J Zheng

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi request reprint [Mechanism of the mitogen-activated protein kinase phosphatase-5 regulating the growth and invasion of a human prostate cancer cell line]
    Hui Ying He
    Department of Pathology, Peking University Health Science Center, Beijing 100083, China
    Zhonghua Yi Xue Za Zhi 83:1812-7. 2003
  2. ncbi request reprint ERK1/2 and p38 pathways are required for P2Y receptor-mediated prostate cancer invasion
    Ling Chen
    Department of Pathology, Peking University Health Science Center, 38 Xue Yuan Road, Beijing 100083, China
    Cancer Lett 215:239-47. 2004
  3. ncbi request reprint [SHP2 and MKP5 in P2Y purinergic receptor-mediated prostate cancer invasion]
    Hui Ying He
    Department of Pathology, Health Science Center, Peking University, Beijing 100083, China
    Zhonghua Bing Li Xue Za Zhi 34:288-92. 2005
  4. ncbi request reprint [Correlation of expression of RhoC with invasiveness of prostate cancer cell line PC-3M in vitro]
    Zheng Yuan
    Department of Pathology, Health Science Center, Peking University, Beijing 100083, China
    Zhonghua Yi Xue Za Zhi 88:51-5. 2008
  5. doi request reprint Oximetric angiosome imaging in diabetic feet
    Jie Zheng
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri, USA
    J Magn Reson Imaging 44:940-6. 2016
  6. doi request reprint Non-contrast MRI perfusion angiosome in diabetic feet
    Jie Zheng
    Mallinckrodt Institute of Radiology, Cardiovascular Imaging Lab, 510 South Kingshighway Blvd Campus Box 8225, St Louis, MO, 63110, USA
    Eur Radiol 25:99-105. 2015
  7. pmc Human coronary plaque wall thickness correlated positively with flow shear stress and negatively with plaque wall stress: an IVUS-based fluid-structure interaction multi-patient study
    Rui Fan
    School of Biological Science and Medical Engineering, Southeast University, Nanjing, China
    Biomed Eng Online 13:32. 2014
  8. pmc Correlations of coronary plaque wall thickness with wall pressure and wall pressure gradient: a representative case study
    Biyue Liu
    Department of Mathematics, Monmouth University, West Long Branch, NJ 07764, USA
    Biomed Eng Online 11:43. 2012
  9. pmc Resting myocardial perfusion quantification with CMR arterial spin labeling at 1.5 T and 3.0 T
    Benjamin E Northrup
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St, Louis, Missouri, USA
    J Cardiovasc Magn Reson 10:53. 2008
  10. pmc Quantification of global myocardial oxygenation in humans: initial experience
    Kyle S McCommis
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 S, Kingshighway Blvd, St, Louis, MO 63110, USA
    J Cardiovasc Magn Reson 12:34. 2010

Research Grants

Detail Information

Publications69

  1. ncbi request reprint [Mechanism of the mitogen-activated protein kinase phosphatase-5 regulating the growth and invasion of a human prostate cancer cell line]
    Hui Ying He
    Department of Pathology, Peking University Health Science Center, Beijing 100083, China
    Zhonghua Yi Xue Za Zhi 83:1812-7. 2003
    ....
  2. ncbi request reprint ERK1/2 and p38 pathways are required for P2Y receptor-mediated prostate cancer invasion
    Ling Chen
    Department of Pathology, Peking University Health Science Center, 38 Xue Yuan Road, Beijing 100083, China
    Cancer Lett 215:239-47. 2004
    ..These results suggest that P2Y receptors and their down-stream ERK1/2 and p38 protein kinases are important regulators promoting prostate cancer invasion...
  3. ncbi request reprint [SHP2 and MKP5 in P2Y purinergic receptor-mediated prostate cancer invasion]
    Hui Ying He
    Department of Pathology, Health Science Center, Peking University, Beijing 100083, China
    Zhonghua Bing Li Xue Za Zhi 34:288-92. 2005
    ....
  4. ncbi request reprint [Correlation of expression of RhoC with invasiveness of prostate cancer cell line PC-3M in vitro]
    Zheng Yuan
    Department of Pathology, Health Science Center, Peking University, Beijing 100083, China
    Zhonghua Yi Xue Za Zhi 88:51-5. 2008
    ..To investigate the expression of RhoC in prostate cancer cells with different metastatic potential and the correlation with invasiveness...
  5. doi request reprint Oximetric angiosome imaging in diabetic feet
    Jie Zheng
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri, USA
    J Magn Reson Imaging 44:940-6. 2016
    ..To develop a noncontrast oximetric angiosome imaging approach to assess skeletal muscle oxygenation in diabetic feet...
  6. doi request reprint Non-contrast MRI perfusion angiosome in diabetic feet
    Jie Zheng
    Mallinckrodt Institute of Radiology, Cardiovascular Imaging Lab, 510 South Kingshighway Blvd Campus Box 8225, St Louis, MO, 63110, USA
    Eur Radiol 25:99-105. 2015
    ..The purpose of this study is to develop a non-contrast magnetic resonance imaging (MRI) approach to evaluate skeletal muscle perfusion in the diabetic foot based on the concept of angiosomes of the foot...
  7. pmc Human coronary plaque wall thickness correlated positively with flow shear stress and negatively with plaque wall stress: an IVUS-based fluid-structure interaction multi-patient study
    Rui Fan
    School of Biological Science and Medical Engineering, Southeast University, Nanjing, China
    Biomed Eng Online 13:32. 2014
    ....
  8. pmc Correlations of coronary plaque wall thickness with wall pressure and wall pressure gradient: a representative case study
    Biyue Liu
    Department of Mathematics, Monmouth University, West Long Branch, NJ 07764, USA
    Biomed Eng Online 11:43. 2012
    ..The role of flow wall shear stress in atherosclerosis progression has been under intensive investigation, while the impact of blood pressure on plaque progression has been under-studied...
  9. pmc Resting myocardial perfusion quantification with CMR arterial spin labeling at 1.5 T and 3.0 T
    Benjamin E Northrup
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St, Louis, Missouri, USA
    J Cardiovasc Magn Reson 10:53. 2008
    ..5 T and 3.0 T. A computer simulation was performed and compared with experimental findings...
  10. pmc Quantification of global myocardial oxygenation in humans: initial experience
    Kyle S McCommis
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 S, Kingshighway Blvd, St, Louis, MO 63110, USA
    J Cardiovasc Magn Reson 12:34. 2010
    ....
  11. pmc MRI-based biomechanical imaging: initial study on early plaque progression and vessel remodeling
    Jie Zheng
    Mallinckrodt Institute of Radiology, Washington University, St Louis, MO 63131, USA
    Magn Reson Imaging 27:1309-18. 2009
    ..This MRI-based biomechanical imaging method may allow for noninvasive dynamic assessment of local hemodynamic forces on the development of atherosclerotic plaques in vivo...
  12. ncbi request reprint Relationship of apparent myocardial T2 and oxygenation: towards quantification of myocardial oxygen extraction fraction
    Jie Zheng
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 S Kingshighway Boulevard, Box 8225, St Louis, MO 63110, USA
    J Magn Reson Imaging 20:233-41. 2004
    ..To explore the relationship of myocardial T(2) and oxygenation for the quantification of myocardial oxygen extraction fraction (OEF)...
  13. ncbi request reprint Single-session magnetic resonance coronary angiography and myocardial perfusion imaging using the new blood pool compound B-22956 (gadocoletic acid): initial experience in a porcine model of coronary artery disease
    Jie Zheng
    Washington University in St Louis, St Louis, Missouri 63110, USA
    Invest Radiol 40:604-13. 2005
    ..The objective of this study was to evaluate a new blood pool contrast agent, B-22956, for detecting myocardial perfusion abnormality and coronary artery stenosis by magnetic resonance imaging (MRI) in 1 setting...
  14. pmc Quantitative assessment of coronary artery plaque vulnerability by high-resolution magnetic resonance imaging and computational biomechanics: a pilot study ex vivo
    Jie Zheng
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Magn Reson Med 54:1360-8. 2005
    ..Noninvasive quantification of the MR contrast and mechanical properties of plaque may provide a comprehensive biomarker for the assessment of vulnerability of atherosclerotic plaques...
  15. pmc Combined MR proton lung perfusion/angiography and helium ventilation: potential for detecting pulmonary emboli and ventilation defects
    Jie Zheng
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Magn Reson Med 47:433-8. 2002
    ..High-resolution MR angiography can unambiguously reveal the location and size of the blood emboli. The combination of the three imaging methods may provide complementary information on abnormal lung anatomy and function...
  16. ncbi request reprint Three-dimensional MR pulmonary perfusion imaging and angiography with an injection of a new blood pool contrast agent B-22956/1
    J Zheng
    Mallinkcrodt Institute of Radiology, Washington University School of Medicine, 510 S Kings Highway, St Louis, MO 63110, USA
    J Magn Reson Imaging 14:425-32. 2001
    ..Our initial results indicate that blood pool agent B-22956/1 may provide opportunities for whole-lung-coverage perfusion mapping and additional high-resolution target angiograms after a single injection...
  17. ncbi request reprint Contrast-enhanced coronary MR angiography: relationship between coronary artery delineation and blood T1
    J Zheng
    Bracco, S p A, Milan, Italy
    J Magn Reson Imaging 14:348-54. 2001
    ..Understanding this relationship may be beneficial to optimizing image protocol and/or design of blood pool contrast agents for contrast-enhanced coronary angiography...
  18. ncbi request reprint Dynamic estimation of the myocardial oxygen extraction ratio during dipyridamole stress by MRI: a preliminary study in canines
    Jie Zheng
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Magn Reson Med 51:718-26. 2004
    ..Combined with vasodilator stress, dynamic assessments of the OEF may provide a putative measurement of myocardial flow reserve and allow consecutive monitoring of myocardial dose and response...
  19. pmc Quantification of regional myocardial oxygenation by magnetic resonance imaging: validation with positron emission tomography
    Kyle S McCommis
    Mallinckrodt Institute of Radiology and Center for Cardiovascular Research, Washington University School of Medicine, 510 S Kingshighway Blvd, St Louis, MO 63110, USA
    Circ Cardiovasc Imaging 3:41-6. 2010
    ..A cardiac MRI method was developed for assessing myocardial oxygenation. The purpose of this study was to evaluate and validate this technique compared with PET during pharmacological stress in a canine model of coronary artery stenosis...
  20. pmc Feasibility of combining MR perfusion, angiography, and 3He ventilation imaging for evaluation of lung function in a porcine model
    Cheng Hong
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Acad Radiol 12:202-9. 2005
    ..To assess the feasibility of combining magnetic resonance (MR) perfusion, angiography, and 3He ventilation imaging for the evaluation of lung function in a porcine model...
  21. ncbi request reprint Contrast-enhanced magnetic resonance imaging of the coronary arteries. A review
    D Li
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri, MO 63110, USA
    Invest Radiol 33:578-86. 1998
    ....
  22. ncbi request reprint Assessment of myocardial oxygen extraction fraction and perfusion reserve with BOLD imaging in a canine model with coronary artery stenosis
    Haosen Zhang
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Magn Reson Imaging 26:72-9. 2007
    ..To determine the feasibility of T2-weighted BOLD imaging for estimating regional myocardial oxygen extraction fraction (OEF) and approximating perfusion reserve (MPR) simultaneously in a canine model with moderate coronary artery stenosis...
  23. pmc Myocardial blood volume is associated with myocardial oxygen consumption: an experimental study with cardiac magnetic resonance in a canine model
    Kyle S McCommis
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    JACC Cardiovasc Imaging 2:1313-20. 2009
    ..In this study, we document a methodology for acquiring BOLD images in the heart and demonstrate the utility of the technique for identifying associations between myocardial oxygen consumption and blood flow...
  24. doi request reprint Fast mapping of myocardial blood flow with MR first-pass perfusion imaging
    Thomas A Goldstein
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Magn Reson Med 59:1394-400. 2008
    ..In addition to its accuracy, this method can also be optimized to run relatively fast, providing potential for fast and accurate myocardial perfusion mapping in a clinical setting...
  25. ncbi request reprint Efficacy of slow infusion of gadolinium contrast agent in three-dimensional MR coronary artery imaging
    J Zheng
    Mallinckrodt Institute of Radiology, Washington University, St Louis, Missouri 63110, USA
    J Magn Reson Imaging 10:800-5. 1999
    ..It is concluded that the former scheme improves the signal-to-noise ratio and edge definition of coronary arteries compared with the latter scheme. J. Magn. Reson. Imaging 1999;10:800-805...
  26. ncbi request reprint Improvement of quantification of myocardial first-pass perfusion mapping: a temporal and spatial wavelet denoising method
    Thomas A Goldstein
    Mallinckrodt Institute of Radiology, Washington University, St Louis, Missouri 63110, USA
    Magn Reson Med 56:439-45. 2006
    ..This suggests that the wavelet denoising method may be an effective way to increase the accuracy of pixel-by-pixel MBF quantification and reduce spatial variation, and may be applicable to other forms of noise-sensitive image analysis...
  27. ncbi request reprint Quantification of myocardial blood volume during dipyridamole and doubtamine stress: a perfusion CMR study
    Kyle S McCommis
    Mallinkcrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Cardiovasc Magn Reson 9:785-92. 2007
    ..The aim of this study is to examine a Cardiovascular Magnetic Resonance (CMR) perfusion method to quantify the changes in MBV, in comparison with the radiolabeled 99mTc-Red-Blood-Cell (RBC) method...
  28. pmc Feasibility study of myocardial perfusion and oxygenation by noncontrast MRI: comparison with PET study in a canine model
    Kyle S McCommis
    Mallinckrodt Institute of Radiology, Box 8225, Washington University School of Medicine, St Louis, MO 63110, USA
    Magn Reson Imaging 26:11-9. 2008
    ..The proposed noncontrast MRI technique is a promising method to quantitatively assess myocardial perfusion and oxygenation...
  29. ncbi request reprint Concurrent multimodality image segmentation by active contours for radiotherapy treatment planning
    Issam El Naqa
    Department of Radiation Oncology, School of Medicine, Washington University, St Louis, Missouri 63110, USA
    Med Phys 34:4738-49. 2007
    ....
  30. pmc Cytokine response after severe respiratory syncytial virus bronchiolitis in early life
    Mario Castro
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    J Allergy Clin Immunol 122:726-733.e3. 2008
    ..Immune response after viral infection usually involves T(H)1-mediated response; however, severe respiratory syncytial virus (RSV) infection appears to be associated with the development of asthma, a T(H)2-predominant phenotype...
  31. pmc Roles of myocardial blood volume and flow in coronary artery disease: an experimental MRI study at rest and during hyperemia
    Kyle S McCommis
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO, USA
    Eur Radiol 20:2005-12. 2010
    ..To validate fast perfusion mapping techniques in a setting of coronary artery stenosis, and to further assess the relationship of absolute myocardial blood volume (MBV) and blood flow (MBF) to global myocardial oxygen demand...
  32. doi request reprint Radiographic structural abnormalities associated with premature, natural hip-joint failure
    John C Clohisy
    Department of Orthopaedic Surgery, Washington University School of Medicine, 1 Barnes Jewish Hospital Plaza, St Louis, MO 63110, USA
    J Bone Joint Surg Am 93:3-9. 2011
    ....
  33. ncbi request reprint Accurate myocardial T1 measurements: toward quantification of myocardial blood flow with arterial spin labeling
    Haosen Zhang
    Mallinckrodt Institute of Radiology, Washington University, St Louis, MO 63110, USA
    Magn Reson Med 53:1135-42. 2005
    ..In summary, the modified ASL technique and T(1) regression algorithm proposed here provide an accurate measurement of myocardial T(1) and demonstrate potential for reliably assessing MBF at steady state...
  34. pmc Improvement of hyperemic myocardial oxygen extraction fraction estimation by a diffusion-prepared sequence
    Kyle S McCommis
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri, USA
    Magn Reson Med 63:1675-82. 2010
    ..6) than the double-inversion-recovery method (hyperemic OEF = 0.56 +/- 0.10). Diffusion-weighted preparation may be a valuable alternative for more accurate oxygenation measurements during irregular ECG-triggering...
  35. pmc Cardiac 17O MRI: toward direct quantification of myocardial oxygen consumption
    Kyle S McCommis
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Magn Reson Med 63:1442-7. 2010
    ..Myocardial oxygen consumption rate can then be quantified in vivo, which may open new doors for the assessment of myocardial metabolism...
  36. ncbi request reprint Targeted contrast agent helps to monitor advanced plaque during progression: a magnetic resonance imaging study in rabbits
    Jie Zheng
    Mallinckrodt Institute of Radiology, Washington University, St Louis, Missouri 63110, USA
    Invest Radiol 43:49-55. 2008
    ..The aim of this study was to examine the use of Gadofluorine M to monitor the progression of advanced plaques in a rabbit model...
  37. pmc Airway remodeling measured by multidetector CT is increased in severe asthma and correlates with pathology
    Ravi S Aysola
    Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Chest 134:1183-91. 2008
    ..To prospectively apply an automated, quantitative three-dimensional approach to imaging and airway analysis to assess airway remodeling in asthma patients...
  38. ncbi request reprint Coronary magnetic resonance angiography
    Alf Hutter
    Cardiovascular Imaging Laboratory, Mallinckrodt Institute of Radiology, Washington University School of Medicine, Department of Medicine, St Louis, MO, USA
    Semin Roentgenol 38:330-41. 2003
  39. pmc Molecular imaging of atherosclerotic plaque with (64)Cu-labeled natriuretic peptide and PET
    Yongjian Liu
    Department of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Nucl Med 51:85-91. 2010
    ....
  40. ncbi request reprint Altered left ventricular geometry changes the border zone temporal distribution of stress in an experimental model of left ventricular aneurysm: a finite element model study
    Pavlos Moustakidis
    Department of Surgery, Division of Cardiothoracic Surgery, Washington University, St Louis, MO, USA
    Circulation 106:I168-75. 2002
    ..In this study we tested the hypothesis that changes in LV geometry cause both an increase in wall stress and a change in the temporal distribution of stress in the LVA border zone (BZ) during systole...
  41. ncbi request reprint 19F MR imaging of ventilation and diffusion in excised lungs
    Richard E Jacob
    Department of Physics, Washington University in St Louis, St Louis, MO 63130 4899, USA
    Magn Reson Med 54:577-85. 2005
    ..033 cm2/s) places it in a regime where the ADC measurement allows the surface-to-volume ratio to be determined in each voxel, a potentially valuable quantitative characterization of regional lung tissue destruction in emphysema...
  42. pmc Local maximal stress hypothesis and computational plaque vulnerability index for atherosclerotic plaque assessment
    Dalin Tang
    Mathematical Sciences Department, Worcester Polytechnic Institute, Worcester, MA 01609, USA
    Ann Biomed Eng 33:1789-801. 2005
    ..Large-scale and long-term patient studies are needed to further validate our findings for more accurate quantitative plaque vulnerability assessment...
  43. ncbi request reprint Gadocoletic acid trisodium salt (b22956/1): a new blood pool magnetic resonance contrast agent with application in coronary angiography
    CHRISTOPH DE HAEN
    Research and Development, Bracco Imaging S p A, Via Egidio Folli 50, Milano, Italy
    Invest Radiol 41:279-91. 2006
    ....
  44. ncbi request reprint Effect of stenosis asymmetry on blood flow and artery compression: a three-dimensional fluid-structure interaction model
    Dalin Tang
    Mathematical Sciences Department, Worcester Polytechnic Institute, Worcester, MA 01609, USA
    Ann Biomed Eng 31:1182-93. 2003
    ..Stenosis asymmetry leads to higher artery compression, higher shear stress and a larger flow separation region. Computational results are verified by available experimental data...
  45. pmc Quantifying effects of plaque structure and material properties on stress distributions in human atherosclerotic plaques using 3D FSI models
    Dalin Tang
    Mathematical Sciences Department, Worcester Polytechnic Institute, Worcester, MA 01609, USA
    J Biomech Eng 127:1185-94. 2005
    ..Atherosclerotic plaques may rupture without warning and cause acute cardiovascular syndromes such as heart attack and stroke. Methods to assess plaque vulnerability noninvasively and predict possible plaque rupture are urgently needed...
  46. ncbi request reprint 3D MRI-based multicomponent FSI models for atherosclerotic plaques
    Dalin Tang
    Mathematical Sciences Department, Worcester Polytechnic Institute, Worcester, MA 01609, USA
    Ann Biomed Eng 32:947-60. 2004
    ..Large-scale patient studies are needed to validate the computational findings for possible plaque vulnerability assessment and rupture predictions...
  47. ncbi request reprint Time-resolved three-dimensional pulmonary MR angiography and perfusion imaging with ultrashort repetition time
    James C Carr
    Department of Radiology, Northwestern University Medical School and Northwestern Memorial Hospital, 251 E Huron St, Feinberg 4 710, Chicago, IL 60611, USA
    Acad Radiol 9:1407-18. 2002
    ....
  48. pmc Structural features of the focal adhesion kinase-paxillin complex give insight into the dynamics of focal adhesion assembly
    Craig M Bertolucci
    Department of Structural Biology, MS 311, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105, USA
    Protein Sci 14:644-52. 2005
    ....
  49. pmc Strong repulsive forces between protein and oligo (ethylene glycol) self-assembled monolayers: a molecular simulation study
    Jie Zheng
    Department of Chemical Engineering, University of Washington, Seattle, Washington 98195, USA
    Biophys J 89:158-66. 2005
    ..Results show that a tightly bound water layer adjacent to the OEG-SAMs is mainly responsible for the large repulsive hydration force...
  50. ncbi request reprint Interaction between the internal motif KTXXXI of Idax and mDvl PDZ domain
    Timothy B C London
    Department of Structural Biology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Biochem Biophys Res Commun 322:326-32. 2004
    ..Such internal motif identified in this study suggests a new type of sequence motif recognition for Dvl PDZ domain...
  51. ncbi request reprint Establishment of the mouse model by rabbit antiserum specific to EC1-2 or EC3-4 epitopes for studying the pathogenesis of pemphigus vulgaris
    Meng Pan
    Department of Dermatology, Rui Jin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China, 200025
    Immunol Invest 35:47-61. 2006
    ..A novel PV mouse model was established by treatment with the specific rabbit antiserum. These data confirmed that both EC1-2 and EC3-4 are pathogenic epitopes in PVA, but EC1-2 is more dominant...
  52. ncbi request reprint [Effects of two variants of ING1 expression on tumor cell growth regulation]
    Jian Ying Liu
    Department of Pathology, Health Science Center, Peking University, Beijing 100083, China
    Zhonghua Bing Li Xue Za Zhi 32:48-51. 2003
    ..To study effects of alternative transcripts of ING1 transfection on human cancer cell lines...
  53. pmc Rational design and characterization of a Rac GTPase-specific small molecule inhibitor
    Yuan Gao
    Division of Experimental Hematology, Children s Hospital Research Foundation, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 101:7618-23. 2004
    ..Thus, NSC23766 constitutes a Rac-specific small-molecule inhibitor that could be useful to study the role of Rac in various cellular functions and to reverse tumor cell phenotypes associated with Rac deregulation...
  54. ncbi request reprint Efficient selection of unique and popular oligos for large EST databases
    Jie Zheng
    Department of Computer Science and Engineering, University of California, Riverside, CA 92521, USA
    Bioinformatics 20:2101-12. 2004
    ....
  55. pmc Suppression subtractive hybridization identifies distinctive expression markers for coronary and internal mammary arteries
    Minghui Qin
    Atherosclerosis Research Center, Division of Cardiology, and Burns and Allen Research Institute, Cedars Sinai Medical Center, Davis Bldg 1016, 8700 Beverly Blvd, Los Angeles, Calif 90048, USA
    Arterioscler Thromb Vasc Biol 23:425-33. 2003
    ..We sought to identify differentially expressed genes in the athero-prone coronary artery and athero-resistant internal mammary arteries...
  56. pmc Structural stability and dynamics of an amyloid-forming peptide GNNQQNY from the yeast prion sup-35
    Jie Zheng
    Basic Research Program, SAIC Frederick, Center for Cancer Research Nanobiology Program, NCI Frederick, Frederick, Maryland 21702, USA
    Biophys J 91:824-33. 2006
    ..Mutant simulations show that substitution of Asn-2, Gln-4, or Asn-6 by Ala would disrupt this steric zipper, leading to unstable oligomers...
  57. ncbi request reprint [P504S and 34betaE12 dual-staining of immunohistochemistry in the diagnosis of prostate cancer]
    Juan Du
    Zhonghua Bing Li Xue Za Zhi 34:311-2. 2005
  58. ncbi request reprint Assignment of orthologous genes via genome rearrangement
    Xin Chen
    Department of Computer Science and Engineering, University of California, Riverside, CA 92521, USA
    IEEE/ACM Trans Comput Biol Bioinform 2:302-15. 2005
    ..The simulation results demonstrate that SOAR, in general, performs better than the iterated exemplar algorithm in terms of computing the reversal distance and assigning correct orthologs...
  59. ncbi request reprint Molecular simulation studies of the structure of phosphorylcholine self-assembled monolayers
    Jie Zheng
    Department of Chemical Engineering, University of Washington, Seattle, WA 98195, USA
    J Chem Phys 125:174714. 2006
    ..The P-->N vector of the head groups forms an angle of 82 degrees with respect to the surface normal. The tilt direction of molecular chains was observed to be towards their next nearest neighbor...
  60. pmc Changing the charge distribution of beta-helical-based nanostructures can provide the conditions for charge transfer
    Nurit Haspel
    School of Computer Science Faculty of Exact Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    Biophys J 93:245-53. 2007
    ....
  61. pmc Modeling the Alzheimer Abeta17-42 fibril architecture: tight intermolecular sheet-sheet association and intramolecular hydrated cavities
    Jie Zheng
    Basic Research Program, SAIC Frederick Center for Cancer Research, Nanobiology Program, NCI Frederick, Frederick, Maryland 21702, USA
    Biophys J 93:3046-57. 2007
    ..Thus, we propose that Abeta fiber architecture consists of alternating layers of tight packing and hydrated cavities running along the fibrillar axis, which might be possibly detected by high-resolution imaging...
  62. ncbi request reprint Stability of tubular structures based on beta-helical proteins: self-assembled versus polymerized nanoconstructs and wild-type versus mutated sequences
    David Zanuy
    Departament d Enginyeria Quimica, ETS d Enginyeria Industrial de Barcelona, Universitat Politecnica de Catalunya, Diagonal 647, Barcelona, Spain
    Biomacromolecules 8:3135-46. 2007
    ....
  63. ncbi request reprint Rational design and applications of a Rac GTPase-specific small molecule inhibitor
    Huzoor Akbar
    Division of Experimental Hematology, Children s Hospital Research Foundation, Cincinnati, OH, USA
    Methods Enzymol 406:554-65. 2006
    ..Thus, NSC23766 is a lead small molecule inhibitor of Rac activity and could be useful for studying Rac-mediated cellular functions and for modulating pathological conditions in which Rac-deregulation may play a role...
  64. doi request reprint Beta2-microglobulin amyloid fragment organization and morphology and its comparison to Abeta suggests that amyloid aggregation pathways are sequence specific
    Jie Zheng
    Department of Chemical and Biomolecular Engineering, The University of Akron, Akron, Ohio 44325, USA
    Biochemistry 47:2497-509. 2008
    ....
  65. doi request reprint Cardioprotective effect of fluvastatin on isoproterenol-induced myocardial infarction in rat
    Ru Zhou
    Department of Pharmacology, School of Basic Medical Science, Ningxia Medical College, 692 Shengli Street, Yinchuan, Ningxia, 750004, PR China
    Eur J Pharmacol 586:244-50. 2008
    ..05). Our results suggest that fluvastatin has a significant effect on the protection of heart against isoproterenol-induced myocardial infarction through maintaining endogenous antioxidant enzyme activities...
  66. ncbi request reprint Intramyocardial injection of allogenic bone marrow-derived mesenchymal stem cells without immunosuppression preserves cardiac function in a porcine model of myocardial infarction
    Raj R Makkar
    Division of Cardiology and Hematology, Cedars Sinai Medical Center, and David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    J Cardiovasc Pharmacol Ther 10:225-33. 2005
    ..We investigated the efficacy of directly injected allogenic bone marrow-derived mesenchymal stem cells in improving left ventricular function in a porcine model of myocardial infarction...
  67. pmc Annular structures as intermediates in fibril formation of Alzheimer Abeta17-42
    Jie Zheng
    Department of Chemical and Biomolecular Engineering, The University of Akron, Akron, Ohio 44325, USA
    J Phys Chem B 112:6856-65. 2008
    ....
  68. ncbi request reprint Identification of a specific inhibitor of the dishevelled PDZ domain
    Jufang Shan
    Department of Structural Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Biochemistry 44:15495-503. 2005
    ..This compound provides a basis for rational design of high-affinity inhibitors of the PDZ domain, which can block Wnt signaling by interrupting the Fz-Dvl interaction...
  69. ncbi request reprint Molecular dynamics simulations of Alzheimer Abeta40 elongation and lateral association
    Jie Zheng
    Department of Chemical and Biomolecular Engineering, The University of Akron, Akron, Ohio 44325, USA
    Front Biosci 13:3919-30. 2008
    ....

Research Grants1

  1. Quantification of Regional Myocardial Oxygenation by MRI
    Jie Zheng; Fiscal Year: 2008
    ..Ultimately, the proposed methods may facilitate more comprehensive MRI assessments of CAD and other cardiac diseases. [unreadable] [unreadable]..