Dwight A Towler

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi request reprint MINT, the Msx2 interacting nuclear matrix target, enhances Runx2-dependent activation of the osteocalcin fibroblast growth factor response element
    Oscar L Sierra
    Department of Internal Medicine, Division of Bone and Mineral Diseases, Washington University School of Medicine, Barnes Jewish Hospital, St Louis, Missouri 63110, USA
    J Biol Chem 279:32913-23. 2004
  2. ncbi request reprint Osteogenic regulation of vascular calcification
    Dwight A Towler
    Department of Internal Medicine, Division of Bone and Mineral Diseases, Washington University School of Medicine, Barnes Jewish Hospital North Campus Box 8301, 660 South Euclid Ave, St Louis, MO 63110, USA
    Ann N Y Acad Sci 1068:327-33. 2006
  3. ncbi request reprint In memorium: Gideon Rodan M.D., Ph.D
    Dwight A Towler
    Internal Medicine, Bone and Mineral Diseases, Washington University Medical Center, St Louis, MO 63110, USA
    Ann N Y Acad Sci 1068:xiii-xvi. 2006
  4. pmc The alchemy of tendon repair: a primer for the (S)mad scientist
    Dwight A Towler
    Department of Medicine, Division of Bone and Mineral Diseases, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 116:863-6. 2006
  5. pmc Vascular biology and bone formation: hints from HIF
    Dwight A Towler
    Department of Medicine, Center for Cardiovascular Research, Division of Bone and Mineral Diseases, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 117:1477-80. 2007
  6. ncbi request reprint Aortic Msx2-Wnt calcification cascade is regulated by TNF-alpha-dependent signals in diabetic Ldlr-/- mice
    Ziyad Al-Aly
    Division of Bone and Mineral Diseases, Washington University School of Medicine, Campus Box 8301, 660 South Euclid Avenue, St Louis, MO 63110
    Arterioscler Thromb Vasc Biol 27:2589-96. 2007
  7. ncbi request reprint The osteogenic-angiogenic interface: novel insights into the biology of bone formation and fracture repair
    Dwight A Towler
    Washington University School of Medicine, Internal Medicine BMD, Barnes Jewish North Campus Box 8301, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Curr Osteoporos Rep 6:67-71. 2008
  8. pmc Thematic series on the pathobiology of vascular calcification: an introduction
    Dwight A Towler
    Department of Medicine, Division of Endocrinology, Washington University in St Louis, St Louis, MO 63110, USA
    Circ Res 108:1378-80. 2011
  9. pmc Activation of vascular smooth muscle parathyroid hormone receptor inhibits Wnt/beta-catenin signaling and aortic fibrosis in diabetic arteriosclerosis
    Su Li Cheng
    Department of Medicine, Washington University, St Louis, MO 63110, USA
    Circ Res 107:271-82. 2010
  10. ncbi request reprint MSX2 promotes osteogenesis and suppresses adipogenic differentiation of multipotent mesenchymal progenitors
    Su Li Cheng
    Department of Medicine, Washington University School of Medicine, Division of Bone and Mineral Diseases, St Louis, Missouri 63110, USA
    J Biol Chem 278:45969-77. 2003

Collaborators

Detail Information

Publications42

  1. ncbi request reprint MINT, the Msx2 interacting nuclear matrix target, enhances Runx2-dependent activation of the osteocalcin fibroblast growth factor response element
    Oscar L Sierra
    Department of Internal Medicine, Division of Bone and Mineral Diseases, Washington University School of Medicine, Barnes Jewish Hospital, St Louis, Missouri 63110, USA
    J Biol Chem 279:32913-23. 2004
    ..Msx2 targets this complex as a mechanism of transcriptional inhibition. In osteoblasts, MINT may serve as a nuclear matrix platform that organizes and integrates osteogenic transcriptional responses...
  2. ncbi request reprint Osteogenic regulation of vascular calcification
    Dwight A Towler
    Department of Internal Medicine, Division of Bone and Mineral Diseases, Washington University School of Medicine, Barnes Jewish Hospital North Campus Box 8301, 660 South Euclid Ave, St Louis, MO 63110, USA
    Ann N Y Acad Sci 1068:327-33. 2006
    ..Strategies that selectively inhibit aortic Msx2-Wnt cascades may help diminish the initiation and progression of diabetic vascular disease...
  3. ncbi request reprint In memorium: Gideon Rodan M.D., Ph.D
    Dwight A Towler
    Internal Medicine, Bone and Mineral Diseases, Washington University Medical Center, St Louis, MO 63110, USA
    Ann N Y Acad Sci 1068:xiii-xvi. 2006
  4. pmc The alchemy of tendon repair: a primer for the (S)mad scientist
    Dwight A Towler
    Department of Medicine, Division of Bone and Mineral Diseases, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 116:863-6. 2006
    ..g., osteoblasts, myocytes, chondrocytes, and tenocytes--that may be useful in cell-based therapeutic approaches to musculoskeletal diseases...
  5. pmc Vascular biology and bone formation: hints from HIF
    Dwight A Towler
    Department of Medicine, Center for Cardiovascular Research, Division of Bone and Mineral Diseases, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 117:1477-80. 2007
    ..Thus, strategies that promote HIF alpha signaling in osteoblasts may augment bone formation and accelerate fracture repair...
  6. ncbi request reprint Aortic Msx2-Wnt calcification cascade is regulated by TNF-alpha-dependent signals in diabetic Ldlr-/- mice
    Ziyad Al-Aly
    Division of Bone and Mineral Diseases, Washington University School of Medicine, Campus Box 8301, 660 South Euclid Avenue, St Louis, MO 63110
    Arterioscler Thromb Vasc Biol 27:2589-96. 2007
    ..Because elevated TNF-alpha is characteristic of obesity with T2DM, we examined contributions of this inflammatory cytokine...
  7. ncbi request reprint The osteogenic-angiogenic interface: novel insights into the biology of bone formation and fracture repair
    Dwight A Towler
    Washington University School of Medicine, Internal Medicine BMD, Barnes Jewish North Campus Box 8301, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Curr Osteoporos Rep 6:67-71. 2008
    ..This brief review recounts these revelations, highlighting the potential impact to human bone health and fracture repair...
  8. pmc Thematic series on the pathobiology of vascular calcification: an introduction
    Dwight A Towler
    Department of Medicine, Division of Endocrinology, Washington University in St Louis, St Louis, MO 63110, USA
    Circ Res 108:1378-80. 2011
    ..Armed with this understanding, it is hoped that novel therapeutic strategies can be crafted to prevent and treat vascular calcium accrual, to the benefit of our patients afflicted with arteriosclerotic valvular and vascular diseases...
  9. pmc Activation of vascular smooth muscle parathyroid hormone receptor inhibits Wnt/beta-catenin signaling and aortic fibrosis in diabetic arteriosclerosis
    Su Li Cheng
    Department of Medicine, Washington University, St Louis, MO 63110, USA
    Circ Res 107:271-82. 2010
    ..Conversely, parathyroid hormone (PTH) inhibits aortic calcification in low-density lipoprotein receptor (LDLR)-deficient mice fed high fat diabetogenic diets (HFD)...
  10. ncbi request reprint MSX2 promotes osteogenesis and suppresses adipogenic differentiation of multipotent mesenchymal progenitors
    Su Li Cheng
    Department of Medicine, Washington University School of Medicine, Division of Bone and Mineral Diseases, St Louis, Missouri 63110, USA
    J Biol Chem 278:45969-77. 2003
    ..Thus, Msx2 regulates osteogenic versus adipogenic differentiation of aortic myofibroblasts. Myofibroblasts capable of both fates can be diverted to the osteogenic lineage by BMP2-Msx2 signaling and contribute to vascular calcification...
  11. pmc Vascular calcification and aortic fibrosis: a bifunctional role for osteopontin in diabetic arteriosclerosis
    Jian Su Shao
    Department of Medicine, Washington University in St Louis, MO 63110, USA
    Arterioscler Thromb Vasc Biol 31:1821-33. 2011
    ..To better understand the role of osteopontin (OPN), a multifunctional protein upregulated in diabetic arteries, we evaluated contributions of OPN in male low-density lipoprotein receptor (LDLR)-/- mice fed a high-fat diet...
  12. ncbi request reprint An osteopontin-NADPH oxidase signaling cascade promotes pro-matrix metalloproteinase 9 activation in aortic mesenchymal cells
    Chung Fang Lai
    Department of Medicine, Washington University School of Medicine, St Louis, MO, USA
    Circ Res 98:1479-89. 2006
    ..Thus, OPN provides a paracrine signal that augments vascular pro-MMP9 activity, mediated in part via superoxide generation and oxylipid formation...
  13. pmc Msx2 exerts bone anabolism via canonical Wnt signaling
    Su Li Cheng
    Department of Medicine, Division of Bone and Mineral Diseases, Washington University School of Medicine, St Louis, MO 63110, USA
    J Biol Chem 283:20505-22. 2008
    ..Msx2 exerts bone anabolism in part by reducing Dkk1 expression and enhancing Wnt signaling, thus promoting osteogenic differentiation of skeletal progenitors...
  14. ncbi request reprint Vascular Bmp Msx2 Wnt signaling and oxidative stress in arterial calcification
    Jian Su Shao
    Washington University School of Medicine, Department of Medicine, Center for Cardiovascular Research, Division of Bone and Mineral Diseases, St Louis, Missouri 63110, USA
    Ann N Y Acad Sci 1117:40-50. 2007
    ..In the brief review, we recount mounting evidence that points to oxidative stress as a major contributor to the pathobiology of diabetic arterial calcification...
  15. ncbi request reprint Teriparatide (human parathyroid hormone (1-34)) inhibits osteogenic vascular calcification in diabetic low density lipoprotein receptor-deficient mice
    Jian Su Shao
    Department of Medicine, Division of Bone and Mineral Diseases, Washington University School of Medicine, Barnes Jewish Hospital North Campus, St Louis, Missouri 63110, USA
    J Biol Chem 278:50195-202. 2003
    ..PTH(1-34) exerts beneficial actions at early stages of macrovascular disease responses to diabetes and dyslipidemia...
  16. pmc Msx2 promotes cardiovascular calcification by activating paracrine Wnt signals
    Jian Su Shao
    Department of Medicine, Division of Bone and Mineral Diseases, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 115:1210-20. 2005
    ..Thus, Msx2-expressing cells elaborated an osteogenic milieu that promotes vascular calcification in part via paracrine Wnt signals...
  17. pmc Runx2 trans-activation mediated by the MSX2-interacting nuclear target requires homeodomain interacting protein kinase-3
    Oscar L Sierra
    Washington University School of Medicine, Internal Medicine Endocrinology Metabolism, Campus Box 8301, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Mol Endocrinol 24:1478-97. 2010
    ..Thus, HIPK3 participates in MINT+FGF2 regulation of Runx2 AD3 activity and controls Runx2-dependent OC expression...
  18. pmc Heterogeneous nuclear ribonucleoprotein K represses transcription from a cytosine/thymidine-rich element in the osteocalcin promoter
    Joseph P Stains
    Division of Bone and Mineral Diseases, Washington University School of Medicine, and Barnes Jewish Hospital, St Louis, MO, USA
    Biochem J 385:613-23. 2005
    ..Rather, hnRNP K represses osteocalcin gene transcription by inhibiting the formation of a transcriptional complex on the CT element of the osteocalcin promoter...
  19. pmc Transcriptional regulation of SM22alpha by Wnt3a: convergence with TGFbeta(1)/Smad signaling at a novel regulatory element
    Shawn L Shafer
    Washington University School of Medicine, Center for Cardiovascular Research, Internal Medicine BMD, Campus Box 8301, 660 South Euclid Ave, St Louis, MO 63110, USA
    J Mol Cell Cardiol 46:621-35. 2009
    ..RNAi "knockdown" of beta-catenin inhibited Wnt3a induction of SM22alpha. Thus, Wnt/beta-catenin signaling interacts with TGFbeta/Smad pathways to control SM22alpha gene transcription...
  20. ncbi request reprint Conditional inactivation of FGF receptor 2 reveals an essential role for FGF signaling in the regulation of osteoblast function and bone growth
    Kai Yu
    Department of Molecular Biology and Pharmacology, Washington University Medical School, Campus Box 8103, 660 S Euclid Avenue, St Louis, Missouri 63110, USA
    Development 130:3063-74. 2003
    ..Although differentiation of the osteoblast lineage was not disturbed, the proliferation of osteoprogenitors and the anabolic function of mature osteoblasts were severely affected...
  21. pmc TNFR1-activated reactive oxidative species signals up-regulate osteogenic Msx2 programs in aortic myofibroblasts
    Chung Fang Lai
    Department of Internal Medicine, Washington University in St Louis, Missouri 63110, USA
    Endocrinology 153:3897-910. 2012
    ..Strategies that reduce vascular Nox- or mitochondrially activated ROS signals may prove useful in mitigating arteriosclerotic calcification...
  22. ncbi request reprint Molecular mechanisms of vascular calcification: lessons learned from the aorta
    Jian Su Shao
    Washington University School of Medicine, Campus Box 8301, 660 South Euclid Ave, St Louis, MO 63110, USA
    Arterioscler Thromb Vasc Biol 26:1423-30. 2006
    ....
  23. ncbi request reprint Osteopontin transcription in aortic vascular smooth muscle cells is controlled by glucose-regulated upstream stimulatory factor and activator protein-1 activities
    Miri Bidder
    Division of Bone and Mineral Diseases, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 277:44485-96. 2002
    ..Thus, OPN gene transcription is regulated by USF and AP1 in aortic VSMCs, entrained to changes in cellular glucose metabolism...
  24. ncbi request reprint Gap junctional communication modulates gene transcription by altering the recruitment of Sp1 and Sp3 to connexin-response elements in osteoblast promoters
    Joseph P Stains
    Division of Bone and Mineral Diseases, Washington University School of Medicine and Barnes Jewish Hospital, St Louis, Missouri 63110, USA
    J Biol Chem 278:24377-87. 2003
    ..Thus, regulation of Sp1/Sp3 recruitment to the promoter may represent a potential general mechanism for transcriptional control of target genes by signals passing through gap junctions...
  25. pmc Vascular smooth muscle LRP6 limits arteriosclerotic calcification in diabetic LDLR-/- mice by restraining noncanonical Wnt signals
    Su Li Cheng
    From the Diabetes and Obesity Research Center, Sanford Burnham Medical Research Institute, Cardiovascular Pathobiology, Orlando, FL S L C, B R, A B, M M, C S, Y B A, K K, L M B, R P, D A T MD Anderson Cancer Center, Cancer Biology, Houston, TX J S S Washington University, Department of Medicine, St Louis, MO K K, A K and Van Andel Research Institute, Department of Cancer and Cell Biology, Grand Rapids, MI B O W
    Circ Res 117:142-56. 2015
    ..Wnt signaling regulates key aspects of diabetic vascular disease...
  26. pmc Stress fracture healing: fatigue loading of the rat ulna induces upregulation in expression of osteogenic and angiogenic genes that mimic the intramembranous portion of fracture repair
    Gregory R Wohl
    Department of Orthopaedic Surgery, Washington University, St Louis, Missouri, USA
    Bone 44:320-30. 2009
    ....
  27. pmc The regulation of valvular and vascular sclerosis by osteogenic morphogens
    KRISTINA I BOSTROM
    Department of Medicine, Division of Cardiology, David Geffen School of Medicine at UCLA, 10833 LeConte Ave, Los Angeles, CA 90095, USA
    Circ Res 109:564-77. 2011
    ..These inhibitory pathways and their regulators afford the development of novel therapeutic strategies to prevent and treat valve and vascular sclerosis...
  28. ncbi request reprint Osteogenic regulation of vascular calcification: an early perspective
    Radhika Vattikuti
    Washington Univ School of Medicine, Dept of Internal Medicine, Division of Bone and Mineral Diseases, Campus Box 8301, 660 South Euclid Ave, St Louis, MO 63110, USA
    Am J Physiol Endocrinol Metab 286:E686-96. 2004
    ....
  29. ncbi request reprint Regulation of osteocalcin gene expression by a novel Ku antigen transcription factor complex
    David M Willis
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 277:37280-91. 2002
    ..In toto, these data indicate that a novel Ku antigen complex assembles on the OC promoter, functioning in concert with Msx2 and Runx2 to regulate OC gene expression...
  30. pmc Diabetic foot osteomyelitis: bone markers and treatment outcomes
    Humaa A Nyazee
    Division of Infectious Diseases, Washington University School of Medicine, St Louis, MO 63110, United States
    Diabetes Res Clin Pract 97:411-7. 2012
    ..We compared levels of two bone turnover markers, serum amino-terminal telopeptides (NTx) and bone alkaline phosphatase (BAP), in diabetic patients with and without osteomyelitis...
  31. pmc Arterial calcification and bone physiology: role of the bone-vascular axis
    Bithika Thompson
    Department of Internal Medicine, Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, Campus Box 8127, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Nat Rev Endocrinol 8:529-43. 2012
    ..A detailed understanding of bone-vascular interactions is necessary to address the unmet clinical needs of an increasingly aged and dysmetabolic population...
  32. pmc De novo lipogenesis maintains vascular homeostasis through endothelial nitric-oxide synthase (eNOS) palmitoylation
    Xiaochao Wei
    Division of Endocrinology, Metabolism, and Lipid Research, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 286:2933-45. 2011
    ..Thus, disrupting eNOS bioavailability through impaired lipogenesis identifies a novel mechanism coordinating nutritional status and tissue repair that may contribute to diabetic vascular disease...
  33. pmc Osteopontin promoter polymorphism is associated with increased carotid intima-media thickness
    Lisa De Las Fuentes
    Cardiovascular Imaging and Clinical Research Core Laboratory, Cardiovascular Division, Washington University School of Medicine, St Louis, MO 63110, USA
    J Am Soc Echocardiogr 21:954-60. 2008
    ..Osteopontin (OPN)-transgenic mice exhibit increased carotid artery intima-media thickness (CIMT), smooth muscle cell proliferation, and atheroma formation...
  34. pmc The pharmacological management of osteoporosis
    Amy E Riek
    Division of Endocrinology, Metabolism, and Lipid Research, Washington University, St Louis, USA
    Mo Med 108:118-23. 2011
    ..We review the best pharmacotherapeutic options currently available for treating osteoporosis...
  35. ncbi request reprint Improving mass measurement of coronary artery calcification using threshold correction and thin collimation in multi-detector row computed tomography: in vitro experiment
    Cheng Hong
    A Mallinckrodt Institute of Radiology, Washington University School of Medicine, Campus Box 8131, 510 S Kingshighway Blvd, St Louis, MO 63110, USA
    Acad Radiol 10:969-77. 2003
    ..This in vitro study was designed to improve the accuracy of coronary calcium mass measurement from computed tomography (CT) images by developing threshold-based calcium CT number correction and thin-slice spiral techniques...
  36. ncbi request reprint 1,25-Dihydroxyvitamin D3 but not cinacalcet HCl (Sensipar/Mimpara) treatment mediates aortic calcification in a rat model of secondary hyperparathyroidism
    Charles Henley
    Department of Metabolic Disorders, Amgen, Inc, One Amgen Center Drive, MS 15 2 A, Thousand Oaks, CA 91320, USA
    Nephrol Dial Transplant 20:1370-7. 2005
    ....
  37. ncbi request reprint Imaging aortic matrix metabolism: mirabile visu!
    Dwight A Towler
    Circulation 115:297-9. 2007
  38. pmc Oxidation, inflammation, and aortic valve calcification peroxide paves an osteogenic path
    Dwight A Towler
    J Am Coll Cardiol 52:851-4. 2008
  39. ncbi request reprint Angiogenesis and marrow stromal cell fates: roles in bone strength
    Dwight A Towler
    Osteoporos Int 14:S46-50; discussion S50-3. 2003
    ....
  40. ncbi request reprint Liver x receptor agonists inhibit cytokine-induced osteopontin expression in macrophages through interference with activator protein-1 signaling pathways
    Daisuke Ogawa
    Division of Endocrinology and Molecular Medicine, University of Kentucky College of Medicine, Lexington, Ken 40536 0200, USA
    Circ Res 96:e59-67. 2005
    ..The full text of this article is available online at http://circres.ahajournals.org...
  41. ncbi request reprint Vascular calcification in ESRD: Another cloud appears in the perfect storm--but highlights a silver lining?
    Dwight A Towler
    Kidney Int 66:2467-8. 2004
  42. ncbi request reprint Inorganic pyrophosphate: a paracrine regulator of vascular calcification and smooth muscle phenotype
    Dwight A Towler
    Arterioscler Thromb Vasc Biol 25:651-4. 2005