B K Suarez

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. pmc Linkage analysis merging replicate phenotypes: an application to three quantitative phenotypes in two African samples
    Anthony L Hinrichs
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Ave, Campus Box 8134, St, Louis, MO 63110, USA
    BMC Proc 5:S81. 2011
  2. pmc Stratify or adjust? Dealing with multiple populations when evaluating rare variants
    ROBERT C CULVERHOUSE
    Department of Medicine, Washington University School of Medicine, 660 South Euclid Avenue, Saint Louis, MO 63110, USA
    BMC Proc 5:S101. 2011
  3. pmc Linkage and association analyses of principal components in expression data
    Anthony L Hinrichs
    Department of Psychiatry, Washington University, 660 South Euclid, Box 8134, St, Louis, Missouri 63110, USA
    BMC Proc 1:S46. 2007
  4. pmc Detecting population stratification using related individuals
    Anthony L Hinrichs
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid, Campus Box 8134, St, Louis, Missouri 63110 USA
    BMC Proc 3:S106. 2009
  5. pmc Multipoint identity-by-descent computations for single-point polymorphism and microsatellite maps
    Anthony L Hinrichs
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, USA
    BMC Genet 6:S34. 2005
  6. pmc Are there mappable genes for family resemblance for the magnitude of intra-individual variation in systolic blood pressure?
    Jennifer Lin
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    BMC Genet 4:S11. 2003
  7. pmc Microsatellites versus single-nucleotide polymorphisms in linkage analysis for quantitative and qualitative measures
    Gerald Dunn
    Department of Psychiatry, Genetics, Washington University School of Medicine, St Louis, Missouri, USA
    BMC Genet 6:S122. 2005
  8. pmc The efficacy of short tandem repeat polymorphisms versus single-nucleotide polymorphisms for resolving population structure
    John S K Kauwe
    Department of Psychiatry, Washington University of Medicine, St Louis, MO, USA
    BMC Genet 6:S84. 2005
  9. pmc A search for non-chromosome 6 susceptibility loci contributing to rheumatoid arthritis
    Brian K Suarez
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid, Campus Box 8134, St, Louis, Missouri 63110, USA
    BMC Proc 3:S15. 2009
  10. pmc Linkage, case-control association, and family-based association tests for complex disorders
    Brian K Suarez
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid, St, Louis, Missouri 63110, USA
    BMC Proc 1:S43. 2007

Detail Information

Publications17

  1. pmc Linkage analysis merging replicate phenotypes: an application to three quantitative phenotypes in two African samples
    Anthony L Hinrichs
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Ave, Campus Box 8134, St, Louis, MO 63110, USA
    BMC Proc 5:S81. 2011
    ..Using both methods, we found numerous significant linkage signals for Q1, although population colocalization was absent for most of these signals. The linkage analysis of Q2 and Q4 failed to reveal any strong linkage signals...
  2. pmc Stratify or adjust? Dealing with multiple populations when evaluating rare variants
    ROBERT C CULVERHOUSE
    Department of Medicine, Washington University School of Medicine, 660 South Euclid Avenue, Saint Louis, MO 63110, USA
    BMC Proc 5:S101. 2011
    ..However, including population as a covariate was not an effective substitute for analyzing the subpopulations separately when only one subpopulation contained a rare variant linked to the phenotype...
  3. pmc Linkage and association analyses of principal components in expression data
    Anthony L Hinrichs
    Department of Psychiatry, Washington University, 660 South Euclid, Box 8134, St, Louis, Missouri 63110, USA
    BMC Proc 1:S46. 2007
    ..Furthermore, we have identified two single-nucleotide polymorphisms that may influence the expression of multiple genes linked to chromosome 14...
  4. pmc Detecting population stratification using related individuals
    Anthony L Hinrichs
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid, Campus Box 8134, St, Louis, Missouri 63110 USA
    BMC Proc 3:S106. 2009
    ..We examine a generalization of principal-component analyses to allow for the inclusion of related individuals by down-weighting the significance of individual comparisons...
  5. pmc Multipoint identity-by-descent computations for single-point polymorphism and microsatellite maps
    Anthony L Hinrichs
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, USA
    BMC Genet 6:S34. 2005
    ..However, increased information has a computational cost: SNP maps require 100 times as many iterations as microsatellites to produce stable estimates...
  6. pmc Are there mappable genes for family resemblance for the magnitude of intra-individual variation in systolic blood pressure?
    Jennifer Lin
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    BMC Genet 4:S11. 2003
    ..To determine whether genomic regions affecting this phenotype could be identified, we pursued a "model-free" multipoint quantitative linkage analysis...
  7. pmc Microsatellites versus single-nucleotide polymorphisms in linkage analysis for quantitative and qualitative measures
    Gerald Dunn
    Department of Psychiatry, Genetics, Washington University School of Medicine, St Louis, Missouri, USA
    BMC Genet 6:S122. 2005
    ..We also considered the effect of high linkage disequilibrium (LD) in regions near the linkage peaks by analysing a "sparse" SNP map obtained by dropping some markers in high LD with other markers in those regions...
  8. pmc The efficacy of short tandem repeat polymorphisms versus single-nucleotide polymorphisms for resolving population structure
    John S K Kauwe
    Department of Psychiatry, Washington University of Medicine, St Louis, MO, USA
    BMC Genet 6:S84. 2005
    ..If SNPs with lower MAFs are used, then more than 250 SNPs may be required to obtain reliable results...
  9. pmc A search for non-chromosome 6 susceptibility loci contributing to rheumatoid arthritis
    Brian K Suarez
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid, Campus Box 8134, St, Louis, Missouri 63110, USA
    BMC Proc 3:S15. 2009
    ..0001. Eight of these SNPs (rs10498105, rs2398966, rs7664880, rs7447161, rs2793471, rs2611279, rs7967594, and rs742605) were common to both lists...
  10. pmc Linkage, case-control association, and family-based association tests for complex disorders
    Brian K Suarez
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid, St, Louis, Missouri 63110, USA
    BMC Proc 1:S43. 2007
    ..These analyses were carried out without knowledge of the model used to generate the simulation...
  11. pmc An analysis of identical single-nucleotide polymorphisms genotyped by two different platforms
    Brian K Suarez
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA
    BMC Genet 6:S152. 2005
    ..Some of this clustering may be due to the presence of a second segregating SNP that obliterates a XbaI site (the restriction enzyme used in the Affymetrix platform), resulting in a fragment too long (>1,000 bp) to be amplified...
  12. ncbi TGFBR1*6A is not associated with prostate cancer in men of European ancestry
    B K Suarez
    Department of Psychiatry, Washington University School of Medicine, Campus Box 8134, 660 S Euclid, St Louis, M 63110, USA
    Prostate Cancer Prostatic Dis 8:50-3. 2005
    ..There is no compelling evidence for an association of the *6A variant with prostate cancer...
  13. ncbi Polymorphisms in the prostate cancer susceptibility gene HPC2/ELAC2 in multiplex families and healthy controls
    B K Suarez
    Department of Psychiatry, Washington University, School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 61:4982-4. 2001
    ..2 in these families. The T allele shows no association with either Gleason score or age-of-onset in segregating families...
  14. ncbi Exploiting linkage disequilibrium in population isolates
    R Culverhouse
    Department of Psychiatry, Washington University School of Medicine, Box 8134, Dept. of Psychiatry, 660 South Euclid, St. Louis, MO 63110, USA
    Genet Epidemiol 21:S429-34. 2001
    ..We describe two statistical methods to utilize D: a method appropriate for a single moderately sized sample and a sequential approach appropriate for multiple small independent samples...
  15. ncbi A genome scan for type 2 diabetes susceptibility loci in a genetically isolated population
    M A Permutt
    Division of Metabolism, Endocrinology, and Diabetes, Washington University Medical School, St Louis, Missouri 63110, USA
    Diabetes 50:681-5. 2001
    ..This population, because of its unique genetic attributes, may facilitate identification of this and other genes contributing to type 2 diabetes...
  16. ncbi A kinship analysis of asthma among the Hutterites
    J Lin
    Department of Psychiatry, Washington University School of Medicine, Box 8134, 660 S. Euclid Ave, St. Louis, MO 63110, USA
    Genet Epidemiol 21:S252-7. 2001
    ..The higher kinship coefficient is shown to be due to an increased probability of the condensed identity state delta 8 which, in turn, is shown to be due to an increased probability of detailed identity state delta 10...
  17. ncbi Sequence variants in the pancreatic islet beta-cell inwardly rectifying K+ channel Kir6.2 (Bir) gene: identification and lack of role in Caucasian patients with NIDDM
    H Inoue
    Division of Endocrinology, Diabetes and Metabolism, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Diabetes 46:502-7. 1997
    ..Diabetes 45:825-831, 1996) and 2) did not contribute to the impaired insulin secretion characteristic of NIDDM in Caucasian patients...