B S Kristal

Summary

Affiliation: Weill Medical College of Cornell University
Country: USA

Publications

  1. ncbi Zinc is a potent inhibitor of thiol oxidoreductase activity and stimulates reactive oxygen species production by lipoamide dehydrogenase
    Irina G Gazaryan
    Burke Medical Research Institute, Weill Medical College of Cornell University, White Plains, New York 10605, USA
    J Biol Chem 277:10064-72. 2002
  2. ncbi Metabolomics in the study of aging and caloric restriction
    Bruce S Kristal
    Dementia Research Service, Burke Medical Research Institute, White Plains and Department of Neuroscience, Weill Medical College of Cornell University, New York, NY, USA
    Methods Mol Biol 371:393-409. 2007
  3. pmc Inhibitors of cytochrome c release with therapeutic potential for Huntington's disease
    Xin Wang
    Neuroapoptosis Laboratory and Department of Neurosurgery, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 28:9473-85. 2008
  4. ncbi Ganglioside GD3, the mitochondrial permeability transition, and apoptosis
    B S Kristal
    Dementia Research Service, Burke Medical Research Institute, White Plains, New York 10605, USA
    Ann N Y Acad Sci 893:321-4. 1999
  5. pmc Clinically approved heterocyclics act on a mitochondrial target and reduce stroke-induced pathology
    Irina G Stavrovskaya
    Dementia Research Service, Burke Medical Research Institute, 785 Mamaroneck Ave, White Plains, NY 10605, USA
    J Exp Med 200:211-22. 2004
  6. ncbi Simultaneous analysis of the majority of low-molecular-weight, redox-active compounds from mitochondria
    B S Kristal
    Dementia Research Service, Burke Medical Research Institute, 785 Mamaroneck Avenue, White Plains, New York 10605, USA
    Anal Biochem 263:18-25. 1998
  7. ncbi Metabolomics: opening another window into aging
    Bruce S Kristal
    Dementia Research Service, Burke Medical Research Institute, White Plains, NY 10605, USA
    Sci Aging Knowledge Environ 2005:pe19. 2005
  8. ncbi The mitochondrial permeability transition as a target for neuroprotection
    Bruce S Kristal
    Dementia Research Service, Burke Medical Research Institute, 785 Mamaroneck Ave, White Plains, New York 10605, USA
    J Bioenerg Biomembr 36:309-12. 2004
  9. ncbi Caloric restriction in trans
    Bruce S Kristal
    Dementia Research Service, Burke Medical Research Institute, White Plains, NY 10605, USA
    Sci Aging Knowledge Environ 2003:PE19. 2003
  10. ncbi Structure-(Dys)function relationships in mitochondrial electron transport chain complex II?
    Bruce S Kristal
    Dementia Research Service of the Burke Medical Research Institute, White Plains, NY 10605, USA
    Sci Aging Knowledge Environ 2003:PE3. 2003

Collaborators

Detail Information

Publications40

  1. ncbi Zinc is a potent inhibitor of thiol oxidoreductase activity and stimulates reactive oxygen species production by lipoamide dehydrogenase
    Irina G Gazaryan
    Burke Medical Research Institute, Weill Medical College of Cornell University, White Plains, New York 10605, USA
    J Biol Chem 277:10064-72. 2002
    ..These results suggest that Zn(2+) can interfere with mitochondrial antioxidant production and may also stimulate production of reactive oxygen species by a novel mechanism...
  2. ncbi Metabolomics in the study of aging and caloric restriction
    Bruce S Kristal
    Dementia Research Service, Burke Medical Research Institute, White Plains and Department of Neuroscience, Weill Medical College of Cornell University, New York, NY, USA
    Methods Mol Biol 371:393-409. 2007
    ..The system also only detects redox-active compounds, which can be either a benefit or a detriment, depending on the experimental goals and design...
  3. pmc Inhibitors of cytochrome c release with therapeutic potential for Huntington's disease
    Xin Wang
    Neuroapoptosis Laboratory and Department of Neurosurgery, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 28:9473-85. 2008
    ..Given that many of these compounds have been approved by the Food and Drug Administration for clinical usage and cross the blood-brain barrier, these drugs may lead to trials in patients...
  4. ncbi Ganglioside GD3, the mitochondrial permeability transition, and apoptosis
    B S Kristal
    Dementia Research Service, Burke Medical Research Institute, White Plains, New York 10605, USA
    Ann N Y Acad Sci 893:321-4. 1999
  5. pmc Clinically approved heterocyclics act on a mitochondrial target and reduce stroke-induced pathology
    Irina G Stavrovskaya
    Dementia Research Service, Burke Medical Research Institute, 785 Mamaroneck Ave, White Plains, NY 10605, USA
    J Exp Med 200:211-22. 2004
    ....
  6. ncbi Simultaneous analysis of the majority of low-molecular-weight, redox-active compounds from mitochondria
    B S Kristal
    Dementia Research Service, Burke Medical Research Institute, 785 Mamaroneck Avenue, White Plains, New York 10605, USA
    Anal Biochem 263:18-25. 1998
    ..Results, including analytical parameters, from a study of liver mitochondria from control and diabetic rats are presented to demonstrate utility of this methodology...
  7. ncbi Metabolomics: opening another window into aging
    Bruce S Kristal
    Dementia Research Service, Burke Medical Research Institute, White Plains, NY 10605, USA
    Sci Aging Knowledge Environ 2005:pe19. 2005
    ..The ability to use metabolomics approaches for classification and mechanistic studies may influence and augment our ability to study and address the aging process scientifically and clinically...
  8. ncbi The mitochondrial permeability transition as a target for neuroprotection
    Bruce S Kristal
    Dementia Research Service, Burke Medical Research Institute, 785 Mamaroneck Ave, White Plains, New York 10605, USA
    J Bioenerg Biomembr 36:309-12. 2004
    ..g., in stroke) and are modulated by diseases of the central nervous system (e.g., Huntington's). Evidence of neuroprotection seen with compounds such as N -Met-Val cyclosporine also support this possibility...
  9. ncbi Caloric restriction in trans
    Bruce S Kristal
    Dementia Research Service, Burke Medical Research Institute, White Plains, NY 10605, USA
    Sci Aging Knowledge Environ 2003:PE19. 2003
    ..This work presents the initial development of a new model with which to approach mechanistic studies of CR and provides a new form of direct evidence that CR exerts at least some of its effects in trans...
  10. ncbi Structure-(Dys)function relationships in mitochondrial electron transport chain complex II?
    Bruce S Kristal
    Dementia Research Service of the Burke Medical Research Institute, White Plains, NY 10605, USA
    Sci Aging Knowledge Environ 2003:PE3. 2003
    ..Furthermore, these results suggest possible mechanisms by which electron leakage might occur at this site in the aged organism...
  11. ncbi Purine catabolism: links to mitochondrial respiration and antioxidant defenses?
    B S Kristal
    Dementia Research Service, Burke Medical Research Institute, White Plains, New York, 10605, USA
    Arch Biochem Biophys 370:22-33. 1999
    ....
  12. ncbi Selective dopaminergic vulnerability: 3,4-dihydroxyphenylacetaldehyde targets mitochondria
    B S Kristal
    Dementia Research Service, Burke Medical Research Institute, White Plains, NY 10605, USA
    Free Radic Biol Med 30:924-31. 2001
    ..These data provide a potential mechanism of action for L-DOPA-mediated neurotoxicity and suggest two potentially interactive mechanisms for the selective vulnerability of neurons exposed to dopamine...
  13. ncbi Biochemical characterization of the mitochondrial permeability transition in isolated forebrain mitochondria
    B S Kristal
    Dementia Research Service, Burke Medical Research Institute, White Plains, NY 10605, USA
    Dev Neurosci 22:376-83. 2000
    ..Na(+), which enhances mitochondrial Ca(2+) efflux, but stimulates mitochondrial free radical production, had no effect on PT induction. These data confirm the existence of tissue-specific differences in the nature of PT induction...
  14. ncbi The powerhouse takes control of the cell: is the mitochondrial permeability transition a viable therapeutic target against neuronal dysfunction and death?
    Irina G Stavrovskaya
    Dementia Research Service, Burke Medical Research Institute, 785 Mamaroneck Avenue, White Plains, NY 10605, USA
    Free Radic Biol Med 38:687-97. 2005
    ....
  15. ncbi Zn2+ inhibits alpha-ketoglutarate-stimulated mitochondrial respiration and the isolated alpha-ketoglutarate dehydrogenase complex
    A M Brown
    Burke Medical Research Institute, White Plains, New York 10605, USA
    J Biol Chem 275:13441-7. 2000
    ..In contrast, extreme or chronic elevation of intracellular Zn(2+) could contribute to persistent reductions in mitochondrial respiration that have been observed in Zn(2+)-rich diseased tissues...
  16. ncbi Comparative kinetic analysis reveals that inducer-specific ion release precedes the mitochondrial permeability transition
    Boris F Krasnikov
    Dementia Research Service, Burke Medical Research Institute, 785 Mamaroneck Avenue, White Plains, NY 10605, USA
    Biochim Biophys Acta 1708:375-92. 2005
    ..Analysis of the temporal relationship among the multiple mitochondrial parameters of isolated mitochondria should provide insights into the mechanisms underlying these responses...
  17. ncbi Zinc irreversibly damages major enzymes of energy production and antioxidant defense prior to mitochondrial permeability transition
    Irina G Gazaryan
    Burke Medical Research Institute, White Plains, New York 10605, USA
    J Biol Chem 282:24373-80. 2007
    ..Inactivation of these enzymes by Zn2+ is irreversible, and thus only their de novo synthesis can restore function, which may underlie persistent loss of oxidative carbohydrate metabolism following transient ischemia...
  18. pmc Effect of vitamin C supplementation on stroke recovery: a case-control study
    Meheroz H Rabadi
    Burke Rehabilitation Hospital, an affiliate of Weill Medical College of Cornell Medical College, 785 Mamaroneck Avenue, White Plains, NY 10605, USA
    Clin Interv Aging 2:147-51. 2007
    ..The effect of vitamin C supplementation on functional recovery after stroke has not been studied...
  19. ncbi Branched chain keto-acids exert biphasic effects on alpha-ketoglutarate-stimulated respiration in intact rat liver mitochondria
    Alexander I Shestopalov
    Dementia Research Service, Burke Medical Research Institute, 785 Mamaroneck Avenue, White Plains, NY 10605, USA
    Neurochem Res 32:947-51. 2007
    ..The data suggest that physiological concentrations of the BCKAs may modulate mitochondrial respiration...
  20. ncbi Apoptogenic ganglioside GD3 directly induces the mitochondrial permeability transition
    B S Kristal
    Dementia Research Service, Burke Medical Research Institute, White Plains, New York 10605, USA
    J Biol Chem 274:23169-75. 1999
    ..These observations suggest that GD3 propagates apoptosis by inducing the PT and cytochrome c release. This model provides a mechanistic link between the earlier and later stages of CD95-induced/ceramide-mediated apoptosis...
  21. ncbi Neuroprotective mechanisms of creatine occur in the absence of mitochondrial creatine kinase
    Peter Klivenyi
    Department of Neurology and Neuroscience, New York Presbyterian Hospital, Weill Medical College of Cornell University, New York, NY 10021, USA
    Neurobiol Dis 15:610-7. 2004
    ....
  22. ncbi Characterization of diet-dependent metabolic serotypes: proof of principle in female and male rats
    Honglian Shi
    Dementia Research Service, Burke Medical Research Institute, White Plains, NY 10605, USA
    J Nutr 132:1031-8. 2002
    ....
  23. ncbi High-performance liquid chromatography separations coupled with coulometric electrode array detectors: a unique approach to metabolomics
    Bruce S Kristal
    Dementia Research Service, Burke Medical Research Institute, White Plains, NY, USA
    Methods Mol Biol 358:159-74. 2007
    ..Here, we discuss the characteristics of this HPLC/coulometric electrode array system in the context of metabolomics, and then present the method as practiced in our groups...
  24. ncbi Characterization of diet-dependent metabolic serotypes: primary validation of male and female serotypes in independent cohorts of rats
    Honglian Shi
    Dementia Research Service, Burke Medical Research Institute, White Plains, NY 10605, USA
    J Nutr 132:1039-46. 2002
    ....
  25. ncbi Simultaneous analysis of multiple redox-active metabolites from biological matrices
    Bruce S Kristal
    Departments of Biochemistry and Neuroscience, Burke Medical Research Institute, Weill Medical College of Cornell University and Dementia Research Service, White Plains, NY, USA
    Methods Mol Biol 186:185-94. 2002
  26. pmc Nortriptyline protects mitochondria and reduces cerebral ischemia/hypoxia injury
    Wen Hua Zhang
    Department of Neurosurgery, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Avenue, LMRC 113, Boston, MA 02115, USA
    Stroke 39:455-62. 2008
    ..Because mitochondrial permeability transition and consequent mitochondrial dysfunction have been implicated in acute neuronal death, we proposed to investigate the possible neuroprotective effects of nortriptyline in cerebral ischemia...
  27. ncbi Kinetic model for Ca2+-induced permeability transition in energized liver mitochondria discriminates between inhibitor mechanisms
    Sergei V Baranov
    Department of Neurosurgery, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Biol Chem 283:665-76. 2008
    ..This model is consistent with/informative about the biochemistry of several mPT inhibitors, and its success suggests that this kinetic approach can aid in the classification of agents or targets that modulate mPT induction...
  28. ncbi Nortriptyline delays disease onset in models of chronic neurodegeneration
    Hongyan Wang
    Neuroapoptosis Laboratory, Department of Neurosurgery, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Avenue, LMRC 113, Boston, MA 02115, USA
    Eur J Neurosci 26:633-41. 2007
    ..In addition, our data suggested a role for mPT in chronic neurodegeneration, particularly at the early rather than the advanced disease stages...
  29. pmc Chemotherapy for the brain: the antitumor antibiotic mithramycin prolongs survival in a mouse model of Huntington's disease
    Robert J Ferrante
    Geriatric Research and Education and Clinical Center, Veterans Administration Medical Center, Bedford, MA, USA
    J Neurosci 24:10335-42. 2004
    ..Because it is Food and Drug Administration-approved, mithramycin is a promising drug for the treatment of HD...
  30. pmc Minocycline inhibits caspase-independent and -dependent mitochondrial cell death pathways in models of Huntington's disease
    Xin Wang
    Neuroapoptosis Laboratory, Department of Neurosurgery, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 100:10483-7. 2003
    ..Our results further delineate the mechanism by which minocycline mediates its remarkably broad neuroprotective effects...
  31. ncbi pH-dependent substrate preference of pig heart lipoamide dehydrogenase varies with oligomeric state: response to mitochondrial matrix acidification
    Natalia L Klyachko
    Department of Chemical Enzymology, M V Lomonosov Moscow State University, 119899 Moscow, Russia
    J Biol Chem 280:16106-14. 2005
    ..Matrix acidification may also disrupt the quaternary structure of other mitochondrial protein complexes critical for cellular homeostasis and survival...
  32. pmc Metabolite identification using a nanoelectrospray LC-EC-array-MS integrated system
    Susan Schiavo
    Barnett Institute and Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, USA
    Anal Chem 80:5912-23. 2008
    ....
  33. doi Metabolomics: a global biochemical approach to drug response and disease
    Rima Kaddurah-Daouk
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Annu Rev Pharmacol Toxicol 48:653-83. 2008
    ..It also highlights potential metabolomic applications to pharmacology and clinical pharmacology...
  34. ncbi Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice
    Shan Zhu
    Neuroapoptosis Laboratory, Department of Neurosurgery, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 417:74-8. 2002
    ..Because of the safety record of minocycline, and its ability to penetrate the blood-brain barrier, this drug may be a novel therapy for ALS...
  35. ncbi Neurotoxicity of MAO metabolites of catecholamine neurotransmitters: role in neurodegenerative diseases
    William J Burke
    Department of Neurology, Veterans Affairs Medical Center, Saint Louis University Health Sciences Center, St Louis, MO 63110, USA
    Neurotoxicology 25:101-15. 2004
    ....
  36. ncbi The metabolomics standards initiative
    Susanna Assunta Sansone
    Nat Biotechnol 25:846-8. 2007
  37. ncbi Prophylactic creatine administration mediates neuroprotection in cerebral ischemia in mice
    Shan Zhu
    Neuroapoptosis Laboratory, Department of Neurosurgery, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 24:5909-12. 2004
    ..Prophylactic creatine supplementation, similar to what is recommended for an agent such as aspirin, may be considered for patients in high stroke-risk categories...
  38. ncbi Nutrition and physical activity and chronic disease prevention: research strategies and recommendations
    Ross L Prentice
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, M3 A410, Seattle, WA 98109 1024, USA
    J Natl Cancer Inst 96:1276-87. 2004
    ....
  39. ncbi Promethazine: a novel application as a neuroprotectant that reduces ischemia-mediated injury by inhibiting mitochondrial dysfunction
    Malini V Narayanan
    Department of Neurosurgery, Brigham and Women s Hospital, Harvard University Medical School, Boston, Massachusetts, USA
    Clin Neurosurg 51:102-7. 2004
  40. pmc Disturbed Ca2+ signaling and apoptosis of medium spiny neurons in Huntington's disease
    Tie Shan Tang
    Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 102:2602-7. 2005
    ..These findings also suggest that Ca2+ and MPTP blockers may have a therapeutic potential for treatment of HD...