Wei Chen

Summary

Affiliation: Wayne State University
Country: USA

Publications

  1. ncbi request reprint A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancer
    Hiromu Suzuki
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, 1650 Orleans Street, Baltimore, Maryland 21231, USA
    Nat Genet 31:141-9. 2002
  2. ncbi request reprint Using the area under the curve to reduce measurement error in predicting young adult blood pressure from childhood measures
    Nancy R Cook
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215 1204, USA
    Stat Med 23:3421-35. 2004
  3. ncbi request reprint A false-discovery-rate-based loss framework for selection of interactions
    Wei Chen
    Karmanos Cancer Institute, 4160 John R, Detroit, MI 48201, U S A
    Stat Med 27:2004-21. 2008
  4. doi request reprint Phase II study of pemetrexed and cisplatin, with chest radiotherapy followed by docetaxel in patients with stage III non-small cell lung cancer
    Shirish M Gadgeel
    Thoracic Oncology Program, Karmanos Cancer Institute Wayne State University, Detroit, Michigan, USA
    J Thorac Oncol 6:927-33. 2011
  5. pmc On Bayesian methods of exploring qualitative interactions for targeted treatment
    Wei Chen
    Department of Oncology, School of Medicine, Wayne State University, Detroit, MI 48201, USA
    Stat Med 31:3693-707. 2012
  6. pmc Bayesian variable selection with joint modeling of categorical and survival outcomes: an application to individualizing chemotherapy treatment in advanced colorectal cancer
    Wei Chen
    Biostatistics Core, Karmanos Cancer Institute, Wayne State University, Detroit, Michigan 48201, USA
    Biometrics 65:1030-40. 2009
  7. pmc Admixture mapping of lung cancer in 1812 African-Americans
    Ann G Schwartz
    Karmanos Cancer Institute, Detroit, MI 48201, USA
    Carcinogenesis 32:312-7. 2011
  8. pmc Engagement of I-branching {beta}-1, 6-N-acetylglucosaminyltransferase 2 in breast cancer metastasis and TGF-{beta} signaling
    Haijun Zhang
    The Breast Cancer Biology Program, Barbara Ann Karmanos Cancer Institute Department of Oncology and Pathology, Wayne State University School of Medicine, HWCRC, Room 840 2, 4100 John R Street, Detroit, MI 48201, USA
    Cancer Res 71:4846-56. 2011
  9. pmc Randomized international phase III trial of ERCC1 and RRM1 expression-based chemotherapy versus gemcitabine/carboplatin in advanced non-small-cell lung cancer
    Gerold Bepler
    Karmanos Cancer Institute, Detroit, MI 48201, USA
    J Clin Oncol 31:2404-12. 2013
  10. pmc Fibroblast growth factor receptor 1 amplification in non-small cell lung cancer by quantitative real-time PCR
    Shirish M Gadgeel
    Karmanos Cancer Institute and Department of Oncology, Wayne State University, Detroit, Michigan, United States of America
    PLoS ONE 8:e79820. 2013

Collaborators

Detail Information

Publications58

  1. ncbi request reprint A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancer
    Hiromu Suzuki
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, 1650 Orleans Street, Baltimore, Maryland 21231, USA
    Nat Genet 31:141-9. 2002
    ....
  2. ncbi request reprint Using the area under the curve to reduce measurement error in predicting young adult blood pressure from childhood measures
    Nancy R Cook
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215 1204, USA
    Stat Med 23:3421-35. 2004
    ....
  3. ncbi request reprint A false-discovery-rate-based loss framework for selection of interactions
    Wei Chen
    Karmanos Cancer Institute, 4160 John R, Detroit, MI 48201, U S A
    Stat Med 27:2004-21. 2008
    ..Methods are illustrated on data from a colorectal cancer study assessing the chemotherapy treatments and data from a diffuse large-B-cell lymphoma study assessing the prognostic effect of gene expressions...
  4. doi request reprint Phase II study of pemetrexed and cisplatin, with chest radiotherapy followed by docetaxel in patients with stage III non-small cell lung cancer
    Shirish M Gadgeel
    Thoracic Oncology Program, Karmanos Cancer Institute Wayne State University, Detroit, Michigan, USA
    J Thorac Oncol 6:927-33. 2011
    ..We conducted a phase II study to assess the efficacy and feasibility of integrating pemetrexed in a concurrent therapy plan for patients with stage III NSCLC...
  5. pmc On Bayesian methods of exploring qualitative interactions for targeted treatment
    Wei Chen
    Department of Oncology, School of Medicine, Wayne State University, Detroit, MI 48201, USA
    Stat Med 31:3693-707. 2012
    ..We illustrate this method in two examples of phase III clinical trials. The algorithm is straightforward and easy to implement using existing software packages. We provide a sample code in Appendix A...
  6. pmc Bayesian variable selection with joint modeling of categorical and survival outcomes: an application to individualizing chemotherapy treatment in advanced colorectal cancer
    Wei Chen
    Biostatistics Core, Karmanos Cancer Institute, Wayne State University, Detroit, Michigan 48201, USA
    Biometrics 65:1030-40. 2009
    ..The application to the advanced colorectal cancer study revealed associations between multiple endpoints and particular biomarkers, demonstrating the potential of individualizing treatment based on genetic profiles...
  7. pmc Admixture mapping of lung cancer in 1812 African-Americans
    Ann G Schwartz
    Karmanos Cancer Institute, Detroit, MI 48201, USA
    Carcinogenesis 32:312-7. 2011
    ..33 (P = 0.0009) at rs181696 among ever smokers with NSCLC. These results add to the findings from the GWAS in Caucasian populations and suggest novel regions of interest...
  8. pmc Engagement of I-branching {beta}-1, 6-N-acetylglucosaminyltransferase 2 in breast cancer metastasis and TGF-{beta} signaling
    Haijun Zhang
    The Breast Cancer Biology Program, Barbara Ann Karmanos Cancer Institute Department of Oncology and Pathology, Wayne State University School of Medicine, HWCRC, Room 840 2, 4100 John R Street, Detroit, MI 48201, USA
    Cancer Res 71:4846-56. 2011
    ....
  9. pmc Randomized international phase III trial of ERCC1 and RRM1 expression-based chemotherapy versus gemcitabine/carboplatin in advanced non-small-cell lung cancer
    Gerold Bepler
    Karmanos Cancer Institute, Detroit, MI 48201, USA
    J Clin Oncol 31:2404-12. 2013
    ..We assessed whether chemotherapy selection based on in situ ERCC1 and RRM1 protein levels would improve survival in patients with advanced non-small-cell lung cancer (NSCLC)...
  10. pmc Fibroblast growth factor receptor 1 amplification in non-small cell lung cancer by quantitative real-time PCR
    Shirish M Gadgeel
    Karmanos Cancer Institute and Department of Oncology, Wayne State University, Detroit, Michigan, United States of America
    PLoS ONE 8:e79820. 2013
    ..Amplification of the fibroblast growth factor receptor 1 (FGFR1) gene has been described in tumors of non-small-cell lung cancer (NSCLC) patients. Prior reports showed conflicting rates of amplification frequency and clinical relevance...
  11. pmc Small protease sensitive oligomers of PrPSc in distinct human prions determine conversion rate of PrP(C)
    Chae Kim
    National Prion Disease Surveillance Center, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA
    PLoS Pathog 8:e1002835. 2012
    ....
  12. pmc Racial diversity of actionable mutations in non-small cell lung cancer
    Aliccia Bollig-Fischer
    Barbara Ann Karmanos Cancer Institute and Department of Oncology, Wayne State University, Detroit, MI
    J Thorac Oncol 10:250-5. 2015
    ..We hypothesized that differential incidence of somatic cancer gene mutations may be a contributing factor. Previous genomic studies of non-small cell lung cancer (NSCLC) have not adequately represented black patients...
  13. doi request reprint Analysis of lung cancer patients enrolled in CTEP (cancer therapy evaluation program)-sponsored phase I trials
    Shirish M Gadgeel
    Karmanos Cancer Institute Wayne State University, Detroit, MI, USA
    Clin Lung Cancer 12:218-23. 2011
    ..We conducted an analysis of the Cancer Therapy Evaluation Program (CTEP)-sponsored phase I trials to assess the outcomes of lung cancer patients enrolled in phase I trials...
  14. pmc Loss of let-7 up-regulates EZH2 in prostate cancer consistent with the acquisition of cancer stem cell signatures that are attenuated by BR-DIM
    Dejuan Kong
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan, United States of America
    PLoS ONE 7:e33729. 2012
    ..These results suggest that the loss of let-7 mediated increased expression of EZH2 contributes to PCa aggressiveness, which could be attenuated by BR-DIM treatment, and thus BR-DIM is likely to have clinical impact...
  15. pmc Androgen receptor splice variants contribute to prostate cancer aggressiveness through induction of EMT and expression of stem cell marker genes
    Dejuan Kong
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan
    Prostate 75:161-74. 2015
    ..The mechanism(s) by which androgen receptor (AR) splice variants contribute to castration-resistant prostate cancer (CRPC) is still lacking...
  16. pmc Results from a prostate cancer admixture mapping study in African-American men
    Cathryn Hufford Bock
    Wayne State University School of Medicine, Detroit, MI 48201, USA
    Hum Genet 126:637-42. 2009
    ..In conclusion, we confirmed ancestry associations on 8q24, and identified additional ancestry-associated regions potentially harboring prostate cancer susceptibility loci...
  17. pmc Cullin-3 protein expression levels correlate with breast cancer progression
    Kelly K Haagenson
    Karmanos Cancer Institute, Detroit, MI, USA
    Cancer Biol Ther 13:1042-6. 2012
    ..These data suggest that Cullin-3 may play an important role in tumor progression from DCIS to invasive cancer and may serve as a biomarker for the diagnosis of aggressive breast cancer...
  18. pmc p38γ mitogen-activated protein kinase contributes to oncogenic properties maintenance and resistance to poly (ADP-ribose)-polymerase-1 inhibition in breast cancer
    Fanyan Meng
    The Breast Cancer Biology Program, Barbara Ann Karmanos Cancer Institute, Detroit, MI, USA
    Neoplasia 13:472-82. 2011
    ....
  19. ncbi request reprint MicroRNA analysis of fine-needle aspirates from pancreatic cancer
    Philip Agop Philip
    Karmanos Cancer Institute, Wayne State University, Detroit, MI Wayne State University, Detroit, MI
    J Clin Oncol 30:200. 2012
    ..Micro-RNAs (miRNAs) are biomarkers with the potential to be developed for prognostic and predictive purposes. Moreover, these molecules can facilitate the development of targeted therapies in PC...
  20. pmc miR-20b is up-regulated in brain metastases from primary breast cancers
    Aamir Ahmad
    Department of Pathology, Wayne State University School of Medicine and Karmanos Cancer Institute, Detroit, Michigan, USA
    Oncotarget 6:12188-95. 2015
    ..Together, our findings suggest a novel role of miR-20b in breast cancer brain metastasis that warrants further investigation for its potential to be developed as prognostic and/or therapeutic target. ..
  21. pmc PDGFRα and β play critical roles in mediating Foxq1-driven breast cancer stemness and chemoresistance
    Fanyan Meng
    Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan Department of Oncology, Wayne State University School of Medicine, Detroit, Michigan
    Cancer Res 75:584-93. 2015
    ..These findings collectively implicate PDGFRs as critical mediators of breast cancer oncogenesis and chemoresistance driven by Foxq1, with potential implications for developing novel therapeutic combinations to treat breast cancer...
  22. pmc Synergistic antitumor interactions between MK-1775 and panobinostat in preclinical models of pancreatic cancer
    Guan Wang
    National Engineering Laboratory for AIDS Vaccine, Key Laboratory for Molecular Enzymology and Engineering, The Ministry of Education, School of Life Sciences, Jilin University, Changchun, China Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI, USA
    Cancer Lett 356:656-68. 2015
    ....
  23. pmc Anti-thymocyte globulin (thymoglobulin), tacrolimus, and sirolimus as acute graft-versus-host disease prophylaxis for unrelated hematopoietic stem cell transplantation
    Zaid Al-Kadhimi
    Blood and Marrow Program, Department of Oncology, Wayne State University Karmanos Cancer Center, Detroit, Michigan 48201, USA
    Biol Blood Marrow Transplant 18:1734-44. 2012
    ....
  24. doi request reprint Circumferential pulmonary vein ablation with additional linear ablation results in an increased incidence of left atrial flutter compared with segmental pulmonary vein isolation as an initial approach to ablation of paroxysmal atrial fibrillation
    Navinder Sawhney
    Division of Cardiology, and Cardiac Electrophysiology Program, University of California, San Diego, School of Medicine, San Diego, CA 92103 8649, USA
    Circ Arrhythm Electrophysiol 3:243-8. 2010
    ..Therefore, we compared circumferential pulmonary vein ablation plus left atrial linear ablation (CPVA+LALA) with segmental pulmonary vein isolation (PVI)in patients with paroxysmal AF...
  25. pmc Cytokine and cytokine receptor single-nucleotide polymorphisms predict risk for non-small cell lung cancer among women
    Alison L Van Dyke
    Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, Michigan, USA
    Cancer Epidemiol Biomarkers Prev 18:1829-40. 2009
    ..Pathway analysis results are presented. Inflammatory pathway genotypes may serve to define a high risk group; further exploration of these genes in minority populations is warranted...
  26. pmc Chronic obstructive lung diseases and risk of non-small cell lung cancer in women
    Ann G Schwartz
    Population Studies and Prevention Program, Karmanos Cancer Institute, Detroit, MI 48201, USA
    J Thorac Oncol 4:291-9. 2009
    ..The link between lung cancer and chronic obstructive lung diseases (COPD) has not been well studied in women even though lung cancer and COPD account for significant and growing morbidity and mortality among women...
  27. pmc Galectin-3 Cleavage Alters Bone Remodeling: Different Outcomes in Breast and Prostate Cancer Skeletal Metastasis
    Kosei Nakajima
    Department of Oncology and Pathology, Karmanos Cancer Institute, Wayne State University, Detroit, Michigan
    Cancer Res 76:1391-402. 2016
    ....
  28. pmc P³DB 3.0: From plant phosphorylation sites to protein networks
    Qiuming Yao
    Department of Computer Science, University of Missouri, Columbia, MO 65211, USA, Bond Life Sciences Center, University of Missouri, Columbia, MO 65211, USA, School of Communication and Information Engineering, Shanghai University, Shanghai 200444, People s Republic of China, Department of Biology, Brandeis University, MA 02453, USA, Computational Biology Center, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA and Department of Biochemistry, University of Missouri, Columbia, MO 65211, USA
    Nucleic Acids Res 42:D1206-13. 2014
    ..Each of these new features supports the goal of making P(3)DB a comprehensive, systematic and interactive platform for phosphoproteomics research...
  29. pmc Panobinostat enhances cytarabine and daunorubicin sensitivities in AML cells through suppressing the expression of BRCA1, CHK1, and Rad51
    Chengzhi Xie
    Department of Oncology, Wayne State University School of Medicine, Detroit, Michigan, United States of America Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan, United States of America The State Engineering Laboratory of AIDS Vaccine, College of Life Science, Jilin University, Changchun, China
    PLoS ONE 8:e79106. 2013
    ....
  30. pmc Antitumor activity of novel fluoro-substituted (-)-epigallocatechin-3-gallate analogs
    Huanjie Yang
    The Prevention Program, Barbara Ann Karmanos Cancer Institute, and Department of Pathology, School of Medicine, Wayne State University, Detroit, MI, USA
    Cancer Lett 292:48-53. 2010
    ....
  31. pmc Protease-sensitive conformers in broad spectrum of distinct PrPSc structures in sporadic Creutzfeldt-Jakob disease are indicator of progression rate
    Chae Kim
    Department of Pathology, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA
    PLoS Pathog 7:e1002242. 2011
    ..The link between disease duration, levels, and stability of protease-sensitive conformers of PrP(Sc) suggests that these conformers play an important role in the pathogenesis of sCJD...
  32. pmc Phosphoglucose isomerase/autocrine motility factor mediates epithelial-mesenchymal transition regulated by miR-200 in breast cancer cells
    Aamir Ahmad
    Department of Pathology and Oncology, Wayne State University School of Medicine, Detroit, MI, USA
    Cancer Res 71:3400-9. 2011
    ..Collectively, these results suggest a role of miR-200s in PGI/AMF-induced EMT and thus approaches for upregulation of miR-200s could be a novel therapeutic strategy for the treatment of highly invasive breast cancer...
  33. doi request reprint Radiographic and CT evaluation of recombinant human bone morphogenetic protein-2-assisted spinal interbody fusion
    Anil Sethi
    Department of Orthopedics, Detroit Receiving Hospital, MI 48201, USA
    AJR Am J Roentgenol 197:W128-33. 2011
    ..We undertook a study to record and analyze the radiographic and CT changes after the use of recombinant human bone morphogenetic protein-2 (rhBMP-2) in spinal fusion surgery...
  34. pmc Meta- and pooled analysis of GSTP1 polymorphism and lung cancer: a HuGE-GSEC review
    Michele L Cote
    Population Studies and Prevention, Karmanos Cancer Institute, Internal Medicine, Wayne State University School of Medicine, 110 East Warren, Detroit, MI 48201, USA
    Am J Epidemiol 169:802-14. 2009
    ..Increased risk varied by histologic type in Asians. There appears to be evidence for interaction between amount of smoking, the GSTP1 exon 5 polymorphism, and risk of lung cancer in whites...
  35. pmc Comparison of seven methods for producing Affymetrix expression scores based on False Discovery Rates in disease profiling data
    Kerby Shedden
    Department of Statistics, University of Michigan, Ann Arbor, Michigan, USA
    BMC Bioinformatics 6:26. 2005
    ....
  36. ncbi request reprint Efficiency and current in a correlated ratchet
    Bao quan Ai
    Department of Physics, Zhongshan University, Guangzhou, China
    Chaos 14:957-62. 2004
    ..The efficiency can be maximized as a function of noise intensity (or temperature), which shows that the thermal fluctuation can facilitate the efficiency of energy transformation...
  37. ncbi request reprint On half gapped seed
    Wei Chen
    School of Computing, National University of Singapore, Singapore, 117543
    Genome Inform 14:176-85. 2003
    ..This property is especially useful when some searching applications want to get more precise results with limitation on hardware resources, or vice versa...
  38. pmc Comparing the DNA hypermethylome with gene mutations in human colorectal cancer
    Kornel E Schuebel
    Cancer Biology Division, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, USA
    PLoS Genet 3:1709-23. 2007
    ....
  39. ncbi request reprint FLT3 ligand administration after hematopoietic cell transplantation increases circulating dendritic cell precursors that can be activated by CpG oligodeoxynucleotides to enhance T-cell and natural killer cell function
    Wei Chen
    University of Minnesota Cancer Center, Minneapolis, Minnesota 5455, USA
    Biol Blood Marrow Transplant 11:23-34. 2005
    ..These findings suggest that FLT3-L mobilization of DC precursors followed by a specific DC stimulus such as CpG ODN may provide a novel strategy to manipulate antitumor immunity in patients after HCT...
  40. pmc Calculation of cyclodextrin binding affinities: energy, entropy, and implications for drug design
    Wei Chen
    Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute, Rockville, Maryland 20850, USA
    Biophys J 87:3035-49. 2004
    ..In close analogy with the common experimental observation of entropy-enthalpy compensation, the computed entropy changes show a near-linear relationship with the changes in mean potential plus solvation energy...
  41. ncbi request reprint The beta(2)-adrenergic receptor Arg16-gly polymorphism and interactions involving beta(2)- and beta(3)-adrenergic receptor polymorphisms are associated with variations in longitudinal serum lipid profiles: the Bogalusa Heart Study
    D Michael Hallman
    Human Genetics Center, University of Texas Health Sciences Center at Houston, Houston, TX 77225, USA
    Metabolism 53:1184-91. 2004
    ....
  42. ncbi request reprint Identification of symmetries in molecules and complexes
    Wei Chen
    Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute, 9600 Gudelsky Drive, Rockville, Maryland 20850, USA
    J Chem Inf Comput Sci 44:1301-13. 2004
    ....
  43. pmc Development of (17)O NMR approach for fast imaging of cerebral metabolic rate of oxygen in rat brain at high field
    Xiao Hong Zhu
    Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, 2021 6th Street SE, Minneapolis, MN 55455, USA
    Proc Natl Acad Sci U S A 99:13194-9. 2002
    ....
  44. pmc CGHPRO -- a comprehensive data analysis tool for array CGH
    Wei Chen
    Max Planck Institute for Molecular Genetics, Ihnestrasse 73, 14195 Berlin, Germany
    BMC Bioinformatics 6:85. 2005
    ....
  45. pmc Preoperative antibiotics and mortality in the elderly
    Jeffrey H Silber
    Center for Outcomes Research, Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Ann Surg 242:107-14. 2005
    ..The objective of this study was to determine whether preoperative antibiotics are associated with a reduced risk of death...
  46. ncbi request reprint Gene expression and immunolocalization of heparin-binding epidermal growth factor-like growth factor and human epidermal growth factor receptors in human corpus luteum
    Yuki Akayama
    Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, Chuo Ku, Japan
    Hum Reprod 20:2708-14. 2005
    ....
  47. ncbi request reprint Real-time detection of respiratory activity using an inertial measurement unit
    Henrik Gollee
    Centre for Rehabilitation Engineering, University of Glasgow, Glasgow, G12 8QQ, Scotland, UK
    Conf Proc IEEE Eng Med Biol Soc 2007:2230-3. 2007
    ..This novel method could therefore be suitable for use in automatic abdominal stimulation systems to support respiratory activity in tetraplegia where the stimulation is applied depending on the respirator activity of the subject...
  48. ncbi request reprint The proteasome subunit PSMA7 located on the 20q13 amplicon is overexpressed and associated with liver metastasis in colorectal cancer
    Xiao Tong Hu
    Biomedical Research Center, Sir Run Run Shaw Hospital, Zhejiang University, Zhejiang 310016, P R China
    Oncol Rep 19:441-6. 2008
    ..The evaluation of PSMA7 expression in primary colorectal cancer at the time of surgery may be a valuable tool for defining patients with a high risk of developing liver metastasis...
  49. doi request reprint Discovering microRNAs from deep sequencing data using miRDeep
    Marc R Friedländer
    Max Delbruck Centrum fur Molekulare Medizin, Robert Rossle Strasse 10, D 13125 Berlin Buch, Germany
    Nat Biotechnol 26:407-15. 2008
    ..miRDeep reports altogether approximately 230 previously unannotated miRNAs, of which four novel C. elegans miRNAs are validated by northern blot analysis...
  50. ncbi request reprint A special issue on luminescence nanomaterials
    Wei Chen
    The University of Texas at Arlington, 76019 0059, USA
    J Nanosci Nanotechnol 8:1017-8. 2008
  51. ncbi request reprint Noninvasive study of neurovascular coupling during graded neuronal suppression
    Nanyin Zhang
    Department of Radiology, Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Cereb Blood Flow Metab 28:280-90. 2008
    ..This study extends the range of the neurovascular coupling relationship from graded neuronal excitation conditions to graded neuronal suppression conditions...
  52. pmc Exposure-toxicity relationships for tipifarnib in cancer patients
    Juan Jose Perez-Ruixo
    Clinical Pharmacology Division, Johnson and Johnson Pharmaceutical Research and Development, Beerse, Belgium
    Br J Clin Pharmacol 64:219-32. 2007
    ..To explore the potential relationship between systemic exposure to tipifarnib and the incidence of toxicity in cancer patients...
  53. ncbi request reprint ConCept: de novo design of synthetic receptors for targeted ligands
    Wei Chen
    Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute, 9600 Gudelsky Drive, Rockville, MD 20850, USA
    J Chem Inf Model 47:425-34. 2007
    ..All three modes of operation are illustrated here through the design of novel adenine receptors...
  54. pmc Ligand configurational entropy and protein binding
    Chia en A Chang
    Department of Chemistry and Biochemistry, and Center for Theoretical Biological Physics, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 104:1534-9. 2007
    ..The results highlight the potential to gain affinity by designing conformationally restricted ligands and have implications for the formulation of energy models for ligand scoring...
  55. ncbi request reprint Efficient in vivo 31P magnetization transfer approach for noninvasively determining multiple kinetic parameters and metabolic fluxes of ATP metabolism in the human brain
    Fei Du
    Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Magn Reson Med 57:103-14. 2007
    ..The MSS MT approach should provide an important modality for noninvasively studying the essential roles of ATP metabolism in brain bioenergetics, function, and diseases...
  56. pmc Flow-enhanced adhesion regulated by a selectin interdomain hinge
    Jizhong Lou
    Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, USA
    J Cell Biol 174:1107-17. 2006
    ..Thus, allosteric changes remote from the ligand-binding interface regulate both bond formation and dissociation...
  57. ncbi request reprint A computer-aided method to expedite the evaluation of prognosis for childhood acute lymphoblastic leukemia
    Xingwei Wang
    Center for Bioengineering and School of Electrical and Computer Engineering, University of Oklahoma, Oklahoma, USA
    Technol Cancer Res Treat 5:429-36. 2006
    ..The results demonstrated the feasibility or potential of using a computerized method to replace the tedious and the reader-dependent diagnostic methods commonly used in genetic laboratories to date...
  58. ncbi request reprint CIMPle origin for promoter hypermethylation in colorectal cancer?
    Kornel Schuebel
    Nat Genet 38:738-40. 2006