Genomes and Genes
Affiliation: Washington University School of Medicine
- Lack of adiponectin leads to increased lymphocyte activation and increased disease severity in a mouse model of multiple sclerosisLaura Piccio
Department of Neurology, Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, MO, USA
Eur J Immunol 43:2089-100. 2013..These data indicate that adiponectin is an important regulator of T-cell functions during EAE, suggesting a new avenue of investigation for MS treatment. ..
- Chronic calorie restriction attenuates experimental autoimmune encephalomyelitisLaura Piccio
Department of Neurology, St Louis, MO 63110, USA
J Leukoc Biol 84:940-8. 2008..CR with adequate nutrition and careful medical monitoring should be explored as a potential treatment for MS...
- Identification of soluble TREM-2 in the cerebrospinal fluid and its association with multiple sclerosis and CNS inflammationLaura Piccio
Department of Neurology and Neurosurgery, Washington University School of Medicine, St Louis, MO 63110, USA
Brain 131:3081-91. 2008..The elevated levels of sTREM-2 in CSF of multiple sclerosis patients may inhibit the anti-inflammatory function of the membrane-bound receptor suggesting sTREM-2 to be a possible target for future therapies...
- Changes in B- and T-lymphocyte and chemokine levels with rituximab treatment in multiple sclerosisLaura Piccio
Department of Neurology, Washington University School of Medicine, St Louis, MO, USA
Arch Neurol 67:707-14. 2010..B cells are implicated in the pathogenesis of multiple sclerosis. A beneficial effect of B-cell depletion using rituximab has been shown, but the complete mechanism of action for this drug is unclear...
- CXCL13 is a biomarker of inflammation in multiple sclerosis, neuromyelitis optica, and other neurological conditionsEnrique Alvarez
Department of Neurology, Washington University in Saint Louis, St Louis, MO 63110, USA
Mult Scler 19:1204-8. 2013..In subgroup analyses, CSF CXCL13 correlated with CSF WBC in neuromyelitis optica and IgG index in multiple sclerosis. Additionally, serum CXCL13 was elevated in neuromyelitis optica. ..
- Adhesion of human T cells to antigen-presenting cells through SIRPbeta2-CD47 interaction costimulates T-cell proliferationLaura Piccio
Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid, St Louis, MO 63110, USA
Blood 105:2421-7. 2005..Consequently, engagement of SIRPbeta2 on T cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation...
- Elevated intrathecal myelin oligodendrocyte glycoprotein antibodies in multiple sclerosisEric C Klawiter
Department of Neurology, Washington University, St Louis, MO 63110, USA
Arch Neurol 67:1102-8. 2010..To evaluate antibodies to myelin oligodendrocyte glycoprotein (MOG) in the serum and cerebrospinal fluid (CSF) of patients with multiple sclerosis (MS) and control individuals...
- Cutting edge: TREM-2 attenuates macrophage activationIsaiah R Turnbull
Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
J Immunol 177:3520-4. 2006..Taken together, these data show that TREM-2 is expressed on newly differentiated and alternatively activated macrophages and functions to restrain macrophage activation...
- ITAM signaling in dendritic cells controls T helper cell priming by regulating MHC class II recyclingDaniel B Graham
Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
Blood 116:3208-18. 2010..We propose a novel mechanism for control of T helper cell priming...
- TREM2 regulates microglial cell activation in response to demyelination in vivoClaudia Cantoni
Department of Neurology, Washington University School of Medicine, 660 S Euclid Avenue, Campus Box 8111, St Louis, MO, 63110, USA
Acta Neuropathol 129:429-47. 2015..These findings place TREM2 as a key regulator of microglia activation in vivo in response to tissue damage. ..
- Genetic risk variants in African Americans with multiple sclerosisNoriko Isobe
Department of Neurology, School of Medicine, University of California, San Francisco, CA, USA
Neurology 81:219-27. 2013..To assess the association of established multiple sclerosis (MS) risk variants in 3,254 African Americans (1,162 cases and 2,092 controls)...
- Pathological expression of CXCL12 at the blood-brain barrier correlates with severity of multiple sclerosisErin E McCandless
Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA
Am J Pathol 172:799-808. 2008....
- Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2JASON D ULRICH
Department of Neurology, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
Mol Neurodegener 9:20. 2014....
- Update on multiple sclerosis, its diagnosis and treatmentsAnne H Cross
Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
Clin Chem Lab Med 50:1203-10. 2012..Several treatments are now available to decrease relapse rate and slow the accumulation of disability in patients with relapsing MS, but there is currently no effective treatment to slow the progressive forms of MS...
- Rituximab combination therapy in relapsing multiple sclerosisAnne H Cross
Department of Neurology, Washington University in St Louis, 660 S Euclid, Campus Box 8111, St Louis, MO 63110, USA
Ther Adv Neurol Disord 5:311-9. 2012..These results suggest that B cells play a role in MS independent from antibody production and possibly related to their role in antigen presentation to T cells or to their chemokine/cytokine production...
- HLA-DRB1*1501 tagging rs3135388 polymorphism is not associated with neuromyelitis opticaMarcelo Matiello
Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
Mult Scler 16:981-4. 2010..Association of the HLA-DRB1*1501 allele with multiple sclerosis is well established, but its association with neuromyelitis optica has only been evaluated in small populations...
- Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility lociPhilip L De Jager
Division of Molecular Immunology, Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
Nat Genet 41:776-82. 2009....
- Efficient recruitment of lymphocytes in inflamed brain venules requires expression of cutaneous lymphocyte antigen and fucosyltransferase-VIILaura Piccio
Department of Pathology, University of Verona, Verona, Italy
J Immunol 174:5805-13. 2005..These observations allow us to conclude that efficient recruitment of activated lymphocytes to the brain in the contexts mimicking EAE is controlled by FucT-VII and its cognate cell surface Ag CLA...