Genomes and Genes
Padma L Channavajhala
Affiliation: Wyeth Research
- Identification of a novel human kinase supporter of Ras (hKSR-2) that functions as a negative regulator of Cot (Tpl2) signalingPadma L Channavajhala
Department of Inflammation, Wyeth Research, 200 Cambridge Park Drive, Cambridge, MA 02140, USA
J Biol Chem 278:47089-97. 2003..Taken together, these results indicate that hKSR-2, a new member of the KSR family, negatively regulates Cot-mediated MAP kinase and NF-kappaB pathway signaling...
- Proteomic characterization of the dynamic KSR-2 interactome, a signaling scaffold complex in MAPK pathwayLin Liu
Department of Biological Technologies, Wyeth, Cambridge, MA 02140, USA
Biochim Biophys Acta 1794:1485-95. 2009..While interactions with these molecules are not known for KSR-1, it's reasonable to hypothesize that KSR-1 may also play a similar role in mediating these downstream signaling pathways...
- Phosphorylation of threonine 290 in the activation loop of Tpl2/Cot is necessary but not sufficient for kinase activityBrenda S Luciano
Department of Molecular Inflammation, Inflammation Signaling, Wyeth Research, Cambridge, Massachusetts 02140, USA
J Biol Chem 279:52117-23. 2004..Together these results showed that phosphorylation of Cot at Thr-290 is necessary but not sufficient for full kinase activity in the MEK/ERK pathway...
- hKSR-2 inhibits MEKK3-activated MAP kinase and NF-kappaB pathways in inflammationPadma L Channavajhala
Department of Inflammation, Wyeth Research, Cambridge, MA 02140, USA
Biochem Biophys Res Commun 334:1214-8. 2005..We find that while hKSR-2 blocks MEKK3 activation, it has little to no effect on other members of the MAP3K family, including MEKK4, TAK1, and Ras-Raf, suggesting that its effects are selective...