Bernadette C Victor
Affiliation: Wayne State University
- Cysteine cathepsin non-inhibitory binding partners: modulating intracellular trafficking and functionBernadette C Victor
Department of Pharmacology and Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
Biol Chem 388:1131-40. 2007..Mechanisms for altered localization are not well understood, but do include the interaction of cysteine cathepsins with binding partners that modulate intracellular trafficking and association with specific regions on the cell surface...
- Fibroblast hepatocyte growth factor promotes invasion of human mammary ductal carcinoma in situChristopher Jedeszko
Department of Pharmacology, Wayne State University, Detroit, Michigan, USA
Cancer Res 69:9148-55. 2009....
- Inhibition of cathepsin B activity attenuates extracellular matrix degradation and inflammatory breast cancer invasionBernadette C Victor
Department of Pharmacology, Wayne State University, Detroit, Michigan 48201, USA
Breast Cancer Res 13:R115. 2011..Breast cancer invasion has been linked to proteolytic activity at the tumor cell surface. Here we explored a role for active cathepsin B on the cell surface in the invasiveness of IBC...
- 3D/4D functional imaging of tumor-associated proteolysis: impact of microenvironmentKamiar Moin
Department of Pharmacology, Wayne State University School of Medicine, Detroit, Michigan, USA
Methods Enzymol 506:175-94. 2012..Of course, all assays have limitations; however, we suggest that the techniques discussed here will, with attention to their limitations, be useful as a screen for drugs to target the invasive phenotype of tumors...