Y Zhang

Summary

Affiliation: Wyeth Research
Country: USA

Publications

  1. pmc Recombinant PhpA protein, a unique histidine motif-containing protein from Streptococcus pneumoniae, protects mice against intranasal pneumococcal challenge
    Y Zhang
    Department of Immunology, Wyeth Lederle Vaccines, West Henrietta, New York 14586 9728, USA
    Infect Immun 69:3827-36. 2001
  2. ncbi Passive immunization with Neisseria meningitidis PorA specific immune sera reduces nasopharyngeal colonization of group B meningococcus in an infant rat nasal challenge model
    S Schmidt
    Wyeth-Lederle Vaccines, 211 Bailey Road, West Henrietta, NY 14586, USA
    Vaccine 19:4851-8. 2001
  3. pmc The influence of competition and vaccination on the coexistence of two pneumococcal serotypes
    Y Zhang
    Department of Medical Biometry, University of Tuebingen, Tuebingen, Germany
    Epidemiol Infect 132:1073-81. 2004
  4. pmc Immunodominant major outer membrane proteins of Ehrlichia chaffeensis are encoded by a polymorphic multigene family
    N Ohashi
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus 43210 1093, USA
    Infect Immun 66:132-9. 1998
  5. ncbi Acetylenic TACE inhibitors. Part 2: SAR of six-membered cyclic sulfonamide hydroxamates
    J I Levin
    Wyeth Research, 401N Middletown Road, Pearl River, NY 10965, USA
    Bioorg Med Chem Lett 15:4345-9. 2005
  6. ncbi Therapeutic potential of TACE inhibitors in stroke
    F Lovering
    Wyeth Research, Cambridge, MA 02140, USA
    Curr Drug Targets CNS Neurol Disord 4:161-8. 2005
  7. ncbi Conservation of structure and function between human and murine IL-16
    J Keane
    The Pulmonary Center, Boston University School of Medicine, MA 02118, USA
    J Immunol 160:5945-54. 1998
  8. ncbi Acetylenic TACE inhibitors. Part 1. SAR of the acyclic sulfonamide hydroxamates
    J I Levin
    Wyeth Research, 401 N Middletown Rd, Pearl River, NY 10965, USA
    Bioorg Med Chem Lett 13:2799-803. 2003
  9. ncbi The regulatory effect of ERK1/2 signal pathway on production of TNFalpha induced by LPS in mice Kupffer cells
    Y Zhang
    Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042, China
    Chin J Traumatol 4:139-42. 2001
  10. ncbi MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex
    H H Ng
    Institute of Cell and Molecular Biology, University of Edinburgh, The King s Buildings, Edinburgh EH9 3JR, UK
    Nat Genet 23:58-61. 1999

Collaborators

Detail Information

Publications62

  1. pmc Recombinant PhpA protein, a unique histidine motif-containing protein from Streptococcus pneumoniae, protects mice against intranasal pneumococcal challenge
    Y Zhang
    Department of Immunology, Wyeth Lederle Vaccines, West Henrietta, New York 14586 9728, USA
    Infect Immun 69:3827-36. 2001
    ..In contrast, immunization with the 20-kDa portion of the PhpA protein did not protect mice. These results suggest that rPhpA-79 is a potential candidate for use as a vaccine against pneumococcal systemic disease and otitis media...
  2. ncbi Passive immunization with Neisseria meningitidis PorA specific immune sera reduces nasopharyngeal colonization of group B meningococcus in an infant rat nasal challenge model
    S Schmidt
    Wyeth-Lederle Vaccines, 211 Bailey Road, West Henrietta, NY 14586, USA
    Vaccine 19:4851-8. 2001
    ..meningitidis colonization in the nasal tissues of these animals. These results demonstrate that this model can be utilized to evaluate the role of antibody to prevent the initial nasopharyngeal colonization by group B meningococcus...
  3. pmc The influence of competition and vaccination on the coexistence of two pneumococcal serotypes
    Y Zhang
    Department of Medical Biometry, University of Tuebingen, Tuebingen, Germany
    Epidemiol Infect 132:1073-81. 2004
    ..These results emphasize the importance of studying whether bacteria compete directly or indirectly and for how long people are protected in order to assess the long-term effects of sero-competition...
  4. pmc Immunodominant major outer membrane proteins of Ehrlichia chaffeensis are encoded by a polymorphic multigene family
    N Ohashi
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus 43210 1093, USA
    Infect Immun 66:132-9. 1998
    ..chaffeensis. These findings suggest that the 30-kDa-range proteins of E. chaffeensis represent a family of antigenically related homologous proteins encoded by a single gene family...
  5. ncbi Acetylenic TACE inhibitors. Part 2: SAR of six-membered cyclic sulfonamide hydroxamates
    J I Levin
    Wyeth Research, 401N Middletown Road, Pearl River, NY 10965, USA
    Bioorg Med Chem Lett 15:4345-9. 2005
    ..In particular, compound 5k has excellent in vitro potency against TACE enzyme and in cells, and oral activity in an in vivo model of TNF-alpha production and a collagen-induced arthritis model...
  6. ncbi Therapeutic potential of TACE inhibitors in stroke
    F Lovering
    Wyeth Research, Cambridge, MA 02140, USA
    Curr Drug Targets CNS Neurol Disord 4:161-8. 2005
    ..The data strongly suggest that TACE/MMP inhibitors have great therapeutic potential and may be valuable alternatives in treating stroke in the clinic...
  7. ncbi Conservation of structure and function between human and murine IL-16
    J Keane
    The Pulmonary Center, Boston University School of Medicine, MA 02118, USA
    J Immunol 160:5945-54. 1998
    ..The data suggest cross-species conservation of IL-16 receptor structures as well. Inhibitory peptides may be useful in disease states where the proinflammatory functions of IL-16 are detrimental to the host...
  8. ncbi Acetylenic TACE inhibitors. Part 1. SAR of the acyclic sulfonamide hydroxamates
    J I Levin
    Wyeth Research, 401 N Middletown Rd, Pearl River, NY 10965, USA
    Bioorg Med Chem Lett 13:2799-803. 2003
    ....
  9. ncbi The regulatory effect of ERK1/2 signal pathway on production of TNFalpha induced by LPS in mice Kupffer cells
    Y Zhang
    Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042, China
    Chin J Traumatol 4:139-42. 2001
    ..PD98059 causes a significant and concentration-dependent reduction of TNFalpha production. ERK1/2 may be a novel target to treat clinical patient of endotoxemia...
  10. ncbi MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex
    H H Ng
    Institute of Cell and Molecular Biology, University of Edinburgh, The King s Buildings, Edinburgh EH9 3JR, UK
    Nat Genet 23:58-61. 1999
    ..12). In our hands, MBD2 does not demethylate DNA. Our data suggest that HeLa cells, which lack the known methylation-dependent repressor MeCP2, use an alternative pathway involving MBD2 to silence methylated genes...
  11. ncbi Elongation factor Ts of Chlamydia trachomatis: structure of the gene and properties of the protein
    Y Zhang
    Maxwell Finland Laboratory for Infectious Diseases, Boston Medical Center, Boston University School of Medicine, Massachusetts 02118, USA
    Arch Biochem Biophys 344:43-52. 1997
    ..coli elongation factor Tu (EF-Tu). These data show that the second gene of the identified cluster is tsf. Unlike EF-Ts from any other species, its activity was comparable to that of E. coli EF-Ts in exchange reaction with E. coli EF-Tu...
  12. ncbi Comparison of lipopolysaccharide and protein profiles between Flavobacterium columnare strains from different genomovars
    Y Zhang
    Department of Fisheries and Allied Aquacultures, Auburn University, Auburn, AL 36849, USA
    J Fish Dis 29:657-63. 2006
    ..Based on the difference of LPS and total protein profiles, it is possible to discriminate the attenuated mutant FC-RR from other F. columnare strains...
  13. ncbi Different subtypes of alpha1-adrenoceptor modulate different K+ currents via different signaling pathways in canine ventricular myocytes
    H Wang
    Research Center, Montreal Heart Institute, Montreal, Quebec H1T 1C8, Canada
    J Biol Chem 276:40811-6. 2001
    ....
  14. ncbi Cloning of the nupC gene of Escherichia coli encoding a nucleoside transport system, and identification of an adjacent insertion element, IS 186
    J E Craig
    Institute of Cell and Molecular Biology, University of Edinburgh, UK
    Mol Microbiol 11:1159-68. 1994
    ..This arrangement is shown to reflect the previously established gene order on the E. coli chromosome...
  15. ncbi Structure-activity relationships within a family of selectively cytotoxic macrolide natural products
    A R Salomon
    Departments of Chemistry and Chemical Engineering, Stanford University, Stanford, California 94305, USA
    Org Lett 3:57-9. 2001
    ....
  16. ncbi Strain variation in the katG region of Mycobacterium tuberculosis
    Y Zhang
    MRC Tuberculosis and Related Infections Unit, Hammersmith Hospital, London, UK
    Mol Microbiol 14:301-8. 1994
    ..These results indicate that the katG region of the M. tuberculosis genome is highly variable and unstable. The presence of repetitive sequences may contribute to instability in this region of the genome...
  17. ncbi Effects of augmented delivery of pyruvate on myocardial high-energy phosphate metabolism at high workstate
    K Ochiai
    Department of Medicine, and Center for Magnetic Resonance Research, University of Minnesota, Minneapolis 55455, USA
    Am J Physiol Heart Circ Physiol 281:H1823-32. 2001
    ....
  18. pmc Molecular cloning and characterization of chemokine-like factor 1 (CKLF1), a novel human cytokine with unique structure and potential chemotactic activity
    W Han
    Laboratory of Medical Immunology, School of Basic Medical Science, Peking University, 38 Xueyuan Road, Beijing, 100083, China
    Biochem J 357:127-35. 2001
    ..These results suggest that CKLF1 might have important roles in inflammation and in the regeneration of skeletal muscle...
  19. ncbi [The inducibility of Amp C enzyme of Enterobacter cloacae and its susceptibility to enzyme inhibitor]
    Y Zhang
    Institute of Clinical Pharmacology, The First Hospital, Peking University, Beijing 100083, China
    Zhonghua Yi Xue Za Zhi 81:227-30. 2001
    ..Imipenem has a strong inductive action to Amp C enzyme. Ro481220 has a strong inhibitory action to Amp C enzyme. CONCLUSION: Infections caused by Enterobacter cloacae producing Amp C enzyme can be treated by cefepime...
  20. pmc Acholeplasma laidlawii up-regulates granulysin gene expression via transcription factor activator protein-1 in a human monocytic cell line, THP-1
    Y Kida
    Department of Bacteriology, Kurume University School of Medicine, Kurume, Fukuoka, Japan
    Immunology 104:324-32. 2001
    ..Therefore, the finding of inducible granulysin gene expression by A. laidlawii suggests that inducible granulysin in macrophages may function as a protective weapon when microbial invasion occurs...
  21. ncbi Nitric oxide synthase inhibitors decrease coronary sinus-free radical concentration and ameliorate myocardial stunning in an ischemia-reperfusion model
    Y Zhang
    Cardiovascular Center, University of Iowa, Iowa City, USA
    J Am Coll Cardiol 38:546-54. 2001
    ..Myocardial perfusion was not altered by L-NNA. CONCLUSIONS: The NO synthase inhibitors decrease coronary sinus free radical concentration and ameliorate myocardial stunning after ischemia-reperfusion...
  22. ncbi Synthesis and biological evaluation of tropane-like 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine (GBR 12909) analogues
    Y Zhang
    Laboratory of Medicinal Chemistry, Building 8, Room B1-22, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0815, USA
    J Med Chem 44:3937-45. 2001
    ..The 3 alpha-substituted tropanes had lower affinity and less selectivity than the comparable unsaturated ligands...
  23. ncbi Identification of human, mouse and rat PPP1R14A, protein phosphatase-1 inhibitor subunit 14A, & mapping human PPP1R14A to chromosome 19q13.13-q13.2
    Z Li
    Institute of Genetics, School of Life Science, Fudan University, Shanghai, PR China
    Mol Biol Rep 28:91-101. 2001
    ..In addition, we mapped human PPP1R14A to chromosome 19q13.13-q13.2 by radiation hybrid mapping, and determined that the human PPP1R14A gene spanned a 5.1-kb region and consisted of four exons and three introns...
  24. ncbi Increased pre-implantation development of cloned bovine embryos treated with 5-aza-2'-deoxycytidine and trichostatin A
    X Ding
    Institute of Bioengineering, Northwest A and F University, Yangling, Shaanxi 712100, China
    Theriogenology 70:622-30. 2008
    ..In conclusion, development of cloned bovine embryos was enhanced by 5-aza-dC and TSA; furthermore, the combination was more effective than either one alone...
  25. ncbi LuxO controls extracellular protease, haemolytic activities and siderophore production in fish pathogen Vibrio alginolyticus
    Q Wang
    State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, People s Republic of China
    J Appl Microbiol 103:1525-34. 2007
    ..To characterize the luxO gene in fish pathogen Vibrio alginolyticus MVP01 and investigate its roles in regulation of extracellular products (ECP) and siderophore production...
  26. ncbi Genetic variability of group A and B human respiratory syncytial viruses isolated from 3 provinces in China
    Y Zhang
    China Center for Disease Control and Prevention, National Institute for Viral Disease Control and Prevention, Beijing, China
    Arch Virol 152:1425-34. 2007
    ..These data provided a preliminary evaluation of patterns of circulation and the genetic diversity of isolates associated with HRSV epidemics within China...
  27. ncbi A novel Bacillus thuringiensis strain LLB6, isolated from bryophytes, and its new cry2Ac-type gene
    L L Zhang
    Key Laboratory of Biopesticide and Chemical Biology, Ministry of Education, Fujian Agriculture and Forestry University, Fuzhou, Fujian, P R China
    Lett Appl Microbiol 44:301-7. 2007
    ..To isolate and characterize the novel Bacillus thuringiensis strains from bryophytes collected from Wuyi Mountain, Fujian Province of China, and identify new B. thuringiensis strains and toxins active against mosquitoes...
  28. ncbi Identification of genetic differences between two clinical isolates of Streptococcus mutans by suppression subtractive hybridization
    L H Guo
    Department of Oral Biology, Peking University School and Hospital of Stomatology, Beijing, China
    Oral Microbiol Immunol 21:372-80. 2006
    ..Differences exist in the genomes of different S. mutans isolates. SSH is effective in screening for S. mutans strain specific DNA sequences...
  29. pmc A CapG gain-of-function mutant reveals critical structural and functional determinants for actin filament severing
    Y Zhang
    Department of Medicine, University of Florida, Gainesville, 32610, USA
    EMBO J 25:4458-67. 2006
    ..We conclude that efficient severing utilizes two actin monomer-binding sites, and that the length of the WH2-containing segment is a critical functional determinant for severing...
  30. ncbi A mutated human tumor necrosis factor-alpha improves the therapeutic index in vitro and in vivo
    Z Yan
    Biotechnology Center, School of Pharmacy of Fourth Military Medical University, Shaanxi, People s Republic of China
    Cytotherapy 8:415-23. 2006
    ..However, clinical trials have revealed high systemic toxicity and this has hampered its utilization as an anti-cancer agent. In this study, a human TNF-alpha mutant was created and tested for its anti-tumor effects...
  31. ncbi Identification of 19 new BoLA-DQB alleles
    K Wang
    Department of Animal Genetics and Breeding, College of Animal Science and Technology, China Agricultural University, Beijing, 100094, China
    Anim Genet 36:166-7. 2005
  32. ncbi High in vitro development after somatic cell nuclear transfer and trichostatin A treatment of reconstructed porcine embryos
    J Li
    Department of Genetics and Biotechnology, Faculty of Agricultural Sciences, University of Aarhus, Tjele DK 8830, Denmark
    Theriogenology 70:800-8. 2008
    ..Our data demonstrate that TSA treatment after HMC in pigs may affect reprogramming of the somatic genome resulting in higher in vitro embryo development, and enable full-term in vivo development...
  33. ncbi Complete sequence of virulence plasmid pEIB1 from the marine fish pathogen Vibrio anguillarum strain MVM425 and location of its replication region
    H Wu
    State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai
    J Appl Microbiol 97:1021-8. 2004
    ..The aim of this study was to determine the whole DNA sequence of pEIB1, one pJM1-like virulence plasmid from Vibrio anguillarum MVM425 and locate the replication region...
  34. ncbi Methylation of histone H4 at arginine 3 facilitating transcriptional activation by nuclear hormone receptor
    H Wang
    Department of Biochemistry and Biophysics, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7295, USA
    Science 293:853-7. 2001
    ..Our finding reveals Arg 3 of H4 as a novel methylation site by PRMT1 and indicates that Arg 3 methylation plays an important role in transcriptional regulation...
  35. ncbi Ionizing radiation-induced apoptosis in ataxia-telangiectasia fibroblasts. Roles of caspase-9 and cellular inhibitor of apoptosis protein-1
    Y Zhang
    Department of Radiation Medicine, Division of Radiation Research, Vincent T. Lombardi Cancer Center, Georgetown University School of Medicine, Washington, D. C. 20007, USA
    J Biol Chem 276:28842-8. 2001
    ..These results indicate that the extent of IR-induced apoptosis in different AT cell lines is inversely related to the abundance of c-IAP-1 and directly related to the extent of activation of caspases-3 and 9...
  36. ncbi T cells enhance production of IL-18 by monocytes in response to an intracellular pathogen
    R Vankayalapati
    Center for Pulmonary and Infectious Disease Control, University of Texas Health Center, 11937 US Highway 271, Tyler, TX 75708, USA
    J Immunol 166:6749-53. 2001
    ..These findings suggest that activated T cells can contribute to the initial immune response by augmenting IL-18 production by monocytes in response to an intracellular pathogen...
  37. ncbi The relationship between hetero-oligomer formation and function of the topological specificity domain of the Escherichia coli MinE protein
    Y Zhang
    Department of Microbiology, University of Connecticut Health Center, Farmington, CT 06032, USA
    Mol Microbiol 30:265-73. 1998
    ..The interference with normal septal placement is ascribed to competition between MinE36-88 and the corresponding domain in the complete MinE protein for a component required for the topological specificity of septal placement...
  38. ncbi Engineering a change in metal-ion specificity of the iron-dependent superoxide dismutase from Mycobacterium tuberculosis-- X-ray structure analysis of site-directed mutants
    K Bunting
    Department of Crystallography, Birkbeck College, University of London, England
    Eur J Biochem 251:795-803. 1998
    ..This alteration in metal specificity may reflect on the preference of manganese ions for anionic ligands...
  39. ncbi Mutational analysis of the roles of residues in Escherichia coli elongation factor Ts in the interaction with elongation factor Tu
    Y Zhang
    Department of Chemistry, University of North Carolina, Chapel Hill, North Carolina 27599 3290, USA
    J Biol Chem 273:4556-62. 1998
    ..Mutations prepared in EF-Tu indicate that His-19 and Gln-114 but not Glu-348 in EF-Tu are moderately important for its interaction with EF-Ts...
  40. ncbi Processing and activation of pro-interleukin-16 by caspase-3
    Y Zhang
    Pulmonary Center, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 273:1144-9. 1998
    ..Pro-IL-16 is a substrate for caspase-3, and cleavage by this enzyme releases biologically active IL-16 from its inactive precursor...
  41. ncbi Ehrlichia sennetsu groE operon and antigenic properties of the GroEL homolog
    Y Zhang
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus 43210, USA
    FEMS Immunol Med Microbiol 18:39-46. 1997
    ..coli. The recombinant 55-kDa protein would be a useful tool for studying the role of this antigen in the immune response to E. sennetsu infection...
  42. pmc Characterization of the Bacillus subtilis thiC operon involved in thiamine biosynthesis
    Y Zhang
    Department of Chemistry, Cornell University, Ithaca, New York 14853, USA
    J Bacteriol 179:3030-5. 1997
    ..Transcription of the thiC operon is not regulated by thiamine or 2-methyl-4-amino-5-hydroxymethylpyrimidine and is only slightly repressed by 4-methyl-5-(beta-hydroxyethyl)thiazole...
  43. pmc Characterization of the katG gene encoding a catalase-peroxidase required for the isoniazid susceptibility of Mycobacterium tuberculosis
    B Heym
    Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, Paris, France
    J Bacteriol 175:4255-9. 1993
    ..tuberculosis, M. smegmatis, and Escherichia coli was demonstrated by Western blotting (immunoblotting). Homologous genes were detected in other mycobacteria, even those which are naturally insensitive to isoniazid...
  44. ncbi Crystallization and preliminary X-ray analysis of the superoxide dismutase from Mycobacterium tuberculosis
    J B Cooper
    Laboratory of Molecular Biology, Birkbeck College, London, England
    J Mol Biol 235:1156-8. 1994
    ..5 A, b = 85.6 A, c = 66.5 A, beta = 99.8 degrees. There are four molecules per asymmetric unit which, from analysis of data to 2.5 A, appear to be related by non-crystallographic 222 symmetry...
  45. ncbi Histidine 326 is critical for the function of GLT-1, a (Na+ + K+)-coupled glutamate transporter from rat brain
    Y Zhang
    Department of Biochemistry, Hadassah Medical School, Hebrew University, Jerusalem, Israel
    J Biol Chem 269:19573-7. 1994
    ..As histidine residues have been implicated in the mechanism of H+ transport in several systems, we propose that histidine 326 may be involved in the proton translocation accompanying sodium- and potassium-coupled glutamate transport...
  46. pmc Effect of an ntrBC mutation on the posttranslational regulation of nitrogenase activity in Rhodospirillum rubrum
    Y Zhang
    Department of Biochemistry, University of Wisconsin Madison 53706, USA
    J Bacteriol 177:5322-6. 1995
    ..rubrum. The expression of glutamine synthetase, as well as its posttranslational regulation, was also altered in this ntrBC mutant...
  47. ncbi Tumor necrosis factor (TNF) is a physiologic regulator of hematopoietic progenitor cells: increase of early hematopoietic progenitor cells in TNF receptor p55-deficient mice in vivo and potent inhibition of progenitor cell proliferation by TNF alpha in vi
    Y Zhang
    Department of Pharmacology, School of Medicine, Kanazawa University, Japan
    Blood 86:2930-7. 1995
    ..These data suggest that TNF may be an important physiologic regulator of hematopoiesis and that TNF-R55 may be essentially involved in TNF-mediated inhibition of the growth of both primitive stem and more committed progenitor cells...
  48. pmc Model of maltose-binding protein/chemoreceptor complex supports intrasubunit signaling mechanism
    Y Zhang
    Department of Biology, Texas A and M University, College Station, TX 77843, USA
    Proc Natl Acad Sci U S A 96:939-44. 1999
    ....
  49. ncbi Caspase-mediated cleavage of p21Waf1/Cip1 converts cancer cells from growth arrest to undergoing apoptosis
    Y Zhang
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan
    Oncogene 18:1131-8. 1999
    ..Thus, caspase-3-mediated cleavage and inactivation of p21 protein may convert cancer cells from growth arrest to undergoing apoptosis, leading to the acceleration of chemotherapy-induced apoptotic process in cancer cells...
  50. pmc Crystal structure of human p32, a doughnut-shaped acidic mitochondrial matrix protein
    J Jiang
    W M Keck Structural Biology Laboratory, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Proc Natl Acad Sci U S A 96:3572-7. 1999
    ..The implications of the structure on previously proposed functions of p32 are discussed and new specific functional properties are suggested...
  51. pmc Analysis of fumonisin B1-induced apoptosis
    C Jones
    Center for Biotechnology, Department of Veterinary and Biomedical Sciences, University of Nebraska-Lincoln, East Campus Loop, Lincoln, Nebraska, USA
    Environ Health Perspect 109:315-20. 2001
    ..Furthermore, Bcl-2 was not an effective inhibitor of FB1-induced apoptosis in CV-1 cells or p53+/+ MEF. In summary, these results provide new information to help understand the mechanism by which FB1 induces apoptosis...
  52. ncbi Identification of a novel type I cytokine receptor CRL2 preferentially expressed by human dendritic cells and activated monocytes
    W Zhang
    Institute of Immunology, Second Military Medical University, 800 Xiangyin Road, Shanghai, 200433, People s Republic of China
    Biochem Biophys Res Commun 281:878-83. 2001
    ..We also prepared a CRL2Ig fusion protein. The identification of its ligand and involvement of signal transduction will help to elucidate its potential function...
  53. ncbi Novel gp91(phox) homologues in vascular smooth muscle cells : nox1 mediates angiotensin II-induced superoxide formation and redox-sensitive signaling pathways
    B Lassegue
    Department of Medicine, Division of Cardiology, Emory University, Atlanta, GA, USA
    Circ Res 88:888-94. 2001
    ..These data support a role for nox1 in redox signaling in VSMCs and provide insight into the molecular identity of the VSMC NAD(P)H oxidase and its potentially critical role in vascular disease...
  54. ncbi Identification of differentially expressed genes following treatment of monkey kidney cells with the mycotoxin fumonisin B(1)
    Y Zhang
    Dept. of Plant Pathology, University of Nebraska, 68503, Lincoln, NE, USA
    Food Chem Toxicol 39:45-53. 2001
    ..The ability of FB(1) to alter gene expression and signal transduction pathways may be necessary for its carcinogenic and toxic effects...
  55. ncbi Developmental expression of catenins and associated proteins during submucosal gland morphogenesis in the airway
    T C Ritchie
    Department of Anatomy and Cell Biology, The University of Iowa, School of Medicine, Iowa City 52242, USA
    Exp Lung Res 27:121-41. 2001
    ..These descriptive results do not rule out a role for wnt signaling in SMG development , but provide no evidence that beta-catenin, or gamma-catenin, is a cofactor in Lef-1 regulation of SMG development...
  56. ncbi Pulmonary hypoplasia in mice lacking tumor necrosis factor-alpha converting enzyme indicates an indispensable role for cell surface protein shedding during embryonic lung branching morphogenesis
    J Zhao
    Center for Craniofacial Molecular Biology, University of Southern California, 2250 Alcazar St, CSA 103, Los Angeles, California, 90033, USA
    Dev Biol 232:204-18. 2001
    ....
  57. ncbi Evolutionary trends of the mitochondrial lineage differentiation in species of genera Martes and Mustela
    T Hosoda
    Gobo Shoko High School, Yukawa, Japan
    Genes Genet Syst 75:259-67. 2000
    ..In addition, the Eurasian continent itself was shown to have been involved in the species diversification in the martens and weasels...
  58. ncbi Constitutive alpha-secretase cleavage of the beta-amyloid precursor protein in the furin-deficient LoVo cell line: involvement of the pro-hormone convertase 7 and the disintegrin metalloprotease ADAM10
    E Lopez-Perez
    IPMC du CNRS, UMR6097, Valbonne, France
    J Neurochem 76:1532-9. 2001
    ..Transfection analysis allowed us to further establish that the pro-hormone convertase 7 and ADAM10 but not ADAM17 (TACE, tumour necrosis factor alpha-converting enzyme) likely contribute to constitutive sAPPalpha secretion by LoVo cells...
  59. ncbi Biochemical and biophysical characterization of OmpG: A monomeric porin
    S Conlan
    Department of Medical Biochemistry and Genetics, The Texas A and M University System Health Science Center, College Station, Texas 77843 1114, USA
    Biochemistry 39:11845-54. 2000
    ..The availability of milligram amounts of a monomeric porin will be useful both for basic studies of porin function and for membrane protein engineering...
  60. ncbi Insights into the mechanism of Escherichia coli methionine aminopeptidase from the structural analysis of reaction products and phosphorus-based transition-state analogues
    W T Lowther
    Institute of Molecular Biology, Howard Hughes Medical Institute and Department of Physics, 1229 University of Oregon, Eugene, Oregon 97403, USA
    Biochemistry 38:14810-9. 1999
    ..The results also suggest parallels between the mechanism of action of methionine aminopeptidase and other "pita-bread" enzymes including aminopeptidase P and creatinase...
  61. pmc Crystal structure of the two-RRM domain of hnRNP A1 (UP1) complexed with single-stranded telomeric DNA
    J Ding
    W M Keck Structural Biology Laboratory, Cold Spring Harbor, New York 11724, USA
    Genes Dev 13:1102-15. 1999
    ..Models for regular packaging of telomere 3' overhangs and for juxtaposition of alternative 5' splice sites are proposed...
  62. ncbi Phosphorylation of Raf by ceramide-activated protein kinase
    B Yao
    Laboratory of Signal Transduction, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Nature 378:307-10. 1995
    ..Moreover, in intact HL-60 cells, CAP kinase complexes with Raf1 and, in response to TNF and ceramide analogues, phosphorylates and activates Raf1, implicating CAP kinase as a link between the TNF receptor and Raf1...