Jean Dominique Gallezot

Summary

Affiliation: Yale University
Country: USA

Publications

  1. pmc Kinetic modeling of the serotonin 5-HT(1B) receptor radioligand [(11)C]P943 in humans
    Jean Dominique Gallezot
    PET Center, Department of Diagnostic Radiology, Yale University, New Haven, Connecticut, USA
    J Cereb Blood Flow Metab 30:196-210. 2010
  2. pmc Parametric Imaging and Test-Retest Variability of ¹¹C-(+)-PHNO Binding to D₂/D₃ Dopamine Receptors in Humans on the High-Resolution Research Tomograph PET Scanner
    Jean Dominique Gallezot
    PET Center, Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut
    J Nucl Med 55:960-6. 2014
  3. pmc Evaluation of [(11)C]MRB for assessment of occupancy of norepinephrine transporters: Studies with atomoxetine in non-human primates
    Jean Dominique Gallezot
    Department of Diagnostic Radiology, Yale University, New Haven, CT 06520, USA
    Neuroimage 56:268-79. 2011
  4. pmc Age effects on serotonin receptor 1B as assessed by PET
    David Matuskey
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Nucl Med 53:1411-4. 2012
  5. pmc Imaging robust microglial activation after lipopolysaccharide administration in humans with PET
    Christine M Sandiego
    Department of Psychiatry, Yale University, New Haven, CT 06511 PET Center, Diagnostic Radiology, Yale University, New Haven, CT 06520
    Proc Natl Acad Sci U S A 112:12468-73. 2015
  6. pmc Tracer kinetic modeling of [(11)C]AFM, a new PET imaging agent for the serotonin transporter
    Mika Naganawa
    Diagnostic Radiology, PET Center, Yale University School of Medicine, New Haven, Connecticut, USA
    J Cereb Blood Flow Metab 33:1886-96. 2013
  7. doi request reprint Test-retest reproducibility of the metabotropic glutamate receptor 5 ligand [¹⁸F]FPEB with bolus plus constant infusion in humans
    Eunkyung Park
    PET Center, Department of Diagnostic Radiology, Yale School of Medicine, 801 Howard Avenue, PO Box 208048, New Haven, CT, 06520 8048, USA
    Eur J Nucl Med Mol Imaging 42:1530-41. 2015
  8. pmc PET imaging of the effects of age and cocaine on the norepinephrine transporter in the human brain using (S,S)-[(11)C]O-methylreboxetine and HRRT
    Yu Shin Ding
    Yale PET Center, Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut 06520 8048, USA
    Synapse 64:30-8. 2010
  9. pmc Decreased norepinephrine transporter availability in obesity: Positron Emission Tomography imaging with (S,S)-[(11)C]O-methylreboxetine
    Chiang Shan R Li
    Department of Psychiatry, Yale University, New Haven, CT, USA Department of Neurobiology, Yale University, New Haven, CT, USA Interdepartmental Neuroscience Program, Yale University, New Haven, CT, USA
    Neuroimage 86:306-10. 2014
  10. doi request reprint Affinity and selectivity of [¹¹C]-(+)-PHNO for the D3 and D2 receptors in the rhesus monkey brain in vivo
    Jean Dominique Gallezot
    PET Center, Department of Diagnostic Radiology, Yale University, New Haven, Connecticut, USA
    Synapse 66:489-500. 2012

Collaborators

Detail Information

Publications31

  1. pmc Kinetic modeling of the serotonin 5-HT(1B) receptor radioligand [(11)C]P943 in humans
    Jean Dominique Gallezot
    PET Center, Department of Diagnostic Radiology, Yale University, New Haven, Connecticut, USA
    J Cereb Blood Flow Metab 30:196-210. 2010
    ..Parametric images of the volume of distribution or binding potential of [(11)C]P943 could be computed using both MA1 and MRTM2. The results show that [(11)C]P943 provides quantitative measurements of 5-HT(1B) binding potential...
  2. pmc Parametric Imaging and Test-Retest Variability of ¹¹C-(+)-PHNO Binding to D₂/D₃ Dopamine Receptors in Humans on the High-Resolution Research Tomograph PET Scanner
    Jean Dominique Gallezot
    PET Center, Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut
    J Nucl Med 55:960-6. 2014
    ..In this study we evaluated the reproducibility of (11)C-(+)-PHNO binding parameters using a within-day design and assessed parametric imaging methods...
  3. pmc Evaluation of [(11)C]MRB for assessment of occupancy of norepinephrine transporters: Studies with atomoxetine in non-human primates
    Jean Dominique Gallezot
    Department of Diagnostic Radiology, Yale University, New Haven, CT 06520, USA
    Neuroimage 56:268-79. 2011
    ..The IC(50) estimate obtained using MRTM2 BP(ND) without arterial blood sampling was 21 ± 3ng/mL (using caudate as the reference region). This study demonstrated that [(11)C]MRB is suitable for drug occupancy studies of NET...
  4. pmc Age effects on serotonin receptor 1B as assessed by PET
    David Matuskey
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Nucl Med 53:1411-4. 2012
    ..This paper addresses whether the availability of 5-hydroxytryptamine receptor 1B (5-HT(1B)) is seen to decrease with aging via PET imaging...
  5. pmc Imaging robust microglial activation after lipopolysaccharide administration in humans with PET
    Christine M Sandiego
    Department of Psychiatry, Yale University, New Haven, CT 06511 PET Center, Diagnostic Radiology, Yale University, New Haven, CT 06520
    Proc Natl Acad Sci U S A 112:12468-73. 2015
    ..This imaging paradigm to measure brain microglial activation with [11C]PBR28 PET provides an approach to test new medications in humans for their putative antiinflammatory effects...
  6. pmc Tracer kinetic modeling of [(11)C]AFM, a new PET imaging agent for the serotonin transporter
    Mika Naganawa
    Diagnostic Radiology, PET Center, Yale University School of Medicine, New Haven, Connecticut, USA
    J Cereb Blood Flow Metab 33:1886-96. 2013
    ..The MA1 and MRTM2 methods were best for parametric imaging. These results showed that [(11)C]AFM is a suitable PET radioligand to image and quantify SERT in humans. ..
  7. doi request reprint Test-retest reproducibility of the metabotropic glutamate receptor 5 ligand [¹⁸F]FPEB with bolus plus constant infusion in humans
    Eunkyung Park
    PET Center, Department of Diagnostic Radiology, Yale School of Medicine, 801 Howard Avenue, PO Box 208048, New Haven, CT, 06520 8048, USA
    Eur J Nucl Med Mol Imaging 42:1530-41. 2015
    ..The purpose of this study was to evaluate the test-retest reproducibility of [(18)F]FPEB in the human brain...
  8. pmc PET imaging of the effects of age and cocaine on the norepinephrine transporter in the human brain using (S,S)-[(11)C]O-methylreboxetine and HRRT
    Yu Shin Ding
    Yale PET Center, Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut 06520 8048, USA
    Synapse 64:30-8. 2010
    ....
  9. pmc Decreased norepinephrine transporter availability in obesity: Positron Emission Tomography imaging with (S,S)-[(11)C]O-methylreboxetine
    Chiang Shan R Li
    Department of Psychiatry, Yale University, New Haven, CT, USA Department of Neurobiology, Yale University, New Haven, CT, USA Interdepartmental Neuroscience Program, Yale University, New Haven, CT, USA
    Neuroimage 86:306-10. 2014
    ..Here we report findings evaluating NET availability in individuals with obesity and matched lean (i.e., normal weight) comparison subjects...
  10. doi request reprint Affinity and selectivity of [¹¹C]-(+)-PHNO for the D3 and D2 receptors in the rhesus monkey brain in vivo
    Jean Dominique Gallezot
    PET Center, Department of Diagnostic Radiology, Yale University, New Haven, Connecticut, USA
    Synapse 66:489-500. 2012
    ..01-0.02 μg kg⁻¹ for awake human positron emission tomography (PET) studies. Our data enabled a rational design and interpretation of future PET studies with [¹¹C]-(+)-PHNO...
  11. pmc Evaluation of [(18)F]-(-)-norchlorofluorohomoepibatidine ([(18)F]-(-)-NCFHEB) as a PET radioligand to image the nicotinic acetylcholine receptors in non-human primates
    Frederic Bois
    PET Center, Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, CT, USA Electronic address
    Nucl Med Biol 42:570-7. 2015
    ....
  12. pmc Measurement of Bmax and Kd with the glycine transporter 1 radiotracer (18)F-MK6577 using a novel multi-infusion paradigm
    Yan Xia
    PET Center, Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut, USA
    J Cereb Blood Flow Metab 35:2001-9. 2015
    ..These in vivo Kd and Bmax values agreed well with those determined in vitro, thus validating our novel multi-infusion approach. ..
  13. pmc Test-retest reproducibility of [11C]-(+)-propyl-hexahydro-naphtho-oxazin positron emission tomography using the bolus plus constant infusion paradigm
    Dianne E Lee
    Department of Psychiatry, Yale University School of Medicine, Yale University, New Haven, CT 06516, USA
    Mol Imaging 12:77-82. 2013
    ..88 and 0.82, respectively). These studies support the reproducibility of the bolus plus constant infusion paradigm with [11C]-(+)-PHNO PET...
  14. pmc Clinically relevant doses of methylphenidate significantly occupy norepinephrine transporters in humans in vivo
    Jonas Hannestad
    Department of Psychiatry, Yale PET Center, Yale University School of Medicine, New Haven, Connecticut, USA
    Biol Psychiatry 68:854-60. 2010
    ..The goal of this study was to use positron emission tomography to measure the occupancy of brain norepinephrine transporter by methylphenidate in vivo in humans...
  15. pmc Serotonin 1B receptor imaging in alcohol dependence
    Jian Hu
    Molecular Imaging Program, Clinical Neurosciences Division, VA National Center for PTSD, VA Connecticut Healthcare System, West Haven, Connecticut, USA
    Biol Psychiatry 67:800-3. 2010
    ..Because of its central role in AD, we were particularly interested in ventral striatal 5-HT(1B)R BP(ND) values...
  16. pmc Imaging nicotine- and amphetamine-induced dopamine release in rhesus monkeys with [(11)C]PHNO vs [(11)C]raclopride PET
    Jean Dominique Gallezot
    Department of Diagnostic Radiology, Yale PET Center, Yale University School of Medicine, New Haven, CT, USA
    Neuropsychopharmacology 39:866-74. 2014
    ..We confirmed that [(11)C]PHNO is more sensitive than [(11)C]raclopride to nicotine- and amphetamine-induced DA release. [(11)C]PHNO PET may be more sensitive to measuring tobacco smoking-induced DA release in human tobacco smokers...
  17. pmc Association of posttraumatic stress disorder with reduced in vivo norepinephrine transporter availability in the locus coeruleus
    Robert H Pietrzak
    Clinical Neurosciences Division, National Center for Posttraumatic Stress Disorder, Veterans Affairs Connecticut Healthcare System, West Haven2Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut
    JAMA Psychiatry 70:1199-205. 2013
    ..However, it is unclear whether such models are relevant to posttraumatic stress disorder (PTSD), which has been linked to noradrenergic dysfunction in humans...
  18. pmc A preliminary study of dopamine D2/3 receptor availability and social status in healthy and cocaine dependent humans imaged with [(11)C](+)PHNO
    David Matuskey
    Department of Diagnostic Radiology, Yale University, New Haven, CT, United States Department of Psychiatry, Yale University, New Haven, CT, United States Electronic address
    Drug Alcohol Depend 154:167-73. 2015
    ..This exploratory study examined the relationship between social status and D2/3R availability in healthy (HH) and cocaine dependent (CD) humans using the D3-preferring, agonist radioligand, [(11)C](+)PHNO...
  19. pmc Evaluation of the sensitivity of the novel α4β2* nicotinic acetylcholine receptor PET radioligand 18F-(-)-NCFHEB to increases in synaptic acetylcholine levels in rhesus monkeys
    Jean Dominique Gallezot
    Department of Diagnostic Radiology, Yale University, New Haven, Connecticut
    Synapse 68:556-64. 2014
    ..The goal of this study was to assess the sensitivity of 18F-(-)-NCFHEB-PET to increases in synaptic acetylcholine concentration induced by acetylcholinesterase inhibitors...
  20. pmc Endotoxin-induced systemic inflammation activates microglia: [¹¹C]PBR28 positron emission tomography in nonhuman primates
    Jonas Hannestad
    Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA
    Neuroimage 63:232-9. 2012
    ..The aim of this study was to evaluate whether the effect of systemic inflammation on microglia could be measured with PET imaging in nonhuman primates, using the TSPO ligand [(11)C]PBR28...
  21. pmc Dopamine D₃ receptor alterations in cocaine-dependent humans imaged with [¹¹C](+)PHNO
    David Matuskey
    Department of Psychiatry, Yale University, New Haven, CT, USA Department of Diagnostic Radiology, Yale University, New Haven, CT, USA Electronic address
    Drug Alcohol Depend 139:100-5. 2014
    ..The objective of this pilot study was to use the D₃R-preferring radioligand [(11)C](+)PHNO to compare receptor availability in groups with and without CD...
  22. pmc Serotonin 1B receptor imaging in pathological gambling
    Marc N Potenza
    Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
    World J Biol Psychiatry 14:139-45. 2013
    ....
  23. pmc Ex vivo and in vivo evaluation of the norepinephrine transporter ligand [11C]MRB for brown adipose tissue imaging
    Shu Fei Lin
    PET Center, Department of Diagnostic Radiology, Yale University, New Haven, CT 06520, USA
    Nucl Med Biol 39:1081-6. 2012
    ..We conducted ex vivo and in vivo evaluation using [(11)C]MRB, a highly selective NET (norepinephrine transporter) ligand for BAT imaging at room temperature, which is not achievable with [(18)F]FDG...
  24. pmc Age-related changes in binding of the D2/3 receptor radioligand [(11)C](+)PHNO in healthy volunteers
    David Matuskey
    Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA Department of Psychiatry, Yale University, New Haven, CT, USA Electronic address
    Neuroimage 130:241-7. 2016
    ..This study sought to investigate whether the receptor availability measured with [(11)C](+)PHNO, a D3R-preferring agonist radiotracer, also declines with age...
  25. pmc Reference region modeling approaches for amphetamine challenge studies with [11C]FLB 457 and PET
    Christine M Sandiego
    1 Department of Psychiatry, Yale University, New Haven, Connecticut, USA 2 Department of Diagnostic Radiology, Yale University, New Haven, Connecticut, USA
    J Cereb Blood Flow Metab 35:623-9. 2015
    ..These data support the sensitivity of [(11)C]FLB 457 for measuring amphetamine-induced dopamine release in extrastriatal regions with SRTM and SRTM2...
  26. pmc Further evaluation of [11C]MP-10 as a radiotracer for phosphodiesterase 10A: PET imaging study in rhesus monkeys and brain tissue metabolite analysis
    Shu Fei Lin
    Department of Diagnostic Radiology, PET Center, Yale University School of Medicine, New Haven, Connecticut
    Synapse 69:86-95. 2015
    ..In summary, results from the present study strongly support the suitability of [(11)C]MP-10 as a radiotracer for PET imaging and quantification of PDE10A in nonhuman primates...
  27. pmc OCD is associated with an altered association between sensorimotor gating and cortical and subcortical 5-HT1b receptor binding
    Christopher Pittenger
    Department of Psychiatry, Yale University School of Medicine, USA Department of Psychology, Yale University School of Medicine, USA Child Study Center, Yale University School of Medicine, USA Interdepartmental Neuroscience Program, Yale University School of Medicine, USA Electronic address
    J Affect Disord 196:87-96. 2016
    ..Differential associations of 5-HT1B receptor availability with PPI in patients suggest functionally important alterations in the serotonergic regulation of cortical/subcortical balance in OCD. ..
  28. doi request reprint (11)C-PBR28 imaging in multiple sclerosis patients and healthy controls: test-retest reproducibility and focal visualization of active white matter areas
    Eunkyung Park
    PET Center, Department of Diagnostic Radiology, Yale School of Medicine, 801 Howard Avenue, PO Box 208048, New Haven, CT, 06520 8048, USA
    Eur J Nucl Med Mol Imaging 42:1081-92. 2015
    ..We evaluated the test-retest variability (TRV) and lesion detectability of (11)C-PBR28 binding in MS subjects and healthy controls (HCs) with high-resolution PET...
  29. doi request reprint Test-retest reliability of the novel 5-HT1B receptor PET radioligand [11C]P943
    Aybala Saricicek
    Department of Psychiatry, Yale University, New Haven, CT, USA
    Eur J Nucl Med Mol Imaging 42:468-77. 2015
    ..The aim of this study was to determine the test-retest reliability of [(11)C]P943 using two different modeling methods and to perform a power analysis with each quantification technique...
  30. pmc Histidine decarboxylase deficiency causes tourette syndrome: parallel findings in humans and mice
    Lissandra Castellan Baldan
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06520, USA
    Neuron 81:77-90. 2014
    ..These data confirm histidine decarboxylase deficiency as a rare cause of TS and identify HA-DA interactions in the basal ganglia as an important locus of pathology. ..
  31. pmc Evaluation of motion correction methods in human brain PET imaging--a simulation study based on human motion data
    Xiao Jin
    Biomedical Engineering, Yale University, New Haven, Connecticut 06520
    Med Phys 40:102503. 2013
    ..Motion correction in PET has become more important as system resolution has improved. The purpose of this study was to evaluate the accuracy of event-by-event and frame-based MC methods in human brain PET imaging...