Jay D Humphrey

Summary

Affiliation: Yale University
Country: USA

Publications

  1. pmc Differential progressive remodeling of coronary and cerebral arteries and arterioles in an aortic coarctation model of hypertension
    H N Hayenga
    Department of Biomedical Engineering, Texas A and M University TX, USA
    Front Physiol 3:420. 2012
  2. pmc Possible mechanical roles of glycosaminoglycans in thoracic aortic dissection and associations with dysregulated transforming growth factor-β
    J D Humphrey
    Department of Biomedical Engineering, Yale University, and Vascular Biology and Therapeutics Program, Yale School of Medicine, New Haven, CT 06520, USA
    J Vasc Res 50:1-10. 2013
  3. pmc Mechanics, mechanobiology, and modeling of human abdominal aorta and aneurysms
    J D Humphrey
    Department of Biomedical Engineering and Vascular Biology and Therapeutics Program, Malone Engineering Center, Yale University, New Haven, CT 06520 8260, USA
    J Biomech 45:805-14. 2012
  4. pmc Enabling tools for engineering collagenous tissues integrating bioreactors, intravital imaging, and biomechanical modeling
    Laura E Niklason
    Department of Biomedical Engineering, Yale University, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 107:3335-9. 2010
  5. pmc Long-Term Functional Efficacy of a Novel Electrospun Poly(Glycerol Sebacate)-Based Arterial Graft in Mice
    Ramak Khosravi
    Department of Biomedical Engineering, Yale University, 55 Prospect Street, New Haven, CT, 06511, USA
    Ann Biomed Eng 44:2402-16. 2016
  6. pmc Biomechanical diversity despite mechanobiological stability in tissue engineered vascular grafts two years post-implantation
    Ramak Khosravi
    1 Department of Biomedical Engineering, Yale University, New Haven, Connecticut
    Tissue Eng Part A 21:1529-38. 2015
  7. pmc Inhibition of microRNA-29 enhances elastin levels in cells haploinsufficient for elastin and in bioengineered vessels--brief report
    Pei Zhang
    Department of Pharmacology, Yale University School of Medicine, Amistad Research Bldg, 10 Amistad St, New Haven, CT 06520, USA
    Arterioscler Thromb Vasc Biol 32:756-9. 2012
  8. pmc Mechanisms of arterial remodeling in hypertension: coupled roles of wall shear and intramural stress
    Jay D Humphrey
    Department of Biomedical Engineering, 337 Zachry Engineering Center, 3120 TAMU, Texas A and M University, College Station, TX 77843 3120, USA
    Hypertension 52:195-200. 2008
  9. pmc A microstructurally motivated model of the mechanical behavior of tissue engineered blood vessels
    Shannon L M Dahl
    Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA
    Ann Biomed Eng 36:1782-92. 2008
  10. pmc Time course of carotid artery growth and remodeling in response to altered pulsatility
    John F Eberth
    Department of Engineering Technology, University of Houston, Houston, USA
    Am J Physiol Heart Circ Physiol 299:H1875-83. 2010

Collaborators

Detail Information

Publications26

  1. pmc Differential progressive remodeling of coronary and cerebral arteries and arterioles in an aortic coarctation model of hypertension
    H N Hayenga
    Department of Biomedical Engineering, Texas A and M University TX, USA
    Front Physiol 3:420. 2012
    ..Taken together, these results suggest a spatiotemporal progression of vascular remodeling, beginning first in large elastic arteries and delayed in distal vessels...
  2. pmc Possible mechanical roles of glycosaminoglycans in thoracic aortic dissection and associations with dysregulated transforming growth factor-β
    J D Humphrey
    Department of Biomedical Engineering, Yale University, and Vascular Biology and Therapeutics Program, Yale School of Medicine, New Haven, CT 06520, USA
    J Vasc Res 50:1-10. 2013
    ..Of these, pooling of glycosaminoglycans appears to be unique to these lesions...
  3. pmc Mechanics, mechanobiology, and modeling of human abdominal aorta and aneurysms
    J D Humphrey
    Department of Biomedical Engineering and Vascular Biology and Therapeutics Program, Malone Engineering Center, Yale University, New Haven, CT 06520 8260, USA
    J Biomech 45:805-14. 2012
    ..We conclude by identifying open problems that we hope will motivate studies to improve our computational modeling and thus general understanding of AAAs...
  4. pmc Enabling tools for engineering collagenous tissues integrating bioreactors, intravital imaging, and biomechanical modeling
    Laura E Niklason
    Department of Biomedical Engineering, Yale University, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 107:3335-9. 2010
    ....
  5. pmc Long-Term Functional Efficacy of a Novel Electrospun Poly(Glycerol Sebacate)-Based Arterial Graft in Mice
    Ramak Khosravi
    Department of Biomedical Engineering, Yale University, 55 Prospect Street, New Haven, CT, 06511, USA
    Ann Biomed Eng 44:2402-16. 2016
    ....
  6. pmc Biomechanical diversity despite mechanobiological stability in tissue engineered vascular grafts two years post-implantation
    Ramak Khosravi
    1 Department of Biomedical Engineering, Yale University, New Haven, Connecticut
    Tissue Eng Part A 21:1529-38. 2015
    ....
  7. pmc Inhibition of microRNA-29 enhances elastin levels in cells haploinsufficient for elastin and in bioengineered vessels--brief report
    Pei Zhang
    Department of Pharmacology, Yale University School of Medicine, Amistad Research Bldg, 10 Amistad St, New Haven, CT 06520, USA
    Arterioscler Thromb Vasc Biol 32:756-9. 2012
    ..The goal of this study was to determine whether antagonizing microRNA (miR)-29 enhances elastin (ELN) levels in cells and tissues lacking ELN...
  8. pmc Mechanisms of arterial remodeling in hypertension: coupled roles of wall shear and intramural stress
    Jay D Humphrey
    Department of Biomedical Engineering, 337 Zachry Engineering Center, 3120 TAMU, Texas A and M University, College Station, TX 77843 3120, USA
    Hypertension 52:195-200. 2008
  9. pmc A microstructurally motivated model of the mechanical behavior of tissue engineered blood vessels
    Shannon L M Dahl
    Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA
    Ann Biomed Eng 36:1782-92. 2008
    ....
  10. pmc Time course of carotid artery growth and remodeling in response to altered pulsatility
    John F Eberth
    Department of Engineering Technology, University of Houston, Houston, USA
    Am J Physiol Heart Circ Physiol 299:H1875-83. 2010
    ....
  11. pmc Biaxial Stretch Improves Elastic Fiber Maturation, Collagen Arrangement, and Mechanical Properties in Engineered Arteries
    Angela H Huang
    1 Department of Biomedical Engineering, School of Engineering and Applied Science, Yale University, New Haven, Connecticut
    Tissue Eng Part C Methods 22:524-33. 2016
    ..In conclusion, biaxial stretching is a potential means to regenerate TEVs with improved matrix production, collagen organization, and mechanical properties. ..
  12. pmc Design and Use of a Novel Bioreactor for Regeneration of Biaxially Stretched Tissue-Engineered Vessels
    Angela Hai Huang
    1 Department of Biomedical Engineering, Yale University, New Haven, Connecticut
    Tissue Eng Part C Methods 21:841-51. 2015
    ..Furthermore, this novel system allows us to optimize biomechanical conditioning by unraveling the interrelationships among the applied mechanical stress, the resulting ECM properties, and the mechanics of TEVs. ..
  13. pmc A hypothesis-driven parametric study of effects of polymeric scaffold properties on tissue engineered neovessel formation
    Kristin S Miller
    Department of Biomedical Engineering, Yale University, New Haven, CT, USA
    Acta Biomater 11:283-94. 2015
    ..In this way, we can begin to move beyond a purely empirical trial-and-error search for optimal combinations of parameters and instead focus our experimental resources on those combinations that are predicted to have the most promise. ..
  14. pmc Toward large-scale computational fluid-solid-growth models of intracranial aneurysms
    Paolo Di Achille
    Department of Biomedical Engineering, Yale University, New Haven, CT 06520, USA
    Yale J Biol Med 85:217-28. 2012
    ....
  15. pmc Modeling effects of axial extension on arterial growth and remodeling
    Arturo Valentín
    Department of Biomedical Engineering, 337 Zachry Engineering Center, Texas A and M University, College Station, TX 77843 3120, USA
    Med Biol Eng Comput 47:979-87. 2009
    ....
  16. pmc Origin of Matrix-Producing Cells That Contribute to Aortic Fibrosis in Hypertension
    Jing Wu
    From the Division of Clinical Pharmacology, Department of Medicine J W, K R C M, M A S, L X, W C, M S M, D G H, Department of Molecular Physiology and Biophysics K R C M, M S M, D G H, Division of Cardiovascular Medicine, Department of Medicine D T P, A K H, and Department of Cell and Developmental Biology D T P, A K H, School of Medicine, Vanderbilt University, Nashville, TN Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt M A S Robert M Berne Cardiovascular Research Center, Department of Physiology, University of Virginia, Charlottesville G K O Department of Biomedical Engineering, Yale University, New Haven, CT J D H Vascular Biology and Therapeutics Program, Yale School of Medicine, New Haven, CT J D H Seattle Children s Research Institute, WA M W M
    Hypertension 67:461-8. 2016
    ..This study shows that vascular stiffening represents a complex process involving recruitment and transformation of multiple cells types that ultimately elaborate adventitial extracellular matrix. ..
  17. pmc Pharmacologically Improved Contractility Protects Against Aortic Dissection in Mice With Disrupted Transforming Growth Factor-β Signaling Despite Compromised Extracellular Matrix Properties
    Jacopo Ferruzzi
    From the Department of Biomedical Engineering, Yale University, New Haven, CT J F, S I M, S U, M Y L T, J D H and Department of Surgery G L, Y J, G T and Vascular Biology and Therapeutics Program G T, J d H, Yale School of Medicine, New Haven, CT
    Arterioscler Thromb Vasc Biol 36:919-27. 2016
    ....
  18. pmc Excessive Adventitial Remodeling Leads to Early Aortic Maladaptation in Angiotensin-Induced Hypertension
    Matthew R Bersi
    From the Department of Biomedical Engineering, Yale University, New Haven, CT M R B, C B, J D H Departments of Medicine and Pharmacology, Vanderbilt University, Nashville, TN J W, K R C M, D G H and Vascular Biology and Therapeutics Program, Yale School of Medicine, New Haven, CT J D H
    Hypertension 67:890-6. 2016
    ..Although most clinical assessments of arterial stiffening focus on intimal-medial thickening, these results suggest a need to measure and control the highly active and important adventitia. ..
  19. pmc Role of mechanotransduction in vascular biology: focus on thoracic aortic aneurysms and dissections
    Jay D Humphrey
    From the Departments of Biomedical Engineering J D H, M A S, Medicine Cardiology M A S, Cell Biology M A S, and Surgery G T, Yale University, New Haven, CT and Department of Internal Medicine, University of Texas Health Science Center, Houston D M M
    Circ Res 116:1448-61. 2015
    ..Thus, improved understanding of the mechanobiology of aortic cells could lead to new therapeutic strategies for thoracic aortic aneurysms and dissections. ..
  20. doi request reprint Sequential multimodal microscopic imaging and biaxial mechanical testing of living multicomponent tissue constructs
    Yuqiang Bai
    Department of Biomedical Engineering, Texas A and M University, College Station, TX, 77843, USA
    Ann Biomed Eng 42:1791-805. 2014
    ....
  21. pmc Ensuring congruency in multiscale modeling: towards linking agent based and continuum biomechanical models of arterial adaptation
    Heather N Hayenga
    Department of Biomedical Engineering, Texas A and M University, College Station, USA
    Ann Biomed Eng 39:2669-82. 2011
    ..We show that congruency-based parameter refinement not only yielded increased consistency across scales, it also yielded predictions that are closer to in vivo observations...
  22. pmc Mechanical assessment of elastin integrity in fibrillin-1-deficient carotid arteries: implications for Marfan syndrome
    Jacopo Ferruzzi
    Department of Biomedical Engineering, Texas A and M University, College Station, TX, USA
    Cardiovasc Res 92:287-95. 2011
    ....
  23. pmc Characterization of the natural history of extracellular matrix production in tissue-engineered vascular grafts during neovessel formation
    Yuji Naito
    Department of Surgery, Yale University School of Medicine, New Haven, Conn, USA
    Cells Tissues Organs 195:60-72. 2012
    ..The extracellular matrix (ECM) is a critical determinant of neovessel integrity...
  24. pmc Characterization of engineered tissue development under biaxial stretch using nonlinear optical microscopy
    Jin Jia Hu
    Department of Biomedical Engineering, Texas A and M University, College Station, TX 77843, USA
    Tissue Eng Part A 15:1553-64. 2009
    ..The integration of intravital NLOM with novel bioreactors enables visualization of dynamic tissue properties in culture...
  25. pmc Characterization of evolving biomechanical properties of tissue engineered vascular grafts in the arterial circulation
    Brooks V Udelsman
    Yale University School of Medicine, 10 Amistad Street, New Haven, CT 06519, USA
    J Biomech 47:2070-9. 2014
    ..Assessing contributions of individual components, such as elastin and collagen, to the developing neovessel is needed to guide computational modeling that may help to optimize the design of the TEVG. ..
  26. pmc Growth and remodeling in a thick-walled artery model: effects of spatial variations in wall constituents
    Patrick W Alford
    Department of Biomedical Engineering, Washington University, Campus Box 1097, St Louis, MO 63130, USA
    Biomech Model Mechanobiol 7:245-62. 2008
    ..These results provide a better understanding of the determinants of residual stress in arteries and could lend insight into the importance of constituent distributions in both natural and tissue-engineered blood vessels...