Affiliation: Washington University School of Medicine
- Luminal chloride-dependent activation of endosome calcium channels: patch clamp study of enlarged endosomesMitsuyoshi Saito
Department of Cell Biology and Physiology, Washington University, 660 S, Euclid Avenue, St Louis, MO 63110, USA
J Biol Chem 282:27327-33. 2007..The ECC shows a similar pharmacology to that of the TRPV2 channel. In addition, the ECC has a unique chloride-dependent regulation; it is inhibited by the endosome luminal chloride with a K(50) of 82 mm...
- Otopetrin 1 activation by purinergic nucleotides regulates intracellular calciumInna Hughes
Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 104:12023-8. 2007..In a physiologic setting, these activities could direct the formation and growth of otoconia and regulate other biomineralization processes...
- Wolframin expression induces novel ion channel activity in endoplasmic reticulum membranes and increases intracellular calciumAbdullah A Osman
Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Biol Chem 278:52755-62. 2003..Disruption of this function may place cells at risk to suffer inappropriate death decisions, thus accounting for the progressive beta-cell loss and neuronal degeneration associated with the disease...