Hoby P Hetherington

Summary

Affiliation: Yale University
Country: USA

Publications

  1. ncbi request reprint A subcortical network of dysfunction in TLE measured by magnetic resonance spectroscopy
    H P Hetherington
    Department of Neurosurgery, Yale University, PO Box 208062, New Haven, CT 06520 8062, USA
    Neurology 69:2256-65. 2007
  2. pmc Novel approaches to imaging epilepsy by MRI
    Hoby Hetherington
    Departments of Neurosurgery and Diagnostic Radiology, Yale University, 404 Tompkins East, 333 Cedar St, New Haven, CT 06525, USA
    Future Neurol 4:295-304. 2009
  3. pmc RF shimming for spectroscopic localization in the human brain at 7 T
    Hoby P Hetherington
    Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Magn Reson Med 63:9-19. 2010
  4. doi request reprint Decreased hippocampal volume on MRI is associated with increased extracellular glutamate in epilepsy patients
    Idil Cavus
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06511, USA
    Epilepsia 49:1358-66. 2008
  5. pmc 7T head volume coils: improvements for rostral brain imaging
    Nikolai I Avdievich
    Department of Neurosurgery, Yale University, New Haven, Connecticut 06520, USA
    J Magn Reson Imaging 29:461-5. 2009
  6. pmc Improved homogeneity of the transmit field by simultaneous transmission with phased array and volume coil
    Nikolai I Avdievich
    Department of Neurosurgery, Yale University, New Haven, CT 06519, USA
    J Magn Reson Imaging 32:476-81. 2010
  7. pmc 4T split TEM volume head and knee coils for improved sensitivity and patient accessibility
    Nikolai I Avdievich
    Department of Radiology, Albert Einstein College of Medicine, Bronx, NY, USA
    J Magn Reson 187:234-41. 2007
  8. ncbi request reprint High-field actively detuneable transverse electromagnetic (TEM) coil with low-bias voltage for high-power RF transmission
    Nikolai I Avdievich
    Department of Radiology, Albert Einstein College of Medicine, Bronx, NY, USA
    Magn Reson Med 57:1190-5. 2007
  9. pmc Hippocampal extracellular GABA correlates with metabolism in human epilepsy
    J W Pan
    Department of Neurosurgery, Yale University School of Medicine, New Haven, CT, 06520, USA
    Metab Brain Dis 23:457-68. 2008
  10. pmc Intracranial EEG power and metabolism in human epilepsy
    J W Pan
    Department of Neurosurgery, Yale University School of Medicine, New Haven, CT 06520, USA
    Epilepsy Res 87:18-24. 2009

Research Grants

  1. MRS Measurements of GABA in Temporal Lobe Epilepsy
    Hoby Hetherington; Fiscal Year: 2007

Detail Information

Publications24

  1. ncbi request reprint A subcortical network of dysfunction in TLE measured by magnetic resonance spectroscopy
    H P Hetherington
    Department of Neurosurgery, Yale University, PO Box 208062, New Haven, CT 06520 8062, USA
    Neurology 69:2256-65. 2007
    ..The goal of this work was to evaluate the relationship between neuronal injury/loss in the hippocampus, thalamus, and putamen in temporal lobe epilepsy (TLE) patients using (1)H magnetic resonance spectroscopic imaging...
  2. pmc Novel approaches to imaging epilepsy by MRI
    Hoby Hetherington
    Departments of Neurosurgery and Diagnostic Radiology, Yale University, 404 Tompkins East, 333 Cedar St, New Haven, CT 06525, USA
    Future Neurol 4:295-304. 2009
    ....
  3. pmc RF shimming for spectroscopic localization in the human brain at 7 T
    Hoby P Hetherington
    Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Magn Reson Med 63:9-19. 2010
    ..5 sec. The short echo time enabled the acquisition of images of the human brain, displaying glutamate, glutamine, macromolecules, and other major cerebral metabolites...
  4. doi request reprint Decreased hippocampal volume on MRI is associated with increased extracellular glutamate in epilepsy patients
    Idil Cavus
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06511, USA
    Epilepsia 49:1358-66. 2008
    ..Temporal lobe epilepsy (TLE) is associated with smaller hippocampal volume and with elevated extracellular (EC) glutamate levels. We investigated the relationship between the hippocampal volume and glutamate in refractory TLE patients...
  5. pmc 7T head volume coils: improvements for rostral brain imaging
    Nikolai I Avdievich
    Department of Neurosurgery, Yale University, New Haven, Connecticut 06520, USA
    J Magn Reson Imaging 29:461-5. 2009
    ....
  6. pmc Improved homogeneity of the transmit field by simultaneous transmission with phased array and volume coil
    Nikolai I Avdievich
    Department of Neurosurgery, Yale University, New Haven, CT 06519, USA
    J Magn Reson Imaging 32:476-81. 2010
    ..Due to radiofrequency (RF) field/tissue interactions at high fields, 4 T to 8 T, the transmit profile from head-sized volume coils shows a distinctive pattern with relatively strong RF magnetic field B(1) in the center of the brain...
  7. pmc 4T split TEM volume head and knee coils for improved sensitivity and patient accessibility
    Nikolai I Avdievich
    Department of Radiology, Albert Einstein College of Medicine, Bronx, NY, USA
    J Magn Reson 187:234-41. 2007
    ..For the knee, the improved access allowed the coil diameter to be reduced, enhancing the sensitivity by 15-20%...
  8. ncbi request reprint High-field actively detuneable transverse electromagnetic (TEM) coil with low-bias voltage for high-power RF transmission
    Nikolai I Avdievich
    Department of Radiology, Albert Einstein College of Medicine, Bronx, NY, USA
    Magn Reson Med 57:1190-5. 2007
    ..A Q(U) of 500 was achieved for the detuneable TEM, such that incorporation of the detuning network had minimal effect (<1 dB) on the performance of the coil in vivo...
  9. pmc Hippocampal extracellular GABA correlates with metabolism in human epilepsy
    J W Pan
    Department of Neurosurgery, Yale University School of Medicine, New Haven, CT, 06520, USA
    Metab Brain Dis 23:457-68. 2008
    ..In epilepsy, ecGABA increases occur across a range of metabolic function. Outside the seizure focus, ecGABA and NAA/Cr increase together; in contrast, within the seizure focus, ecGABA increases with declining mitochondrial function...
  10. pmc Intracranial EEG power and metabolism in human epilepsy
    J W Pan
    Department of Neurosurgery, Yale University School of Medicine, New Haven, CT 06520, USA
    Epilepsy Res 87:18-24. 2009
    ..These data are also consistent with the hypothesis that high frequency activity is an abnormal manifestation of tissue injury...
  11. pmc J-refocused coherence transfer spectroscopic imaging at 7 T in human brain
    J W Pan
    Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06520 0882, USA
    Magn Reson Med 64:1237-46. 2010
    ..This method is demonstrated in spectroscopic imaging mode with n = 5 healthy volunteers resulting in metabolite values consistent with literature and in a patient with epilepsy...
  12. pmc 4 T Actively detuneable double-tuned 1H/31P head volume coil and four-channel 31P phased array for human brain spectroscopy
    N I Avdievich
    Department of Radiology, Albert Einstein College of Medicine, Bronx, NY, USA
    J Magn Reson 186:341-6. 2007
    ..Threefold SNR improvement was obtained at the periphery of the brain using the phased array as compared to the volume coil...
  13. pmc Resonant inductive decoupling (RID) for transceiver arrays to compensate for both reactive and resistive components of the mutual impedance
    Nikolai I Avdievich
    Department of Neurosurgery, Yale University, New Haven, CT, USA
    NMR Biomed 26:1547-54. 2013
    ..In combination with overlapped coils, the RID technique achieved better than -24 dB of decoupling for all adjacent coils...
  14. pmc Role of very high order and degree B0 shimming for spectroscopic imaging of the human brain at 7 tesla
    Jullie W Pan
    Department of Neurosurgery, Yale University, New Haven, Connecticut 06511 0820, USA
    Magn Reson Med 68:1007-17. 2012
    ....
  15. doi request reprint High-field head radiofrequency volume coils using transverse electromagnetic (TEM) and phased array technologies
    Nikolai I Avdievich
    Department of Neurosurgery, Yale University, New Haven, CT, USA
    NMR Biomed 22:960-74. 2009
    ..Conversely, simultaneous transmission can be used to boost the transmit field in peripheral brain regions from the volume coil to provide a more homogeneous transmit field...
  16. pmc Neurometabolism in human epilepsy
    Jullie W Pan
    Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut, USA
    Epilepsia 49:31-41. 2008
    ..Thus abnormal neurometabolism may be not only a chronic accompaniment of the epileptic brain, but also a direct contributor to epileptogenesis...
  17. pmc MRSI of the medial temporal lobe at 7 T in explosive blast mild traumatic brain injury
    Hoby P Hetherington
    Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut, USA
    Magn Reson Med 71:1358-67. 2014
    ..The goal of this work was to develop methods to acquire hippocampal MRSI at 7 T and evaluate their sensitivity to detect injury in veterans with mild traumatic brain injury...
  18. pmc Short echo spectroscopic imaging of the human brain at 7T using transceiver arrays
    N I Avdievich
    Department of Neurosurgery, Yale University, New Haven, CT, 06520, USA
    Magn Reson Med 62:17-25. 2009
    ..The short TE sequence enabled visualization of a variety of resonances, including glutamate, in both a control subject and a patient with a Grade II oligodendroglioma...
  19. ncbi request reprint Differentiation of glucose transport in human brain gray and white matter
    R A de Graaf
    Department of Radiology, Yale University, School of Medicine, New Haven, Connecticut 06520-8043, USA
    J Cereb Blood Flow Metab 21:483-92. 2001
    ..The regulation of glucose transport activity at the blood--brain barrier may be an important mechanism for maintaining glucose homeostasis throughout the cerebral cortex...
  20. pmc Hippocampal neurochemistry, neuromorphometry, and verbal memory in nondemented older adults
    M E Zimmerman
    Albert Einstein College of Medicine, Saul R Korey Department of Neurology, 1165 Morris Park Ave, Room 343, Bronx, NY 10461, USA
    Neurology 70:1594-600. 2008
    ..The objective of this study was to test the hypothesis that a measure of hippocampal neuronal metabolism was associated with verbal memory in nondemented older adults after controlling for hippocampal volume...
  21. ncbi request reprint Spectroscopic imaging of the pilocarpine model of human epilepsy suggests that early NAA reduction predicts epilepsy
    W A Gomes
    Department of Radiology, Montefiore Medical Center, Bronx, New York 10467, USA
    Magn Reson Med 58:230-5. 2007
    ..Therefore, spectroscopic imaging provides an early marker for metabolic dysfunction in this model of TLE...
  22. ncbi request reprint Regional energetic dysfunction in hippocampal epilepsy
    J W Pan
    Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Acta Neurol Scand 111:218-24. 2005
    ..To further describe this, we evaluated the bioenergetic status in unilateral MTLE inter-regionally and in relation to neuropathology...
  23. ncbi request reprint Metabolic differences between multiple sclerosis subtypes measured by quantitative MR spectroscopy
    J W Pan
    Department of Medicine, Brookhaven National Laboratory, State University of New York, Stony Brook, USA
    Mult Scler 8:200-6. 2002
    ..Thus, early PP disease appears to be relatively intact with respect to neuronal loss...
  24. ncbi request reprint Alkaline pH changes in the cerebellum of asymptomatic HIV-infected individuals
    H K Patton
    Department of Physiology and Biophysics, University of Alabama at Birmingham, 1918 University Boulevard, Birmingham, AL 35294-0005, USA
    NMR Biomed 14:12-8. 2001
    ..We hypothesize that this propensity towards alterations in cerebellar pH(i) may portend later neurological involvement resulting from HIV infection...

Research Grants1

  1. MRS Measurements of GABA in Temporal Lobe Epilepsy
    Hoby Hetherington; Fiscal Year: 2007
    ..Therefore the development of robust methods for measuring GABA from the temporal lobe in patients with temporal lobe epilepsy would be of significant benefit. [unreadable] [unreadable] [unreadable]..