Michael A Choma
Affiliation: Yale University
- A novel approach to quantifying ciliary physiology: microfluidic mixing driven by a ciliated biological surfaceStephan Jonas
Dept of Diagnostic Radiology, Yale University, New Haven, CT, USA
Lab Chip 13:4160-3. 2013..Here, we report a novel microfluidic approach for quantifying the performance of a ciliated surface using mixing performance as an integrated readout. ..
- Heart wall velocimetry and exogenous contrast-based cardiac flow imaging in Drosophila melanogaster using Doppler optical coherence tomographyMichael A Choma
Children s Hospital Boston, and Harvard Medical School, Department of Pediatrics, Boston, Massachusetts 02115, USA
J Biomed Opt 15:056020. 2010..The results presented here open up new possibilities for functional cardiovascular phenotyping of normal and mutant D. melanogaster...
- Physiological homology between Drosophila melanogaster and vertebrate cardiovascular systemsMichael A Choma
Children s Hospital Boston, Boston, MA 02115, USA
Dis Model Mech 4:411-20. 2011..Our results demonstrate physiological homology and support the use of D. melanogaster as an animal model of complex cardiovascular disease...
- Spatial coherence of random laser emissionBrandon Redding
Department of Applied Physics, Yale University, New Haven, Connecticut 06511, USA
Opt Lett 36:3404-6. 2011..This work demonstrates that random lasers can be controlled to provide intense, spatially incoherent emission for applications in which spatial cross talk or speckle limit performance...
- Endogenous contrast blood flow imaging in embryonic hearts using hemoglobin contrast subtraction angiographyEngin Deniz
Department of Pediatrics, Yale University, 333 Cedar Street, New Haven, Connecticut 06510, USA
Opt Lett 37:2979-81. 2012..We demonstrated that hemoglobin contrast angiography can be used to quantify physiological response to treatment with well-established cardioactive drugs...
- Quantitative optical coherence tomography imaging of intermediate flow defect phenotypes in ciliary physiology and pathophysiologyBrendan K Huang
Yale University, Department of Biomedical Engineering, 55 Prospect Street, New Haven, Connecticut 06511, United States
J Biomed Opt 20:030502. 2015..Of note, we demonstrate decreased flow secondary to gene knockdown of kif3a, a protein involved in ciliogenesis, as well as a dose-response decrease in flow secondary to knockdown of dnah9, an important ciliary motor protein...
- Quantifying hyperoxia-mediated damage to mammalian respiratory cilia-driven fluid flow using particle tracking velocimetry optical coherence tomographyUte A Gamm
Yale University, Department of Diagnostic Radiology, P O Box 208043, New Haven, Connecticut 06520, United States
J Biomed Opt 20:80505. 2015..Overall, PTV-OCT imaging of cilia-driven fluid flow in ex vivo mouse trachea is a powerful and straightforward approach for studying factors that modulate and damage mammalian respiratory ciliary physiology...
- Target-of-rapamycin complex 1 (Torc1) signaling modulates cilia size and function through protein synthesis regulationShiaulou Yuan
Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA
Proc Natl Acad Sci U S A 109:2021-6. 2012..Our findings reveal a unique role for the TOR pathway in regulating cilia size through protein synthesis and suggest that appropriate and defined lengths are necessary for proper function of the cilium...