Genomes and Genes
Affiliation: Yale University
- Myosins: tails (and heads) of functional diversityMira Krendel
Department of Molecular Biology, Yale University, New Haven, CN, USA
Physiology (Bethesda) 20:239-51. 2005..In this review, recent insights into the remarkable diversity in the mechanochemical and functional properties associated with this family of molecular motors are discussed...
- Myosin 1E interacts with synaptojanin-1 and dynamin and is involved in endocytosisMira Krendel
Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06511, USA
FEBS Lett 581:644-50. 2007..Expression of Myo1E tail, which acts in a dominant-negative manner, inhibits endocytosis of transferrin. Our findings suggest that myosin 1E may contribute to receptor-mediated endocytosis...
- Nucleotide exchange factor GEF-H1 mediates cross-talk between microtubules and the actin cytoskeletonMira Krendel
Department of Immunology, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
Nat Cell Biol 4:294-301. 2002..Furthermore, these effects are inhibited by dominant-negative versions of GEF-H1. Thus, GEF-H1 links changes in microtubule integrity to Rho-dependent regulation of the actin cytoskeleton...
- p21-activated kinase 1 phosphorylates and regulates 14-3-3 binding to GEF-H1, a microtubule-localized Rho exchange factorFrank T Zenke
Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
J Biol Chem 279:18392-400. 2004..Phosphorylation of GEF-H1 by PAK may be involved in regulation of GEF-H1 activity and may serve to coordinate Rho-, Rac-, and Cdc42-mediated signaling pathways...