Michael A Egan

Summary

Affiliation: Wyeth Research
Country: USA

Publications

  1. ncbi request reprint Current prospects for the development of a therapeutic vaccine for the treatment of HIV type 1 infection
    Michael A Egan
    Department of Immunobiology, Wyeth Vaccines Research, Pearl River, New York, 10965, USA
    AIDS Res Hum Retroviruses 20:794-806. 2004
  2. ncbi request reprint Immunogenicity of attenuated vesicular stomatitis virus vectors expressing HIV type 1 Env and SIV Gag proteins: comparison of intranasal and intramuscular vaccination routes
    Michael A Egan
    Wyeth Vaccines Research, Pearl River, New York 10965, USA
    AIDS Res Hum Retroviruses 20:989-1004. 2004
  3. ncbi request reprint Priming with plasmid DNAs expressing interleukin-12 and simian immunodeficiency virus gag enhances the immunogenicity and efficacy of an experimental AIDS vaccine based on recombinant vesicular stomatitis virus
    Michael A Egan
    Wyeth Vaccines Research, Pearl River, New York 10965, USA
    AIDS Res Hum Retroviruses 21:629-43. 2005
  4. doi request reprint Modifying the HIV-1 env gp160 gene to improve pDNA vaccine-elicited cell-mediated immune responses
    Shakuntala Megati
    Wyeth Vaccines Research, Pearl River, NY 10965, United States
    Vaccine 26:5083-94. 2008
  5. ncbi request reprint Comparative ability of plasmid IL-12 and IL-15 to enhance cellular and humoral immune responses elicited by a SIVgag plasmid DNA vaccine and alter disease progression following SHIV(89.6P) challenge in rhesus macaques
    Siew Yen Chong
    Wyeth Vaccines Discovery, 401 N Middletown Road, Pearl River, NY 10965, USA
    Vaccine 25:4967-82. 2007
  6. ncbi request reprint A dose sparing effect by plasmid encoded IL-12 adjuvant on a SIVgag-plasmid DNA vaccine in rhesus macaques
    Eva B Schadeck
    Wyeth Vaccines Research, Pearl River, NY 10965, USA
    Vaccine 24:4677-87. 2006
  7. pmc Effect of plasmid DNA vaccine design and in vivo electroporation on the resulting vaccine-specific immune responses in rhesus macaques
    Amara Luckay
    Wyeth Vaccines Research, 401 N Middletown Rd, Bldg 180 216 10, Pearl River, NY 10965, USA
    J Virol 81:5257-69. 2007
  8. doi request reprint Comparative ability of various plasmid-based cytokines and chemokines to adjuvant the activity of HIV plasmid DNA vaccines
    Rong Xu
    Wyeth Vaccines Research, Pearl River, NY 10992, United States
    Vaccine 26:4819-29. 2008
  9. ncbi request reprint A comparative evaluation of nasal and parenteral vaccine adjuvants to elicit systemic and mucosal HIV-1 peptide-specific humoral immune responses in cynomolgus macaques
    Michael A Egan
    Wyeth Vaccines Research, Pearl River, NY 10965, USA
    Vaccine 22:3774-88. 2004
  10. ncbi request reprint Recombinant vesicular stomatitis virus as an HIV-1 vaccine vector
    David K Clarke
    Department of Vaccines Discovery Research, Wyeth Research, Wyeth, Pearl River, NY 10965, USA
    Springer Semin Immunopathol 28:239-53. 2006

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Current prospects for the development of a therapeutic vaccine for the treatment of HIV type 1 infection
    Michael A Egan
    Department of Immunobiology, Wyeth Vaccines Research, Pearl River, New York, 10965, USA
    AIDS Res Hum Retroviruses 20:794-806. 2004
  2. ncbi request reprint Immunogenicity of attenuated vesicular stomatitis virus vectors expressing HIV type 1 Env and SIV Gag proteins: comparison of intranasal and intramuscular vaccination routes
    Michael A Egan
    Wyeth Vaccines Research, Pearl River, New York 10965, USA
    AIDS Res Hum Retroviruses 20:989-1004. 2004
    ....
  3. ncbi request reprint Priming with plasmid DNAs expressing interleukin-12 and simian immunodeficiency virus gag enhances the immunogenicity and efficacy of an experimental AIDS vaccine based on recombinant vesicular stomatitis virus
    Michael A Egan
    Wyeth Vaccines Research, Pearl River, New York 10965, USA
    AIDS Res Hum Retroviruses 21:629-43. 2005
    ....
  4. doi request reprint Modifying the HIV-1 env gp160 gene to improve pDNA vaccine-elicited cell-mediated immune responses
    Shakuntala Megati
    Wyeth Vaccines Research, Pearl River, NY 10965, United States
    Vaccine 26:5083-94. 2008
    ..These results have important implications for the design and development of an efficacious vaccine for the prevention of HIV-1 infection...
  5. ncbi request reprint Comparative ability of plasmid IL-12 and IL-15 to enhance cellular and humoral immune responses elicited by a SIVgag plasmid DNA vaccine and alter disease progression following SHIV(89.6P) challenge in rhesus macaques
    Siew Yen Chong
    Wyeth Vaccines Discovery, 401 N Middletown Road, Pearl River, NY 10965, USA
    Vaccine 25:4967-82. 2007
    ..These results have important implications for the continued development of plasmid DNA vaccines for the prevention of HIV-1 infection...
  6. ncbi request reprint A dose sparing effect by plasmid encoded IL-12 adjuvant on a SIVgag-plasmid DNA vaccine in rhesus macaques
    Eva B Schadeck
    Wyeth Vaccines Research, Pearl River, NY 10965, USA
    Vaccine 24:4677-87. 2006
    ..0002) between the magnitude and breadth of the immune responses in the vaccines. These results have important implications for the continuing development of an effective, safe low dose pDNA vaccine adjuvant suitable for human use...
  7. pmc Effect of plasmid DNA vaccine design and in vivo electroporation on the resulting vaccine-specific immune responses in rhesus macaques
    Amara Luckay
    Wyeth Vaccines Research, 401 N Middletown Rd, Bldg 180 216 10, Pearl River, NY 10965, USA
    J Virol 81:5257-69. 2007
    ..Collectively, these results have important implications for the design and development of an efficacious vaccine for the prevention of HIV-1 infection...
  8. doi request reprint Comparative ability of various plasmid-based cytokines and chemokines to adjuvant the activity of HIV plasmid DNA vaccines
    Rong Xu
    Wyeth Vaccines Research, Pearl River, NY 10992, United States
    Vaccine 26:4819-29. 2008
    ..These data support the testing of pmGM-CSF and pmIL-12, used alone or in combination, as plasmid DNA vaccine adjuvants in future macaque challenge studies...
  9. ncbi request reprint A comparative evaluation of nasal and parenteral vaccine adjuvants to elicit systemic and mucosal HIV-1 peptide-specific humoral immune responses in cynomolgus macaques
    Michael A Egan
    Wyeth Vaccines Research, Pearl River, NY 10965, USA
    Vaccine 22:3774-88. 2004
    ..These results suggest that parenteral vaccine administration in combination with the appropriate adjuvant formulation can elicit vaccine-specific humoral immune responses in both systemic and mucosal compartments...
  10. ncbi request reprint Recombinant vesicular stomatitis virus as an HIV-1 vaccine vector
    David K Clarke
    Department of Vaccines Discovery Research, Wyeth Research, Wyeth, Pearl River, NY 10965, USA
    Springer Semin Immunopathol 28:239-53. 2006
    ..Additional modifications of further attenuated rVSV vectors to upregulate expression of HIV-1 antigens and coexpress molecular adjuvants are also being developed in an effort to balance immunogenicity and attenuation...
  11. ncbi request reprint Alphavirus replicon particles encoding the fusion or attachment glycoproteins of respiratory syncytial virus elicit protective immune responses in BALB/c mice and functional serum antibodies in rhesus macaques
    Matthew B Elliott
    Wyeth Research, 401 N Middletown Road, Pearl River, NY 10965, USA
    Vaccine 25:7132-44. 2007
    ..The immune responses in mice were also protective against intranasal challenge with RSV. Thus, the replicon-based platform represents a promising new strategy for vaccines against RSV...
  12. ncbi request reprint Rational design of a plasmid DNA vaccine capable of eliciting cell-mediated immune responses to multiple HIV antigens in mice
    Michael A Egan
    Vaccine Discovery, Wyeth Vaccines Research, 401 N Middletown Rd, Bldg 180 216 10, Pearl River, NY 10965, USA
    Vaccine 24:4510-23. 2006
    ..These results have important implications for the design and development of an efficacious vaccine for the prevention of HIV-1 infection...
  13. pmc Neurovirulence and immunogenicity of attenuated recombinant vesicular stomatitis viruses in nonhuman primates
    David K Clarke
    Profectus BioSciences, Tarrytown, New York, USA
    J Virol 88:6690-701. 2014
    ....
  14. pmc Viral escape from dominant simian immunodeficiency virus epitope-specific cytotoxic T lymphocytes in DNA-vaccinated rhesus monkeys
    Dan H Barouch
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Virol 77:7367-75. 2003
    ..These data suggest that CTL exert selective pressure on viral replication and that viral escape from CTL may be a limitation of CTL-based AIDS vaccine strategies...
  15. ncbi request reprint Towards the development of a therapeutic vaccine for the treatment of HIV-1 infection: are we closer than ever?
    Michael A Egan
    Expert Rev Vaccines 6:289-91. 2007