Affiliation: Washington University School of Medicine
- Gamma-secretase composed of PS1/Pen2/Aph1a can cleave notch and amyloid precursor protein in the absence of nicastrinGuojun Zhao
Department of Developmental Biology, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Neurosci 30:1648-56. 2010..This PS1/Pen2/Aph1a complex, however, is highly unstable. Thus, NCT acts to stabilize gamma-secretase but is not required for substrate recognition...