I Mark Olfert

Summary

Affiliation: West Virginia University
Country: USA

Publications

  1. pmc Inflammatory cytokine response to exercise in alpha-1-antitrypsin deficient COPD patients 'on' or 'off' augmentation therapy
    I Mark Olfert
    Center for Cardiovascular and Respiratory Sciences, Division of Exercise Physiology, One Medical Center Dr, West Virginia University School of Medicine, Morgantown, WV 26506 9105, USA
    BMC Pulm Med 14:106. 2014
  2. pmc Temporal response of positive and negative regulators in response to acute and chronic exercise training in mice
    Sara A Olenich
    I M Olfert West Virginia University School of Medicine, Center for Cardiovascular and Respiratory Sciences, Division of Exercise Physiology, One Medical Center Dr, Morgantown, WV 26506 9105, USA
    J Physiol 591:5157-69. 2013
  3. pmc Myocyte vascular endothelial growth factor is required for exercise-induced skeletal muscle angiogenesis
    I Mark Olfert
    Department of Medicine, University of California, San Diego, La Jolla, USA
    Am J Physiol Regul Integr Comp Physiol 299:R1059-67. 2010
  4. doi request reprint Importance of anti-angiogenic factors in the regulation of skeletal muscle angiogenesis
    I Mark Olfert
    Division of Exercise Physiology, Center for Cardiovascular and Respiratory Sciences, West Virginia University School of Medicine, Morgantown, West Virginia 26506, USA
    Microcirculation 18:316-30. 2011
  5. doi request reprint Sildenafil and bosentan improve arterial oxygenation during acute hypoxic exercise: a controlled laboratory trial
    I Mark Olfert
    Center for Cardiovascular and Respiratory Sciences, Division of Exercise Physiology, West Virginia University School of Medicine, Morgantown, WV 26506, USA
    Wilderness Environ Med 22:211-21. 2011
  6. pmc Muscle-specific VEGF deficiency greatly reduces exercise endurance in mice
    I Mark Olfert
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093 0623, USA
    J Physiol 587:1755-67. 2009
  7. ncbi request reprint HIF-1alpha in endurance training: suppression of oxidative metabolism
    Steven D Mason
    Div of Biologicay, University of California, San Diego, La Jolla, CA 92093 0377, USA
    Am J Physiol Regul Integr Comp Physiol 293:R2059-69. 2007
  8. ncbi request reprint Tidal volume dependency of gas exchange in bronchoconstricted pig lungs
    Axel Kleinsasser
    Department of Medicine, Division of Physiology, University of California San Diego, La Jolla, California 92093 0623, USA
    J Appl Physiol 103:148-55. 2007
  9. ncbi request reprint Muscle-targeted deletion of VEGF and exercise capacity in mice
    Peter D Wagner
    Division of Physiology, Department of Medicine, University of California, San Diego, 9500 Gilman Drive, DEPT 0623A, La Jolla, CA 92093, USA
    Respir Physiol Neurobiol 151:159-66. 2006
  10. pmc Loss of skeletal muscle HIF-1alpha results in altered exercise endurance
    Steven D Mason
    Molecular Biology Section, Division of Biology, School of Medicine, University of California, San Diego, USA
    PLoS Biol 2:e288. 2004

Collaborators

Detail Information

Publications33

  1. pmc Inflammatory cytokine response to exercise in alpha-1-antitrypsin deficient COPD patients 'on' or 'off' augmentation therapy
    I Mark Olfert
    Center for Cardiovascular and Respiratory Sciences, Division of Exercise Physiology, One Medical Center Dr, West Virginia University School of Medicine, Morgantown, WV 26506 9105, USA
    BMC Pulm Med 14:106. 2014
    ..We also hypothesized that cytokine response to exercise would be lower in AATD + AUG compared to AATD-AUG or COPD subjects...
  2. pmc Temporal response of positive and negative regulators in response to acute and chronic exercise training in mice
    Sara A Olenich
    I M Olfert West Virginia University School of Medicine, Center for Cardiovascular and Respiratory Sciences, Division of Exercise Physiology, One Medical Center Dr, Morgantown, WV 26506 9105, USA
    J Physiol 591:5157-69. 2013
    ....
  3. pmc Myocyte vascular endothelial growth factor is required for exercise-induced skeletal muscle angiogenesis
    I Mark Olfert
    Department of Medicine, University of California, San Diego, La Jolla, USA
    Am J Physiol Regul Integr Comp Physiol 299:R1059-67. 2010
    ..However, skeletal muscle metabolic adaptation to exercise training takes place independent of myocyte VEGF expression...
  4. doi request reprint Importance of anti-angiogenic factors in the regulation of skeletal muscle angiogenesis
    I Mark Olfert
    Division of Exercise Physiology, Center for Cardiovascular and Respiratory Sciences, West Virginia University School of Medicine, Morgantown, West Virginia 26506, USA
    Microcirculation 18:316-30. 2011
    ....
  5. doi request reprint Sildenafil and bosentan improve arterial oxygenation during acute hypoxic exercise: a controlled laboratory trial
    I Mark Olfert
    Center for Cardiovascular and Respiratory Sciences, Division of Exercise Physiology, West Virginia University School of Medicine, Morgantown, WV 26506, USA
    Wilderness Environ Med 22:211-21. 2011
    ..This study was designed to examine and compare the effect of sildenafil and bosentan on pulmonary gas exchange during acute hypoxic exercise in a controlled laboratory setting...
  6. pmc Muscle-specific VEGF deficiency greatly reduces exercise endurance in mice
    I Mark Olfert
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093 0623, USA
    J Physiol 587:1755-67. 2009
    ..Furthermore, VEGF is essential in regulating postnatal muscle capillarity, and that adult mice, deficient in cardiac and skeletal muscle VEGF, exhibit a major intolerance to aerobic exercise...
  7. ncbi request reprint HIF-1alpha in endurance training: suppression of oxidative metabolism
    Steven D Mason
    Div of Biologicay, University of California, San Diego, La Jolla, CA 92093 0377, USA
    Am J Physiol Regul Integr Comp Physiol 293:R2059-69. 2007
    ..These data demonstrate that removal of HIF-1alpha causes an adaptive response in skeletal muscle akin to endurance training and provides evidence for the suppression of mitochondrial biogenesis by HIF-1alpha in normal tissue...
  8. ncbi request reprint Tidal volume dependency of gas exchange in bronchoconstricted pig lungs
    Axel Kleinsasser
    Department of Medicine, Division of Physiology, University of California San Diego, La Jolla, California 92093 0623, USA
    J Appl Physiol 103:148-55. 2007
    ..However, our data do not allow exclusion of other mechanisms that may lead to improved ventilatory distribution when tidal volume is increased...
  9. ncbi request reprint Muscle-targeted deletion of VEGF and exercise capacity in mice
    Peter D Wagner
    Division of Physiology, Department of Medicine, University of California, San Diego, 9500 Gilman Drive, DEPT 0623A, La Jolla, CA 92093, USA
    Respir Physiol Neurobiol 151:159-66. 2006
    ..Because VEGF deletion is embryonically lethal, its study requires conditional and/or organ-targeted strategies. We inactivated the muscle VEGF gene in two ways:..
  10. pmc Loss of skeletal muscle HIF-1alpha results in altered exercise endurance
    Steven D Mason
    Molecular Biology Section, Division of Biology, School of Medicine, University of California, San Diego, USA
    PLoS Biol 2:e288. 2004
    ..Thus, these results demonstrate an important role for the HIF-1 pathway in the metabolic control of muscle function...
  11. pmc Effect of acetazolamide on pulmonary and muscle gas exchange during normoxic and hypoxic exercise
    Amy M Jonk
    Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0623, USA
    J Physiol 579:909-21. 2007
    ..05). In summary, ACZ improved arterial oxygenation during exercise, due to both greater ventilation and more efficient pulmonary gas exchange. However, muscle gas exchange was unaffected...
  12. doi request reprint Global deletion of thrombospondin-1 increases cardiac and skeletal muscle capillarity and exercise capacity in mice
    Moh H Malek
    University of California, San Diego, School of Medicine, Department of Medicine, Division of Physiology, La Jolla, CA 92093 0623A, USA
    Exp Physiol 94:749-60. 2009
    ..The increased capillarity alone was sufficient to increase (P < 0.05) exercise capacity. These data demonstrate that the capillary-to-muscle interface is a critical factor that limits oxygen transport during exercise...
  13. doi request reprint Expression of angiogenic regulators and skeletal muscle capillarity in selectively bred high aerobic capacity mice
    Gerald N Audet
    West Virginia University School of Medicine, Center for Cardiovascular and Respiratory Sciences, Division of Exercise Physiology, Morgantown, WV 26508, USA
    Exp Physiol 96:1138-50. 2011
    ..e. VEGF versus TSP-1, respectively). Based on the greater capillarity and significant VEGF response to exercise in MM mice, these data suggest that VEGF expression may, at least in part, be genetically determined...
  14. ncbi request reprint The effect of incomplete acetylene washout on cardiac output measurement using open circuit acetylene uptake
    Jamal Balouch
    Department of Medicine, Division of Physiology, University of California, San Diego, La Jolla, California 92093 0623, USA
    Respir Physiol Neurobiol 155:177-83. 2007
    ....
  15. pmc Rapid intravenous infusion of 20 ml/kg saline does not impair resting pulmonary gas exchange in the healthy human lung
    G Kim Prisk
    Dept of Medicine, Univ of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0931, USA
    J Appl Physiol (1985) 108:53-9. 2010
    ..05] with similar effects on ventilation in the face of unchanged (.)VA and (.)Q. These results suggest active control of blood flow to regions of decreased ventilation during air breathing, thus minimizing the gas exchange consequences...
  16. pmc Does gender affect human pulmonary gas exchange during exercise?
    I Mark Olfert
    Department of Medicine, University of California, San Diego, CA 92093 0623, USA
    J Physiol 557:529-41. 2004
    ..Possibly fitness level and lung size are more important in determining whether or not pulmonary gas exchange impairment occurs during exercise than sex per se...
  17. ncbi request reprint Temporal thrombospondin-1 mRNA response in skeletal muscle exposed to acute and chronic exercise
    I Mark Olfert
    Division of Physiology, Department of Medicine, University of California San Diego, La Jolla, CA 92093 0623, USA
    Growth Factors 24:253-9. 2006
    ....
  18. doi request reprint Detraining losses of skeletal muscle capillarization are associated with vascular endothelial growth factor protein expression in rats
    Moh H Malek
    University of California, San Diego, School of Medicine, Division of Physiology, 9500 Gilman Drive, DEPT 0623A, La Jolla, CA 92093 0623A, USA
    Exp Physiol 95:359-68. 2010
    ..The results indicated that training-induced angiogenic remodelling was reversible following 1 week of detraining and may be modulated by VEGF...
  19. pmc Increased peripheral vascular disease risk progressively constrains perfusion adaptability in the skeletal muscle microcirculation
    Jefferson C Frisbee
    Department of Physiology and Pharmacology, West Virginia University Health Sciences Center, Morgantown, West Virginia Center for Basic and Translational Stroke Research, West Virginia University Health Sciences Center, Morgantown, West Virginia Center for Cardiovascular and Respiratory Sciences, West Virginia University Health Sciences Center, Morgantown, West Virginia and
    Am J Physiol Heart Circ Physiol 310:H488-504. 2016
    ....
  20. pmc Improved arterial-ventricular coupling in metabolic syndrome after exercise training: a pilot study
    Sara B Fournier
    1Department of Human Performance and Applied Sciences, Division of Exercise Physiology, School of Medicine, West Virginia University, Morgantown, WV and 2Center for Cardiovascular and Respiratory Sciences, School of Medicine, West Virginia University, Morgantown, WV
    Med Sci Sports Exerc 47:2-11. 2015
    ..The objective of this study was to examine the effects of 8 wk of aerobic exercise training in individuals with MetS on resting and peak exercise CV function...
  21. pmc Aerobic exercise training reduces arterial stiffness in metabolic syndrome
    David A Donley
    Division of Exercise Physiology, School of Medicine, West Virginia University, Morgantown, West Virginia
    J Appl Physiol (1985) 116:1396-404. 2014
    ..These findings suggest that some of the pathophysiological changes associated with MetS can be improved after aerobic exercise training, thereby lowering their cardiovascular risk. ..
  22. ncbi request reprint Arteriolar and venular capillary distribution in skeletal muscles of old rats
    Li Cui
    Department of Medicine, 0623A, University of California, San Diego, La Jolla, CA 92093 0623, USA
    J Gerontol A Biol Sci Med Sci 63:928-35. 2008
    ..These data suggest that age-associated increases in skeletal muscle capillarity may be due to the venular portion of capillaries and that the increase occurs primarily in muscles that demonstrate increased oxidative potential with age...
  23. pmc Distinct temporal phases of microvascular rarefaction in skeletal muscle of obese Zucker rats
    Jefferson C Frisbee
    Department of Physiology and Pharmacology, West Virginia University Health Sciences Center, Morgantown, West Virginia Center for Cardiovascular and Respiratory Sciences, West Virginia University Health Sciences Center, Morgantown, West Virginia
    Am J Physiol Heart Circ Physiol 307:H1714-28. 2014
    ....
  24. pmc Steep head-down tilt has persisting effects on the distribution of pulmonary blood flow
    A Cortney Henderson
    Univ of California, San Diego, Dept of Medicine, 9500 Gilman Dr, 0931, La Jolla, CA 92093 0931, USA
    J Appl Physiol (1985) 101:583-9. 2006
    ..05). We speculate that the mechanism most likely responsible for our findings is that increased pulmonary capillary pressures and fluid efflux in the lung resulting from head-down tilt alters regional blood flow distribution...
  25. pmc Chronic delivery of a thrombospondin-1 mimetic decreases skeletal muscle capillarity in mice
    Gerald N Audet
    Division of Exercise Physiology, Center for Cardiovascular and Respiratory Sciences, West Virginia University School of Medicine, Morgantown, West Virginia, United States of America
    PLoS ONE 8:e55953. 2013
    ..It also suggests that under physiologic conditions the TSP-1/CD36 axis plays a role in regulating basal skeletal muscle microvessel density...
  26. ncbi request reprint Oxygen consumption during maximal exercise in Fischer 344 x Brown Norway F1 hybrid rats
    I Mark Olfert
    Department of Medicine, University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0623, USA
    J Gerontol A Biol Sci Med Sci 59:801-8. 2004
    ..The underlying mechanism responsible for increasing O2 consumption in aged F344BNF1 rats during exercise, although partly explained by mechanical inefficiencies of locomotion, still remains to be determined...
  27. pmc Increase in relative deposition of fine particles in the rat lung periphery in the absence of gravity
    Chantal Darquenne
    Department of Medicine, University of California, San Diego, La Jolla, California
    J Appl Physiol (1985) 117:880-6. 2014
    ..Although not measured, the difference in the spatial distribution of deposited particles between μG and 1G could also affect particle retention rates, with an increase in retention for particles deposited more peripherally. ..
  28. pmc Effects of detraining on the temporal expression of positive and negative angioregulatory proteins in skeletal muscle of mice
    Sara A Olenich
    Division of Exercise Physiology, West Virginia University School of Medicine, One Medical Center Dr, Morgantown, WV, 26506, USA
    J Physiol 592:3325-38. 2014
    ..The responses of matrix metalloproteinases, endostatin and nucleolin poorly correlated with detraining-induced capillary regression. ..
  29. ncbi request reprint Effect of 60 degrees head-down tilt on peripheral gas mixing in the human lung
    I Mark Olfert
    Department of Medicine, University of California, San Diego, La Jolla, California 92093 0623, USA
    J Appl Physiol (1985) 97:827-34. 2004
    ..These findings support the notion that changes in thoracic fluid volume alter ventilation distribution in the lung periphery but also demonstrate that the effect during HDT does not wholly mimic that observed in microG...
  30. pmc Divergence between arterial perfusion and fatigue resistance in skeletal muscle in the metabolic syndrome
    Jefferson C Frisbee
    Center for Cardiovascular and Respiratory Sciences, Department of Physiology and Pharmacology, West Virginia University Health Sciences Center, 3152 HSN, 1 Medical Center Drive, Morgantown, WV 26506, USA
    Exp Physiol 96:369-83. 2011
    ..Further, these data suggest that increasing skeletal muscle blood flow in OZRs is not sufficient to improve performance, unless distal perfusion inhomogeneities are rectified...
  31. pmc Loss of Adipocyte VEGF Impairs Endurance Exercise Capacity in Mice
    Nicole J Zachwieja
    1Division of Exercise Physiology, School of Medicine, West Virginia University, Morgantown, WV 2Department of Physiology and Pharmacology, School of Medicine, West Virginia University, Morgantown, WV 3Biomedical Sciences Program, School of Medicine, West Virginia University, Morgantown, WV 4Department of Surgery, School of Medicine, West Virginia University, Morgantown, WV 5Mary Babb Randolph Cancer Center, School of Medicine, West Virginia University, Morgantown, WV and 6Center for Cardiovascular and Respiratory Sciences, School of Medicine, West Virginia University, Morgantown, WV
    Med Sci Sports Exerc 47:2329-39. 2015
    ..We hypothesized that this would also affect metabolic responses during exercise-induced stress and that adipocyte-specific VEGF-deficient (adipoVEGF-/-) mice would have impaired endurance capacity...
  32. pmc Exercise reveals impairments in left ventricular systolic function in patients with metabolic syndrome
    Sara B Fournier
    P D Chantler West Virginia University, 1 Medical Center Drive, PO Box 9227, Morgantown, WV 26508, USA
    Exp Physiol 99:149-63. 2014
    ..These findings are of clinical importance, because they provide insight into the pathophysiological changes in MetS that may predispose this population of individuals to an increased risk of cardiovascular morbidity and mortality. ..
  33. pmc Sirtuin 1 (SIRT1) deacetylase activity is not required for mitochondrial biogenesis or peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) deacetylation following endurance exercise
    Andrew Philp
    Department of Neurobiology, Physiology, and Behavior, University of California, Davis, California 95616, USA
    J Biol Chem 286:30561-70. 2011
    ....