Michael C Joiner

Summary

Affiliation: Wayne State University
Country: USA

Publications

  1. ncbi request reprint A simple alpha/beta-independent method to derive fully isoeffective schedules following changes in dose per fraction
    Michael C Joiner
    Department of Radiation Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, MI, USA
    Int J Radiat Oncol Biol Phys 58:871-5. 2004
  2. pmc The effects of G2-phase enrichment and checkpoint abrogation on low-dose hyper-radiosensitivity
    Sarah A Krueger
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, Michigan 48073, USA
    Int J Radiat Oncol Biol Phys 77:1509-17. 2010
  3. ncbi request reprint How to overcome (and exploit) tumor hypoxia for targeted gene therapy
    Olga Greco
    Department of Radiation Oncology, Karmanos Cancer Institute and Wayne State University, Hudson Webber CRC, Detroit, Michigan, USA
    J Cell Physiol 197:312-25. 2003
  4. ncbi request reprint Significant dose can be lost by extended delivery times in IMRT with x rays but not high-LET radiations
    Michael C Joiner
    Department of Radiation Oncology, Wayne State University, Detroit, Michigan 48201, USA
    Med Phys 37:2457-65. 2010
  5. doi request reprint Characteristic 8 keV X rays possess radiobiological properties of higher-LET radiation
    Ravi Shridhar
    Wayne State University, Detroit, Michigan 48201 2013, USA
    Radiat Res 173:290-7. 2010
  6. ncbi request reprint Prostate cancer treatment is enhanced by genistein in vitro and in vivo in a syngeneic orthotopic tumor model
    Yu Wang
    Department of Radiation Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan, 48201, USA
    Radiat Res 166:73-80. 2006
  7. ncbi request reprint Gene therapy vectors containing CArG elements from the Egr1 gene are activated by neutron irradiation, cisplatin and doxorubicin
    Olga Greco
    Department of Radiation Oncology, Wayne State University, Detroit, Michigan, USA
    Cancer Gene Ther 12:655-62. 2005
  8. ncbi request reprint Genistein potentiates inhibition of tumor growth by radiation in a prostate cancer orthotopic model
    Gilda G Hillman
    Department of Radiation Oncology, Barbara Ann Karmanos Cancer Institute at Wayne State University School of Medicine and Harper University Hospital, Detroit, MI 48201, USA
    Mol Cancer Ther 3:1271-9. 2004
  9. ncbi request reprint Transition in survival from low-dose hyper-radiosensitivity to increased radioresistance is independent of activation of ATM Ser1981 activity
    Sarah A Krueger
    Department of Radiation Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, MI, USA
    Int J Radiat Oncol Biol Phys 69:1262-71. 2007
  10. doi request reprint Dose escalation using a hypofractionated, intensity-modulated radiation therapy boost for localized prostate cancer: preliminary results addressing concerns of high or low alpha/beta ratio
    Ravi Shridhar
    Department of Radiation Oncology, Moffitt Cancer Center, Tampa, FL 33612, USA
    Clin Genitourin Cancer 7:E52-7. 2009

Collaborators

Detail Information

Publications15

  1. ncbi request reprint A simple alpha/beta-independent method to derive fully isoeffective schedules following changes in dose per fraction
    Michael C Joiner
    Department of Radiation Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, MI, USA
    Int J Radiat Oncol Biol Phys 58:871-5. 2004
    ..This study shows how these calculations can be carried out independently of any alpha/beta ratios to bring the treatment back exactly to planned tolerance simultaneously for all tissues and tumor involved...
  2. pmc The effects of G2-phase enrichment and checkpoint abrogation on low-dose hyper-radiosensitivity
    Sarah A Krueger
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, Michigan 48073, USA
    Int J Radiat Oncol Biol Phys 77:1509-17. 2010
    ..This study was conducted to characterize the dose response of the early G2/M checkpoint and then determine whether low-dose radiation sensitivity could be increased by synchronization or chemical inhibition of the cell cycle...
  3. ncbi request reprint How to overcome (and exploit) tumor hypoxia for targeted gene therapy
    Olga Greco
    Department of Radiation Oncology, Karmanos Cancer Institute and Wayne State University, Hudson Webber CRC, Detroit, Michigan, USA
    J Cell Physiol 197:312-25. 2003
    ..Ultimately, it is proposed that by adopting specific transgene activation and molecular amplification systems, resistant hypoxic tumor tissues may be effectively targeted with gene therapy...
  4. ncbi request reprint Significant dose can be lost by extended delivery times in IMRT with x rays but not high-LET radiations
    Michael C Joiner
    Department of Radiation Oncology, Wayne State University, Detroit, Michigan 48201, USA
    Med Phys 37:2457-65. 2010
    ....
  5. doi request reprint Characteristic 8 keV X rays possess radiobiological properties of higher-LET radiation
    Ravi Shridhar
    Wayne State University, Detroit, Michigan 48201 2013, USA
    Radiat Res 173:290-7. 2010
    ..462-0.520) for (60)Co gamma rays (P < 0.0001). Characteristic 8 keV X rays produce two to three times the biological effectiveness of megavoltage photons, with a radiobiological profile similar to higher-LET radiations...
  6. ncbi request reprint Prostate cancer treatment is enhanced by genistein in vitro and in vivo in a syngeneic orthotopic tumor model
    Yu Wang
    Department of Radiation Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan, 48201, USA
    Radiat Res 166:73-80. 2006
    ....
  7. ncbi request reprint Gene therapy vectors containing CArG elements from the Egr1 gene are activated by neutron irradiation, cisplatin and doxorubicin
    Olga Greco
    Department of Radiation Oncology, Wayne State University, Detroit, Michigan, USA
    Cancer Gene Ther 12:655-62. 2005
    ..These data indicate that combining CArG-mediated HSVtk/GCV suicide gene therapy with radio- and chemotherapy can enhance antitumor toxicity, and validates future in vivo investigations...
  8. ncbi request reprint Genistein potentiates inhibition of tumor growth by radiation in a prostate cancer orthotopic model
    Gilda G Hillman
    Department of Radiation Oncology, Barbara Ann Karmanos Cancer Institute at Wayne State University School of Medicine and Harper University Hospital, Detroit, MI 48201, USA
    Mol Cancer Ther 3:1271-9. 2004
    ..We tested this approach in vivo using an orthotopic prostate carcinoma model of PC-3 cells in nude mice...
  9. ncbi request reprint Transition in survival from low-dose hyper-radiosensitivity to increased radioresistance is independent of activation of ATM Ser1981 activity
    Sarah A Krueger
    Department of Radiation Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, MI, USA
    Int J Radiat Oncol Biol Phys 69:1262-71. 2007
    ..The aim of this study was to define the roles of ataxia telangiectasia mutated (ATM) activity and the downstream ATM-dependent G(2)-phase cell cycle checkpoint in overcoming HRS and triggering radiation resistance...
  10. doi request reprint Dose escalation using a hypofractionated, intensity-modulated radiation therapy boost for localized prostate cancer: preliminary results addressing concerns of high or low alpha/beta ratio
    Ravi Shridhar
    Department of Radiation Oncology, Moffitt Cancer Center, Tampa, FL 33612, USA
    Clin Genitourin Cancer 7:E52-7. 2009
    ..The possibility that prostate cancers have a low alpha/beta ratio led to a schedule including a hypofractionated boost. The purpose of this study was to analyze the outcomes of this regimen...
  11. ncbi request reprint MIRD continuing education: Bystander and low dose-rate effects: are these relevant to radionuclide therapy?
    George Sgouros
    School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    J Nucl Med 48:1683-91. 2007
    ....
  12. ncbi request reprint Low-dose hyperradiosensitivity of human glioblastoma cell lines in vitro does not translate into improved outcome of ultrafractionated radiotherapy in vivo
    Mechthild Krause
    Clinic for Radiotherapy and Radiation Oncology, Medical Faculty Carl Gustav Carus, University of Technology, Dresden, Germany
    Int J Radiat Biol 81:751-8. 2005
    ..Low dose hyperradiosensitivity (HRS) has been observed in HGL21- and T98G human glioblastoma cells in vitro. The present study investigates whether these effects translate into improved outcome of ultrafractionated irradiation (UF) in vivo...
  13. ncbi request reprint Ultrafractionation does not improve the results of radiotherapy in radioresistant murine DDL1 lymphoma
    Mechthild Krause
    Clinic for Radiotherapy and Radiation Oncology, Medical Faculty Carl Gustav Carus, University of Technology, Dresden, Germany
    Strahlenther Onkol 181:540-4. 2005
    ..e., application of very low doses per fraction, has been proposed to improve the effects of radiotherapy. The present study investigates ultrafractionation (UF) in radioresistant murine DDL1 T-cell lymphoma in mice...
  14. ncbi request reprint The evaluation of low dose hyper-radiosensitivity in normal human skin
    Jackie Harney
    Marie Curie Research Wing, Mount Vernon Hospital, Rickmansworth Road, Northwood, Middlesex HA6 2RN, UK
    Radiother Oncol 70:319-29. 2004
    ..These data have stimulated clinical investigation into LDHRS in vivo...
  15. ncbi request reprint Effects of exposure to low-dose-rate (60)co gamma rays on human tumor cells in vitro
    Catherine R Mitchell
    Gray Cancer Institute, Mount Vernon Hospital, Northwood, United Kingdom
    Radiat Res 158:311-8. 2002
    ..We conclude that this inverse dose-rate effect in continuous exposures reflects the hyper-radiosensitivity seen in the same cell lines in response to very small acute single doses...