Affiliation: Waters Corporation
- Characterization of protein impurities and site-specific modifications using peptide mapping with liquid chromatography and data independent acquisition mass spectrometryHongwei Xie
Biopharmaceutical Sciences, Waters Corporation, 34 Maple Street, Massachusetts 01757, USA
Anal Chem 81:5699-708. 2009..LC-eluted peptides were successfully sequenced and covered 97% target protein sequences. Protein impurities and site-specific modifications (e.g., M-oxidation and N-deamidation) were identified and quantified...
- Characterization of a recombinant influenza vaccine candidate using complementary LC-MS methodsHongwei Xie
Department of Biopharmaceutical Sciences, Waters Corporation, Milford, MA 01757, USA
Curr Pharm Biotechnol 12:1568-79. 2011..These methods can contribute to the monitoring of vaccine quality especially as it pertains to product comparability studies to evaluate the impact of production process changes...
- Characterization of glycoprotein digests with hydrophilic interaction chromatography and mass spectrometryMartin Gilar
Waters Corporation, Milford, MA 01757, USA
Anal Biochem 417:80-8. 2011..The analysis of site-specific glycan microheterogeneity was illustrated for the CD44 fusion protein...
- Utility of retention prediction model for investigation of peptide separation selectivity in reversed-phase liquid chromatography: impact of concentration of trifluoroacetic acid, column temperature, gradient slope and type of stationary phaseMartin Gilar
Waters Corporation, 34 Maple Street, Milford, Massachusetts 01757, USA
Anal Chem 82:265-75. 2010..The trends suggested by calculated retention coefficients were confirmed using a set of synthetic peptides with specifically designed sequences...