Affiliation: Wilford Hall Medical Center
- Are diamond nanoparticles cytotoxic?Amanda M Schrand
Department of Chemical and Materials Engineering, University of Dayton, 300 College Park, Dayton, Ohio 45469 0240, USA
J Phys Chem B 111:2-7. 2007..Cells can grow on nanodiamond-coated substrates without morphological changes compared to controls. These results suggest that nanodiamonds could be ideal for many biological applications in a diverse range of cell types...
- The interaction of manganese nanoparticles with PC-12 cells induces dopamine depletionSaber M Hussain
Applied Biotechnology Branch, Human Effectiveness Directorate, Air Force Research Laboratory, Wright Patterson AFB, Ohio 45431, USA
Toxicol Sci 92:456-63. 2006....
- Cellular toxicity of hydrazine in primary rat hepatocytesSaber M Hussain
Operational Toxicology Branch AFRL HEST, Air Force Research Laboratory, ManTech Environmental Technology, Inc, PO Box 31009, Dayton, OH 45437, USA
Toxicol Sci 69:424-32. 2002..The results suggest that acute HzN-induced cytotoxicity in rat hepatocytes is likely to be mediated through oxidative stress...
- Zinc potentiates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine induced dopamine depletion in caudate nucleus of mice brainSaber Hussain
Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research FDA Jefferson, AR 72079, USA
Neurosci Lett 335:25-8. 2002..In summary the data suggest that Zn treatment potentiates depletion of dopamine in MPTP treated mice...
- Involvement of apoptosis in hydrazine induced toxicity in rat primary hepatocytesSaber M Hussain
ManTech Environmental Technology, Inc 45437, Dayton, OH, USA
Toxicol In Vitro 17:343-55. 2003..The possibility that HzN induces apoptosis without the involvement of DNA fragmentation can not be ruled out. The present results, overall, suggest that apoptosis may be a contributing factor in acute HzN toxicity...
- In vitro toxicity of nanoparticles in BRL 3A rat liver cellsS M Hussain
Applied Biotechnology, Air Force Research Laboratory HEPB, Wright Patterson AFB, OH, USA
Toxicol In Vitro 19:975-83. 2005....
- Interaction of silver nanoparticles with Tacaribe virusJanice L Speshock
Applied Biotechnology Branch, Human Effectiveness Directorate, 711th Human Performance Wing, U, S, Air Force Research Laboratory, 2729 R Street, Wright Patterson Air Force Base, OH, 45433 5707, USA
J Nanobiotechnology 8:19. 2010..An area that has been largely unexplored is the interaction of nanomaterials with viruses and the possible use of silver nanoparticles as an antiviral agent...
- Unique cellular interaction of silver nanoparticles: size-dependent generation of reactive oxygen speciesC Carlson
Applied Biotechnology Branch, Human Effectiveness Directorate, Wright Patterson Air Force Base, Dayton, Ohio 45433, USA
J Phys Chem B 112:13608-19. 2008..In summary, a size-dependent toxicity was produced by silver nanoparticles, and one predominant mechanism of toxicity was found to be largely mediated through oxidative stress...
- In vitro toxicity assessment of a new series of high energy compoundsS M Hussain
Air Force Research Laboratory, HEST, Wright-Patterson Air Force Base, OH 45433-7400, USA
Sci Total Environ 274:151-60. 2001..Depletion of GSH in hepatocytes by buthionine sulfoximine (BSO) prior to exposure to HZN increased its toxicity. The results suggest that at least one mechanism of HEC toxicity is mediated through oxidative stress...
- The effect of shear flow on nanoparticle agglomeration and deposition in in vitro dynamic flow modelsChristin Grabinski
a Molecular Bioeffects Branch, Air Force Research Laboratory, Wright Patterson Air Force Base, OH, USA
Nanotoxicology 10:74-83. 2016..Our results reveal that dynamic systems are capable of producing a more predictable dose compared to static systems, which has strong implications for improving repeatability in nanotoxicity assessments. ..
- Expression of genes related to oxidative stress in the mouse brain after exposure to silver-25 nanoparticlesM F Rahman
Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research, U S Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079 9502, USA
Toxicol Lett 187:15-21. 2009..The data suggest that Ag-25 nanoparticles may produce neurotoxicity by generating free radical-induced oxidative stress and by altering gene expression, producing apoptosis and neurotoxicity...
- Hyperspectral microscopy for characterization of gold nanoparticles in biological media and cells for toxicity assessmentChristin Grabinski
Air Force Research Laboratory, Wright Patterson Air Force Base, Dayton, OH, USA
Methods Mol Biol 1025:167-78. 2013..Nano Lett 5:829-834, 2005). Here we describe an approach for using hyperspectral microscopy to characterize the agglomeration and stability of plasmonic NPs in biological media and their interactions with cells. ..
- Silver nanoparticles decrease body weight and locomotor activity in adult male ratsYongbin Zhang
Nanotechnology Core Facility, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA
Small 9:1715-20. 2013..The dose-dependent activity and body weight alterations are evaluated after rats were exposed to Ag nanoparticles, suggesting a major human health risk, given the wide application of silver nanomaterials...
- Surface charge of gold nanoparticles mediates mechanism of toxicityNicole M Schaeublin
Applied Biotechnology Branch, Human Effectiveness Directorate, 711 Human Performance Wing, Air Force Research Laboratory, Area B, R Street, Bldg 837, Wright Patterson AFB, OH 45433 5707, USA
Nanoscale 3:410-20. 2011..In conclusion, these results indicate that surface charge is a major determinant of how Au NPs impact cellular processes, with the charged NPs inducing cell death through apoptosis and neutral NPs leading to necrosis...
- Risk assessment of high-energy chemicals by in vitro toxicity screening and quantitative structure-activity relationshipsSteven Trohalaki
Technical Management Concepts, Inc, P O Box 340345, Beavercreek, Ohio 45434 0345, USA
Toxicol Sci 68:498-507. 2002..Application of our derived QSARs will assist in predicting toxicity for newly proposed propellants...
- Characterization of nanomaterial dispersion in solution prior to in vitro exposure using dynamic light scattering techniqueRichard C Murdock
Applied Biotechnology Branch, Human Effectiveness Directorate Air Force Research Laboratory HEPB, Wright Patterson Air Force Board, Ohio 45433, USA
Toxicol Sci 101:239-53. 2008..It was also observed that sonication slightly reduces agglomeration and has minimal effect on particle surface charge. Finally, the stock solution experienced significant changes in particle agglomeration and surface charge over time...
- Integrating time-course microarray gene expression profiles with cytotoxicity for identification of biomarkers in primary rat hepatocytes exposed to cadmiumYongxi Tan
Cedars Sinai Research Institute, Cedars Sinai Medical Center Los Angeles, CA 90048, USA
Bioinformatics 22:77-87. 2006..It is important to investigate the multi-scale biological system in a systematic way to better understand the gene regulation networks and signal transduction pathways involved in the cellular responses to environmental factors...
- Cellular interaction of different forms of aluminum nanoparticles in rat alveolar macrophagesAndrew J Wagner
Air Force Institute of Technology, Applied Biotechnology Branch, Human Effectiveness Directorate, Air Force, Research Laboratory, Wright Patterson AFB, Ohio, USA
J Phys Chem B 111:7353-9. 2007..In summary, these results show that Al-NP exhibit greater toxicity and more significantly diminish the phagocytotic ability of macrophages after 24 h of exposure when compared to Al2O3-NP...
- Assessment of metal nanoparticle agglomeration, uptake, and interaction using high-illuminating systemJeanne E Skebo
Applied Biotechnology Branch, Human Effectiveness Directorate, Air Force Research Laboratory HEPB, Wright Patterson Air Force Base, Ohio 45433 5707, USA
Int J Toxicol 26:135-41. 2007..Additionally, an example application of nanoparticle labeling onto the surface and neurite extensions of murine neuroblastoma cells (N2A) is presented as a potential imaging tool...