Genomes and Genes
Jennifer J Hill
Affiliation: Wyeth Research
- Regulation of myostatin in vivo by growth and differentiation factor-associated serum protein-1: a novel protein with protease inhibitor and follistatin domainsJennifer J Hill
Department of Protein Chemistry and Proteomics, Wyeth Research, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, USA
Mol Endocrinol 17:1144-54. 2003..Surprisingly, recombinant GASP-1 binds directly not only to mature myostatin, but also to the myostatin propeptide. Thus, GASP-1 represents a novel class of inhibitory TGFbeta binding proteins...
- The myostatin propeptide and the follistatin-related gene are inhibitory binding proteins of myostatin in normal serumJennifer J Hill
Department of Protein Chemistry and Proteomics, Wyeth Research, 87 Cambridge Park Drive, Cambridge, MA 02140, USA
J Biol Chem 277:40735-41. 2002..Functional studies show that FLRG inhibits myostatin activity in a reporter gene assay. These experiments suggest that the myostatin propeptide and FLRG are major negative regulators of myostatin in vivo...
- Proteomic identification and functional validation of activins and bone morphogenetic protein 11 as candidate novel muscle mass regulatorsTatyana A Souza
Department of Biological Technologies, Wyeth Research, Cambridge, Massachusetts 02149, USA
Mol Endocrinol 22:2689-702. 2008....
- Inhibition of myostatin in adult mice increases skeletal muscle mass and strengthLisa Anne Whittemore
Musculoskeletal Sciences Department, Wyeth Research, 200 CambridgePark Drive, Cambridge, MA 02140, USA
Biochem Biophys Res Commun 300:965-71. 2003..These data show for the first time that myostatin acts postnatally as a negative regulator of skeletal muscle growth and suggest that myostatin inhibitors could provide a therapeutic benefit in diseases for which muscle mass is limiting...