- Neurotransmitter release - four years of SNARE complexesP I Hanson
Department of Pharmacology, 295 Congress Avenue, Yale University School of Medicine, New Haven, Connecticut 06510, USA
Curr Opin Neurobiol 7:310-5. 1997..Recent results have shed new light on the mechanisms underlying SNARE (SNAP receptor) complex assembly and disassembly, and suggest changes in models that relate these reactions to vesicle docking and fusion...
- Structure and conformational changes in NSF and its membrane receptor complexes visualized by quick-freeze/deep-etch electron microscopyP I Hanson
Department of Pharmacology and HHMI, Yale University School of Medicine, New Haven, CT 06510, USA
Cell 90:523-35. 1997..Together, these images suggest how NSF could dissociate the SNARE complex and how association and dissociation of the complex could be related to membrane fusion...
- The N-ethylmaleimide-sensitive fusion protein and alpha-SNAP induce a conformational change in syntaxinP I Hanson
Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
J Biol Chem 270:16955-61. 1995..This suggests that the conformational change normally induced by NSF in syntaxin depends on an interaction between carboxyl- and amino-terminal domains of syntaxin...
- Structure of the ATP-dependent oligomerization domain of N-ethylmaleimide sensitive factor complexed with ATPR C Yu
The Howard Hughes Medical Institute and Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520, USA
Nat Struct Biol 5:803-11. 1998..Of particular importance are three well-ordered and conserved lysine residues that form ionic interactions with the beta- and gamma-phosphates, one of which likely contributes to the low hydrolytic activity of D2...