Affiliation: Wayne State University
- Maximising therapeutic outcomes in patients failing on current therapyChristina Caon
Multiple Sclerosis Center, Department of Neurology, Wayne State University, Detroit, MI, USA
J Neurol Sci 277:S33-6. 2009..Formal switching algorithms need to be developed in order to ensure that all patients who could benefit from such an approach are managed in a timely and optimal manner...
- Injectable disease-modifying therapy for relapsing-remitting multiple sclerosis: a review of adherence dataChristina Caon
Multiple Sclerosis Center at Wayne State University School of Medicine, Detroit, MI, USA
J Neurosci Nurs 42:S5-9. 2010..Nursing interventions that can improve adherence, including telephone counseling and motivational interview techniques, are also addressed...
- Long-term study of brain 1H-MRS study in multiple sclerosis: effect of glatiramer acetate therapy on axonal metabolic function and feasibility of long-Term H-MRS monitoring in multiple sclerosisOmar Khan
Multiple Sclerosis Clinical Research Center, Department of Neurology, The Detroit Medical Center, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
J Neuroimaging 18:314-9. 2008..These data support the long-term effect of GA on maintaining axonal metabolic function and protection from sublethal injury as well as the feasibility of employing brain (1)H-MRS in long-term investigative studies in MS...
- Longitudinal study of the substantia nigra in Parkinson disease: A high-field (1) H-MR spectroscopy imaging studyNavid Seraji-Bozorgzad
The Sastry Foundation Advanced Imaging Laboratory, Department of Neurology, Wayne State University School of Medicine, Detroit, MI, USA
Mov Disord 30:1400-4. 2015..The value of biomarkers in early diagnosis and development of therapeutics in Parkinson's disease (PD) is well established...
- Effect of disease-modifying therapies on brain volume in relapsing-remitting multiple sclerosis: results of a five-year brain MRI studyOmar Khan
MR Image Analysis Laboratory, Department of Neurology, Wayne State University School of Medicine, Detroit, MI 48201, USA
J Neurol Sci 312:7-12. 2012..To compare the long-term effect of disease-modifying therapies (DMT) on brain volume loss in relapsing-remitting MS (RRMS) patients...
- Progressive multifocal leukoencephalopathy and relapsing-remitting multiple sclerosis: a comparative studyAaron Boster
Department of Neurology, Wayne State University School of Medicine, Detroit, MI 48201, USA
Arch Neurol 66:593-9. 2009..To identify clinical and magnetic resonance imaging (MRI) features that distinguish progressive multifocal leukoencephalopathy (PML) from relapsing-remitting multiple sclerosis (RRMS)...
- Acute transverse myelitis with normal brain MRI : long-term risk of MSJui Perumal
Multiple Sclerosis Center, Dept of Neurology, Wayne State University School of Medicine, Detroit, MI, USA
J Neurol 255:89-93. 2008..To investigate the long-term risk of developing MS in patients presenting with acute transverse myelitis (ATM) and normal brain MRI scans at onset...
- Glatiramer acetate for multiple sclerosis: a comprehensive review of mechanisms and clinical efficacyMarina Zvartau-Hind
Department of Neurology, 8D University Health Center, 4201 St Antoine, Detroit, MI 48201, USA
Expert Rev Neurother 2:285-94. 2002..This review will highlight the immune mechanisms and clinical data reported with glatiramer acetate in multiple sclerosis over the past three decades...
- Characterizing retinal structure injury in African-Americans with multiple sclerosisNavid Seraji-Bozorgzad
Retinal Biology Program in Neurosciences and The Sastry Foundation Advanced Imaging Laboratory, United States Multiple Sclerosis Center, Department of Neurology, Wayne State University School of Medicine, Detroit, United States Electronic address
Mult Scler Relat Disord 7:16-20. 2016..Our findings are consistent with other studies demonstrating a more severe CNS tissue injury in AAMS patients. ..
- Spinal cord atrophy in multiple sclerosis and relationship with disability across clinical phenotypesEvanthia Bernitsas
Multiple Sclerosis Center, Wayne State University School of Medicine, Detroit, USA
Mult Scler Relat Disord 4:47-51. 2015..Several studies have shown a relationship between spinal cord atrophy and clinical disability in patients with multiple sclerosis (MS)...
- Axonal metabolic recovery and potential neuroprotective effect of glatiramer acetate in relapsing-remitting multiple sclerosisOmar Khan
Department of Neurology, Multiple Sclerosis Center, Wayne State University School of Medicine, Detroit, MI 48201, USA
Mult Scler 11:646-51. 2005..These results support an in situ effect of GA therapy inside the CNS and suggest potential neuroprotective effects of GA...
- Pediatric-onset multiple sclerosis in African-American black and European-origin white patientsAaron L Boster
Department of Neurology, The Ohio State University, Columbus, Ohio, USA
Pediatr Neurol 40:31-3. 2009..50; P < 0.001). These findings are consistent with data suggesting a more aggressive disease phenotype among African-American blacks with adult-onset multiple sclerosis. Larger multicenter studies are warranted to confirm the findings...
- Comparative assessment of immunomodulating therapies for relapsing-remitting multiple sclerosisOmar Khan
Department of Neurology, Multiple Sclerosis Center, Wayne State University School of Medicine, D University Health Center, 4201 St Antoine, Detroit, MI 48201, USA
CNS Drugs 16:563-78. 2002..In a pharmaceutical environment with an estimated worldwide market of $US2.5 billion annually for RRMS, comparative studies are understandably provocative, but at the same time provide meaningful information to clinicians and patients...