Joshua S Shimony

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. pmc Comparison of cortical folding measures for evaluation of developing human brain
    Joshua S Shimony
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, 660 South Euclid Ave, St Louis, MO 63110, USA Electronic address
    Neuroimage 125:780-90. 2016
  2. pmc The circuitry of abulia: insights from functional connectivity MRI
    J S Siegel
    Department of Neurology, Washington University School of Medicine at Washington University, St Louis, MO, USA
    Neuroimage Clin 6:320-6. 2014
  3. pmc Impact of therapeutic hypothermia on MRI diffusion changes in neonatal encephalopathy
    N Bednarek
    Neonatology Unit, Alix de Champagne, Reims, France
    Neurology 78:1420-7. 2012
  4. ncbi request reprint Percutaneous vertebroplasty for malignant compression fractures with epidural involvement
    Joshua S Shimony
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 S Kingshighway Blvd, Campus Box 8131, St Louis, MO 63110, USA
    Radiology 232:846-53. 2004
  5. pmc Improved in vivo diffusion tensor imaging of human cervical spinal cord
    Junqian Xu
    Department of Neurology, Washington University School of Medicine, St Louis, MO, USA
    Neuroimage 67:64-76. 2013
  6. pmc Noninvasive functional and structural connectivity mapping of the human thalamocortical system
    Dongyang Zhang
    Department of Radiology, Washington University, St Louis, MO 63110, USA
    Cereb Cortex 20:1187-94. 2010
  7. pmc A novel data-driven approach to preoperative mapping of functional cortex using resting-state functional magnetic resonance imaging
    Timothy J Mitchell
    Departments of Neurological Surgery, Neurology, Biomedical Engineering, and Mechanical Engineering and Material Sciences, Mallinckrodt Institute of Radiology, Center for Innovation in Neuroscience and Technology, Washington University School of Medicine, St Louis, Missouri
    Neurosurgery 73:969-82; discussion 982-3. 2013
  8. pmc White matter integrity and executive abilities in individuals with phenylketonuria
    Jo Ann V Antenor-Dorsey
    Department of Psychiatry, Campus Box 8134, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Genet Metab 109:125-31. 2013
  9. pmc Preoperative sensorimotor mapping in brain tumor patients using spontaneous fluctuations in neuronal activity imaged with functional magnetic resonance imaging: initial experience
    Dongyang Zhang
    Department of Radiology, Washington University in St Louis, St Louis, Missouri 63110, USA
    Neurosurgery 65:226-36. 2009
  10. pmc White matter integrity and executive abilities following treatment with tetrahydrobiopterin (BH4) in individuals with phenylketonuria
    Desiree A White
    Department of Psychology, Campus Box 1125, Washington University, St Louis, MO 63130, USA Electronic address
    Mol Genet Metab 110:213-7. 2013

Detail Information

Publications51

  1. pmc Comparison of cortical folding measures for evaluation of developing human brain
    Joshua S Shimony
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, 660 South Euclid Ave, St Louis, MO 63110, USA Electronic address
    Neuroimage 125:780-90. 2016
    ..In contrast, gyrification index was effective in differentiating these groups...
  2. pmc The circuitry of abulia: insights from functional connectivity MRI
    J S Siegel
    Department of Neurology, Washington University School of Medicine at Washington University, St Louis, MO, USA
    Neuroimage Clin 6:320-6. 2014
    ..We hypothesized that, although structural imaging revealed no damage to the patient's ACC, fcMRI would uncover aberrant function in this region and in the relevant cortical networks...
  3. pmc Impact of therapeutic hypothermia on MRI diffusion changes in neonatal encephalopathy
    N Bednarek
    Neonatology Unit, Alix de Champagne, Reims, France
    Neurology 78:1420-7. 2012
    ..The objective of this work was to determine the impact of therapeutic hypothermia (TH) on the magnitude and time course of mean diffusivity (MD) changes following hypoxic-ischemic encephalopathy (HIE) in newborns...
  4. ncbi request reprint Percutaneous vertebroplasty for malignant compression fractures with epidural involvement
    Joshua S Shimony
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 S Kingshighway Blvd, Campus Box 8131, St Louis, MO 63110, USA
    Radiology 232:846-53. 2004
    ..To evaluate safety and effectiveness of performance of percutaneous vertebroplasty (PVP) in patients with malignant compression fractures and involvement of the epidural space...
  5. pmc Improved in vivo diffusion tensor imaging of human cervical spinal cord
    Junqian Xu
    Department of Neurology, Washington University School of Medicine, St Louis, MO, USA
    Neuroimage 67:64-76. 2013
    ..We also recommend using a mixed-effects model to account for systematic measurement bias depending on cord segment...
  6. pmc Noninvasive functional and structural connectivity mapping of the human thalamocortical system
    Dongyang Zhang
    Department of Radiology, Washington University, St Louis, MO 63110, USA
    Cereb Cortex 20:1187-94. 2010
    ..However, important differences between structural and functional mapping results are also manifest which suggests a more complex interpretation and emphasizes the unique contributions from structural and functional mapping...
  7. pmc A novel data-driven approach to preoperative mapping of functional cortex using resting-state functional magnetic resonance imaging
    Timothy J Mitchell
    Departments of Neurological Surgery, Neurology, Biomedical Engineering, and Mechanical Engineering and Material Sciences, Mallinckrodt Institute of Radiology, Center for Innovation in Neuroscience and Technology, Washington University School of Medicine, St Louis, Missouri
    Neurosurgery 73:969-82; discussion 982-3. 2013
    ..In addition to their neuroscientific implications, the networks identified by resting-state functional magnetic resonance imaging (rs-fMRI) may prove useful for clinical brain mapping...
  8. pmc White matter integrity and executive abilities in individuals with phenylketonuria
    Jo Ann V Antenor-Dorsey
    Department of Psychiatry, Campus Box 8134, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Genet Metab 109:125-31. 2013
    ..These findings are the first to demonstrate the interplay among microstructural white matter integrity, executive abilities, and Phe control in individuals with PKU...
  9. pmc Preoperative sensorimotor mapping in brain tumor patients using spontaneous fluctuations in neuronal activity imaged with functional magnetic resonance imaging: initial experience
    Dongyang Zhang
    Department of Radiology, Washington University in St Louis, St Louis, Missouri 63110, USA
    Neurosurgery 65:226-36. 2009
    ..To describe initial experience with resting-state correlation mapping as a potential aid for presurgical planning of brain tumor resection...
  10. pmc White matter integrity and executive abilities following treatment with tetrahydrobiopterin (BH4) in individuals with phenylketonuria
    Desiree A White
    Department of Psychology, Campus Box 1125, Washington University, St Louis, MO 63130, USA Electronic address
    Mol Genet Metab 110:213-7. 2013
    ..To our knowledge, our study is the first to explore relationships among Phe, white matter integrity, executive abilities, and BH(4) treatment within a single study...
  11. pmc Intrinsic functional relations between human cerebral cortex and thalamus
    Dongyang Zhang
    Washington University, Department of Radiology, Campus Box 8225, 510 South Kingshighway Blvd, St Louis, MO 63110, USA
    J Neurophysiol 100:1740-8. 2008
    ..These results extend our understanding of the intrinsic network organization of the human brain to the thalamus and highlight the potential of resting-state fMRI BOLD imaging to elucidate thalamocortical relationships...
  12. pmc Mapping sensorimotor cortex with slow cortical potential resting-state networks while awake and under anesthesia
    Jonathan D Breshears
    Washington University School of Medicine, St Louis, Missouri 63130, USA
    Neurosurgery 71:305-16; discussion 316. 2012
    ....
  13. doi request reprint Clinical Resting-state fMRI in the Preoperative Setting: Are We Ready for Prime Time?
    Megan H Lee
    Mallinckrodt Institute of Radiology Department of Neurosurgery Department of Biomedical Engineering, Washington University School of Medicine, St Louis, MO
    Top Magn Reson Imaging 25:11-8. 2016
    ..Although RS-fMRI is still investigational, our experience indicates that this method is ready for clinical application in the presurgical setting. ..
  14. pmc Prolonged exposure to high and variable phenylalanine levels over the lifetime predicts brain white matter integrity in children with phenylketonuria
    Anna Hood
    Department of Psychology, Washington University, Campus Box 1125, St Louis, MO 63130, USA
    Mol Genet Metab 114:19-24. 2015
    ....
  15. pmc Heterogeneous Optimization Framework: Reproducible Preprocessing of Multi-Spectral Clinical MRI for Neuro-Oncology Imaging Research
    MIKHAIL MILCHENKO
    Neuroinformatics Research Group, Department of Radiology, Washington University School of Medicine, St Louis, MO, USA
    Neuroinformatics 14:305-17. 2016
    ..Introduction of the MGA pipeline improved image processing throughput and, most importantly, effectively produced co-registered datasets that were suitable for advanced analysis despite high heterogeneity in acquisition protocols. ..
  16. pmc Upstream dysfunction of somatomotor functional connectivity after corticospinal damage in stroke
    Alex R Carter
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neurorehabil Neural Repair 26:7-19. 2012
    ..Recent studies have shown that focal injuries can have remote effects on network function that affect behavior, but these network-wide repercussions are poorly understood...
  17. doi request reprint Resting-State Blood Oxygen Level-Dependent Functional MRI: A Paradigm Shift in Preoperative Brain Mapping
    Eric C Leuthardt
    Washington University School of Medicine, Saint Louis, MO, USA
    Stereotact Funct Neurosurg 93:427-39. 2015
    ..In this article, a brief introduction into rs-fMRI processing methods is followed by a detailed discussion on the role rs-fMRI plays in presurgical planning. ..
  18. ncbi request reprint Correlation between preprocedural MRI findings and clinical outcomes in the treatment of chronic symptomatic vertebral compression fractures with percutaneous vertebroplasty
    Daniel B Brown
    Mallinckrodt Institute of Radiology, Washington University Medical Center, 510 S Kingshighway Blvd, Box 8131, St Louis, MO 63110, USA
    AJR Am J Roentgenol 184:1951-5. 2005
    ..The purpose of our study was to correlate findings of prevertebroplasty MRI with outcomes in the treatment of chronic osteoporotic compression fractures...
  19. pmc Functional Imaging of the Developing Brain at the Bedside Using Diffuse Optical Tomography
    Silvina L Ferradal
    Department of Biomedical Engineering, Washington University, St Louis, MO, USA Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO, USA
    Cereb Cortex 26:1558-68. 2016
    ....
  20. pmc Neuroimaging evidence of deficient axon myelination in Wolfram syndrome
    Heather M Lugar
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA
    Sci Rep 6:21167. 2016
    ..These measures may provide objective indices of Wolfram syndrome pathophysiology that will be useful in unraveling the underlying mechanisms and in testing the impact of treatments on the brain...
  21. ncbi request reprint The study of neural connectivity using diffusion tensor tracking
    Joshua S Shimony
    Neuroimaging Laboratory, Washington University Medical School, St Louis, Missouri 63110, USA
    Cortex 40:213-5. 2004
  22. pmc White matter microstructural integrity in youth with type 1 diabetes
    Jo Ann V Antenor-Dorsey
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, USA
    Diabetes 62:581-9. 2013
    ..Longitudinal analyses will be necessary to determine how these alterations change with age or additional glycemic exposure...
  23. pmc Resting-state blood oxygen level-dependent functional magnetic resonance imaging for presurgical planning
    Mudassar Kamran
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, 4525 Scott Avenue, St Louis, MO 63110, USA
    Neuroimaging Clin N Am 24:655-69. 2014
    ..Example cases are provided to highlight the strengths and limitations of the technique. ..
  24. pmc Magnetic resonance imaging-guided focused laser interstitial thermal therapy for intracranial lesions: single-institution series
    Ammar H Hawasli
    Departments of Neurosurgery and Mallinckrodt Institute of Radiology, Washington University School of Medicine, Washington University in St Louis, St Louis, Missouri
    Neurosurgery 73:1007-17. 2013
    ..Real-time magnetic resonance imaging-guided focused laser interstitial thermal therapy (LITT) offers a minimally invasive surgical treatment option for such lesions...
  25. pmc Diminished performance on neuropsychological testing in late life depression is correlated with microstructural white matter abnormalities
    Joseph M Mettenburg
    Department of Radiology, 660 S Euclid Ave, Campus Box 8131, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuroimage 60:2182-90. 2012
    ..Furthermore, comprehensive correlation of diffusion tensor imaging (DTI) measurements, including axial and radial diffusivity measurements, has not been demonstrated in the late life depression population...
  26. pmc Regional alterations in cerebral growth exist preoperatively in infants with congenital heart disease
    Cynthia Ortinau
    Department of Pediatrics, St Louis Children s Hospital and Washington University, St Louis, MO 63110, USA
    J Thorac Cardiovasc Surg 143:1264-70. 2012
    ..The present study used qualitative scoring, cerebral biometry, and diffusion imaging to characterize the preoperative brain abnormalities in infants with CHD, including the identification of regions of greater vulnerability...
  27. ncbi request reprint Brain White Matter Integrity Mediates the Relationship Between Phenylalanine Control and Executive Abilities in Children with Phenylketonuria
    Anna Hood
    Department of Psychological and Brain Sciences, Washington University, Campus Box 1125, St Louis, MO, 63130, USA
    JIMD Rep . 2016
    ..These exploratory findings demonstrate the importance of using sophisticated modeling procedures to understand the interplay among metabolic control, neural factors, and functional outcomes in individuals with PKU...
  28. pmc Longitudinal analysis of neural network development in preterm infants
    Christopher D Smyser
    Department of Neurology, Division of Pediatric Neurology, Washington University School ofMedicine, 660 South Euclid Avenue, Saint Louis, MO 63110 1093, USA
    Cereb Cortex 20:2852-62. 2010
    ....
  29. doi request reprint Thrombotic complications of a basilar artery aneurysm in a young adult with Pompe disease
    Daniel Refai
    Department of Neurological Surgery, School of Medicine, Washington University in St Louis, Saint Louis, MO 63110, USA
    Surg Neurol 70:518-20. 2008
    ..Pompe disease or type 2 glycogen storage disease is an inherited condition that generally afflicts the heart and skeletal muscle. Nervous tissue involvement is known; however, the effect on cerebral vasculature is less well understood...
  30. pmc Age-related decline in the microstructural integrity of white matter in children with early- and continuously-treated PKU: a DTI study of the corpus callosum
    Desiree A White
    Department of Psychology, Campus Box 1125, Washington University, One Brookings Drive, St Louis, MO 63130, USA
    Mol Genet Metab 99:S41-6. 2010
    ..e., genu, rostral body). These findings point to an age-related decrement in the microstructural integrity of the anterior white matter of the corpus callosum in children with PKU...
  31. pmc The comprehensive neuro-oncology data repository (CONDR): a research infrastructure to develop and validate imaging biomarkers
    Sarah Jost Fouke
    Department of Neurological Surgery, Swedish Medical Center, Seattle, Washington Department of Radiology, Washington University School of Medicine, St Louis, Missouri Department of Neurological Surgery, Washington University School of Medicine, St Louis, Missouri Swedish Neuroscience Institute, Seattle, Washington, Radia PS, Everett, Washington
    Neurosurgery 74:88-98. 2014
    ..Standardization of these methods and an organized archival platform are required to better validate and apply these markers in research settings and, ultimately, in clinical practice...
  32. pmc MR imaging correlates of white-matter pathology in a preterm baboon model
    Jennifer L Griffith
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri, USA
    Pediatr Res 71:185-91. 2012
    ..Cerebral white-matter (WM) abnormalities on magnetic resonance imaging (MRI) correlate with neurodevelopmental disability in infants born prematurely...
  33. pmc Diffuse microstructural abnormalities of normal-appearing white matter in late life depression: a diffusion tensor imaging study
    Joshua S Shimony
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri, USA
    Biol Psychiatry 66:245-52. 2009
    ..However, no study of LLD to date has examined the integrity of white matter outside of WMH (i.e., in normal-appearing white matter)...
  34. pmc Increased radial diffusivity in spinal cord lesions in neuromyelitis optica compared with multiple sclerosis
    Eric C Klawiter
    Department of Neurology, Washington University School of Medicine, St Louis, USA
    Mult Scler 18:1259-68. 2012
    ..Multiple sclerosis (MS) and neuromyelitis optica (NMO) both affect spinal cord with notable differences in pathology...
  35. pmc Relationship between age and white matter integrity in children with phenylketonuria
    Erika Wesonga
    Department of Psychological and Brain Sciences, One Brookings Drive, Campus Box 1125, Washington University, St Louis, MO 63130, USA
    Mol Genet Metab Rep 7:45-9. 2016
    ..Further research using longitudinal methodology is needed to fully elucidate our understanding of white matter development in children with PKU. ..
  36. pmc Brain aerobic glycolysis and motor adaptation learning
    Benjamin J Shannon
    Mallinckrodt Institute of Radiology, Washington University in St Louis, St Louis, MO 63110
    Proc Natl Acad Sci U S A 113:E3782-91. 2016
    ..Intersubject variability in behavioral adaptation rate correlated strongly with changes in AG in this region, as well as functional connectivity, which is consistent with a role for AG in synaptic plasticity. ..
  37. pmc Detection of blast-related traumatic brain injury in U.S. military personnel
    Christine L Mac Donald
    Washington University School of Medicine, St Louis, MO 63110, USA
    N Engl J Med 364:2091-100. 2011
    ..Blast-related traumatic brain injuries have been common in the Iraq and Afghanistan wars, but fundamental questions about the nature of these injuries remain unanswered...
  38. pmc Dynamic susceptibility contrast MRI with localized arterial input functions
    John J Lee
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Magn Reson Med 63:1305-14. 2010
    ..Regression analysis for localized arterial input function gave estimates of a scaling factor for quantitation that described perfusion accurately in patients with substantial variability in hemodynamic impairment...
  39. pmc Comparison of perfusion- and diffusion-weighted imaging parameters in brain tumor studies processed using different software platforms
    Mikhail V Milchenko
    Department of Radiology, Washington University School of Medicine, St Louis, Missouri Electronic address
    Acad Radiol 21:1294-303. 2014
    ..To compare quantitative imaging parameter measures from diffusion- and perfusion-weighted imaging magnetic resonance imaging (MRI) sequences in subjects with brain tumors that have been processed with different software platforms...
  40. pmc Early brain vulnerability in Wolfram syndrome
    Tamara Hershey
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS ONE 7:e40604. 2012
    ..Longitudinal studies will be critical for confirming and expanding our understanding of the impact of ER stress dysregulation on brain development...
  41. pmc Resting-state spontaneous fluctuations in brain activity: a new paradigm for presurgical planning using fMRI
    Joshua S Shimony
    Mallinckrodt Institute of Radiology and the Department of Neurosurgery, Washington University School of Medicine, 510 S Kingshighway Blvd, St Louis, MO 63110, USA
    Acad Radiol 16:578-83. 2009
    ..1 Hz) fluctuations of the fMRI signal over time. Our objective in the present work is to provide preliminary information on the possible clinical utility of this technique for presurgical planning and on possible future applications...
  42. pmc Loss of resting interhemispheric functional connectivity after complete section of the corpus callosum
    James M Johnston
    Department of Neurosurgery, Washington University, St Louis, Missouri 63110, USA
    J Neurosci 28:6453-8. 2008
    ..Such observations have the potential to increase our understanding of large-scale brain systems in health and disease as well as improve the treatment of neurologic disorders...
  43. ncbi request reprint Differential vulnerability of anterior white matter in nondemented aging with minimal acceleration in dementia of the Alzheimer type: evidence from diffusion tensor imaging
    Denise Head
    Howard Hughes Medical Institute, Washington University, St Louis, MO 63130, USA
    Cereb Cortex 14:410-23. 2004
    ..The dissociation between the regional effects of age and dementia status suggests that the mechanisms underlying age-associated cognitive decline are likely distinct from those underlying DAT...
  44. doi request reprint Imaging for diagnosis and treatment of cerebral palsy
    Joshua S Shimony
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri, USA
    Clin Obstet Gynecol 51:787-99. 2008
    ..In the future, imaging may provide more functional methods, including novel methods such as optical tomography, map regeneration, adaptation, and functional recovery...
  45. ncbi request reprint Treatment of chronic symptomatic vertebral compression fractures with percutaneous vertebroplasty
    Daniel B Brown
    Mallinckrodt Institute of Radiology, 510 S Kingshighway Blvd, Box 8131, St Louis, MO 63110, USA
    AJR Am J Roentgenol 182:319-22. 2004
    ..Most fractures treated with percutaneous vertebroplasty are subacute and less than 1 year old. We report our experience treating chronic vertebral fractures with vertebroplasty...
  46. ncbi request reprint Diffusion-tensor MR imaging of gray and white matter development during normal human brain maturation
    Pratik Mukherjee
    Mallinckrodt Institute of Radiology, St Louis Children s Hospital, Washington University Medical Center, St Louis, MO, USA
    AJNR Am J Neuroradiol 23:1445-56. 2002
    ..We use diffusion-tensor MR imaging to test theoretical models that incorporate hypotheses regarding how these maturational processes influence water diffusion in developing gray and white matter...
  47. doi request reprint Current and future diagnostic tools for traumatic brain injury: CT, conventional MRI, and diffusion tensor imaging
    David L Brody
    Department of Neurology, Washington University School of Medicine, St Louis, MO, USA Electronic address
    Handb Clin Neurol 127:267-75. 2015
    ..Clearly, both the imaging assessments and the pathologic assessments will require iterative refinement. ..
  48. pmc Teaching NeuroImages: T2 hyperintensities in neurofibromatosis type 1
    Adam P Ostendorf
    From the Department of Neurology A O, D H G and Mallinkrodt Institute of Radiology R C M, J S S, Washington University School of Medicine, St Louis, MO
    Neurology 80:e215-6. 2013
    ..Coupled with the development of new neurologic signs, these MRI features are worrisome for neoplasm in a patient with NF1...
  49. doi request reprint Tract-based analysis of white matter integrity in psychotic and nonpsychotic bipolar disorder
    ANDREW JI
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO, United States
    J Affect Disord 209:124-134. 2017
    ..This study aims to explore potential differences between bipolar disorder subtypes by measuring white matter integrity of the brain and relationships with clinical measures...
  50. pmc Periventricular hyperintensity in children with hydrocephalus
    S Hassan A Akbari
    Department of Neurological Surgery, St Louis Children s Hospital, Washington University School of Medicine, St Louis, MO, USA
    Pediatr Radiol 45:1189-97. 2015
    ..Magnetic resonance images of children with hydrocephalus often include a rim of hyperintensity in the periventricular white matter (halo)...
  51. pmc Cerebral white matter integrity during primary HIV infection
    Patrick W Wright
    aDepartment of Biomedical Engineering bDepartment of Neurology, School of Medicine, St Louis, Missouri cDepartment of Family and Preventive Medicine, UCSD, San Diego, California, USA dDepartment of Biology, University of Puerto Rico, Rio Piedras, San Juan, Puerto Rico eDepartment of Psychiatry, WUSTL School of Medicine, St Louis, Missouri fDepartment of Neurology, UCSF, San Francisco, California, USA gDivision of Biological Chemistry, Innsbruck Medical University, Innsbruck, Austria hDepartment of Radiology, WUSTL School of Medicine, St Louis, Missouri iDepartment of Neurology, UNC, Chapel Hill, North Carolina jCenter for Imaging of Neurodegenerative Diseases, VA Medical Center, San Francisco kDepartment of Radiology and Biomedical Imaging, UCSF, San Francisco, California lDepartment of Neurology, Yale University, New Haven, Connecticut, USA Drs Serena S Spudich and Beau M Ances contributed equally to the writing of this article
    AIDS 29:433-42. 2015
    ..Inflammation and infection within the central nervous system is initiated during primary HIV infection (PHI), but the association of these processes with the integrity of brain white matter during PHI is unknown...