Juan Pedro Kusanovic

Summary

Affiliation: Wayne State University
Country: USA

Publications

  1. pmc Nuclear factor-kappa B localization and function within intrauterine tissues from term and preterm labor and cultured fetal membranes
    Sonali Vora
    Laboratory of Perinatal Research, Department of Obstetrics and Gynecology, College of Medicine, The Ohio State University, Columbus, OH, USA
    Reprod Biol Endocrinol 8:8. 2010
  2. pmc Fetal ERAP2 variation is associated with preeclampsia in African Americans in a case-control study
    Lori D Hill
    Department of Obstetrics and Gynecology and Center on Health Disparities, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA
    BMC Med Genet 12:64. 2011
  3. pmc Amniotic fluid sTREM-1 in normal pregnancy, spontaneous parturition at term and preterm, and intra-amniotic infection/inflammation
    Juan Pedro Kusanovic
    Perinatology Research Branch, NICHD NIH DHHS, Bethesda, Maryland, USA
    J Matern Fetal Neonatal Med 23:34-47. 2010
  4. pmc A prospective cohort study of the value of maternal plasma concentrations of angiogenic and anti-angiogenic factors in early pregnancy and midtrimester in the identification of patients destined to develop preeclampsia
    Juan Pedro Kusanovic
    Perinatology Research Branch, NICHD NIH DHHS, Bethesda, Maryland, USA
    J Matern Fetal Neonatal Med 22:1021-38. 2009
  5. pmc A link between a hemostatic disorder and preterm PROM: a role for tissue factor and tissue factor pathway inhibitor
    Offer Erez
    Perinatology Research Branch, NICHD, NIH, DHHS, Detroit, Michigan, USA
    J Matern Fetal Neonatal Med 21:732-44. 2008
  6. doi request reprint The maternal plasma soluble vascular endothelial growth factor receptor-1 concentration is elevated in SGA and the magnitude of the increase relates to Doppler abnormalities in the maternal and fetal circulation
    Tinnakorn Chaiworapongsa
    Perinatology Research Branch, National Institute of Child Health and Human Development, NIH DHHS, Bethesda, MD 20892, USA
    J Matern Fetal Neonatal Med 21:25-40. 2008
  7. pmc The change in concentrations of angiogenic and anti-angiogenic factors in maternal plasma between the first and second trimesters in risk assessment for the subsequent development of preeclampsia and small-for-gestational age
    Offer Erez
    Perinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, DHHS, Bethesda, Maryland, USA
    J Matern Fetal Neonatal Med 21:279-87. 2008
  8. pmc Evidence in support of a role for anti-angiogenic factors in preterm prelabor rupture of membranes
    Zeynep Alpay Savasan
    Perinatology Research Branch, NICHD, NIH, DHHS, Detroit, Michigan, USA
    J Matern Fetal Neonatal Med 23:828-41. 2010
  9. pmc A longitudinal study of angiogenic (placental growth factor) and anti-angiogenic (soluble endoglin and soluble vascular endothelial growth factor receptor-1) factors in normal pregnancy and patients destined to develop preeclampsia and deliver a small for
    Roberto Romero
    Perinatology Research Branch, National Institute of Child Health and Human Development, NIH DHHS, Bethesda, MD 20892, USA
    J Matern Fetal Neonatal Med 21:9-23. 2008
  10. pmc Amniotic fluid soluble human leukocyte antigen-G in term and preterm parturition, and intra-amniotic infection/inflammation
    Juan Pedro Kusanovic
    Perinatology Research Branch, NICHD NIH DHHS, Bethesda, Maryland, USA
    J Matern Fetal Neonatal Med 22:1151-66. 2009

Collaborators

Detail Information

Publications77

  1. pmc Nuclear factor-kappa B localization and function within intrauterine tissues from term and preterm labor and cultured fetal membranes
    Sonali Vora
    Laboratory of Perinatal Research, Department of Obstetrics and Gynecology, College of Medicine, The Ohio State University, Columbus, OH, USA
    Reprod Biol Endocrinol 8:8. 2010
    ....
  2. pmc Fetal ERAP2 variation is associated with preeclampsia in African Americans in a case-control study
    Lori D Hill
    Department of Obstetrics and Gynecology and Center on Health Disparities, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA
    BMC Med Genet 12:64. 2011
    ..Furthermore, ERAP2 expression is altered in first trimester placentas of women destined to develop preeclampsia...
  3. pmc Amniotic fluid sTREM-1 in normal pregnancy, spontaneous parturition at term and preterm, and intra-amniotic infection/inflammation
    Juan Pedro Kusanovic
    Perinatology Research Branch, NICHD NIH DHHS, Bethesda, Maryland, USA
    J Matern Fetal Neonatal Med 23:34-47. 2010
    ..The aim of this study was to determine the effect of gestational age, parturition (term and preterm) and IAI in the amniotic fluid (AF) concentrations of sTREM-1...
  4. pmc A prospective cohort study of the value of maternal plasma concentrations of angiogenic and anti-angiogenic factors in early pregnancy and midtrimester in the identification of patients destined to develop preeclampsia
    Juan Pedro Kusanovic
    Perinatology Research Branch, NICHD NIH DHHS, Bethesda, Maryland, USA
    J Matern Fetal Neonatal Med 22:1021-38. 2009
    ..This study was conducted to examine the role of maternal plasma PlGF, sEng, and sVEGFR-1 concentrations in early pregnancy and midtrimester in the identification of patients destined to develop preeclampsia...
  5. pmc A link between a hemostatic disorder and preterm PROM: a role for tissue factor and tissue factor pathway inhibitor
    Offer Erez
    Perinatology Research Branch, NICHD, NIH, DHHS, Detroit, Michigan, USA
    J Matern Fetal Neonatal Med 21:732-44. 2008
    ..A decidual hemostatic disorder may link vaginal bleeding, PPROM and placental abruption. This study was conducted to determine the behaviour of maternal TF and its natural inhibitor, the tissue factor pathway inhibitor (TFPI) in PPROM...
  6. doi request reprint The maternal plasma soluble vascular endothelial growth factor receptor-1 concentration is elevated in SGA and the magnitude of the increase relates to Doppler abnormalities in the maternal and fetal circulation
    Tinnakorn Chaiworapongsa
    Perinatology Research Branch, National Institute of Child Health and Human Development, NIH DHHS, Bethesda, MD 20892, USA
    J Matern Fetal Neonatal Med 21:25-40. 2008
    ....
  7. pmc The change in concentrations of angiogenic and anti-angiogenic factors in maternal plasma between the first and second trimesters in risk assessment for the subsequent development of preeclampsia and small-for-gestational age
    Offer Erez
    Perinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, DHHS, Bethesda, Maryland, USA
    J Matern Fetal Neonatal Med 21:279-87. 2008
    ....
  8. pmc Evidence in support of a role for anti-angiogenic factors in preterm prelabor rupture of membranes
    Zeynep Alpay Savasan
    Perinatology Research Branch, NICHD, NIH, DHHS, Detroit, Michigan, USA
    J Matern Fetal Neonatal Med 23:828-41. 2010
    ..The purpose of this study was to determine whether the soluble form of VEGFR-1 and -2 concentrations in amniotic fluid (AF) change with preterm PROM, intra-amniotic infection/inflammation (IAI), or parturition...
  9. pmc A longitudinal study of angiogenic (placental growth factor) and anti-angiogenic (soluble endoglin and soluble vascular endothelial growth factor receptor-1) factors in normal pregnancy and patients destined to develop preeclampsia and deliver a small for
    Roberto Romero
    Perinatology Research Branch, National Institute of Child Health and Human Development, NIH DHHS, Bethesda, MD 20892, USA
    J Matern Fetal Neonatal Med 21:9-23. 2008
    ....
  10. pmc Amniotic fluid soluble human leukocyte antigen-G in term and preterm parturition, and intra-amniotic infection/inflammation
    Juan Pedro Kusanovic
    Perinatology Research Branch, NICHD NIH DHHS, Bethesda, Maryland, USA
    J Matern Fetal Neonatal Med 22:1151-66. 2009
    ....
  11. pmc Characterization of the fetal blood transcriptome and proteome in maternal anti-fetal rejection: evidence of a distinct and novel type of human fetal systemic inflammatory response
    Joonho Lee
    Perinatology Research Branch, NICHD NIH DHHS, Bethesda, MD, Detroit, MI, USA
    Am J Reprod Immunol 70:265-84. 2013
    ....
  12. pmc A decrease in maternal plasma concentrations of sVEGFR-2 precedes the clinical diagnosis of preeclampsia
    Tinnakorn Chaiworapongsa
    Perinatology Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Detroit, MI 48201, USA
    Am J Obstet Gynecol 202:550.e1-10. 2010
    ..The aim of this study was to examine if maternal plasma concentrations of soluble vascular endothelial growth factor receptor (sVEGFR)-2 change prior to the diagnosis of preeclampsia...
  13. pmc Acute pyelonephritis during pregnancy changes the balance of angiogenic and anti-angiogenic factors in maternal plasma
    Tinnakorn Chaiworapongsa
    Perinatology Research Branch, NICHD, NIH, DHHS, Detroit, Michigan, USA
    J Matern Fetal Neonatal Med 23:167-78. 2010
    ....
  14. pmc Maternal serum adiponectin multimers in patients with a small-for-gestational-age newborn
    Shali Mazaki-Tovi
    Perinatology Research Branch, Intramural Division, NICHD NIH DHHS, Hutzel Women s Hospital, Detroit, MI 48201, USA
    J Perinat Med 37:623-35. 2009
    ..Thus, the aim of this study was to determine if third trimester adiponectin concentrations differed between women with normal weight infants and those with an SGA neonate...
  15. pmc A role for CXCL13 (BCA-1) in pregnancy and intra-amniotic infection/inflammation
    Chia Ling Nhan-Chang
    Perinatology Research Branch, Intramural Division, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NICHD NIH DHHS, Hutzel Women s Hospital, Detroit, MI 48201, USA
    J Matern Fetal Neonatal Med 21:763-75. 2008
    ....
  16. pmc Dysregulation of maternal serum adiponectin in preterm labor
    Shali Mazaki-Tovi
    Perinatology Research Branch, Intramural Division, NICHD NIH DHHS, HutzelWomen s Hospital, Bethesda, Maryland, USA
    J Matern Fetal Neonatal Med 22:887-904. 2009
    ..The aim of this study was to determine whether spontaneous preterm labor (PTL) with intact membranes and intra-amniotic infection/inflammation (IAI) is associated with changes in maternal serum circulating adiponectin multimers...
  17. doi request reprint Maternal anti-protein Z antibodies in pregnancies complicated by pre-eclampsia, SGA and fetal death
    Offer Erez
    Perinatology Research Branch, NICHD NIH DHHS, Bethesda, Maryland, USA
    J Matern Fetal Neonatal Med 22:662-71. 2009
    ..The objective of this study was to determine the maternal plasma concentration of APZ-AB in women with a normal pregnancy, and patients with PE, an SGA neonate or a FD...
  18. pmc Proteomic analysis of amniotic fluid to identify women with preterm labor and intra-amniotic inflammation/infection: the use of a novel computational method to analyze mass spectrometric profiling
    Roberto Romero
    Perinatology Research Branch, NICHD NIH DHHS, Bethesda, Maryland, USA
    J Matern Fetal Neonatal Med 21:367-88. 2008
    ..The purpose of this study was to combine a novel computational method of pattern discovery with mass spectrometric proteomic profiling of amniotic fluid to discover biomarkers of intra-amniotic infection/inflammation (IAI)...
  19. pmc The frequency and clinical significance of intra-amniotic infection and/or inflammation in women with placenta previa and vaginal bleeding: an unexpected observation
    Ichchha Madan
    Perinatology Research Branch, NICHD NIH DHHS, Bethesda, Maryland and Detroit, MI 48201, USA
    J Perinat Med 38:275-9. 2010
    ..The aim of this study was to determine the frequency and clinical significance of IAI in women with placenta previa and vaginal bleeding in the absence of preterm labor...
  20. pmc Fetal death: a condition with a dissociation in the concentrations of soluble vascular endothelial growth factor receptor-2 between the maternal and fetal compartments
    Tinnakorn Chaiworapongsa
    Perinatology Research Branch, NICHD, NIH, DHHS, Bethesda, Maryland, USA
    J Matern Fetal Neonatal Med 23:960-72. 2010
    ..The aim of this study was to determine if fetal death was associated with changes in the concentrations of sVEGFR-2 in maternal plasma and amniotic fluid...
  21. pmc A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM)
    Roberto Romero
    Perinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health Department of Health and Human Services, Bethesda, MD, USA
    Am J Obstet Gynecol 203:361.e1-361.e30. 2010
    ..We sought to determine whether maternal/fetal single-nucleotide polymorphisms (SNPs) in candidate genes are associated with preterm prelabor rupture of membranes (pPROM)...
  22. pmc Late-onset preeclampsia is associated with an imbalance of angiogenic and anti-angiogenic factors in patients with and without placental lesions consistent with maternal underperfusion
    Eleazar Soto
    Perinatology Research Branch, NICHD NIH DHHS, Detroit, MI, USA
    J Matern Fetal Neonatal Med 25:498-507. 2012
    ....
  23. pmc Fragment Bb in amniotic fluid: evidence for complement activation by the alternative pathway in women with intra-amniotic infection/inflammation
    Edi Vaisbuch
    Perinatology Research Branch, NICHD NIH DHHS, Bethesda, Maryland, USA
    J Matern Fetal Neonatal Med 22:905-16. 2009
    ..The aim of this study was to determine whether the amniotic fluid (AF) concentrations of fragment Bb change with gestational age, spontaneous labor (term and preterm) and in the presence of intra-amniotic infection/inflammation (IAI)...
  24. pmc Serum and plasma determination of angiogenic and anti-angiogenic factors yield different results: the need for standardization in clinical practice
    Giovanna Ogge
    Perinatology Research Branch, NICHD NIH DHHS, Detroit, Michigan, USA
    J Matern Fetal Neonatal Med 23:820-7. 2010
    ..The purpose of this study was to determine if there are differences in the concentrations of these analytes between plasma and serum in normal pregnancy and in preeclampsia...
  25. pmc Adiponectin in amniotic fluid in normal pregnancy, spontaneous labor at term, and preterm labor: a novel association with intra-amniotic infection/inflammation
    Shali Mazaki-Tovi
    Perinatology Research Branch, Intramural Division, NICHD NIH DHHS, Hutzel Women s Hospital, Bethesda, Maryland, USA
    J Matern Fetal Neonatal Med 23:120-30. 2010
    ....
  26. doi request reprint The anti-inflammatory limb of the immune response in preterm labor, intra-amniotic infection/inflammation, and spontaneous parturition at term: a role for interleukin-10
    Francesca Gotsch
    Perinatology Research Branch, NICHD NIH DHHS, Bethesda, Maryland, USA
    J Matern Fetal Neonatal Med 21:529-47. 2008
    ..The objectives of this study were to determine whether there is a relationship between amniotic fluid concentrations of IL-10 and gestational age, parturition (at term and preterm), and intra-amniotic infection/inflammation (IAI)...
  27. pmc Surfactant protein-A as an anti-inflammatory component in the amnion: implications for human pregnancy
    Deug Chan Lee
    Perinatology Research Branch, Department of Health and Human Services, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, USA
    J Immunol 184:6479-91. 2010
    ..However, AF SP-A and fetal macrophages by themselves do not seem to be exclusive effectors of parturition in humans...
  28. pmc High tissue factor activity and low tissue factor pathway inhibitor concentrations in patients with preterm labor
    Offer Erez
    Perinatology Research Branch, NICHD NIH DHHS, Bethesda, MD, USA
    J Matern Fetal Neonatal Med 23:23-33. 2010
    ..The aims of this study were to determine whether spontaneous PTL with intact membranes is associated with changes in the maternal plasma concentrations and activity of TF as well as tissue factor pathway inhibitor (TFPI)...
  29. pmc Retinol binding protein 4: an adipokine associated with intra-amniotic infection/inflammation
    Edi Vaisbuch
    Perinatology Research Branch, NICHD NIH DHHS, Bethesda, Maryland, USA
    J Matern Fetal Neonatal Med 23:111-9. 2010
    ..The aim of this study was to determine whether RBP4 is present in AF, and if its concentrations change with gestational age, in the presence of labor, and intra-amniotic infection/inflammation (IAI) in patients with spontaneous PTL...
  30. pmc Activation of the alternative pathway of complement is a feature of pre-term parturition but not of spontaneous labor at term
    Edi Vaisbuch
    Perinatology Research Branch, NICHD NIH DHHS, Bethesda, Maryland, USA
    Am J Reprod Immunol 63:318-30. 2010
    ....
  31. pmc Could alterations in maternal plasma visfatin concentration participate in the phenotype definition of preeclampsia and SGA?
    Shali Mazaki-Tovi
    Perinatology Research Branch, Intramural Division, NICHD NIH DHHS, Hutzel Women s Hospital, Bethesda, MD, and Detroit, MI 48201, USA
    J Matern Fetal Neonatal Med 23:857-68. 2010
    ..Visfatin is a novel adipocytokine with metabolic and immunomodulating properties. The objective of this study was to determine whether preeclampsia and SGA are associated with alterations in maternal circulating visfatin concentrations...
  32. pmc Changes in amniotic fluid concentration of thrombin-antithrombin III complexes in patients with preterm labor: evidence of an increased thrombin generation
    Offer Erez
    Perinatology Research Branch, NICHD, NIH, DHHS, Bethesda, Maryland, USA
    J Matern Fetal Neonatal Med 22:971-82. 2009
    ..The aim of this study was to determine whether intra-amniotic infection/inflammation (IAI) is associated with increased amniotic fluid (AF) thrombin generation in women with preterm and term deliveries...
  33. doi request reprint Maternal plasma visfatin in preterm labor
    Shali Mazaki-Tovi
    Intramural Division, Perinatology Research Branch, NICHD NIH DHHS, Hutzel Women s Hospital, Bethesda, Maryland, USA
    J Matern Fetal Neonatal Med 22:693-704. 2009
    ..The aim of this study was to determine whether spontaneous PTL with intact membranes and intra-amniotic infection/inflammation (IAI) is associated with changes in maternal plasma circulating visfatin concentrations...
  34. pmc Differential expression of microRNAs with progression of gestation and inflammation in the human chorioamniotic membranes
    Daniel Montenegro
    Perinatology Research Branch, National Institute of Child Health and Human Development National Institutes of Health Department of Health and Human Services, Bethesda, MD, USA
    Am J Obstet Gynecol 197:289.e1-6. 2007
    ..The aim of this study was to identify differential expression of microRNAs (miRNAs) in chorioamniotic membranes with advancing gestation, labor, and inflammation...
  35. pmc Tissue factor and its natural inhibitor in pre-eclampsia and SGA
    Offer Erez
    Perinatology Research Branch, NICHD, NIH, DHHS, Detroit, MI 48201, USA
    J Matern Fetal Neonatal Med 21:855-69. 2008
    ..The aim of this study was to determine the maternal plasma concentrations of TF and its primary inhibitor, tissue factor pathway inhibitor (TFPI), in women who delivered small for gestational age (SGA) neonates, and in pre-eclampsia...
  36. pmc Twin-to-twin transfusion syndrome: an antiangiogenic state?
    Juan Pedro Kusanovic
    Perinatology Research Branch, NICHD NIH DHHS, Bethesda, MD, USA
    Am J Obstet Gynecol 198:382.e1-8. 2008
    ..This study was conducted to determine maternal plasma concentrations of placental growth factor (PlGF), soluble VEGFR-1, and soluble endoglin (s-Eng) in monochorionic-diamniotic pregnancies with and without TTTS...
  37. pmc Amniotic fluid angiopoietin-2 in term and preterm parturition, and intra-amniotic infection/inflammation
    Percy Pacora
    Perinatology Research Branch, NICHD NIH DHHS, Wayne State University Hutzel Women s Hospital, Detroit, MI 48201, USA
    J Perinat Med 37:503-11. 2009
    ....
  38. pmc Widespread microbial invasion of the chorioamniotic membranes is a consequence and not a cause of intra-amniotic infection
    Mi Jeong Kim
    Perinatology Research Branch, NICHD NIH DHHS, Bethesda, MD, USA
    Lab Invest 89:924-36. 2009
    ..This study emphasizes the importance of assessing the intra-amniotic compartment for diagnosis and treatment of preterm birth...
  39. pmc A signature of maternal anti-fetal rejection in spontaneous preterm birth: chronic chorioamnionitis, anti-human leukocyte antigen antibodies, and C4d
    Joonho Lee
    Perinatology Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    PLoS ONE 6:e16806. 2011
    ..Antibody-mediated rejection is another type of transplantation rejection. We investigated whether there was evidence for antibody-mediated rejection against the fetus in spontaneous preterm birth...
  40. pmc Amniotic fluid fetal hemoglobin in normal pregnancies and pregnancies complicated with preterm labor or prelabor rupture of membranes
    Edi Vaisbuch
    Perinatology Research Branch, NICHD, NIH, DHHS, Wayne State University, Hutzel Women s Hospital, 3990 John R, Box 4, Detroit, MI 48201, USA
    J Matern Fetal Neonatal Med 22:388-97. 2009
    ....
  41. pmc Leukocytes of pregnant women with small-for-gestational age neonates have a different phenotypic and metabolic activity from those of women with preeclampsia
    Giovanna Ogge
    Perinatology Research Branch, NICHD NIH DHHS, Bethesda, Maryland, USA
    J Matern Fetal Neonatal Med 23:476-87. 2010
    ..The aim of this study was to determine phenotypic and metabolic changes in granulocytes and monocytes of women who develop preeclampsia and those who deliver an SGA neonate, compared to normal pregnant women...
  42. pmc Identification of patients at risk for early onset and/or severe preeclampsia with the use of uterine artery Doppler velocimetry and placental growth factor
    Jimmy Espinoza
    Perinatology Research Branch, NICHD NIH DHHS, Bethesda, MD, USA
    Am J Obstet Gynecol 196:326.e1-13. 2007
    ....
  43. pmc Clinical chorioamnionitis is characterized by changes in the expression of the alarmin HMGB1 and one of its receptors, sRAGE
    Roberto Romero
    Perinatology Research Branch, NICHD NIH DHHS, Detroit, Michigan 48201, USA
    J Matern Fetal Neonatal Med 25:558-67. 2012
    ....
  44. pmc Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes
    Roberto Romero
    Perinatology Research Branch, NICHD NIH DHHS, Bethesda, MD, USA
    Am J Obstet Gynecol 202:431.e1-34. 2010
    ..The purpose of this study was to determine whether maternal/fetal single nucleotide polymorphisms (SNPs) in candidate genes are associated with spontaneous preterm labor/delivery...
  45. pmc Characterization of the transcriptome of chorioamniotic membranes at the site of rupture in spontaneous labor at term
    Chia Ling Nhan-Chang
    Perinatology Research Branch, Intramural Division, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NICHD NIH DHHS, Bethesda, MD, USA
    Am J Obstet Gynecol 202:462.e1-41. 2010
    ..The purpose of this study was to compare the transcriptome between the site of membrane rupture and the chorioamniotic membranes away from the site of rupture...
  46. pmc The frequency, clinical significance, and pathological features of chronic chorioamnionitis: a lesion associated with spontaneous preterm birth
    Chong Jai Kim
    Perinatology Research Branch, NICHD NIH DHHS, Bethesda, MD, USA
    Mod Pathol 23:1000-11. 2010
    ..Its association with villitis of unknown etiology and the chemokine profile in amniotic fluid suggests an immunological origin, akin to transplantation rejection and graft-versus-host disease in the chorioamniotic membranes...
  47. pmc The role of the sagittal view of the ductal arch in identification of fetuses with conotruncal anomalies using 4-dimensional ultrasonography
    Jimmy Espinoza
    Perinatology Research Branch, NICHD NIH DHHS, Wayne State University Hutzel Women s Hospital, 3990 John R, Box 4, Detroit, MI 48201 USA
    J Ultrasound Med 26:1181-8; quiz 1189-90. 2007
    ..This study was designed to determine the role of this ultrasonographic plane for the prenatal diagnosis of conotruncal anomalies...
  48. pmc Maternal plasma retinol binding protein 4 in acute pyelonephritis during pregnancy
    Edi Vaisbuch
    Perinatology Research Branch, Intramural Division, NICHD NIH DHHS, Hutzel Women s Hospital, Bethesda, MD, and Detroit, MI, USA
    J Perinat Med 38:359-66. 2010
    ..The aim of this study was to determine whether there are changes in maternal plasma concentrations of RBP4 in pregnant women with acute pyelonephritis...
  49. pmc First-trimester maternal serum PP13 in the risk assessment for preeclampsia
    Roberto Romero
    Department of Health and Human Services, Perinatology Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA
    Am J Obstet Gynecol 199:122.e1-122.e11. 2008
    ..The objective of the study was to determine whether first-trimester maternal serum placental protein 13 (PP13) concentrations can be used in the risk assessment for preeclampsia...
  50. pmc Maternal plasma concentration of the pro-inflammatory adipokine pre-B-cell-enhancing factor (PBEF)/visfatin is elevated in pregnant patients with acute pyelonephritis
    Shali Mazaki-Tovi
    Perinatology Research Branch, Intramural Division, NICHD NIH DHHS, Hutzel Women s Hospital, Bethesda, MD, USA
    Am J Reprod Immunol 63:252-62. 2010
    ..The aim of this study was to determine whether pyelonephritis during pregnancy is associated with changes in maternal plasma visfatin concentration in normal weight and overweight/obese patients...
  51. pmc Maternal serum soluble CD30 is increased in normal pregnancy, but decreased in preeclampsia and small for gestational age pregnancies
    Juan Pedro Kusanovic
    Perinatology Research Branch, NICHD NIH DHHS, Bethesda, Maryland, USA
    J Matern Fetal Neonatal Med 20:867-78. 2007
    ..The objective of this study was to determine whether the maternal serum concentration of sCD30 changes with normal pregnancy, as well as in mothers with preeclampsia and those who deliver SGA neonates...
  52. pmc Total hemoglobin concentration in amniotic fluid is increased in intraamniotic infection/inflammation
    Edi Vaisbuch
    Perinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health Department of Health and Human Services, Bethesda, MD, USA
    Am J Obstet Gynecol 199:426.e1-7. 2008
    ..The aim of this study was to determine whether there is an association between total hemoglobin concentration in AF and gestational age, spontaneous labor (term and preterm), and the presence or absence of IAI...
  53. pmc Discordant placental echogenicity: a novel sign of impaired placental perfusion in twin-twin transfusion syndrome?
    Juan Pedro Kusanovic
    Perinatology Research Branch, NICHD NIH DHHS, Bethesda, Maryland, USA
    J Matern Fetal Neonatal Med 23:103-6. 2010
    ....
  54. doi request reprint Fetal membranes as an interface between inflammation and metabolism: increased aquaporin 9 expression in the presence of spontaneous labor at term and chorioamnionitis
    Pooja Mittal
    Perinatology Research Branch, NICHD, NIH, DHHS, Detroit, Michigan, USA
    J Matern Fetal Neonatal Med 22:1167-75. 2009
    ....
  55. pmc A subset of patients destined to develop spontaneous preterm labor has an abnormal angiogenic/anti-angiogenic profile in maternal plasma: evidence in support of pathophysiologic heterogeneity of preterm labor derived from a longitudinal study
    Tinnakorn Chaiworapongsa
    Perinatology Research Branch, NICHD NIH DHHS, Detroit, Michigan, USA
    J Matern Fetal Neonatal Med 22:1122-39. 2009
    ..The aim of this study was to determine if patients prior to the clinical diagnosis of PTL leading to preterm delivery had plasma concentrations of angiogenic and anti-angiogenic factors different from normal pregnant women...
  56. pmc Premature labor: a state of platelet activation?
    Offer Erez
    Perinatology Research Branch, NICHD NIH DHHS, Bethesda, MD 20892, USA
    J Perinat Med 36:377-87. 2008
    ..This study was undertaken to determine whether premature labor is associated with changes in the maternal plasma concentration of soluble CD40 ligand (sCD40L), a marker of platelet activation...
  57. pmc Visfatin/Pre-B cell colony-enhancing factor in amniotic fluid in normal pregnancy, spontaneous labor at term, preterm labor and prelabor rupture of membranes: an association with subclinical intrauterine infection in preterm parturition
    Shali Mazaki-Tovi
    Perinatology Research Branch, Intramural Division, NICHD NIH DHHS, Hutzel Women s Hospital, Bethesda, MD, USA
    J Perinat Med 36:485-96. 2008
    ....
  58. pmc Maternal HLA panel-reactive antibodies in early gestation positively correlate with chronic chorioamnionitis: evidence in support of the chronic nature of maternal anti-fetal rejection
    Joonho Lee
    Perinatology Research Branch, NICHD NIH DHHS, Bethesda, MD, USA
    Am J Reprod Immunol 66:510-26. 2011
    ....
  59. pmc The prognosis of pregnancy conceived despite the presence of an intrauterine device (IUD)
    Sun Kwon Kim
    Perinatology Research Branch, NICHD NIH DHHS, Bethesda, Maryland and Detroit, Michigan, USA
    J Perinat Med 38:45-53. 2010
    ..Intrauterine devices (IUDs) are used for contraception worldwide; however, the management of pregnancies with an IUD poses a clinical challenge. The purpose of this study was to determine the outcome of pregnancy in patients with an IUD...
  60. pmc Adiponectin in severe preeclampsia
    Jyh Kae Nien
    Perinatology Research Branch, Intramural Division, NICHD NIH DHHS, Hutzel Women s Hospital, Bethesda, MD, USA
    J Perinat Med 35:503-12. 2007
    ....
  61. pmc Preeclampsia and pregnancies with small-for-gestational age neonates have different profiles of complement split products
    Eleazar Soto
    Perinatology Research Branch, National Institute of Child Health and Human Development, NIH DHHS, Bethesda, MD 20892, USA
    J Matern Fetal Neonatal Med 23:646-57. 2010
    ..The objective of this study was to determine whether preeclampsia and small-for-gestational age (SGA) are associated with changes in the maternal plasma concentrations of anaphylatoxins C3a, C4a and C5a...
  62. pmc Over-expression of the thrombin receptor (PAR-1) in the placenta in preeclampsia: a mechanism for the intersection of coagulation and inflammation
    Offer Erez
    Perinatology Research Branch, NICHD, NIH, DHHS, Bethesda, Maryland, USA
    J Matern Fetal Neonatal Med 21:345-55. 2008
    ..The aim of this study was to determine whether preterm PE is associated with changes in placental expression of PAR-1...
  63. pmc Resistin in amniotic fluid and its association with intra-amniotic infection and inflammation
    Juan Pedro Kusanovic
    Perinatology Research Branch, NICHD NIH DHHS, Wayne State University HutzelWomen s Hospital, Detroit, MI 48201, USA
    J Matern Fetal Neonatal Med 21:902-16. 2008
    ....
  64. pmc Evidence for differential regulation of the adipokine visfatin in the maternal and fetal compartments in normal spontaneous labor at term
    Shali Mazaki-Tovi
    Perinatology Research Branch, NICHD NIH DHHS, Bethesda, MD, and Detroit, MI, USA
    J Perinat Med 38:281-8. 2010
    ..The aim of this study was to determine if the presence of labor at term is associated with alterations in maternal and neonatal plasma visfatin concentrations...
  65. pmc Maternal serum adiponectin multimers in gestational diabetes
    Shali Mazaki-Tovi
    Perinatology Research Branch, Intramural Division, NICHD NIH DHHS, Hutzel Women s Hospital, Detroit, MI 48201, USA
    J Perinat Med 37:637-50. 2009
    ....
  66. pmc Region-specific gene expression profiling: novel evidence for biological heterogeneity of the human amnion
    Yu Mi Han
    Perinatology Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Biol Reprod 79:954-61. 2008
    ..The novel observations herein strongly suggest that the seemingly homogeneous amnion is biologically heterogeneous and compartmentalized, with implications for the physiology of pregnancy and parturition...
  67. pmc Should bilateral uterine artery notching be used in the risk assessment for preeclampsia, small-for-gestational-age, and gestational hypertension?
    Jimmy Espinoza
    Perinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland, USA
    J Ultrasound Med 29:1103-15. 2010
    ..The purpose of this study was to determine the value of bilateral uterine artery notching in the second trimester in the risk assessment for preeclampsia, gestational hypertension, and small-for-gestational-age (SGA) without preeclampsia...
  68. pmc Maternal plasma concentrations of angiogenic/anti-angiogenic factors are of prognostic value in patients presenting to the obstetrical triage area with the suspicion of preeclampsia
    Tinnakorn Chaiworapongsa
    Perinatology Research Branch, NICHD NIH DHHS, Bethesda, Maryland, USA
    J Matern Fetal Neonatal Med 24:1187-207. 2011
    ....
  69. pmc Villitis of unknown etiology is associated with a distinct pattern of chemokine up-regulation in the feto-maternal and placental compartments: implications for conjoint maternal allograft rejection and maternal anti-fetal graft-versus-host disease
    Mi Jeong Kim
    Perinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 and Detroit, MI 48201, USA
    J Immunol 182:3919-27. 2009
    ..We propose that VUE be a unique state combining maternal allograft rejection and maternal antifetal graft-vs-host disease mechanisms...
  70. pmc Pyelonephritis during pregnancy: a cause for an acquired deficiency of protein Z
    Jyh Kae Nien
    Perinatology Research Branch, NICHD, NIH, DHHS, Bethesda, Maryland, USA
    J Matern Fetal Neonatal Med 21:629-37. 2008
    ..The aim of this study was to determine whether pyelonephritis during pregnancy is associated with changes in maternal plasma protein Z concentrations...
  71. pmc Evidence of the involvement of caspase-1 under physiologic and pathologic cellular stress during human pregnancy: a link between the inflammasome and parturition
    Francesca Gotsch
    Perinatology Research Branch, NICHD NIH DHHS, Bethesda, Maryland, USA
    J Matern Fetal Neonatal Med 21:605-16. 2008
    ..The objectives of this study were to determine whether there is a relationship between amniotic fluid concentrations of caspase-1 and gestational age, parturition (term and preterm), and intra-amniotic infection/inflammation (IAI)...
  72. pmc Chorioamnionitis and increased galectin-1 expression in PPROM --an anti-inflammatory response in the fetal membranes?
    Nandor Gabor Than
    Perinatology Research Branch, NICHD NIH DHHS, Wayne State University Hutzel Women s Hospital, 3990 John R, Box 4, Detroit, MI 48201, USA
    Am J Reprod Immunol 60:298-311. 2008
    ..Galectin-1 can regulate immune responses upon infection and inflammation. We determined galectin-1 expression in the chorioamniotic membranes and its changes during histological chorioamnionitis...
  73. pmc Repeatability and reproducibility of fetal cardiac ventricular volume calculations using spatiotemporal image correlation and virtual organ computer-aided analysis
    Neil Hamill
    Perinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Wayne State University, Detroit, MI 48201, USA
    J Ultrasound Med 28:1301-11. 2009
    ....
  74. pmc Evidence of changes in the immunophenotype and metabolic characteristics (intracellular reactive oxygen radicals) of fetal, but not maternal, monocytes and granulocytes in the fetal inflammatory response syndrome
    Sun Kwon Kim
    Perinatology Research Branch, NICHD, NIH, DHHS, Wayne State University Hutzel Women s Hospital, Detroit, MI 48201, USA
    J Perinat Med 37:543-52. 2009
    ..The aim of this study was to determine whether fetal and maternal granulocytes and monocytes have the phenotypic and metabolic characteristics of activation in cases with FIRS...
  75. pmc CXCL10/IP-10: a missing link between inflammation and anti-angiogenesis in preeclampsia?
    Francesca Gotsch
    Perinatology Research Branch, NICHD NIH DHHS, Bethesda, Maryland, USA
    J Matern Fetal Neonatal Med 20:777-92. 2007
    ..The aim of this study was to determine whether preeclampsia and delivery of a small for gestational age (SGA) neonate are associated with changes in maternal serum concentration of CXCL10/IP-10...
  76. doi request reprint Low maternal concentrations of soluble vascular endothelial growth factor receptor-2 in preeclampsia and small for gestational age
    Tinnakorn Chaiworapongsa
    Perinatology Research Branch, National Institute of Child Health and Human Development, NIH DHHS, Bethesda, MD 20892, USA
    J Matern Fetal Neonatal Med 21:41-52. 2008
    ..This study was conducted to determine whether: (1) plasma sVEGFR-2 concentration changes throughout pregnancy; and (2) preeclampsia and SGA are associated with abnormalities in the maternal plasma concentration of sVEGFR-2...
  77. pmc Retinol-binding protein 4: a novel adipokine implicated in the genesis of LGA in the absence of gestational diabetes mellitus
    Shali Mazaki-Tovi
    Perinatology Research Branch, NICHD NIH DHHS, Bethesda, MD, USA
    J Perinat Med 38:147-55. 2010
    ..The goal of this study was to determine whether there is an association between maternal plasma RBP4 concentration and the birth of a large-for-gestational-age (LGA) newborn in women with and without gestational diabetes mellitus (GDM)...