Genomes and Genes
Affiliation: Wyeth Research
- Characterization of mGluR5R, a novel, metabotropic glutamate receptor 5-related geneBrian Bates
Wyeth Research, Functional Genomics, 35 Cambridge Park Drive, Cambridge, MA 02140, USA
Brain Res Mol Brain Res 109:18-33. 2002..The ability of mGluR5R to associate with mGluR1alpha and mGluR5 suggests that it may be a modulator of class I metabotropic glutamate receptor function...
- Characterization of Gpr101 expression and G-protein coupling selectivityBrian Bates
Wyeth Research, Biological Technologies, 87 Cambridge Park Drive, Cambridge, MA 02140, USA
Brain Res 1087:1-14. 2006..These results indicate that GPR101 participates in a potentially wide range of activities in the CNS via modulation of cAMP levels...
- Cloning and expression of MRG receptors in macaque, mouse, and humanLin Zhang
Wyeth Research, Functional Genomics Department, 87 Cambridge Park Drive, Cambridge, MA 02140, United States
Brain Res Mol Brain Res 133:187-97. 2005..Although expression in DRG neurons was the prominent feature of this family, we also found that MrgE was expressed in numerous brain regions of macaque, mouse, and human...
- Tissue distribution and functional analyses of the constitutively active orphan G protein coupled receptors, GPR26 and GPR78Philip G Jones
Neuroscience Discovery Research, Wyeth Research, CN8000, Princeton, NJ 08543, USA
Biochim Biophys Acta 1770:890-901. 2007..50) in the so-called DRY box. Site-directed mutants R3.50 in GPR26 were constructed and retained their constitutive activity suggesting that these 2 receptors activate G proteins in a manner that is distinct from other group 1 GPCRs...
- Functional expression of human and mouse P2Y12 receptors in Saccharomyces cerevisiaeMark H Pausch
Discovery Neuroscience, Wyeth Research, Princeton, NJ 08543 8000, USA
Biochem Biophys Res Commun 324:171-7. 2004..Murine P2Y12 mRNA was expressed at high levels in the brain and at lower levels in a variety of peripheral tissues. In situ hybridization analysis indicated glia-specific expression within the brain...
- The orphan GPCR, GPR88, modulates function of the striatal dopamine system: a possible therapeutic target for psychiatric disorders?Sheree F Logue
Discovery Neuroscience, Wyeth Research, CN 8000, Princeton, NJ 08543, USA
Mol Cell Neurosci 42:438-47. 2009..Antipsychotic administration to Gpr88KOs normalized the PPI deficit and blocked AICS. The modulatory role of Gpr88 in striatal dopamine function suggests it may be a new target for treatments for psychiatric disorders...
- An approach to quantifying N-linked glycoproteins by enzyme-catalyzed 18O3-labeling of solid-phase enriched glycopeptidesQuazi Shakey
Global Biotherapeutics Technologies, Pfizer, Cambridge, Massachusetts 02140, USA
Anal Chem 82:7722-8. 2010..The strategy can be easily adapted to the analysis of glycoproteins in tissues, cell lines, and other sample origins...
- Dynamic changes in the microRNA expression profile reveal multiple regulatory mechanisms in the spinal nerve ligation model of neuropathic painDavid von Schack
Biological Technologies, Pfizer Global Research and Development, Cambridge, Massachusetts, United States of America
PLoS ONE 6:e17670. 2011..Our results suggest the potential for miRNAs to play a direct role in neuropathic pain...
- SLIC-1/sorting nexin 20: a novel sorting nexin that directs subcellular distribution of PSGL-1Ulrich Y Schaff
Department of Biomedical Engineering, University of California Davis, Davis, CA 95616, USA
Eur J Immunol 38:550-64. 2008..We conclude that SLIC-1 serves as a sorting molecule that cycles PSGL-1 into endosomes with no impact on leukocyte recruitment...