Yo Sasaki

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. pmc Characterization of Leber Congenital Amaurosis-associated NMNAT1 Mutants
    Yo Sasaki
    From the Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110
    J Biol Chem 290:17228-38. 2015
  2. pmc Amyloid precursor protein cleavage-dependent and -independent axonal degeneration programs share a common nicotinamide mononucleotide adenylyltransferase 1-sensitive pathway
    Bhupinder P S Vohra
    Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 30:13729-38. 2010
  3. pmc Nicotinamide mononucleotide adenylyl transferase-mediated axonal protection requires enzymatic activity but not increased levels of neuronal nicotinamide adenine dinucleotide
    Yo Sasaki
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 29:5525-35. 2009
  4. pmc Mitofusin2 mutations disrupt axonal mitochondrial positioning and promote axon degeneration
    Albert L Misko
    Department of Neurology and Genetics, Washington University School of Medicine, St Louis, MO 63110, USA
    J Neurosci 32:4145-55. 2012
  5. pmc SCG10 is a JNK target in the axonal degeneration pathway
    Jung Eun Shin
    Department of Developmental Biology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 109:E3696-705. 2012
  6. pmc A model of toxic neuropathy in Drosophila reveals a role for MORN4 in promoting axonal degeneration
    Martha R C Bhattacharya
    Department of Developmental Biology, Washington University in St Louis School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 32:5054-61. 2012
  7. pmc Axonal degeneration is blocked by nicotinamide mononucleotide adenylyltransferase (Nmnat) protein transduction into transected axons
    Yo Sasaki
    Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 285:41211-5. 2010
  8. pmc Sarm1-mediated axon degeneration requires both SAM and TIR interactions
    Josiah Gerdts
    Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 33:13569-80. 2013
  9. pmc Nicotinamide mononucleotide adenylyl transferase 1 protects against acute neurodegeneration in developing CNS by inhibiting excitotoxic-necrotic cell death
    Philip B Verghese
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 108:19054-9. 2011
  10. pmc Image-based screening identifies novel roles for IkappaB kinase and glycogen synthase kinase 3 in axonal degeneration
    Josiah Gerdts
    Department of Genetics, Washington University Medical School, St Louis, Missouri 63110, USA
    J Biol Chem 286:28011-8. 2011

Collaborators

Detail Information

Publications14

  1. pmc Characterization of Leber Congenital Amaurosis-associated NMNAT1 Mutants
    Yo Sasaki
    From the Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110
    J Biol Chem 290:17228-38. 2015
    ..These results suggest that LCA-associated NMNAT1 mutants are more vulnerable to stressful conditions that lead to protein unfolding, a potential contributor to the retinal degeneration observed in this syndrome. ..
  2. pmc Amyloid precursor protein cleavage-dependent and -independent axonal degeneration programs share a common nicotinamide mononucleotide adenylyltransferase 1-sensitive pathway
    Bhupinder P S Vohra
    Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 30:13729-38. 2010
    ....
  3. pmc Nicotinamide mononucleotide adenylyl transferase-mediated axonal protection requires enzymatic activity but not increased levels of neuronal nicotinamide adenine dinucleotide
    Yo Sasaki
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 29:5525-35. 2009
    ..These results provide the possibility of a role for new Nmnat enzymatic activity in axonal protection in addition to NAD(+) synthesis...
  4. pmc Mitofusin2 mutations disrupt axonal mitochondrial positioning and promote axon degeneration
    Albert L Misko
    Department of Neurology and Genetics, Washington University School of Medicine, St Louis, MO 63110, USA
    J Neurosci 32:4145-55. 2012
    ....
  5. pmc SCG10 is a JNK target in the axonal degeneration pathway
    Jung Eun Shin
    Department of Developmental Biology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 109:E3696-705. 2012
    ..Taken together, these data support the model that SCG10 is an axonal-maintenance factor whose loss is permissive for execution of the injury-induced axonal degeneration program...
  6. pmc A model of toxic neuropathy in Drosophila reveals a role for MORN4 in promoting axonal degeneration
    Martha R C Bhattacharya
    Department of Developmental Biology, Washington University in St Louis School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 32:5054-61. 2012
    ..Hence, this new model can identify evolutionarily conserved genes that promote axonal degeneration, and so could identify candidate therapeutic targets for a wide-range of axonopathies...
  7. pmc Axonal degeneration is blocked by nicotinamide mononucleotide adenylyltransferase (Nmnat) protein transduction into transected axons
    Yo Sasaki
    Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 285:41211-5. 2010
    ..The post-injury efficacy of Nmnat indicates that its protective effects occur locally within the axon and provides an opportunity to develop novel agents to treat axonal damage...
  8. pmc Sarm1-mediated axon degeneration requires both SAM and TIR interactions
    Josiah Gerdts
    Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 33:13569-80. 2013
    ..These findings suggest that inhibitors of SAM and TIR interactions represent therapeutic candidates for blocking pathological axon loss and neuronal cell death. ..
  9. pmc Nicotinamide mononucleotide adenylyl transferase 1 protects against acute neurodegeneration in developing CNS by inhibiting excitotoxic-necrotic cell death
    Philip B Verghese
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 108:19054-9. 2011
    ..As such, the Nmnat1 protective pathway could be a useful therapeutic target for acute and chronic neurodegenerative insults mediated by excitotoxicity...
  10. pmc Image-based screening identifies novel roles for IkappaB kinase and glycogen synthase kinase 3 in axonal degeneration
    Josiah Gerdts
    Department of Genetics, Washington University Medical School, St Louis, Missouri 63110, USA
    J Biol Chem 286:28011-8. 2011
    ..Knockdown of each of these targets by shRNA lentivirus also delays axon degeneration in vitro, further supporting their role in the axon degeneration program...
  11. pmc Protection of mouse retinal ganglion cell axons and soma from glaucomatous and ischemic injury by cytoplasmic overexpression of Nmnat1
    Yanli Zhu
    Department of Neurosurgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Invest Ophthalmol Vis Sci 54:25-36. 2013
    ....
  12. pmc Aberrant Schwann cell lipid metabolism linked to mitochondrial deficits leads to axon degeneration and neuropathy
    Andreu Viader
    Department of Genetics, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuron 77:886-98. 2013
    ..Importantly, we show that ACs are released from SCs and induce axonal degeneration. A maladaptive ISR as well as altered SC lipid metabolism are thus underlying pathological mechanisms in mitochondria-related peripheral neuropathies...
  13. pmc Transgenic mice expressing the Nmnat1 protein manifest robust delay in axonal degeneration in vivo
    Yo Sasaki
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 29:6526-34. 2009
    ..These results highlight the importance of understanding the mechanism of Nmnat-mediated axonal protection for the development of new treatment strategies for neurological disorders...
  14. pmc Mechanisms of nucleotide trafficking during siRNA delivery to endothelial cells using perfluorocarbon nanoemulsions
    Megan M Kaneda
    Biomedical Engineering, Washington University School of Medicine, St Louis, MO 63108, USA
    Biomaterials 31:3079-86. 2010
    ..We further demonstrate markedly enhanced efficacy over conventional transfection agents for suppressing endothelial cell expression of upregulated vascular adhesion molecules...