, USA
    Am J Clin Pathol 133:569-76. 2010
  8. pmc Early Lyme disease with spirochetemia - diagnosed by DNA sequencing
    Sin Hang Lee
    Department of Pathology, Milford Hospital, 300 Seaside Avenue, Milford, 06460, USA
    BMC Res Notes 3:273. 2010
  9. doi request reprint Guidelines for the use of molecular tests for the detection and genotyping of human papilloma virus from clinical specimens
    Sin Hang Lee
    Department of Pathology, Milford Hospital, Milford, CT, USA
    Methods Mol Biol 903:65-101. 2012
  10. pmc From Human Papillomavirus (HPV) Detection to Cervical Cancer Prevention in Clinical Practice
    Sin Hang Lee
    Department of Pathology, Milford Hospital, 300 Seaside Ave, Milford, CT 06460, USA
    Cancers (Basel) 6:2072-99. 2014

Detail Information

Publications15

  1. pmc Routine human papillomavirus genotyping by DNA sequencing in community hospital laboratories
    Sin Hang Lee
    Department of Pathology, Milford Hospital, Milford, Connecticut, USA
    Infect Agent Cancer 2:11. 2007
    ..With this protocol, template purification before enzymatic cycle primer extensions is no longer necessary...
  2. doi request reprint DNA sequencing validation of Chlamydia trachomatis and Neisseria gonorrhoeae nucleic acid tests
    Sin Hang Lee
    Department of Pathology, Milford Hospital, Milford, CT
    Am J Clin Pathol 129:852-9. 2008
    ..DNA sequencing is a useful tool in validating molecular diagnostics...
  3. doi request reprint HPV infection among women in a representative rural and suburban population of the USA
    Sin Hang Lee
    Department of Pathology, Milford Hospital, Milford, Connecticut 06460, USA
    Int J Gynaecol Obstet 105:210-4. 2009
    ....
  4. pmc Molecular tests for human papillomavirus (HPV), Chlamydia trachomatis and Neisseria gonorrhoeae in liquid-based cytology specimen
    Sin Hang Lee
    Department of Pathology, Milford Hospital, Milford, Connecticut, USA
    BMC Womens Health 9:8. 2009
    ..The aim of this study was to find a practical approach to perform automated Sanger DNA sequencing in clinical laboratories for validation of the DNA tests for these three infectious agents...
  5. pmc Validation of human papillomavirus genotyping by signature DNA sequence analysis
    Sin Hang Lee
    Department of Pathology, Milford Hospital, Milford, Connecticut, USA
    BMC Clin Pathol 9:3. 2009
    ..How best to capitalize on the enhanced sensitivity of HPV DNA testing while minimizing false-positive results from its lower specificity is an important task for the clinical pathologists...
  6. pmc Signature sequence validation of human papillomavirus type 16 (HPV-16) in clinical specimens
    Sin Hang Lee
    Milford Hospital, Milford, Connecticut 06460, USA
    J Clin Pathol 63:235-9. 2010
    ..The purpose of this study was to introduce a robust laboratory procedure to validate HPV-16 detected in clinical specimens, using the GenBank sequence database as the standard reference for genotyping...
  7. doi request reprint Increased sensitivity and specificity of Borrelia burgdorferi 16S ribosomal DNA detection
    Sin Hang Lee
    Department of Pathology, Milford Hospital, CT, USA
    Am J Clin Pathol 133:569-76. 2010
    ..This technology may be a valuable supplement to the current serologic tests for Lyme disease...
  8. pmc Early Lyme disease with spirochetemia - diagnosed by DNA sequencing
    Sin Hang Lee
    Department of Pathology, Milford Hospital, 300 Seaside Avenue, Milford, 06460, USA
    BMC Res Notes 3:273. 2010
    ..A sensitive and analytically specific nucleic acid amplification test (NAAT) is valuable in confirming the diagnosis of early Lyme disease at the stage of spirochetemia...
  9. doi request reprint Guidelines for the use of molecular tests for the detection and genotyping of human papilloma virus from clinical specimens
    Sin Hang Lee
    Department of Pathology, Milford Hospital, Milford, CT, USA
    Methods Mol Biol 903:65-101. 2012
    ....
  10. pmc From Human Papillomavirus (HPV) Detection to Cervical Cancer Prevention in Clinical Practice
    Sin Hang Lee
    Department of Pathology, Milford Hospital, 300 Seaside Ave, Milford, CT 06460, USA
    Cancers (Basel) 6:2072-99. 2014
    ....
  11. pmc Sanger Sequencing for BRCA1 c.68_69del, BRCA1 c.5266dup and BRCA2 c.5946del Mutation Screen on Pap Smear Cytology Samples
    Sin Hang Lee
    Milford Hospital and Milford Molecular Diagnostics Laboratory, 2044 Bridgeport Avenue, Milford, CT 06460, USA
    Int J Mol Sci 17:229. 2016
    ....
  12. pmc DNA sequencing diagnosis of off-season spirochetemia with low bacterial density in Borrelia burgdorferi and Borrelia miyamotoi infections
    Sin Hang Lee
    Department of Pathology, Milford Hospital, 300 Seaside Ave, Milford, CT 06460, USA
    Int J Mol Sci 15:11364-86. 2014
    ....
  13. pmc Detection of borreliae in archived sera from patients with clinically suspect Lyme disease
    Sin Hang Lee
    Department of Pathology, Milford Hospital, 300 Seaside Ave, Milford, CT 06460, USA
    Int J Mol Sci 15:4284-98. 2014
    ..We conclude that a sensitive and reliable DNA-based test is needed to support the diagnosis of Lyme disease and Lyme disease-like borreliosis. ..
  14. ncbi request reprint Melting profiles may affect detection of residual HPV L1 gene DNA fragments in Gardasil®
    Sin Hang Lee
    Milford Hospital and 1Milford Molecular Laboratory, 2044 Bridgeport Avenue, Milford, CT 06460, USA
    Curr Med Chem 21:932-40. 2014
    ..All methods developed for detecting residual HPV DNA in the vaccine Gardasil® for quality assurance must take into consideration the variable melting profiles of the DNA to avoid false negative results...
  15. doi request reprint Detection of human papillomavirus (HPV) L1 gene DNA possibly bound to particulate aluminum adjuvant in the HPV vaccine Gardasil
    Sin Hang Lee
    Milford Hospital and Milford Molecular Laboratory, 2044 Bridgeport Avenue, Milford, CT 06460, USA
    J Inorg Biochem 117:85-92. 2012
    ..The clinical significance of these residual HPV DNA fragments bound to a particulate mineral-based adjuvant is uncertain after intramuscular injection, and requires further investigation for vaccination safety...