James G Wilson
- Potential role of increased iron stores in diabetesJames G Wilson
G V Sonny Montgomery Veterans Affairs Medical Center and University of Mississippi Medical Center, Jackson, 39216, USA
Am J Med Sci 325:332-9. 2003..The current article reviews evidence suggesting that tissue iron contributes to DM and its complications and presents preliminary data that emphasize the potential importance of iron overload in DM of African Americans...
- Study design for genetic analysis in the Jackson Heart StudyJames G Wilson
School of Medicine, Examination Center, Jackson Heart Study, University of Mississippi Medical Center, USA
Ethn Dis 15:S6-30-37. 2005..Family Study participants completed the same questionnaires, measures, and procedures as all other JHS participants and provided blood samples for lymphocyte cryopreservation and transformation...
- Iron and glucose homeostasis: new lessons from hereditary haemochromatosisJ G Wilson
G V Sonny Montgomery, Department of Veterans Affairs Medical Center, 1500 E Woodrow Wilson Avenue, Jackson, MS 39216, USA
Diabetologia 49:1459-61. 2006
- Epidemiology, heritability, and genetic linkage of C-reactive protein in African Americans (from the Jackson Heart Study)Ervin R Fox
University of Mississippi School of Medicine, Jackson, Mississippi, USA
Am J Cardiol 102:835-41. 2008..72. In conclusion, in this large population-based cohort of African Americans, circulating CRP concentration was heritable and associated with several traditional cardiovascular risk factors, particularly body mass index...
- Gene-environment interaction between SCN5A-1103Y and hypokalemia influences QT interval prolongation in African Americans: the Jackson Heart StudyErmeg L Akylbekova
Jackson Heart Study, Jackson State University, Jackson, MS
Am Heart J 167:116-122.e1. 2014..SCN5A-1103Y is known to interact with QT-prolonging factors to promote ventricular arrhythmias in persons at high risk for SCD, but its clinical impact in the general African-American population has not been established...
- Toward resolution of cardiovascular health disparities in African Americans: design and methods of the Jackson Heart StudyHerman A Taylor
School of Medicine and the Examination Center, Jackson Heart Study, University of Mississippi Medical Center, Jackson 39216 4505, USA
Ethn Dis 15:S6-4-17. 2005..The design, overall methods, and major phenotypes for the all-African-American Jackson Heart Study (JHS) are detailed...
- Gene-centric meta-analysis of lipid traits in African, East Asian and Hispanic populationsClara C Elbers
Department of Genetics, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania, USA
PLoS ONE 7:e50198. 2012..However, differences between populations, especially differences in allele frequency, can be leveraged to identify novel signals, as shown by the discovery of ICAM1 and CD36 in the current report...
- Fatty liver, abdominal adipose tissue and atherosclerotic calcification in African Americans: the Jackson Heart StudyJiankang Liu
Jackson Heart Study, University of Mississippi Medical Center, 350 W Woodrow Wilson Dr, Jackson State University, Jackson, MS 39213 4505, USA
Atherosclerosis 224:521-5. 2012..Both fatty liver and abdominal visceral fat (VAT) are associated with cardiometabolic risk factors. Whether fatty liver and VAT are jointly associated with coronary artery (CAC) or abdominal aortic (AAC) calcification is not clear...
- Genetic ancestry is associated with measures of subclinical atherosclerosis in African Americans: the Jackson Heart StudySamson Y Gebreab
From the National Human Genome Research Institute, Metabolic, Cardiovascular and Inflammatory Disease Genomics Branch, Bethesda, MD S Y G, P R, R J K, R X, F T A, C N R, S K D and Jackson Heart Study S K M, A C, and Department of Physiology and Biophysics J G W, University of Mississippi Medical Center, Jackson
Arterioscler Thromb Vasc Biol 35:1271-8. 2015....
- Imputation of coding variants in African Americans: better performance using data from the exome sequencing projectQing Duan
Department of Genetics and Department of Computer Science, University of North Carolina, Chapel Hill, NC 27599, USA, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA, Department of Biostatistics, University of North Carolina, Chapel Hill, NC 27599, USA, Department of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA, Renaissance Computing Institute, University of North Carolina, Chapel Hill, NC 27599, USA, Department of Statistics and Department of Genetics, Rutgers University, Piscataway, NJ 08854, USA, Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599, USA, Department of Epidemiology, University of Washington, Seattle, WA 98195, USA, Division of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA, Department of Epidemiology and Medicine, University of Iowa, Iowa City, IA 52242, Division of Cardiology, George Washington University School of Medicine and Health Sciences, Washington, DC 20037, USA, Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, France
Bioinformatics 29:2744-9. 2013..We recommend using haplotypes from Exome Sequencing Project alone or concatenation of the two panels over quality score-based post-imputation selection or IMPUTE2's two-panel combination...
- Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studiesBrendan J Keating
The Institute for Translational Medicine and Therapeutics, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvannia, USA
PLoS ONE 3:e3583. 2008..These datasets will also facilitate more robust secondary analyses, such as explorations with alternative genetic models, epistasis and gene-environment interactions...
- Whole-exome imputation of sequence variants identified two novel alleles associated with adult body height in African AmericansMengmeng Du
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, School of Public Health and Channing Division of Network Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
Hum Mol Genet 23:6607-15. 2014..Our findings demonstrate that whole-exome imputation of sequence variants can identify low-frequency variants and discover novel variants in non-European populations. ..
- P-selectin Plasma Levels and Genetic Variant Associated With Diabetic Retinopathy in African AmericansAlan Penman
Center of Biostatistics and Bioinformatics, University of Mississippi Medical Center, Jackson, Mississippi
Am J Ophthalmol 159:1152-1160.e2. 2015....
- FEM1A is a candidate gene for polycystic ovary syndromeJoseph F Maher
G V Sonny Montgomery Veterans Affairs Medical Center and Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
Gynecol Endocrinol 21:330-5. 2005..In conclusion, FEM1A should be considered a candidate gene for PCOS, and more extensive analysis of FEM1A, both coding and regulatory sequences, is warranted in patients and families with PCOS...
- Admixture mapping of white cell count: genetic locus responsible for lower white blood cell count in the Health ABC and Jackson Heart studiesMichael A Nalls
Laboratory of Epidemiology, Demography and Biometry, Intramural Research Program, National Institute on Aging, Bethesda, MD 20892, USA
Am J Hum Genet 82:81-7. 2008..Additional studies are needed to determine the biological mechanism for this effect and its clinical implications...