R D Bungiro

Summary

Affiliation: Yale University
Country: USA

Publications

  1. ncbi request reprint Ancylostoma ceylanicum excretory/secretory protein 1: purification and molecular cloning of a major secretory protein from adult hookworms
    Richard D Bungiro
    Division of Infectious Diseases, Department of Pediatrics, Child Health Research Center, Yale School of Medicine, 464 Congress Avenue, New Haven, CT 06520 8081, USA
    Mol Biochem Parasitol 119:147-51. 2002
  2. ncbi request reprint Detection of excretory/secretory coproantigens in experimental hookworm infection
    Richard D Bungiro
    Program in International Child Health, Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06520 8081, USA
    Am J Trop Med Hyg 73:915-20. 2005
  3. ncbi request reprint Mucosal antibody responses in experimental hookworm infection
    R D Bungiro
    Program in International Child Health, Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520, USA
    Parasite Immunol 30:293-303. 2008
  4. pmc Oral transfer of adult Ancylostoma ceylanicum hookworms into permissive and nonpermissive host species
    Richard D Bungiro
    Infectious Diseases Section, Department of Pediatrics, Yale Child Health Research Center, Yale University School of Medicine, PO Box 208081, New Haven, CA 06520 8081, USA
    Infect Immun 71:1880-6. 2003
  5. pmc Purification and molecular cloning of and immunization with Ancylostoma ceylanicum excretory-secretory protein 2, an immunoreactive protein produced by adult hookworms
    Richard D Bungiro
    Child Health Research Center, Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06520 8081, USA
    Infect Immun 72:2203-13. 2004
  6. pmc CD4 T cells mediate mucosal and systemic immune responses to experimental hookworm infection
    B Dondji
    Program in International Child Health, Department of Pediatrics, Yale University School of Medicine, New Haven CT, USA
    Parasite Immunol 32:406-13. 2010
  7. ncbi request reprint Mitigation of hookworm disease by immunization with soluble extracts of Ancylostoma ceylanicum
    R D Bungiro
    Department of Pediatrics, Infectious Diseases Section, Yale Child Health Research Center, Yale University School of Medicine, New Haven, CT 06520-8081, USA
    J Infect Dis 183:1380-7. 2001
  8. pmc Molecular characterization of Ancylostoma ceylanicum Kunitz-type serine protease inhibitor: evidence for a role in hookworm-associated growth delay
    Daniel Chu
    Child Health Research Center, Department of Pediatrics, Yale School of Medicine, New Haven, Connecticut 06520 8081, USA
    Infect Immun 72:2214-21. 2004
  9. pmc A purified Bacillus thuringiensis crystal protein with therapeutic activity against the hookworm parasite Ancylostoma ceylanicum
    Michael Cappello
    Program in International Child Health, Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 103:15154-9. 2006
  10. pmc Role for nitric oxide in hookworm-associated immune suppression
    Blaise Dondji
    Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520, USA
    Infect Immun 76:2560-7. 2008

Research Grants

  1. Mucosal Immune Responses in Hookworm Infection
    Richard Bungiro; Fiscal Year: 2006

Collaborators

  • L M Harrison
  • J J Vermeire
  • Diane McMahon-Pratt
  • Michael Cappello
  • B Dondji
  • Blaise Dondji
  • Melissa R Held
  • Daniel Chu
  • M Cappello
  • T Sun
  • C Bifulco
  • Carlo Bifulco
  • Larry J Bischof
  • Iqbal Hamza
  • Brad D Barrows
  • Joel S Griffitts
  • Raffi V Aroian
  • Brian F Jones
  • Juliusz Mieszczanek
  • Maureen Ibanez
  • Eva Campodonico
  • Petr Kuzmic

Detail Information

Publications12

  1. ncbi request reprint Ancylostoma ceylanicum excretory/secretory protein 1: purification and molecular cloning of a major secretory protein from adult hookworms
    Richard D Bungiro
    Division of Infectious Diseases, Department of Pediatrics, Child Health Research Center, Yale School of Medicine, 464 Congress Avenue, New Haven, CT 06520 8081, USA
    Mol Biochem Parasitol 119:147-51. 2002
  2. ncbi request reprint Detection of excretory/secretory coproantigens in experimental hookworm infection
    Richard D Bungiro
    Program in International Child Health, Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06520 8081, USA
    Am J Trop Med Hyg 73:915-20. 2005
    ..Examination of individual hookworm antigens by this method will provide new insights into the molecular host-parasite interaction and may form the basis for future diagnostic methods...
  3. ncbi request reprint Mucosal antibody responses in experimental hookworm infection
    R D Bungiro
    Program in International Child Health, Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520, USA
    Parasite Immunol 30:293-303. 2008
    ..Together these results suggest that secretory IgA may act in concert with other components of the mucosal and systemic immune response to promote protective immunity against hookworm infection and/or disease...
  4. pmc Oral transfer of adult Ancylostoma ceylanicum hookworms into permissive and nonpermissive host species
    Richard D Bungiro
    Infectious Diseases Section, Department of Pediatrics, Yale Child Health Research Center, Yale University School of Medicine, PO Box 208081, New Haven, CA 06520 8081, USA
    Infect Immun 71:1880-6. 2003
    ..The technique of AWT to mice may further our understanding of hookworm pathogenesis by allowing the study of adult hookworm infections in a species with well-characterized genetics and an abundance of available reagents...
  5. pmc Purification and molecular cloning of and immunization with Ancylostoma ceylanicum excretory-secretory protein 2, an immunoreactive protein produced by adult hookworms
    Richard D Bungiro
    Child Health Research Center, Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06520 8081, USA
    Infect Immun 72:2203-13. 2004
    ..These data suggest that AceES-2 plays an important role in the host-parasite interaction and that vaccination against this protein may represent a useful strategy for controlling hookworm anemia...
  6. pmc CD4 T cells mediate mucosal and systemic immune responses to experimental hookworm infection
    B Dondji
    Program in International Child Health, Department of Pediatrics, Yale University School of Medicine, New Haven CT, USA
    Parasite Immunol 32:406-13. 2010
    ..Ultimately, these studies may yield important insights into the relationship between intestinal nematode infections and diseases that are associated with CD4(+) T-cell depletion, including HIV...
  7. ncbi request reprint Mitigation of hookworm disease by immunization with soluble extracts of Ancylostoma ceylanicum
    R D Bungiro
    Department of Pediatrics, Infectious Diseases Section, Yale Child Health Research Center, Yale University School of Medicine, New Haven, CT 06520-8081, USA
    J Infect Dis 183:1380-7. 2001
    ..This intriguing result may have important implications for human vaccine development...
  8. pmc Molecular characterization of Ancylostoma ceylanicum Kunitz-type serine protease inhibitor: evidence for a role in hookworm-associated growth delay
    Daniel Chu
    Child Health Research Center, Department of Pediatrics, Yale School of Medicine, New Haven, Connecticut 06520 8081, USA
    Infect Immun 72:2214-21. 2004
    ..Taken together, the data suggest that AceKI plays a role in the pathogenesis of hookworm-associated malnutrition and growth delay, perhaps through inhibition of nutrient absorption in infected hosts...
  9. pmc A purified Bacillus thuringiensis crystal protein with therapeutic activity against the hookworm parasite Ancylostoma ceylanicum
    Michael Cappello
    Program in International Child Health, Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 103:15154-9. 2006
    ..These data demonstrate that Cry5B is highly active in vitro and in vivo against a globally significant nematode parasite and that Cry5B warrants further clinical development for human and veterinary use...
  10. pmc Role for nitric oxide in hookworm-associated immune suppression
    Blaise Dondji
    Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520, USA
    Infect Immun 76:2560-7. 2008
    ....
  11. pmc Dietary iron content mediates hookworm pathogenesis in vivo
    Melissa R Held
    Program in International Child Health, Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520, USA
    Infect Immun 74:289-95. 2006
    ..These data suggest that severe dietary iron restriction impairs hookworm development in vivo but that moderate iron restriction enhances host susceptibility to severe disease...
  12. ncbi request reprint Molecular characterization of Ancylostoma inhibitors of coagulation factor Xa. Hookworm anticoagulant activity in vitro predicts parasite bloodfeeding in vivo
    Lisa M Harrison
    Yale Child Health Research Center, Division of Infectious Diseases, Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06520 8081, USA
    J Biol Chem 277:6223-9. 2002
    ..These fundamental differences in the mechanism of action and immunoreactivity of the major anticoagulant virulence factors from related Ancylostoma hookworm species may have significant implications for human vaccine development...

Research Grants1

  1. Mucosal Immune Responses in Hookworm Infection
    Richard Bungiro; Fiscal Year: 2006
    ..These studies are expected to further our understanding of host-parasite immunological interaction and advance hookworm vaccine research through the development of novel immunization techniques. ..