Laura Piccio

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. pmc Cerebrospinal fluid soluble TREM2 is higher in Alzheimer disease and associated with mutation status
    Laura Piccio
    Department of Neurology, Washington University School of Medicine, Campus Box 8111, 660 S Euclid Avenue, Saint Louis, MO, 63110, USA
    Acta Neuropathol 131:925-33. 2016
  2. pmc Lack of adiponectin leads to increased lymphocyte activation and increased disease severity in a mouse model of multiple sclerosis
    Laura Piccio
    Department of Neurology, Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, MO, USA
    Eur J Immunol 43:2089-100. 2013
  3. pmc Chronic calorie restriction attenuates experimental autoimmune encephalomyelitis
    Laura Piccio
    Department of Neurology, St Louis, MO 63110, USA
    J Leukoc Biol 84:940-8. 2008
  4. pmc Identification of soluble TREM-2 in the cerebrospinal fluid and its association with multiple sclerosis and CNS inflammation
    Laura Piccio
    Department of Neurology and Neurosurgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Brain 131:3081-91. 2008
  5. pmc Changes in B- and T-lymphocyte and chemokine levels with rituximab treatment in multiple sclerosis
    Laura Piccio
    Department of Neurology, Washington University School of Medicine, St Louis, MO, USA
    Arch Neurol 67:707-14. 2010
  6. pmc CXCL13 is a biomarker of inflammation in multiple sclerosis, neuromyelitis optica, and other neurological conditions
    Enrique Alvarez
    Department of Neurology, Washington University in Saint Louis, St Louis, MO 63110, USA
    Mult Scler 19:1204-8. 2013
  7. ncbi request reprint Adhesion of human T cells to antigen-presenting cells through SIRPbeta2-CD47 interaction costimulates T-cell proliferation
    Laura Piccio
    Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid, St Louis, MO 63110, USA
    Blood 105:2421-7. 2005
  8. pmc Elevated intrathecal myelin oligodendrocyte glycoprotein antibodies in multiple sclerosis
    Eric C Klawiter
    Department of Neurology, Washington University, St Louis, MO 63110, USA
    Arch Neurol 67:1102-8. 2010
  9. ncbi request reprint Cutting edge: TREM-2 attenuates macrophage activation
    Isaiah R Turnbull
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 177:3520-4. 2006
  10. pmc TREM2 regulates microglial cell activation in response to demyelination in vivo
    Claudia Cantoni
    Department of Neurology, Washington University School of Medicine, 660 S Euclid Avenue, Campus Box 8111, St Louis, MO, 63110, USA
    Acta Neuropathol 129:429-47. 2015

Detail Information

Publications21

  1. pmc Cerebrospinal fluid soluble TREM2 is higher in Alzheimer disease and associated with mutation status
    Laura Piccio
    Department of Neurology, Washington University School of Medicine, Campus Box 8111, 660 S Euclid Avenue, Saint Louis, MO, 63110, USA
    Acta Neuropathol 131:925-33. 2016
    ..Furthermore, SNPs involved in pathways related to virus cellular entry and vesicular trafficking were overrepresented, suggesting that CSF sTREM2 levels could be an informative phenotype for AD. ..
  2. pmc Lack of adiponectin leads to increased lymphocyte activation and increased disease severity in a mouse model of multiple sclerosis
    Laura Piccio
    Department of Neurology, Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, MO, USA
    Eur J Immunol 43:2089-100. 2013
    ..These data indicate that adiponectin is an important regulator of T-cell functions during EAE, suggesting a new avenue of investigation for MS treatment. ..
  3. pmc Chronic calorie restriction attenuates experimental autoimmune encephalomyelitis
    Laura Piccio
    Department of Neurology, St Louis, MO 63110, USA
    J Leukoc Biol 84:940-8. 2008
    ..CR with adequate nutrition and careful medical monitoring should be explored as a potential treatment for MS...
  4. pmc Identification of soluble TREM-2 in the cerebrospinal fluid and its association with multiple sclerosis and CNS inflammation
    Laura Piccio
    Department of Neurology and Neurosurgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Brain 131:3081-91. 2008
    ..The elevated levels of sTREM-2 in CSF of multiple sclerosis patients may inhibit the anti-inflammatory function of the membrane-bound receptor suggesting sTREM-2 to be a possible target for future therapies...
  5. pmc Changes in B- and T-lymphocyte and chemokine levels with rituximab treatment in multiple sclerosis
    Laura Piccio
    Department of Neurology, Washington University School of Medicine, St Louis, MO, USA
    Arch Neurol 67:707-14. 2010
    ..B cells are implicated in the pathogenesis of multiple sclerosis. A beneficial effect of B-cell depletion using rituximab has been shown, but the complete mechanism of action for this drug is unclear...
  6. pmc CXCL13 is a biomarker of inflammation in multiple sclerosis, neuromyelitis optica, and other neurological conditions
    Enrique Alvarez
    Department of Neurology, Washington University in Saint Louis, St Louis, MO 63110, USA
    Mult Scler 19:1204-8. 2013
    ..In subgroup analyses, CSF CXCL13 correlated with CSF WBC in neuromyelitis optica and IgG index in multiple sclerosis. Additionally, serum CXCL13 was elevated in neuromyelitis optica. ..
  7. ncbi request reprint Adhesion of human T cells to antigen-presenting cells through SIRPbeta2-CD47 interaction costimulates T-cell proliferation
    Laura Piccio
    Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid, St Louis, MO 63110, USA
    Blood 105:2421-7. 2005
    ..Consequently, engagement of SIRPbeta2 on T cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation...
  8. pmc Elevated intrathecal myelin oligodendrocyte glycoprotein antibodies in multiple sclerosis
    Eric C Klawiter
    Department of Neurology, Washington University, St Louis, MO 63110, USA
    Arch Neurol 67:1102-8. 2010
    ..To evaluate antibodies to myelin oligodendrocyte glycoprotein (MOG) in the serum and cerebrospinal fluid (CSF) of patients with multiple sclerosis (MS) and control individuals...
  9. ncbi request reprint Cutting edge: TREM-2 attenuates macrophage activation
    Isaiah R Turnbull
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 177:3520-4. 2006
    ..Taken together, these data show that TREM-2 is expressed on newly differentiated and alternatively activated macrophages and functions to restrain macrophage activation...
  10. pmc TREM2 regulates microglial cell activation in response to demyelination in vivo
    Claudia Cantoni
    Department of Neurology, Washington University School of Medicine, 660 S Euclid Avenue, Campus Box 8111, St Louis, MO, 63110, USA
    Acta Neuropathol 129:429-47. 2015
    ..These findings place TREM2 as a key regulator of microglia activation in vivo in response to tissue damage. ..
  11. pmc ITAM signaling in dendritic cells controls T helper cell priming by regulating MHC class II recycling
    Daniel B Graham
    Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Blood 116:3208-18. 2010
    ..We propose a novel mechanism for control of T helper cell priming...
  12. pmc Dimethyl fumarate selectively reduces memory T cells in multiple sclerosis patients
    Erin E Longbrake
    Department of Neurology, Washington University, Saint Louis, MO, USA
    Mult Scler 22:1061-70. 2016
    ..Dimethyl fumarate (DMF) alters the phenotype of circulating immune cells and causes lymphopenia in a subpopulation of treated multiple sclerosis (MS) patients...
  13. pmc Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2
    JASON D ULRICH
    Department of Neurology, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    Mol Neurodegener 9:20. 2014
    ....
  14. ncbi request reprint Mir-223 regulates the number and function of myeloid-derived suppressor cells in multiple sclerosis and experimental autoimmune encephalomyelitis
    Claudia Cantoni
    Department of Neurology, Washington University School of Medicine, 660 S Euclid Avenue, Campus Box 8111, St Louis, MO, 63110, USA
    Acta Neuropathol . 2016
    ..These results support a critical role for miR-223 in modulating MDSC biology in EAE and in MS and suggest potential novel therapeutic applications...
  15. pmc Genetic risk variants in African Americans with multiple sclerosis
    Noriko Isobe
    Department of Neurology, School of Medicine, University of California, San Francisco, CA, USA
    Neurology 81:219-27. 2013
    ..To assess the association of established multiple sclerosis (MS) risk variants in 3,254 African Americans (1,162 cases and 2,092 controls)...
  16. pmc Pathological expression of CXCL12 at the blood-brain barrier correlates with severity of multiple sclerosis
    Erin E McCandless
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA
    Am J Pathol 172:799-808. 2008
    ....
  17. doi request reprint Update on multiple sclerosis, its diagnosis and treatments
    Anne H Cross
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Clin Chem Lab Med 50:1203-10. 2012
    ..Several treatments are now available to decrease relapse rate and slow the accumulation of disability in patients with relapsing MS, but there is currently no effective treatment to slow the progressive forms of MS...
  18. pmc Rituximab combination therapy in relapsing multiple sclerosis
    Anne H Cross
    Department of Neurology, Washington University in St Louis, 660 S Euclid, Campus Box 8111, St Louis, MO 63110, USA
    Ther Adv Neurol Disord 5:311-9. 2012
    ..These results suggest that B cells play a role in MS independent from antibody production and possibly related to their role in antigen presentation to T cells or to their chemokine/cytokine production...
  19. pmc Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci
    Philip L De Jager
    Division of Molecular Immunology, Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Nat Genet 41:776-82. 2009
    ....
  20. doi request reprint HLA-DRB1*1501 tagging rs3135388 polymorphism is not associated with neuromyelitis optica
    Marcelo Matiello
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Mult Scler 16:981-4. 2010
    ..Association of the HLA-DRB1*1501 allele with multiple sclerosis is well established, but its association with neuromyelitis optica has only been evaluated in small populations...
  21. ncbi request reprint Efficient recruitment of lymphocytes in inflamed brain venules requires expression of cutaneous lymphocyte antigen and fucosyltransferase-VII
    Laura Piccio
    Department of Pathology, University of Verona, Verona, Italy
    J Immunol 174:5805-13. 2005
    ..These observations allow us to conclude that efficient recruitment of activated lymphocytes to the brain in the contexts mimicking EAE is controlled by FucT-VII and its cognate cell surface Ag CLA...