Robert H Ring

Summary

Affiliation: Wyeth Research
Country: USA

Publications

  1. doi Receptor and behavioral pharmacology of WAY-267464, a non-peptide oxytocin receptor agonist
    Robert H Ring
    Discovery Neuroscience, Wyeth Research, CN8000, Princeton, NJ 08543, USA
    Neuropharmacology 58:69-77. 2010
  2. ncbi The central vasopressinergic system: examining the opportunities for psychiatric drug development
    Robert H Ring
    Discovery Neuroscience, Wyeth Research, CN800, Princeton, NJ 08543, USA
    Curr Pharm Des 11:205-25. 2005
  3. ncbi Anxiolytic-like activity of oxytocin in male mice: behavioral and autonomic evidence, therapeutic implications
    Robert H Ring
    Depression and Anxiety Disorders, Discovery Neuroscience, Wyeth Research, CN8000, Princeton, NJ 08543, USA
    Psychopharmacology (Berl) 185:218-25. 2006
  4. ncbi The LXR agonist TO901317 selectively lowers hippocampal Abeta42 and improves memory in the Tg2576 mouse model of Alzheimer's disease
    David R Riddell
    Discovery Neuroscience, Wyeth Research, CN8000, Princeton, NJ 08543, USA
    Mol Cell Neurosci 34:621-8. 2007
  5. ncbi Increasing the levels of insulin-like growth factor-I by an IGF binding protein inhibitor produces anxiolytic and antidepressant-like effects
    Jessica E Malberg
    Wyeth Research, Discovery Neuroscience, Princeton, NJ, USA
    Neuropsychopharmacology 32:2360-8. 2007
  6. doi Pharmacology of neuropeptide S in mice: therapeutic relevance to anxiety disorders
    Sarah K Leonard
    Depression and Anxiety Disorders, Discovery Neuroscience, Wyeth Research, CN8000, Princeton, NJ 08543, USA
    Psychopharmacology (Berl) 197:601-11. 2008
  7. ncbi Differentiating antidepressants of the future: efficacy and safety
    Sharon Rosenzweig-Lipson
    Wyeth Discovery Neuroscience, Depression and Anxiety, CN 8000, Princeton, NJ 08543, USA
    Pharmacol Ther 113:134-53. 2007
  8. doi Inhibition of uptake 2 (or extraneuronal monoamine transporter) by normetanephrine potentiates the neurochemical effects of venlafaxine
    Zia Rahman
    Wyeth Research, Discovery Neuroscience, Depression and Anxiety Disorders, CN 8000, Princeton, NJ 08543 8000, USA
    Brain Res 1203:68-78. 2008
  9. ncbi Anxiolytic-like activity of the non-selective galanin receptor agonist, galnon
    S Johannes R Rajarao
    Depression and Anxiety Research, Discovery Neuroscience, Wyeth Research, CN8000, Princeton, NJ 08543, USA
    Neuropeptides 41:307-20. 2007
  10. ncbi Estrogen receptor neurobiology and its potential for translation into broad spectrum therapeutics for CNS disorders
    Zoe A Hughes
    Wyeth Research, Discovery Neuroscience, Princeton, New Jersey 08543, USA
    Curr Mol Pharmacol 2:215-36. 2009

Detail Information

Publications15

  1. doi Receptor and behavioral pharmacology of WAY-267464, a non-peptide oxytocin receptor agonist
    Robert H Ring
    Discovery Neuroscience, Wyeth Research, CN8000, Princeton, NJ 08543, USA
    Neuropharmacology 58:69-77. 2010
    ..A selective OTR antagonist also failed to block the effects of OT on immobility in the TST. The significance of these findings for shaping the clinical development of OTR agonists is discussed...
  2. ncbi The central vasopressinergic system: examining the opportunities for psychiatric drug development
    Robert H Ring
    Discovery Neuroscience, Wyeth Research, CN800, Princeton, NJ 08543, USA
    Curr Pharm Des 11:205-25. 2005
    ..Specific lines of evidence will be presented which rationalize each AVP receptor subtype (V(1)R or V(1a), V(2)R, V(3)R or V(1b)) as a molecular target for particular psychiatric indications...
  3. ncbi Anxiolytic-like activity of oxytocin in male mice: behavioral and autonomic evidence, therapeutic implications
    Robert H Ring
    Depression and Anxiety Disorders, Discovery Neuroscience, Wyeth Research, CN8000, Princeton, NJ 08543, USA
    Psychopharmacology (Berl) 185:218-25. 2006
    ..Notably, evidence from studies in females has revealed an important role for OT in regulating anxiety behavior...
  4. ncbi The LXR agonist TO901317 selectively lowers hippocampal Abeta42 and improves memory in the Tg2576 mouse model of Alzheimer's disease
    David R Riddell
    Discovery Neuroscience, Wyeth Research, CN8000, Princeton, NJ 08543, USA
    Mol Cell Neurosci 34:621-8. 2007
    ..These data demonstrate that LXR agonists do not directly inhibit APP processing but rather facilitate the clearance of Abeta42 and may represent a novel therapeutic approach to Alzheimer's disease...
  5. ncbi Increasing the levels of insulin-like growth factor-I by an IGF binding protein inhibitor produces anxiolytic and antidepressant-like effects
    Jessica E Malberg
    Wyeth Research, Discovery Neuroscience, Princeton, NJ, USA
    Neuropsychopharmacology 32:2360-8. 2007
    ..The present studies demonstrate that an IGFBP inhibitor mimics the behavioral effects of IGF-I and that IGFBP inhibition may represent a novel mechanism by which to increase IGF-I to treat depression and anxiety...
  6. doi Pharmacology of neuropeptide S in mice: therapeutic relevance to anxiety disorders
    Sarah K Leonard
    Depression and Anxiety Disorders, Discovery Neuroscience, Wyeth Research, CN8000, Princeton, NJ 08543, USA
    Psychopharmacology (Berl) 197:601-11. 2008
    ..Neuropeptide S (NPS) and its receptor (NPSR) comprise a recently deorphaned G protein-coupled receptor system. Recent reports implicate NPS in the mediation of anxiolytic-like activity in rodents...
  7. ncbi Differentiating antidepressants of the future: efficacy and safety
    Sharon Rosenzweig-Lipson
    Wyeth Discovery Neuroscience, Depression and Anxiety, CN 8000, Princeton, NJ 08543, USA
    Pharmacol Ther 113:134-53. 2007
    ..This review will discuss the many facets of differentiation and potential strategies for the development of novel antidepressants...
  8. doi Inhibition of uptake 2 (or extraneuronal monoamine transporter) by normetanephrine potentiates the neurochemical effects of venlafaxine
    Zia Rahman
    Wyeth Research, Discovery Neuroscience, Depression and Anxiety Disorders, CN 8000, Princeton, NJ 08543 8000, USA
    Brain Res 1203:68-78. 2008
    ....
  9. ncbi Anxiolytic-like activity of the non-selective galanin receptor agonist, galnon
    S Johannes R Rajarao
    Depression and Anxiety Research, Discovery Neuroscience, Wyeth Research, CN8000, Princeton, NJ 08543, USA
    Neuropeptides 41:307-20. 2007
    ..Moreover, these data indicate rodent GALR1 receptors do not mediate galnon's in vivo activity...
  10. ncbi Estrogen receptor neurobiology and its potential for translation into broad spectrum therapeutics for CNS disorders
    Zoe A Hughes
    Wyeth Research, Discovery Neuroscience, Princeton, New Jersey 08543, USA
    Curr Mol Pharmacol 2:215-36. 2009
    ..In particular we will highlight the molecular mechanisms and signal transduction pathways most likely underlying the effects of estrogen in the CNS...
  11. pmc Innovative approaches for the development of antidepressant drugs: current and future strategies
    Lee E Schechter
    Discovery Neuroscience, Wyeth Research, CN 8000, Princeton, New Jersey 08543, USA
    NeuroRx 2:590-611. 2005
    ..The present review addresses the most exciting approaches and reviews the localization, neurochemical and behavioral data that provide the supporting rationale for each of these targets or target combinations...
  12. ncbi High-throughput confirmation of differential display PCR results using reverse Northern blotting
    Daniel W Dilks
    Wyeth Research, Neuroscience, CN 8000, Princeton, NJ 08543 8000, USA
    J Neurosci Methods 123:47-54. 2003
    ..Such an approach provides a rapid means to eliminate the high percentage of false positive clones from DD-PCR and enables independent confirmation of differential gene expression patterns generated by various experimental conditions...
  13. ncbi Transcriptional profiling of brain-derived-neurotrophic factor-induced neuronal plasticity: a novel role for nociceptin in hippocampal neurite outgrowth
    Robert H Ring
    Wyeth Research, Discovery Neuroscience, CN8000, Princeton, New Jersey 08543, USA
    J Neurobiol 66:361-77. 2006
    ..These results reveal a novel role for nociceptin and suggest that these neuropeptide systems may contribute to the regulation of neuronal function by BDNF...
  14. doi Monoacylglycerol lipase activity is a critical modulator of the tone and integrity of the endocannabinoid system
    Pranab K Chanda
    Neuroscience Research Unit, Pfizer Global Research, Princeton, New Jersey, USA
    Mol Pharmacol 78:996-1003. 2010
    ..These findings provide the first genetic in vivo evidence that MAGL is the major regulator of 2-AG levels and signaling and reveal a pivotal role for 2-AG in modulating CB1 receptor sensitization and endocannabinoid tone...
  15. ncbi The Cdkn1a gene (p21Waf1/Cip1) is an inflammatory response gene in the mouse central nervous system
    Robert H Ring
    Division of Biology, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA
    Neurosci Lett 350:73-6. 2003
    ..Combined use of laser capture microdissection and quantitative reverse transcription-polymerase chain reaction showed that there was a similar change in Cdkn1a expression for the pyramidal cell layer as for total hippocampus...