Sarah K Leonard
Affiliation: Wyeth Research
- Pharmacology of neuropeptide S in mice: therapeutic relevance to anxiety disordersSarah K Leonard
Depression and Anxiety Disorders, Discovery Neuroscience, Wyeth Research, CN8000, Princeton, NJ 08543, USA
Psychopharmacology (Berl) 197:601-11. 2008..Neuropeptide S (NPS) and its receptor (NPSR) comprise a recently deorphaned G protein-coupled receptor system. Recent reports implicate NPS in the mediation of anxiolytic-like activity in rodents...
- Receptor and behavioral pharmacology of WAY-267464, a non-peptide oxytocin receptor agonistRobert H Ring
Discovery Neuroscience, Wyeth Research, CN8000, Princeton, NJ 08543, USA
Neuropharmacology 58:69-77. 2010..A selective OTR antagonist also failed to block the effects of OT on immobility in the TST. The significance of these findings for shaping the clinical development of OTR agonists is discussed...
- Synthesis and pharmacological evaluation of substituted naphth[1,2,3-de]isoquinolines (dinapsoline analogues) as D1 and D2 dopamine receptor ligandsAmjad M Qandil
Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, IN 47907, USA
Bioorg Med Chem 11:1451-64. 2003..Moreover, as rigid ligands in which small substituents can cause significant changes in selectivity, they are important tools for deriving 'differential' SARs of the dopamine receptor isoforms...