Wyeth Research

Summary

Organization: Wyeth Research
Country: USA

Top Publications

  1. doi B-Raf kinase inhibitors: hit enrichment through scaffold hopping
    Ariamala Gopalsamy
    Chemical Sciences, Wyeth Research, Pearl River, NY 10965, USA
    Bioorg Med Chem Lett 20:2431-4. 2010
  2. ncbi Global profiling of phosphopeptides by titania affinity enrichment
    Jiang Wu
    Biological Technologies, Wyeth Research, Cambridge, Massachusetts 02140, USA
    J Proteome Res 6:4684-9. 2007
  3. ncbi 5'-Phenyl-3'H-spiro[indoline-3,2'-[1,3,4]thiadiazol]-2-one inhibitors of ADAMTS-5 (aggrecanase-2)
    Matthew G Bursavich
    Exploratory Medicinal Chemistry, Chemical and Screening Sciences, Wyeth Research, 401 North Middletown Road, Pearl River, NY 10965, USA
    Bioorg Med Chem Lett 17:5630-3. 2007
  4. pmc Moraxella catarrhalis outer membrane protein CD elicits antibodies that inhibit CD binding to human mucin and enhance pulmonary clearance of M. catarrhalis in a mouse model
    Dai Fang Liu
    Wyeth Vaccines Research, 401 N Middletown Road 205 281, Pearl River, NY 10965, USA
    Infect Immun 75:2818-25. 2007
  5. ncbi Estimating the protective concentration of anti-pneumococcal capsular polysaccharide antibodies
    George R Siber
    Wyeth Vaccines Research, Pearl River, New York, USA
    Vaccine 25:3816-26. 2007
  6. ncbi AdeABC multidrug efflux pump is associated with decreased susceptibility to tigecycline in Acinetobacter calcoaceticus-Acinetobacter baumannii complex
    Alexey Ruzin
    Department of Infectious Disease, Wyeth Research, Pearl River, NY 10965, USA
    J Antimicrob Chemother 59:1001-4. 2007
  7. ncbi Estrogen receptor ligands in the control of pathogenic inflammation
    Douglas C Harnish
    Cardiovascular and Metabolic Disease Research, Wyeth Research, 500 Arcola Rd, Collegeville, PA 19246, USA
    Curr Opin Investig Drugs 7:997-1001. 2006
  8. ncbi American Chemical Society 232nd national meeting. 10-14 September 2006, San Francisco, CA, USA
    David Rotella
    Wyeth Research, CN 8000, Princeton, NJ 0854, USA
    IDrugs 9:745-7. 2006
  9. ncbi The structure of the Lingo-1 ectodomain, a module implicated in central nervous system repair inhibition
    Lidia Mosyak
    Department of Chemical and Screening Sciences, Wyeth Research, Cambridge, Massachusetts 02140, USA
    J Biol Chem 281:36378-90. 2006
  10. ncbi Estimating national drug consumption using data at different points in the pharmaceutical supply chain
    Michael N Cook
    Global Safety Surveillance, Epidemiology and Labeling, Wyeth Research, Arcola Road, Collegeville, PA 19426, USA
    Pharmacoepidemiol Drug Saf 15:754-7. 2006

Research Grants

Detail Information

Publications62

  1. doi B-Raf kinase inhibitors: hit enrichment through scaffold hopping
    Ariamala Gopalsamy
    Chemical Sciences, Wyeth Research, Pearl River, NY 10965, USA
    Bioorg Med Chem Lett 20:2431-4. 2010
    ..This strategy led to the identification of additional lead compound 11b which had good enzyme and cell potency, while maintaining selectivity over a number of kinases...
  2. ncbi Global profiling of phosphopeptides by titania affinity enrichment
    Jiang Wu
    Biological Technologies, Wyeth Research, Cambridge, Massachusetts 02140, USA
    J Proteome Res 6:4684-9. 2007
    ..7% and 5.5%, respectively, for singly and doubly phosphorylated peptides...
  3. ncbi 5'-Phenyl-3'H-spiro[indoline-3,2'-[1,3,4]thiadiazol]-2-one inhibitors of ADAMTS-5 (aggrecanase-2)
    Matthew G Bursavich
    Exploratory Medicinal Chemistry, Chemical and Screening Sciences, Wyeth Research, 401 North Middletown Road, Pearl River, NY 10965, USA
    Bioorg Med Chem Lett 17:5630-3. 2007
    ..This series of compounds represents progress toward a selective ADAMTS-5 inhibitor as a disease modifying osteoarthritis drug...
  4. pmc Moraxella catarrhalis outer membrane protein CD elicits antibodies that inhibit CD binding to human mucin and enhance pulmonary clearance of M. catarrhalis in a mouse model
    Dai Fang Liu
    Wyeth Vaccines Research, 401 N Middletown Road 205 281, Pearl River, NY 10965, USA
    Infect Immun 75:2818-25. 2007
    ..Our results demonstrate that the recombinant CD is a promising vaccine candidate for preventing Moraxella infection...
  5. ncbi Estimating the protective concentration of anti-pneumococcal capsular polysaccharide antibodies
    George R Siber
    Wyeth Vaccines Research, Pearl River, New York, USA
    Vaccine 25:3816-26. 2007
    ..35 microg/ml to 0.32 microg/ml. These data support retaining the 0.35 microg/ml minimum protective concentration recommended by WHO for assessing the efficacy of pneumococcal conjugate vaccines in infants...
  6. ncbi AdeABC multidrug efflux pump is associated with decreased susceptibility to tigecycline in Acinetobacter calcoaceticus-Acinetobacter baumannii complex
    Alexey Ruzin
    Department of Infectious Disease, Wyeth Research, Pearl River, NY 10965, USA
    J Antimicrob Chemother 59:1001-4. 2007
    ..To investigate the role of the AdeABC multidrug efflux pump in the decreased susceptibility of clinical isolates of Acinetobacter calcoaceticus-Acinetobacter baumannii complex to tigecycline...
  7. ncbi Estrogen receptor ligands in the control of pathogenic inflammation
    Douglas C Harnish
    Cardiovascular and Metabolic Disease Research, Wyeth Research, 500 Arcola Rd, Collegeville, PA 19246, USA
    Curr Opin Investig Drugs 7:997-1001. 2006
    ....
  8. ncbi American Chemical Society 232nd national meeting. 10-14 September 2006, San Francisco, CA, USA
    David Rotella
    Wyeth Research, CN 8000, Princeton, NJ 0854, USA
    IDrugs 9:745-7. 2006
  9. ncbi The structure of the Lingo-1 ectodomain, a module implicated in central nervous system repair inhibition
    Lidia Mosyak
    Department of Chemical and Screening Sciences, Wyeth Research, Cambridge, Massachusetts 02140, USA
    J Biol Chem 281:36378-90. 2006
    ..Potential functional binding sites that can be identified on the ectodomain surface, including the site of self-recognition, suggest a model for protein assembly on the membrane...
  10. ncbi Estimating national drug consumption using data at different points in the pharmaceutical supply chain
    Michael N Cook
    Global Safety Surveillance, Epidemiology and Labeling, Wyeth Research, Arcola Road, Collegeville, PA 19426, USA
    Pharmacoepidemiol Drug Saf 15:754-7. 2006
  11. ncbi Inhibition of Tpl2 kinase and TNFalpha production with quinoline-3-carbonitriles for the treatment of rheumatoid arthritis
    Yonghan Hu
    Department of Chemical and Screening Sciences, Wyeth Research, 200 CambridgePark Drive, Cambridge, MA 02140, USA
    Bioorg Med Chem Lett 16:6067-72. 2006
    ..Selected inhibitors with moderate activity in human whole blood assay effectively inhibited LPS/D-Gal induced TNFalpha release when administered intraperitoneally in mice...
  12. pmc Diverse CD81 proteins support hepatitis C virus infection
    Mike Flint
    Wyeth Research, 500 Arcola Road, S 1111, Collegeville, PA 19426, USA
    J Virol 80:11331-42. 2006
    ..In addition, the capacity to support viral entry is only partially reflected by assays measuring sE2 interaction with recombinant or full-length CD81 proteins...
  13. ncbi An antisense oligodeoxynucleotide to the mu opioid receptor attenuates cocaine-induced behavioral sensitization and reward in mice
    M Hummel
    Department of Pharmacology and the Center for Substance Abuse Research, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Neuroscience 142:481-91. 2006
    ..MOR AS ODN also reduced [3H]DAMGO binding. Collectively, these findings implicate the MOR as playing an important neuromodulatory role in the behavioral effects of cocaine in mice...
  14. ncbi rhBMP-2 delivered in a calcium phosphate cement accelerates bridging of critical-sized defects in rabbit radii
    Howard J Seeherman
    Department of Surgery, School of Medicine, Oregon Health Sciences University, Portland, Oregon, USA
    J Bone Joint Surg Am 88:1553-65. 2006
    ....
  15. ncbi Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist
    Derek C Cole
    Chemical and Screening Sciences, Wyeth Research, 401 N Middletown Road, Pearl River, New York 10965, USA
    J Med Chem 50:5535-8. 2007
    ....
  16. doi Thematic review series: glycerolipids. Mammalian glycerol-3-phosphate acyltransferases: new genes for an old activity
    Ruth E Gimeno
    Cardiovascular and Metabolic Diseases, Wyeth Research, Cambridge, MA 02140, USA
    J Lipid Res 49:2079-88. 2008
    ..This review summarizes the current state of knowledge on mammalian GPAT isoforms...
  17. doi Multimodal magnetic resonance imaging for assessing evolution of ischemic penumbra: a key translational medicine strategy to manage the risk of developing novel therapies for acute ischemic stroke
    Juan C Chavez
    Discovery Translational Medicine, Wyeth Research, Collegeville, Pennsylvania 19468, USA
    J Cereb Blood Flow Metab 29:217-9. 2009
    ..This could serve as a biomarker indicative of neuroprotective potential and could increase likelihood of success in clinical studies by allowing selection of patients who are most likely to respond to therapy...
  18. doi rhBMP-2 induces transient bone resorption followed by bone formation in a nonhuman primate core-defect model
    Howard J Seeherman
    Musculoskeletal Therapies, Wyeth Discovery Research, Cambridge, MA 02140, USA
    J Bone Joint Surg Am 92:411-26. 2010
    ..This study characterizes treatment with rhBMP-2/ACS in metaphyseal bone with use of a nonhuman primate core-defect model...
  19. doi Di-substituted pyridinyl aminohydantoins as potent and highly selective human beta-secretase (BACE1) inhibitors
    Michael S Malamas
    Department of Chemical Sciences, Wyeth Research, CN 8000, Princeton, NJ 08543 8000, USA
    Bioorg Med Chem 18:630-9. 2010
    ..One of the more potent compounds (S)-39 displayed an IC(50) value for BACE1 of 10nM, and exhibited cellular activity with an EC(50) value of 130nM in the ELISA assay...
  20. doi Dual acting norepinephrine reuptake inhibitors and 5-HT(2A) receptor antagonists: Identification, synthesis and activity of novel 4-aminoethyl-3-(phenylsulfonyl)-1H-indoles
    Gavin D Heffernan
    Chemical Sciences, Wyeth Research, 500 Arcola Road, Collegeville, PA 19426, USA
    Bioorg Med Chem 17:7802-15. 2009
    ..The synthesis and structure-activity relationship (SAR) of this novel series of compounds is also presented...
  21. doi WS-50030 [7-{4-[3-(1H-inden-3-yl)propyl]piperazin-1-yl}-1,3-benzoxazol-2(3H)-one]: a novel dopamine D2 receptor partial agonist/serotonin reuptake inhibitor with preclinical antipsychotic-like and antidepressant-like activity
    Julie A Brennan
    Discovery Neuroscience, Wyeth Research, CN8000, Princeton, NJ 08543, USA
    J Pharmacol Exp Ther 332:190-201. 2010
    ..Furthermore, WS-50030 provides a tool to further explore how combining these mechanisms might differentiate from other antipsychotics or antidepressants...
  22. doi First generation 5-vinyl-3-pyridinecarbonitrile PKCtheta inhibitors
    Chuansheng Niu
    Wyeth Research, Chemical Sciences, 401 N Middletown Road, Pearl River, NY 10965, USA
    Bioorg Med Chem Lett 19:5829-32. 2009
    ..The systematic optimization of 4-[(4-methyl-1H-indol-5-yl)amino]-5-[(E)-2-phenylvinyl]-3-pyridinecarbonitrile 3 resulted in the identification of compound 23e as a potent PKCtheta inhibitor with good selectivity over PKCdelta...
  23. doi Suitability of tetrahydofuran as a dopant and the comparison to other existing dopants in dopant-assisted atmospheric pressure photoionization mass spectrometry in support of drug discovery
    Yanxuan Cai
    Discovery Analytical Chemistry, Chemical Sciences, Wyeth Research, CN 8000, Princeton, NJ 08543, USA
    Rapid Commun Mass Spectrom 23:2283-91. 2009
    ..Our findings indicate that THF is a suitable dopant in the daily usage for increasing ionization efficiency, especially when THF is used as the mobile phase or as an organic modifier in the mobile phase...
  24. doi Global serotype distribution among Streptococcus pneumoniae isolates causing otitis media in children: potential implications for pneumococcal conjugate vaccines
    Gail L Rodgers
    Scientific Affairs and Global Medical Affairs, Vaccines, Wyeth Pharmaceuticals Inc, Collegeville, PA 19426, USA
    Vaccine 27:3802-10. 2009
    ....
  25. doi Identification of a novel series of 3-piperidinyl-5-sulfonylindazoles as potent 5-HT6 ligands
    Kevin G Liu
    Chemical Sciences, Wyeth Research, CN 8000, Princeton, NJ 08543, USA
    Bioorg Med Chem Lett 19:3214-6. 2009
    ..Herein, we report the identification of a novel series of 3-piperidinyl-5-sulfonylindazole derivatives as potent 5-HT(6) antagonists. The synthesis and SAR of this class of compounds are reported...
  26. doi Novel carbamate cholinesterase inhibitors that release biologically active amines following enzyme inhibition
    Jeroen C Verheijen
    Sention Inc, 1 Richmond Square, Providence, RI 02906, USA
    Bioorg Med Chem Lett 19:3243-6. 2009
    ..Release of amphetamine from 4a was demonstrated following in vitro and in vivo inhibition of cholinesterase. Compound 4a was also effective in alleviating scopolamine induced amnesia in a rat passive avoidance model...
  27. doi Efficient, regioselective palladium-catalyzed tandem Heck-isomerization reaction of aryl bromides and non-allylic benzyl alcohols
    Matthew L Crawley
    Discovery Medicinal Chemistry, Chemical Sciences, Wyeth Research, 500 Arcola Road, Collegeville, Pennsylvania 19426, USA
    Org Lett 11:1183-5. 2009
    ..Mechanistic insight was gained through NMR studies of products derived from deuterium-labeled intermediates...
  28. pmc Mapping similarities in mTOR pathway perturbations in mouse lupus nephritis models and human lupus nephritis
    Padmalatha S Reddy
    Biological Technologies, Wyeth Research, Cambridge, Massachusetts 02140, USA
    Arthritis Res Ther 10:R127. 2008
    ..Therefore, a more profound understanding of the mechanistic similarities and differences between various animal models and human diseases is highly desirable...
  29. doi The persistence of a long-term negative affective state following the induction of either acute or chronic pain
    Michele Hummel
    Neuroscience Discovery Research, Wyeth Research, CN 8000, Princeton, NJ 08543, USA
    Pain 140:436-45. 2008
    ....
  30. ncbi American Chemical Society--236th National Meeting & Exposition. Drug development for tuberculosis and cancer
    David P Rotella
    Wyeth Research, CN 8000, Princeton, NJ 08543, USA
    IDrugs 11:699-701. 2008
  31. ncbi Characterization of Gpr101 expression and G-protein coupling selectivity
    Brian Bates
    Wyeth Research, Biological Technologies, 87 Cambridge Park Drive, Cambridge, MA 02140, USA
    Brain Res 1087:1-14. 2006
    ..These results indicate that GPR101 participates in a potentially wide range of activities in the CNS via modulation of cAMP levels...
  32. ncbi Congenital arboviral infections: something new, something old
    Theodore F Tsai
    Asia Pacific Medical Affairs, Wyeth Research, Collegeville, PA 19426, USA
    Pediatrics 117:936-9. 2006
  33. ncbi Synthesis and structure-activity relationships of 6,7-disubstituted 4-anilinoquinoline-3-carbonitriles. The design of an orally active, irreversible inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR) and the human epi
    Allan Wissner
    Chemical Sciences, Oncology and Immunoinflammatory Research, Wyeth Research, 401 North Middletown Road, Pearl River, New York 10965, USA
    J Med Chem 46:49-63. 2003
    ..One compound, 5 (EKB-569), which shows excellent oral in vivo activity, was selected for further studies and is currently in phase I clinical trials for the treatment of cancer...
  34. ncbi Licensure of gemtuzumab ozogamicin for the treatment of selected patients 60 years of age or older with acute myeloid leukemia in first relapse
    Mark S Berger
    Department of Clinical Research and Development, Wyeth Research, Collegeville, PA, USA
    Invest New Drugs 20:395-406. 2002
    ..The recommended dosage of gemtuzumab ozogamicin is 9 mg/m2, administered as a 2-hour intravenous infusion for a total of 2 doses with 14 days between doses...
  35. ncbi Acid-labile isotope-coded extractants: a class of reagents for quantitative mass spectrometric analysis of complex protein mixtures
    Yongchang Qiu
    Proteomics Protein Chemistry Department, Wyeth, Cambridge, Massachusetts 02140, USA
    Anal Chem 74:4969-79. 2002
    ..Overall, the use of ALICE provides improved dynamic range and sensitivity for quantitative mass spectrometric analysis of peptide or protein mixtures...
  36. ncbi The role of live influenza vaccines in children
    William C Gruber
    Vanderbilt University, Nashville, TN, USA
    Vaccine 20:S66-73. 2002
    ..Studies of vaccine use in community settings will aid in determining the public health future of this approach...
  37. ncbi A decision analytic approach to a futility analysis of a phase II pharmaceutical study
    A Pallay
    Wyeth Ayerst Research, Clinical Biostatistics, Philadelphia, Pennsylvania 19101, USA
    J Biopharm Stat 11:209-25. 2001
    ..For this analysis we build a model that estimates the expected monetary value of the drug and the expected costs of development. These statistics are used to help decide whether to continue the study...
  38. ncbi Technology evaluation: cystic fibrosis therapy, Genzyme
    M I Cockett
    Wyeth Ayerst Research, Princeton, NJ 08543, USA
    Curr Opin Mol Ther 1:279-83. 1999
    ..Protein replacement therapy is currently in preclinical investigation and research efforts have been reduced infavor of the gene therapeutic approach [177633]...
  39. ncbi The 5-HT(6) receptor antagonist SB-271046 selectively enhances excitatory neurotransmission in the rat frontal cortex and hippocampus
    L A Dawson
    Neuroscience Research, Wyeth Ayerst CN 8000, Princeton, NJ 08543 8000, USA
    Neuropsychopharmacology 25:662-8. 2001
    ....
  40. ncbi QS-21 synergizes with recombinant interleukin-12 to create a potent adjuvant formulation for the fusion protein of respiratory syncytial virus
    G E Hancock
    Department of Immunology Research, Wyeth Lederle Vaccines, West Henrietta, New York 14586 9728, USA
    Viral Immunol 13:503-9. 2000
    ..01 to 1.0 microg) were also significantly elevated in the presence of 0.8 microg QS-21. Thus, rIL-12 and QS-21 together form a potent adjuvant for eliciting functional cell-mediated and humoral immune responses against F protein...
  41. ncbi Application of genomics and proteomics for identification of bacterial gene products as potential vaccine candidates
    D N Chakravarti
    Wyeth Lederle Vaccines, 211 Bailey Road, West Henrietta, NY 14586, USA
    Vaccine 19:601-12. 2000
    ....
  42. ncbi Synthesis and 5-hydroxytryptamine (5-HT) activity of 2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5-(6H)ones and 2,3,4,4a,5,6-hexahydro-1H-pyrazino[1,2-a]quinoxalines
    G S Welmaker
    Medicinal Chemistry, Chemical Sciences, Wyeth Ayerst Research, Princeton, NJ 08543, USA
    Bioorg Med Chem Lett 10:1991-4. 2000
    ..Compound 21R inhibited food intake over 2 h in fasted, male Sprague Dawley rats with ED50 values of 2 mg/kg (i.p.) and 10 mg/kg (p.o.)...
  43. ncbi Mechanism of inhibition of the class A beta -lactamases PC1 and TEM-1 by tazobactam. Observation of reaction products by electrospray ionization mass spectrometry
    Y Yang
    Wyeth Ayerst Research, Pearl River, New York 10965, USA
    J Biol Chem 275:26674-82. 2000
    ....
  44. pmc In vivo activities of peptidic prodrugs of novel aminomethyl tetrahydrofuranyl-1 beta-methylcarbapenems
    W J Weiss
    Infectious Disease Research Section, Antimicrobial Chemotherapy, Wyeth Ayerst Research, Pearl River, New York 10965, USA
    Antimicrob Agents Chemother 43:460-4. 1999
    ..The parent molecule was detectable in the sera of mice after oral administration of the peptidic prodrugs...
  45. ncbi Neuroprotective interaction effects of NMDA and AMPA receptor antagonists in an in vitro model of cerebral ischemia
    R L Arias
    CNS Disorders Division, Wyeth Ayerst Research, CN 8000, Princeton, NJ 08543 8000, USA
    Brain Res 816:299-308. 1999
    ..The results indicate that neuroprotection against acute ischemic insults may require a combination therapy approach...
  46. ncbi From anticholinesterase toxicity to Alzheimer's disease: important interactions of cholinergic and NMDA receptor systems
    E Jon Popke
    Safety Pharmacology, Wyeth Research, 641 Ridge Road Chazy, NY 12921, USA
    Toxicol Sci 72:185-7. 2003
    ..Alzheimer's disease is discussed as an example of how knowledge of the interactions between NMDA and cholinergic receptors may lead to a better understanding of human disease...
  47. ncbi Synthesis and evaluation of ether and halogenated derivatives of mannopeptimycin glycopeptide antibiotics
    Phaik Eng Sum
    Chemical Sciences, Wyeth Research, Pearl River, NY 10965, USA
    Bioorg Med Chem Lett 13:2805-8. 2003
    ..These compounds were synthesized via electrophilic aromatic substitution. Many of the new ether derivatives exhibited potent antibacterial activity against Gram-positive resistant strains including VRE, MRSA, and PRSP...
  48. ncbi A gene expression profile for endochondral bone formation: oligonucleotide microarrays establish novel connections between known genes and BMP-2-induced bone formation in mouse quadriceps
    Brian M Clancy
    Division of Musculoskeletal Sciences, Wyeth, 200 Cambridge Park Drive, Cambridge, MA 02140, USA
    Bone 33:46-63. 2003
    ..An increased understanding of the roles played by these gene products will improve our understanding of skeletogenesis, fracture repair, and pathological conditions such as osteoporosis...
  49. ncbi Investigating beta-hydroxyenduracididine formation in the biosynthesis of the mannopeptimycins
    Brad Haltli
    Natural Products Discovery, Wyeth Research, Pearl River, New York 10965, USA
    Chem Biol 12:1163-8. 2005
    ..Characterization in vitro of recombinant His6-MppO expressed in E. coli revealed that MppO selectively hydroxylates the beta carbon of free L-enduracididine...
  50. ncbi Risk factors associated with beta-amyloid(1-42) immunotherapy in preimmunization gene expression patterns of blood cells
    Margot O'Toole
    Biological Technologies, Wyeth Research, Cambridge, MA 02140, USA
    Arch Neurol 62:1531-6. 2005
    ..Six immunizations were planned but were halted when meningoencephalitis was recognized as an adverse event in 6% of immunized patients...
  51. ncbi (4-Substituted-phenyl)-(5H-10,11-dihydro-pyrrolo [2,1-c][1,4] benzodiazepin-10-yl)-methanone derivatives as vasopressin receptor modulators
    Aranapakam M Venkatesan
    Chemical and Screening Sciences, Wyeth Research, Pearl River, NY 10965, USA
    Bioorg Med Chem Lett 15:5003-6. 2005
    ..Potent and selective compounds are prepared when the amide linkage connecting rings A and B of VPA-985 is replaced with a bond, CO, -O-, -S-, or -SO2- bond...
  52. pmc Effect of medium age and supplementation with the biocatalytic oxygen-reducing reagent oxyrase on in vitro activities of tigecycline against recent clinical isolates
    Peter J Petersen
    Infectious Disease Research, Wyeth Research, Bldg 200, Rm 3301, 401 N Middletown Rd, Pearl River, NY 10965, USA
    Antimicrob Agents Chemother 49:3910-8. 2005
    ..This study was performed to examine the effect of medium age and supplementation with Oxyrase on the activity of tigecycline using a large number of clinical isolates...
  53. ncbi mTOR--beyond transplantation
    Deborah A Young
    Wyeth Research, 200 CambridgePark Drive, Cambridge, Massachusetts 02140, USA
    Curr Opin Pharmacol 5:418-23. 2005
    ..Selective inhibition of cell activation in the appropriate setting might prove to be beneficial for several autoimmune or inflammatory diseases...
  54. ncbi Targeting JNK3 for the treatment of neurodegenerative disorders
    Lynn Resnick
    Wyeth Research, CN 8000, Princeton, NJ 08543 8000, USA
    Drug Discov Today 9:932-9. 2004
    ..Because of the involvement of JNK3 in neuronal diseases, the inhibition of this enzyme is an attractive therapeutic target...
  55. ncbi Functional expression of human and mouse P2Y12 receptors in Saccharomyces cerevisiae
    Mark H Pausch
    Discovery Neuroscience, Wyeth Research, Princeton, NJ 08543 8000, USA
    Biochem Biophys Res Commun 324:171-7. 2004
    ..Murine P2Y12 mRNA was expressed at high levels in the brain and at lower levels in a variety of peripheral tissues. In situ hybridization analysis indicated glia-specific expression within the brain...
  56. ncbi The orphan receptor tyrosine kinase Ror2 modulates canonical Wnt signaling in osteoblastic cells
    Julia Billiard
    Women s Health Research Institute, Wyeth Research, 500 Arcola Road, Collegeville, Pennsylvania 19426, USA
    Mol Endocrinol 19:90-101. 2005
    ....
  57. ncbi Thiourea inhibitors of herpes viruses. Part 2: N-Benzyl-N'-arylthiourea inhibitors of CMV
    Jonathan D Bloom
    Chemical and Screening Sciences and Infectious Disease Research, Wyeth Research, 401 N Middletown Rd, Pearl River, NY 10965, USA
    Bioorg Med Chem Lett 14:3401-6. 2004
    ..A series of highly potent thiourea inhibitors of cytomegalovirus (CMV) with improved stability properties was prepared and evaluated. Compound 29 inhibited the virus in cultured HFF cells with IC50 of 0.2 nM...
  58. ncbi Persistent suppression of contact hypersensitivity, and altered T-cell parameters in F344 rats exposed perinatally to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
    Dana B Walker
    Wyeth Research, 641 Ridge Road, Chazy, NY 12921, USA
    Toxicology 197:57-66. 2004
    ..The CHS proved to be a valuable bioassay for investigating long-term immunotoxic effects of perinatal TCDD exposure in rats...
  59. ncbi Characterization of a membrane-associated estrogen receptor in a rat hypothalamic cell line (D12)
    Darlene C Deecher
    Women s Health Research Institute, Wyeth Research, Collegeville, PA 19426, USA
    Endocrine 22:211-23. 2003
    ..These data support the expression of mER in these brain-derived endothelial cells that is similar to, but biochemically distinguishable from, nuclear ERalpha...
  60. ncbi Mannopeptimycin esters and carbonates, potent antibiotic agents against drug-resistant bacteria
    Haiyin He
    Department of Natural Products Chemistry, Chemical Sciences, Wyeth, Pearl River, NY 10965, USA
    Bioorg Med Chem Lett 14:279-82. 2004
    ..The SAR data obtained from natural and semisynthetic compounds demonstrated the importance of a hydrophobic group in the terminal mannosyl moiety for antibacterial activity...
  61. ncbi Full-length estrogen receptor alpha and its ligand-binding domain adopt different conformations upon binding ligand
    Ashok R Bapat
    Women s Health Research Institute, Wyeth Research, 500 Arcola Road, Collegeville, PA 19426, USA
    J Steroid Biochem Mol Biol 86:143-9. 2003
    ..Furthermore, the ability of a ligand to induce a strong interaction of pepalphaII with the estrogen receptor alpha ligand-binding domain predicts that the ligand will have greater antagonist activity on the full-length receptor...
  62. ncbi Synthesis and tyrosine kinase inhibitory activity of a series of 2-amino-8H-pyrido[2,3-d]pyrimidines: identification of potent, selective platelet-derived growth factor receptor tyrosine kinase inhibitors
    D H Boschelli
    Departments of Medicinal Chemistry, Cancer Research, Vascular, Cardiac Diseases, Pharmacokinetics and Drug Metabolism, Parke Davis Pharmaceutical Research, Division of Warner Lambert Company, Ann Arbor, Michigan 48105, USA
    J Med Chem 41:4365-77. 1998
    ....

Research Grants1

  1. Conference:Cytokines, Disease & Therapeutic Intervention
    Mary Collins; Fiscal Year: 2004
    ..abstract_text> ..