Malini Harigopal

Summary

Affiliation: Yale University
Country: USA

Publications

  1. doi request reprint Estrogen receptor co-activator (AIB1) protein expression by automated quantitative analysis (AQUA) in a breast cancer tissue microarray and association with patient outcome
    Malini Harigopal
    Yale University School of Medicine, New Haven, CT 06510, USA
    Breast Cancer Res Treat 115:77-85. 2009
  2. doi request reprint Increasing cytotechnologist workload above 100 slides per day using the BD FocalPoint GS imaging system negatively affects screening performance
    Angelique W Levi
    Department of Pathology, Yale University, New Haven, CT 06519, USA
    Am J Clin Pathol 138:811-5. 2012
  3. ncbi request reprint Quantitative justification of the change from 10% to 30% for human epidermal growth factor receptor 2 scoring in the American Society of Clinical Oncology/College of American Pathologists guidelines: tumor heterogeneity in breast cancer and its implicatio
    Christopher B Moeder
    Department of Pathology, Yale University School of Medicine, New Haven, CT 06520 8023, USA
    J Clin Oncol 25:5418-25. 2007
  4. doi request reprint Implementation of FocalPoint GS location-guided imaging system: experience in a clinical setting
    Angelique W Levi
    Department of Pathology, Yale University, 430 Congress Avenue, New Haven, CT 06520, USA
    Cancer Cytopathol 120:126-33. 2012
  5. doi request reprint Use of high-risk human papillomavirus testing in patients with low-grade squamous intraepithelial lesions
    Angelique W Levi
    Department of Pathology, Yale University, New Haven, Connecticut, USA
    Cancer Cytopathol 119:228-34. 2011
  6. ncbi request reprint Classification of breast cancer using genetic algorithms and tissue microarrays
    Marisa Dolled-Filhart
    Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06520 8023, USA
    Clin Cancer Res 12:6459-68. 2006
  7. pmc Quantitative analysis of estrogen receptor expression shows SP1 antibody is more sensitive than 1D5
    Allison W Welsh
    Department of Pathology, Yale University School of Medicine, New Haven, CT 06520, USA
    Appl Immunohistochem Mol Morphol 21:139-47. 2013
  8. doi request reprint Comparing two methods of detection for Chlamydia trachomatis in liquid-based Papanicolaou tests
    Angelique W Levi
    Department of Pathology, Yale University, New Haven, CT, USA
    Am J Clin Pathol 138:236-40. 2012
  9. pmc Multiplexed assessment of the Southwest Oncology Group-directed Intergroup Breast Cancer Trial S9313 by AQUA shows that both high and low levels of HER2 are associated with poor outcome
    Malini Harigopal
    Department of Pathology, Yale University School of Medicine, New Haven, CT 06520 8023, USA
    Am J Pathol 176:1639-47. 2010
  10. doi request reprint The positive impact of simultaneous implementation of the BD FocalPoint GS Imaging System and lean principles on the operation of gynecologic cytology
    Rebecca Wong
    Department of Pathology, Yale University, New Haven, Connecticut 06525, USA
    Arch Pathol Lab Med 136:183-9. 2012

Collaborators

Detail Information

Publications21

  1. doi request reprint Estrogen receptor co-activator (AIB1) protein expression by automated quantitative analysis (AQUA) in a breast cancer tissue microarray and association with patient outcome
    Malini Harigopal
    Yale University School of Medicine, New Haven, CT 06510, USA
    Breast Cancer Res Treat 115:77-85. 2009
    ....
  2. doi request reprint Increasing cytotechnologist workload above 100 slides per day using the BD FocalPoint GS imaging system negatively affects screening performance
    Angelique W Levi
    Department of Pathology, Yale University, New Haven, CT 06519, USA
    Am J Clin Pathol 138:811-5. 2012
    ..Workloads were increased by decreasing the time spent reviewing 10 fields of view and the percentage of cases that underwent full manual review...
  3. ncbi request reprint Quantitative justification of the change from 10% to 30% for human epidermal growth factor receptor 2 scoring in the American Society of Clinical Oncology/College of American Pathologists guidelines: tumor heterogeneity in breast cancer and its implicatio
    Christopher B Moeder
    Department of Pathology, Yale University School of Medicine, New Haven, CT 06520 8023, USA
    J Clin Oncol 25:5418-25. 2007
    ..6-mm spot is equivalent to two to three high-power fields, we used TMAs to assess levels of heterogeneity and to determine optimal representation as a function of outcome...
  4. doi request reprint Implementation of FocalPoint GS location-guided imaging system: experience in a clinical setting
    Angelique W Levi
    Department of Pathology, Yale University, 430 Congress Avenue, New Haven, CT 06520, USA
    Cancer Cytopathol 120:126-33. 2012
    ....
  5. doi request reprint Use of high-risk human papillomavirus testing in patients with low-grade squamous intraepithelial lesions
    Angelique W Levi
    Department of Pathology, Yale University, New Haven, Connecticut, USA
    Cancer Cytopathol 119:228-34. 2011
    ..The objective of the current study was to correlate the status of HR HPV with the incidence of cervical intraepithelial neoplasia 2 and more severe lesions (CIN 2+) on tissue follow-up in women with LSIL...
  6. ncbi request reprint Classification of breast cancer using genetic algorithms and tissue microarrays
    Marisa Dolled-Filhart
    Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06520 8023, USA
    Clin Cancer Res 12:6459-68. 2006
    ..It would be ideal if the familiarity and streamlined nature of immunohistochemistry could be combined with the rigorously quantitative and highly specific properties of nucleic acid-based analysis to predict patient outcome...
  7. pmc Quantitative analysis of estrogen receptor expression shows SP1 antibody is more sensitive than 1D5
    Allison W Welsh
    Department of Pathology, Yale University School of Medicine, New Haven, CT 06520, USA
    Appl Immunohistochem Mol Morphol 21:139-47. 2013
    ..Future efforts are needed to determine whether response to endocrine therapies show superiority of either antibody as a companion diagnostic test...
  8. doi request reprint Comparing two methods of detection for Chlamydia trachomatis in liquid-based Papanicolaou tests
    Angelique W Levi
    Department of Pathology, Yale University, New Haven, CT, USA
    Am J Clin Pathol 138:236-40. 2012
    ..3% and 88.9% with the CTQ and HC2 assays, respectively. In this study, the CTQ assay was found to be more sensitive than the HC2 assay in detecting chlamydial infection; the CTQ assay also demonstrated a higher positive predictive value...
  9. pmc Multiplexed assessment of the Southwest Oncology Group-directed Intergroup Breast Cancer Trial S9313 by AQUA shows that both high and low levels of HER2 are associated with poor outcome
    Malini Harigopal
    Department of Pathology, Yale University School of Medicine, New Haven, CT 06520 8023, USA
    Am J Pathol 176:1639-47. 2010
    ..This assay method may provide a new companion diagnostic approach for targeted therapies...
  10. doi request reprint The positive impact of simultaneous implementation of the BD FocalPoint GS Imaging System and lean principles on the operation of gynecologic cytology
    Rebecca Wong
    Department of Pathology, Yale University, New Haven, Connecticut 06525, USA
    Arch Pathol Lab Med 136:183-9. 2012
    ..Our cytology laboratory, like many others, is under pressure to improve quality and provide test results faster while decreasing costs. We sought to address these issues by introducing new technology and lean principles...
  11. pmc Standardization of estrogen receptor measurement in breast cancer suggests false-negative results are a function of threshold intensity rather than percentage of positive cells
    Allison W Welsh
    Department of Pathology, BML 116, Yale University School of Medicine, 310 Cedar St, PO Box 208023, New Haven, CT, USA
    J Clin Oncol 29:2978-84. 2011
    ..Here we define a new method for standardization of ER measurement and then examine both change in percentage and threshold of intensity (immunoreactivity) to assess sources for test discordance...
  12. doi request reprint Methylation of twelve CpGs in human papillomavirus type 16 (HPV16) as an informative biomarker for the triage of women positive for HPV16 infection
    Janet L Brandsma
    Section of Comparative Medicine, Yale University School of Medicine, P O Box 8016, 310 Cedar Street, New Haven, Connecticut 06520 8016
    Cancer Prev Res (Phila) 7:526-33. 2014
    ..Our results support the prognostic potential of the HPV16 methylation biomarker for the triage to colposcopy of women with HPV16-positive screening tests and, eventually, for the management of women with HPV16-positive CIN2...
  13. ncbi request reprint Automated quantitative analysis of E-cadherin expression in lymph node metastases is predictive of survival in invasive ductal breast cancer
    Malini Harigopal
    Department of Pathology, Yale University School of Medicine, New Haven, Connecticut, USA
    Clin Cancer Res 11:4083-9. 2005
    ..We investigated the relationship between E-cadherin expression in primary invasive ductal tumors and corresponding nodal metastases, and determined the prognostic value of E-cadherin expression in node-positive breast cancer...
  14. pmc Distinct human papillomavirus type 16 methylomes in cervical cells at different stages of premalignancy
    Janet L Brandsma
    Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
    Virology 389:100-7. 2009
    ....
  15. ncbi request reprint Vascular endothelial growth factor, FLT-1, and FLK-1 analysis in a pancreatic cancer tissue microarray
    Gina G Chung
    Yale Cancer Center and Department of Internal Medicine, Section of Medical Oncology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Cancer 106:1677-84. 2006
    ....
  16. ncbi request reprint Molecular classification identifies a subset of human papillomavirus--associated oropharyngeal cancers with favorable prognosis
    Paul M Weinberger
    Department of Medical Oncology, Yale University School of Medicine, New Haven, CT, USA
    J Clin Oncol 24:736-47. 2006
    ..Retinoblastoma (Rb) downregulation by HPV E7 results in p16 upregulation. We hypothesized that p16 overexpression in OSCC defines HPV-induced tumors with favorable prognosis...
  17. pmc Automated measurement of estrogen receptor in breast cancer: a comparison of fluorescent and chromogenic methods of measurement
    Elizabeth R Zarrella
    Department of Pathology, Yale University School of Medicine, New Haven, CT, USA
    Lab Invest 96:1016-25. 2016
    ..These data support the usage of automated methods for measurement of this and other biomarkers that may be used in companion diagnostic tests...
  18. doi request reprint Cytoplasmic vacuolization: an under-recognized cytomorphologic feature in endocrine tumors of the pancreas
    Gillian H Levy
    Department of Pathology, Yale University School of Medicine, New Haven, CT 06520, USA
    Diagn Cytopathol 41:623-8. 2013
    ..Awareness of this rare cytomorphologic feature with application of immunocytochemical studies is crucial for rendering an accurate diagnosis and avoiding diagnostic pitfalls...
  19. doi request reprint Is Ki-67 expression prognostic for local relapse in early-stage breast cancer patients treated with breast conservation therapy (BCT)?
    Farhaan Hafeez
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut 06520 8040, USA
    Int J Radiat Oncol Biol Phys 87:344-8. 2013
    ..The purpose of this study was to assess Ki-67 expression in a cohort of early-stage breast cancer patients to determine whether a significant independent association between Ki-67 and locoregional relapse exists...
  20. doi request reprint Comparison of Affirm VPIII and Papanicolaou tests in the detection of infectious vaginitis
    Angelique W Levi
    Department of Pathology, Yale University, New Haven, CT, USA
    Am J Clin Pathol 135:442-7. 2011
    ....
  21. doi request reprint Littoral cell angioma of the spleen diagnosed by endoscopic ultrasound-guided fine-needle aspiration biopsy
    Priyadharsini Nagarajan
    Department of Pathology, Cytopathology, Yale University, School of Medicine, New Haven, CT, USA
    Diagn Cytopathol 39:318-22. 2011
    ..We suggest that EUS-FNAB is a safe and reliable method in the diagnosis of vascular lesions of the spleen...