Yiyun Huang

Summary

Affiliation: Yale University
Country: USA

Publications

  1. pmc An-jun-ning, a traditional herbal formula, attenuates spontaneous withdrawal symptoms via modulation of the dopamine system in morphine-dependent rats
    Jin Long Gao
    Key Laboratory of Radiopharmaceuticals, Ministry of Education, Department of Chemistry, Beijing Normal University, Beijing 100875, China
    BMC Complement Altern Med 14:308. 2014
  2. ncbi request reprint In vivo imaging of the metabotropic glutamate receptor 1 (mGluR1) with positron emission tomography: recent advance and perspective
    Songye Li
    PET Center, Department of Diagnostic Radiology, Yale University School of Medicine, 801 Howard Avenue, PO Box 208048, New Haven, CT 06520 8048, USA
    Curr Med Chem 21:113-23. 2014
  3. doi request reprint Synthesis and characterization of two PET radioligands for the metabotropic glutamate 1 (mGlu1) receptor
    Yiyun Huang
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Synapse 66:1002-14. 2012
  4. doi request reprint Enhanced selective serotonin re-uptake inhibitors as antidepressants: 2004 - 2006
    Yiyun Huang
    Yale University School of Medicine, PO Box 208048, 801 Howard Avenue, New Haven, CT 06520 8048, USA
    Expert Opin Ther Pat 17:889-907. 2007
  5. ncbi request reprint In vivo vulnerability to competition by endogenous dopamine: comparison of the D2 receptor agonist radiotracer (-)-N-[11C]propyl-norapomorphine ([11C]NPA) with the D2 receptor antagonist radiotracer [11C]-raclopride
    Rajesh Narendran
    Department of Psychiatry, Columbia University College of Physicians and Surgeons and the New York State Psychiatric Institute, New York, NY 10032, USA
    Synapse 52:188-208. 2004
  6. ncbi request reprint The new PET imaging agent [11C]AFE is a selective serotonin transporter ligand with fast brain uptake kinetics
    Zhihong Zhu
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Nucl Med Biol 31:983-94. 2004
  7. doi request reprint Increased synaptic dopamine function in associative regions of the striatum in schizophrenia
    Lawrence S Kegeles
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Arch Gen Psychiatry 67:231-9. 2010
  8. ncbi request reprint Serotonin transporter availability in patients with schizophrenia: a positron emission tomography imaging study with [11C]DASB
    W Gordon Frankle
    Department of Psychiatry, Columbia University College of Physicians and Surgeons and the New York State Psychiatric Institute, New York, New York 10032, USA
    Biol Psychiatry 57:1510-6. 2005
  9. ncbi request reprint Amphetamine-induced dopamine release: markedly blunted in cocaine dependence and predictive of the choice to self-administer cocaine
    Diana Martinez
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Am J Psychiatry 164:622-9. 2007
  10. ncbi request reprint A PET imaging agent with fast kinetics: synthesis and in vivo evaluation of the serotonin transporter ligand [11C]2-[2-dimethylaminomethylphenylthio)]-5-fluorophenylamine ([11C]AFA)
    Yiyun Huang
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, 1051 Riverside Drive, Box 31, New York, NY 10032, USA
    Nucl Med Biol 31:727-38. 2004

Detail Information

Publications80

  1. pmc An-jun-ning, a traditional herbal formula, attenuates spontaneous withdrawal symptoms via modulation of the dopamine system in morphine-dependent rats
    Jin Long Gao
    Key Laboratory of Radiopharmaceuticals, Ministry of Education, Department of Chemistry, Beijing Normal University, Beijing 100875, China
    BMC Complement Altern Med 14:308. 2014
    ....
  2. ncbi request reprint In vivo imaging of the metabotropic glutamate receptor 1 (mGluR1) with positron emission tomography: recent advance and perspective
    Songye Li
    PET Center, Department of Diagnostic Radiology, Yale University School of Medicine, 801 Howard Avenue, PO Box 208048, New Haven, CT 06520 8048, USA
    Curr Med Chem 21:113-23. 2014
    ..In this report we review the development and evaluation of PET radiotracers for mGluR1 and provide an assessment of the tracers that are likely to succeed in the imaging and quantification of mGluR1 in humans. ..
  3. doi request reprint Synthesis and characterization of two PET radioligands for the metabotropic glutamate 1 (mGlu1) receptor
    Yiyun Huang
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Synapse 66:1002-14. 2012
    ..Radioligands with higher affinity and/or lower lipophilicity are needed to successfully image the mGlu1 receptor in humans...
  4. doi request reprint Enhanced selective serotonin re-uptake inhibitors as antidepressants: 2004 - 2006
    Yiyun Huang
    Yale University School of Medicine, PO Box 208048, 801 Howard Avenue, New Haven, CT 06520 8048, USA
    Expert Opin Ther Pat 17:889-907. 2007
    ..Despite mixed results from clinical trials with several NK(1) antagonists, effective therapeutic agents for depression may still emerge from compounds with combined serotonin reuptake inhibitor/NK(1) antagonist properties...
  5. ncbi request reprint In vivo vulnerability to competition by endogenous dopamine: comparison of the D2 receptor agonist radiotracer (-)-N-[11C]propyl-norapomorphine ([11C]NPA) with the D2 receptor antagonist radiotracer [11C]-raclopride
    Rajesh Narendran
    Department of Psychiatry, Columbia University College of Physicians and Surgeons and the New York State Psychiatric Institute, New York, NY 10032, USA
    Synapse 52:188-208. 2004
    ..In conclusion, [11C]NPA might provide a superior radiotracer to probe presynaptic DA function with PET in health and disease...
  6. ncbi request reprint The new PET imaging agent [11C]AFE is a selective serotonin transporter ligand with fast brain uptake kinetics
    Zhihong Zhu
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Nucl Med Biol 31:983-94. 2004
    ..In summary, [(11)C]AFE appears to be a PET radioligand with fast brain uptake kinetics and can be used for the visualization and quantification of SERT in vivo...
  7. doi request reprint Increased synaptic dopamine function in associative regions of the striatum in schizophrenia
    Lawrence S Kegeles
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Arch Gen Psychiatry 67:231-9. 2010
    ....
  8. ncbi request reprint Serotonin transporter availability in patients with schizophrenia: a positron emission tomography imaging study with [11C]DASB
    W Gordon Frankle
    Department of Psychiatry, Columbia University College of Physicians and Surgeons and the New York State Psychiatric Institute, New York, New York 10032, USA
    Biol Psychiatry 57:1510-6. 2005
    ..The aim of this study was to compare SERT availability in vivo in patients with schizophrenia and matched control subjects...
  9. ncbi request reprint Amphetamine-induced dopamine release: markedly blunted in cocaine dependence and predictive of the choice to self-administer cocaine
    Diana Martinez
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Am J Psychiatry 164:622-9. 2007
    ..Furthermore, the relationship between this dopamine response and the choice to self-administer cocaine in a laboratory model of relapse was investigated...
  10. ncbi request reprint A PET imaging agent with fast kinetics: synthesis and in vivo evaluation of the serotonin transporter ligand [11C]2-[2-dimethylaminomethylphenylthio)]-5-fluorophenylamine ([11C]AFA)
    Yiyun Huang
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, 1051 Riverside Drive, Box 31, New York, NY 10032, USA
    Nucl Med Biol 31:727-38. 2004
    ..In summary, [11C]AFA appears to be an appropriate PET radioligand with a fast brain uptake kinetics:..
  11. ncbi request reprint A new positron emission tomography imaging agent for the serotonin transporter: synthesis, pharmacological characterization, and kinetic analysis of [11C]2-[2-(dimethylaminomethyl)phenylthio]-5-fluoromethylphenylamine ([11C]AFM)
    Yiyun Huang
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, 1051 Riverside Drive, Box 31, New York, NY 10032, USA
    Nucl Med Biol 31:543-56. 2004
    ..In summary, [(11)C]AFM appears to be an excellent PET radioligand for the visualization and reliable quantification of SERT in vivo...
  12. ncbi request reprint Altered prefrontal dopaminergic function in chronic recreational ketamine users
    Rajesh Narendran
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Am J Psychiatry 162:2352-9. 2005
    ..In this study, dopamine D1 receptor availability was assessed by using positron emission tomography and the selective D1 receptor radioligand [11C]NNC 112 in a group of 14 recreational chronic ketamine users and matched healthy subjects...
  13. pmc Positron emission tomography imaging of the serotonin transporter and 5-HT(1A) receptor in alcohol dependence
    Diana Martinez
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, 1051 Riverside Drive, New York, NY 10032, USA
    Biol Psychiatry 65:175-80. 2009
    ..This is the first report of combined tracers for pre- and postsynaptic serotonergic transmission in the same alcoholic subjects and the first study of 5-HT(1A) receptors in alcoholism...
  14. ncbi request reprint Modulation of amphetamine-induced dopamine release by group II metabotropic glutamate receptor agonist LY354740 in non-human primates studied with positron emission tomography
    Bart N M van Berckel
    Department of Psychiatry, Columbia University, New York, NY, USA
    Neuropsychopharmacology 31:967-77. 2006
    ....
  15. ncbi request reprint Effects of reduced endogenous 5-HT on the in vivo binding of the serotonin transporter radioligand 11C-DASB in healthy humans
    Peter S Talbot
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute, New York, New York 10032, USA
    Synapse 55:164-75. 2005
    ..These results suggest that (11)C-DASB in vivo binding is not affected by reductions in endogenous 5-HT...
  16. ncbi request reprint Comparative evaluation of serotonin transporter radioligands 11C-DASB and 11C-McN 5652 in healthy humans
    W Gordon Frankle
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, and the New York State Psychiatric Institute, New York, New York, USA
    J Nucl Med 45:682-94. 2004
    ..The purpose of this study was to compare these 2 agents in healthy humans...
  17. doi request reprint Measurement of the serotonin 1A receptor availability in patients with schizophrenia during treatment with the antipsychotic medication ziprasidone
    W Gordon Frankle
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, USA
    J Psychopharmacol 25:734-43. 2011
    ..The finding of a relationship between 5-HT(1A) binding and the degree of improvement in negative symptoms provides further support for the role of the 5-HT(1A) receptor in the pathophysiology and treatment of this symptom domain...
  18. ncbi request reprint Fluorinated diaryl sulfides as serotonin transporter ligands: synthesis, structure-activity relationship study, and in vivo evaluation of fluorine-18-labeled compounds as PET imaging agents
    Yiyun Huang
    Department of Psychiatry and Radiology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Med Chem 48:2559-70. 2005
    ..Among these four ligands, three appear to be promising radioligands suitable for the labeling of SERT in vivo, with 18a providing a higher specific binding in vivo than 16 or 18b...
  19. doi request reprint Determination of the in vivo selectivity of a new κ-opioid receptor antagonist PET tracer 11C-LY2795050 in the rhesus monkey
    Su Jin Kim
    Yale PET Center, Yale University, New Haven, Connecticut 06510, USA
    J Nucl Med 54:1668-74. 2013
    ..72 and 25.8 nM, respectively. Thus, the in vitro KOR/MOR binding selectivity is about 36:1. Our goal in this study was to determine the in vivo selectivity of this new KOR antagonist tracer in the monkey...
  20. ncbi request reprint A positron emission tomography radioligand for the in vivo labeling of metabotropic glutamate 1 receptor: (3-ethyl-2-[11C]methyl-6-quinolinyl)(cis- 4-methoxycyclohexyl)methanone
    Yiyun Huang
    Departments of Psychiatry and Radiology, Columbia University College of Physicians and Surgeons, 1051 Riverside Drive, New York, NY 10032, USA
    J Med Chem 48:5096-9. 2005
    ..Results from animal experiments demonstrate that the radioligand [11C]2 is the first PET tracer capable of labeling the rat mGlu1 receptor in vivo...
  21. ncbi request reprint 11C-GR103545, a radiotracer for imaging kappa-opioid receptors in vivo with PET: synthesis and evaluation in baboons
    Peter S Talbot
    Department of Psychiatry, Columbia University College of Physicians and Surgeons and the New York State Psychiatric Institute, New York, NY 10032, USA
    J Nucl Med 46:484-94. 2005
    ..The (-)-isomer, GR103545, is the active enantiomer of GR89696. The aim of this study was to characterize the potential of 11C-GR103545 to image kappa-OR in vivo with PET...
  22. pmc Determination of in vivo Bmax and Kd for 11C-GR103545, an agonist PET tracer for κ-opioid receptors: a study in nonhuman primates
    Giampaolo Tomasi
    PET Center, Department of Diagnostic Radiology, Yale University, New Haven, CT 06520, USA
    J Nucl Med 54:600-8. 2013
    ..We used a recently developed selective KOR agonist tracer, (11)C-GR103545, and performed a study in rhesus monkeys to estimate the in vivo receptor concentration (Bmax) and dissociation equilibrium constant (Kd)...
  23. ncbi request reprint Synthesis and pharmacological characterization of a new PET ligand for the serotonin transporter: [11C]5-bromo-2-[2-(dimethylaminomethylphenylsulfanyl)]phenylamine ([11C]DAPA)
    Yiyun Huang
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Nucl Med Biol 29:741-51. 2002
    ..In summary, [11C]DAPA appears to be a promising radioligand suitable for the visualization of SERT in vivo using PET...
  24. ncbi request reprint Brain serotonin transporter distribution in subjects with impulsive aggressivity: a positron emission study with [11C]McN 5652
    W Gordon Frankle
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, and the New York State Psychiatric Institute, 1051 Riverside Dr, Box 31, New York, NY 10032, USA
    Am J Psychiatry 162:915-23. 2005
    ..This study evaluated regional serotonin transporter distribution in the brain of individuals with impulsive aggression by using positron emission tomography (PET) with the serotonin transporter PET radiotracer [(11)C]McN 5652...
  25. ncbi request reprint Comparative evaluation in nonhuman primates of five PET radiotracers for imaging the serotonin transporters: [11C]McN 5652, [11C]ADAM, [11C]DASB, [11C]DAPA, and [11C]AFM
    Yiyun Huang
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA
    J Cereb Blood Flow Metab 22:1377-98. 2002
    ....
  26. ncbi request reprint Alcohol dependence is associated with blunted dopamine transmission in the ventral striatum
    Diana Martinez
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, USA
    Biol Psychiatry 58:779-86. 2005
    ..This study measured D2 receptors and dopamine transmission in human alcohol-dependent (AD) subjects using positron emission tomography (PET) and [11C]raclopride...
  27. ncbi request reprint Cocaine dependence and d2 receptor availability in the functional subdivisions of the striatum: relationship with cocaine-seeking behavior
    Diana Martinez
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Neuropsychopharmacology 29:1190-202. 2004
    ..Additional research is warranted to unravel potential neurobiological traits that might confer vulnerability to relapse in detoxified CCD subjects...
  28. ncbi request reprint Measurement of the proportion of D2 receptors configured in state of high affinity for agonists in vivo: a positron emission tomography study using [11C]N-propyl-norapomorphine and [11C]raclopride in baboons
    Rajesh Narendran
    New York State Psychiatric Institute, 1051 Riverside Dr, Box 31, New York, NY 10032, USA
    J Pharmacol Exp Ther 315:80-90. 2005
    ....
  29. ncbi request reprint Quantitative analysis of (-)-N-(11)C-propyl-norapomorphine in vivo binding in nonhuman primates
    Dah Ren Hwang
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA
    J Nucl Med 45:338-46. 2004
    ..The goal of this study was to develop and evaluate analytic strategies to derive in vivo (11)C-NPA binding parameters...
  30. ncbi request reprint Effect of amphetamine on [(18)F]fallypride in vivo binding to D(2) receptors in striatal and extrastriatal regions of the primate brain: Single bolus and bolus plus constant infusion studies
    Mark Slifstein
    Department of Psychiatry, Columbia University College of Physicians and Surgeons and the New York State Psychiatric Institute, New York, New York 10032, USA
    Synapse 54:46-63. 2004
    ....
  31. ncbi request reprint Biodistribution and radiation dosimetry of the dopamine D2 ligand 11C-raclopride determined from human whole-body PET
    Mark Slifstein
    Department of Psychiatry, Columbia University, New York, New York 10032, USA
    J Nucl Med 47:313-9. 2006
    ..Whole-body radiation dosimetry of 11C-raclopride was performed in healthy human volunteers...
  32. ncbi request reprint Lower serotonin transporter binding potential in the human brain during major depressive episodes
    Ramin V Parsey
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, USA
    Am J Psychiatry 163:52-8. 2006
    ..On the basis of postmortem and imaging studies, the authors hypothesized that subjects with major depressive disorder in a major depressive episode have fewer serotonin transporter sites, compared with healthy subjects...
  33. ncbi request reprint Imaging human mesolimbic dopamine transmission with positron emission tomography. Part II: amphetamine-induced dopamine release in the functional subdivisions of the striatum
    Diana Martinez
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, 1051 Riverside Drive, New York, NY 10032, USA
    J Cereb Blood Flow Metab 23:285-300. 2003
    ....
  34. pmc Tracer kinetic modeling of [(11)C]AFM, a new PET imaging agent for the serotonin transporter
    Mika Naganawa
    Diagnostic Radiology, PET Center, Yale University School of Medicine, New Haven, Connecticut, USA
    J Cereb Blood Flow Metab 33:1886-96. 2013
    ..The MA1 and MRTM2 methods were best for parametric imaging. These results showed that [(11)C]AFM is a suitable PET radioligand to image and quantify SERT in humans. ..
  35. ncbi request reprint Estimation of serotonin transporter parameters with 11C-DASB in healthy humans: reproducibility and comparison of methods
    W Gordon Frankle
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute, New York, NY 10032, USA
    J Nucl Med 47:815-26. 2006
    ..The aim of the present study was to define the optimal analytic method to derive accurate and reliable serotonin transporter (SERT) receptor parameters with (11)C-3-amino-4-(2-[(dimethylamino)methyl]phenylthio)benzonitrile ((11)C-DASB)...
  36. ncbi request reprint Occupancy of brain serotonin transporters during treatment with paroxetine in patients with social phobia: a positron emission tomography study with 11C McN 5652
    Justine M Kent
    New York State Psychiatry Institute, New York, NY 10032, USA
    Psychopharmacology (Berl) 164:341-8. 2002
    ....
  37. doi request reprint Affinity and selectivity of [¹¹C]-(+)-PHNO for the D3 and D2 receptors in the rhesus monkey brain in vivo
    Jean Dominique Gallezot
    PET Center, Department of Diagnostic Radiology, Yale University, New Haven, Connecticut, USA
    Synapse 66:489-500. 2012
    ..01-0.02 μg kg⁻¹ for awake human positron emission tomography (PET) studies. Our data enabled a rational design and interpretation of future PET studies with [¹¹C]-(+)-PHNO...
  38. ncbi request reprint In vivo affinity of [18F]fallypride for striatal and extrastriatal dopamine D2 receptors in nonhuman primates
    Mark Slifstein
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Psychopharmacology (Berl) 175:274-86. 2004
    ..The high signal to noise ratio of [18F]fallypride has been attributed to its high affinity for D2 receptors (K(D) of 0.03 nM, measured in vitro at room temperature)...
  39. pmc Reduced amygdala serotonin transporter binding in posttraumatic stress disorder
    James W Murrough
    Mood and Anxiety Disorders Program, Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    Biol Psychiatry 70:1033-8. 2011
    ....
  40. pmc Kinetic modeling of the serotonin 5-HT(1B) receptor radioligand [(11)C]P943 in humans
    Jean Dominique Gallezot
    PET Center, Department of Diagnostic Radiology, Yale University, New Haven, Connecticut, USA
    J Cereb Blood Flow Metab 30:196-210. 2010
    ..Parametric images of the volume of distribution or binding potential of [(11)C]P943 could be computed using both MA1 and MRTM2. The results show that [(11)C]P943 provides quantitative measurements of 5-HT(1B) binding potential...
  41. ncbi request reprint Relationships between radiotracer properties and image quality in molecular imaging of the brain with positron emission tomography
    Marc Laruelle
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Mol Imaging Biol 5:363-75. 2003
    ..It is shown that, within a given structural family, affinity and lipophilicity are associated with scan outcome in a relatively predictable manner...
  42. pmc Imaging robust microglial activation after lipopolysaccharide administration in humans with PET
    Christine M Sandiego
    Department of Psychiatry, Yale University, New Haven, CT 06511 PET Center, Diagnostic Radiology, Yale University, New Haven, CT 06520
    Proc Natl Acad Sci U S A 112:12468-73. 2015
    ..This imaging paradigm to measure brain microglial activation with [11C]PBR28 PET provides an approach to test new medications in humans for their putative antiinflammatory effects...
  43. doi request reprint Test-retest reproducibility of the metabotropic glutamate receptor 5 ligand [¹⁸F]FPEB with bolus plus constant infusion in humans
    Eunkyung Park
    PET Center, Department of Diagnostic Radiology, Yale School of Medicine, 801 Howard Avenue, PO Box 208048, New Haven, CT, 06520 8048, USA
    Eur J Nucl Med Mol Imaging 42:1530-41. 2015
    ..The purpose of this study was to evaluate the test-retest reproducibility of [(18)F]FPEB in the human brain...
  44. pmc Test-retest reproducibility of binding parameters in humans with 11C-LY2795050, an antagonist PET radiotracer for the κ opioid receptor
    Mika Naganawa
    PET Center, Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut
    J Nucl Med 56:243-8. 2015
    ..11)C-LY2795050 is a new antagonist PET radioligand for the κ opioid receptor (KOR). In this study, we assessed the reproducibility of the binding parameters of (11)C-LY2795050 in healthy human subjects...
  45. pmc Studies of the metabotropic glutamate receptor 5 radioligand [¹¹C]ABP688 with N-acetylcysteine challenge in rhesus monkeys
    Christine M Sandiego
    Department of Biomedical Engineering, Yale University, New Haven, Connecticut 06520, USA
    Synapse 67:489-501. 2013
    ..Additionally, the net reduction in BP(ND) from the baseline-NAC scans may be obscured due to observed increases in test-retest BP(ND). Thus, we did not strictly replicate the findings in the baboon study based on BP(ND)...
  46. pmc Positron emission tomography shows elevated cannabinoid CB1 receptor binding in men with alcohol dependence
    Alexander Neumeister
    Molecular Imaging Program, Department of Psychiatry and Radiology, New York University School of Medicine, New York, New York 10016, USA
    Alcohol Clin Exp Res 36:2104-9. 2012
    ..This is an important gap in the literature, because recent therapeutic developments suggest that these receptors could be targeted for the treatment for AD...
  47. pmc Extended characterisation of the serotonin 2A (5-HT2A) receptor-selective PET radiotracer 11C-MDL100907 in humans: quantitative analysis, test-retest reproducibility, and vulnerability to endogenous 5-HT tone
    Peter S Talbot
    Department of Psychiatry, Columbia University College of Physicians and Surgeons and the New York State Psychiatric Institute, New York, NY 10032, USA
    Neuroimage 59:271-85. 2012
    ..We present an extended characterisation in healthy human subjects...
  48. pmc The effect of early trauma exposure on serotonin type 1B receptor expression revealed by reduced selective radioligand binding
    James W Murrough
    Mood and Anxiety Disorders Program, Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, USA
    Arch Gen Psychiatry 68:892-900. 2011
    ..However, the specific role of the serotonin type 1B receptor has not been studied in patients with PTSD...
  49. doi request reprint PET imaging of α7 nicotinic acetylcholine receptors: a comparative study of [18F]ASEM and [18F]DBT-10 in nonhuman primates, and further evaluation of [18F]ASEM in humans
    Ansel T Hillmer
    PET Center, Yale University, PO Box 208048, 801 Howard Ave, New Haven, CT, 06520 8048, USA
    Eur J Nucl Med Mol Imaging . 2017
    ..2.2]nonan-4-yl)-2-([18F]fluorodibenzo[b,d]thiophene 5,5-dioxide), in nonhuman primates. The second aim was to assess further the quantification and test-retest variability of [18F]ASEM in humans...
  50. pmc Parametric Imaging and Test-Retest Variability of ¹¹C-(+)-PHNO Binding to D₂/D₃ Dopamine Receptors in Humans on the High-Resolution Research Tomograph PET Scanner
    Jean Dominique Gallezot
    PET Center, Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut
    J Nucl Med 55:960-6. 2014
    ..In this study we evaluated the reproducibility of (11)C-(+)-PHNO binding parameters using a within-day design and assessed parametric imaging methods...
  51. pmc Kinetic modeling of (11)C-LY2795050, a novel antagonist radiotracer for PET imaging of the kappa opioid receptor in humans
    Mika Naganawa
    Department of Diagnostic Radiology, PET Center, Yale University School of Medicine, New Haven, Connecticut, USA
    J Cereb Blood Flow Metab 34:1818-25. 2014
    ..In conclusion, results from the present study show the suitability of (11)C-LY2795050 to image and quantify KOR in humans. ..
  52. ncbi request reprint Synthesis of potent and selective serotonin 5-HT1B receptor ligands
    Yiyun Huang
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Bioorg Med Chem Lett 15:4786-9. 2005
    ..Many of these new compounds displayed high affinity and selectivity for the 5-HT1B receptor and compound 6c was found to have the in vitro binding profile necessary for development as a PET radioligand...
  53. pmc Measurement of Bmax and Kd with the glycine transporter 1 radiotracer ¹⁸F-MK6577 using a novel multi-infusion paradigm
    Yan Xia
    PET Center, Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut, USA
    J Cereb Blood Flow Metab 35:2001-9. 2015
    ..These in vivo Kd and Bmax values agreed well with those determined in vitro, thus validating our novel multi-infusion approach. ..
  54. pmc Evaluation of [(18)F]-(-)-norchlorofluorohomoepibatidine ([(18)F]-(-)-NCFHEB) as a PET radioligand to image the nicotinic acetylcholine receptors in non-human primates
    Frederic Bois
    PET Center, Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, CT, USA Electronic address
    Nucl Med Biol 42:570-7. 2015
    ....
  55. pmc An Improved Antagonist Radiotracer for the κ-Opioid Receptor: Synthesis and Characterization of (11)C-LY2459989
    Ming Qiang Zheng
    PET Center, Department of Diagnostic Radiology, Yale University, New Haven, Connecticut and
    J Nucl Med 55:1185-91. 2014
    ..The purpose of this study was to develop the selective KOR antagonist (11)C-LY2459989 as a PET radioligand and characterize its imaging performance in nonhuman primates...
  56. pmc Imaging the cannabinoid CB1 receptor in humans with [11C]OMAR: assessment of kinetic analysis methods, test-retest reproducibility, and gender differences
    Marc D Normandin
    PET Center, Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut, USA
    J Cereb Blood Flow Metab 35:1313-22. 2015
    ..In addition, results from the present study indicate that gender difference in receptor binding should be taken into consideration when [(11)C]OMAR is used to quantify CB1R availability in neuropsychiatric disorders...
  57. pmc Synthesis and evaluation of 11C-LY2795050 as a κ-opioid receptor antagonist radiotracer for PET imaging
    Ming Qiang Zheng
    PET Center, Department of Diagnostic Radiology, Yale University, New Haven, Connecticut and
    J Nucl Med 54:455-63. 2013
    ..The goal of the present study was to synthesize the selective KOR antagonist (11)C-LY2795050 and evaluate its potential as a PET tracer to image KOR in vivo...
  58. pmc Reduced Brain Cannabinoid Receptor Availability in Schizophrenia
    Mohini Ranganathan
    Schizophrenia and Neuropharmacology Research Group, Veterans Affairs Connecticut Healthcare System, West Haven Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, New Haven Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut Electronic address
    Biol Psychiatry 79:997-1005. 2016
    ..Several lines of evidence suggest the presence of abnormalities in the endocannabinoid (eCB) system in schizophrenia (SCZ). However, there are limited in vivo measures of the eCB system in SCZ...
  59. pmc Radiolabeling of poly(lactic-co-glycolic acid) (PLGA) nanoparticles with biotinylated F-18 prosthetic groups and imaging of their delivery to the brain with positron emission tomography
    Rachael W Sirianni
    PET Center, Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut 06510, United States
    Bioconjug Chem 25:2157-65. 2014
    ..This work thus validates new methods for radiolabeling PEG-biotin derivatives and also provides insight into the fate of nanoparticles that have been infused directly into the brain. ..
  60. pmc Evaluation of the sensitivity of the novel α4β2* nicotinic acetylcholine receptor PET radioligand 18F-(-)-NCFHEB to increases in synaptic acetylcholine levels in rhesus monkeys
    Jean Dominique Gallezot
    Department of Diagnostic Radiology, Yale University, New Haven, Connecticut
    Synapse 68:556-64. 2014
    ..The goal of this study was to assess the sensitivity of 18F-(-)-NCFHEB-PET to increases in synaptic acetylcholine concentration induced by acetylcholinesterase inhibitors...
  61. pmc Direct, quantitative, and noninvasive imaging of the transport of active agents through intact brain with positron emission tomography
    Rachael W Sirianni
    Diagnostic Radiology, Yale School of Medicine, New Haven, CT, 06511, USA
    Mol Imaging Biol 15:596-605. 2013
    ..Our goal was to use positron emission tomography (PET) to analyze the movement of radiolabeled agents in tissue to enable direct measurement of drug delivery to the brain...
  62. ncbi request reprint Prefrontal dopamine D1 receptors and working memory in schizophrenia
    Anissa Abi-Dargham
    Department of Psychiatry, Columbia University College of Physicians and Surgeons and New York State Psychiatric Institute, New York, New York 10032, USA
    J Neurosci 22:3708-19. 2002
    ..Increased D1 receptor availability observed in patients with schizophrenia might represent a compensatory (but ineffective) upregulation secondary to sustained deficiency in mesocortical DA function...
  63. pmc Kinetic analysis of the metabotropic glutamate subtype 5 tracer [(18)F]FPEB in bolus and bolus-plus-constant-infusion studies in humans
    Jenna M Sullivan
    Yale PET Center, Department of Diagnostic Radiology, Yale University, New Haven, CT, USA
    J Cereb Blood Flow Metab 33:532-41. 2013
    ..Bolus-plus-constant-infusion of [(18)F]FPEB reduced intersubject variability in V(T) and allowed equilibrium analysis to be completed with a 30-minute scan, acquired 90-120 minutes after the start of injection...
  64. ncbi request reprint Epibatidine analogues as selective ligands for the alpha(x)beta2-containing subtypes of nicotinic acetylcholine receptors
    Yiyun Huang
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Bioorg Med Chem Lett 15:4385-8. 2005
    ..As a result they might become lead structures for the design and synthesis of highly selective ligands for nAChR subtypes containing the beta2 subunit...
  65. doi request reprint [11C]GR103545: novel one-pot radiosynthesis with high specific activity
    Nabeel B Nabulsi
    Department of Diagnostic Radiology, PET Center, Yale School of Medicine, PO Box 208048, New Haven, CT 06520 8048, USA
    Nucl Med Biol 38:215-21. 2011
    ..We report herein an alternative radiosynthesis of [(11)C]GR103545 with higher SA and radiochemical yields...
  66. pmc Cannabinoid type 1 receptor availability in the amygdala mediates threat processing in trauma survivors
    Robert H Pietrzak
    1 Clinical Neurosciences Division, National Center for Posttraumatic Stress Disorder, Veterans Affairs Connecticut Healthcare System, West Haven, CT, USA 2 Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Neuropsychopharmacology 39:2519-28. 2014
    ..They further suggest that novel pharmacotherapies that target the CB1 system may provide a more focused, mechanism-based approach to mitigating this core aspect of trauma-related psychopathology. ..
  67. pmc Evaluation of the agonist PET radioligand [¹¹C]GR103545 to image kappa opioid receptor in humans: kinetic model selection, test-retest reproducibility and receptor occupancy by the antagonist PF-04455242
    Mika Naganawa
    PET Center, Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, CT, USA Electronic address
    Neuroimage 99:69-79. 2014
    ..In addition, KOR occupancy of PF-04455242, a selective KOR antagonist that is active in preclinical models of depression, was also investigated...
  68. pmc Imaging nicotine- and amphetamine-induced dopamine release in rhesus monkeys with [(11)C]PHNO vs [(11)C]raclopride PET
    Jean Dominique Gallezot
    Department of Diagnostic Radiology, Yale PET Center, Yale University School of Medicine, New Haven, CT, USA
    Neuropsychopharmacology 39:866-74. 2014
    ..We confirmed that [(11)C]PHNO is more sensitive than [(11)C]raclopride to nicotine- and amphetamine-induced DA release. [(11)C]PHNO PET may be more sensitive to measuring tobacco smoking-induced DA release in human tobacco smokers...
  69. pmc Imaging glutamate homeostasis in cocaine addiction with the metabotropic glutamate receptor 5 positron emission tomography radiotracer [(11)C]ABP688 and magnetic resonance spectroscopy
    Diana Martinez
    Department of Psychiatry, Columbia University College of Physicians and Surgeons and the New York State Psychiatric Institute, New York, New York Electronic address
    Biol Psychiatry 75:165-71. 2014
    ..The goal of this study was to use imaging of the human brain to investigate alterations in the glutamate signaling in cocaine addiction...
  70. pmc Test-retest reproducibility of [11C]-(+)-propyl-hexahydro-naphtho-oxazin positron emission tomography using the bolus plus constant infusion paradigm
    Dianne E Lee
    Department of Psychiatry, Yale University School of Medicine, Yale University, New Haven, CT 06516, USA
    Mol Imaging 12:77-82. 2013
    ..88 and 0.82, respectively). These studies support the reproducibility of the bolus plus constant infusion paradigm with [11C]-(+)-PHNO PET...
  71. pmc Pancreatic beta cell mass PET imaging and quantification with [11C]DTBZ and [18F]FP-(+)-DTBZ in rodent models of diabetes
    Tarun Singhal
    Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, CT, USA
    Mol Imaging Biol 13:973-84. 2011
    ....
  72. pmc High-resolution imaging of brain 5-HT 1B receptors in the rhesus monkey using [11C]P943
    Nabeel Nabulsi
    Yale PET Center, Department of Diagnostic Radiology and Psychiatry, Yale University School of Medicine, P O Box 208048, New Haven, CT 06520 8048, USA
    Nucl Med Biol 37:205-14. 2010
    ..These results demonstrate the saturability and specificity of [(11)C]P943 for 5-HT(1B) receptors, suggesting its suitability as a PET radiotracer for in vivo evaluations of the 5-HT(1B) receptor system in humans...
  73. ncbi request reprint Effect of a triallelic functional polymorphism of the serotonin-transporter-linked promoter region on expression of serotonin transporter in the human brain
    Ramin V Parsey
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, USA
    Am J Psychiatry 163:48-51. 2006
    ....
  74. pmc Quantitative analysis of [11C]-erlotinib PET demonstrates specific binding for activating mutations of the EGFR kinase domain
    J Ryan Petrulli
    Department of Diagnostic Radiology, Yale University, New Haven, CT Department of Biomedical Engineering, Yale University, New Haven, CT
    Neoplasia 15:1347-53. 2013
    ....
  75. pmc Recovery from chronic spinal cord contusion after Nogo receptor intervention
    Xingxing Wang
    Cellular Neuroscience, Neurodegeneration, and Repair Program, and Department of Neurology, Yale School of Medicine, New Haven, CT 06536 0812, USA
    Ann Neurol 70:805-21. 2011
    ..We examined the efficacy of this intervention in the much more prevalent and refractory condition of chronic spinal cord injury...
  76. pmc Arterial transit time effects in pulsed arterial spin labeling CBF mapping: insight from a PET and MR study in normal human subjects
    Maolin Qiu
    Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut 06520 2048, USA
    Magn Reson Med 63:374-84. 2010
    ..The results also provide spatially specific ATT data that may aid in optimizing the ASL imaging parameters...
  77. pmc Highly penetrative, drug-loaded nanocarriers improve treatment of glioblastoma
    Jiangbing Zhou
    Department of Biomedical Engineering, Yale University, New Haven, CT 06511, USA
    Proc Natl Acad Sci U S A 110:11751-6. 2013
    ....
  78. ncbi request reprint NMDA antagonist effects on striatal dopamine release: positron emission tomography studies in humans
    Lawrence S Kegeles
    Department of Psychiatry, Columbia University College of Physicians and Surgeons and the New York State Psychiatric Institute, New York, NY 10032, USA
    Synapse 43:19-29. 2002
    ....
  79. ncbi request reprint Positron emission tomography: imaging and quantification of neurotransporter availability
    Marc Laruelle
    Department of Psychiatry and Department of Radiology, Columbia University College of Physicians and Surgeons, 1051 Riverside Drive, Unit 31, New York, New York 10032, USA
    Methods 27:287-99. 2002
    ..In conclusion, no universally "best" method is applicable to all neurotransporter imaging studies, and careful evaluation of model-based methods is required for each radiotracer...
  80. ncbi request reprint Development of effective PET and SPECT imaging agents for the serotonin transporter: has a twenty-year journey reached its destination?
    Yiyun Huang
    PET Center, Department of Diagnostic Radiology, Yale University School of Medicine, 801 Howard Avenue, New Haven, CT 06520 8048, USA
    Curr Top Med Chem 10:1499-526. 2010
    ..The applications of these efficacious SERT imaging agents will further advance our understanding of this important transporter in psychiatric and neurodegenerative disorders...