CHRISTINE T PHAM

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. pmc Dipeptidyl peptidase I activates neutrophil-derived serine proteases and regulates the development of acute experimental arthritis
    April M Adkison
    Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    J Clin Invest 109:363-71. 2002
  2. ncbi request reprint Neutrophil serine proteases: specific regulators of inflammation
    Christine T N Pham
    Division of Rheumatology, Department of Internal Medicine, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    Nat Rev Immunol 6:541-50. 2006
  3. pmc Neutrophil serine proteases fine-tune the inflammatory response
    Christine T N Pham
    Division of Rheumatology, Department of Internal Medicine, Washington University, 660 South Euclid Avenue, Box 8045, St Louis, MO 63110, USA
    Int J Biochem Cell Biol 40:1317-33. 2008
  4. ncbi request reprint Papillon-Lefèvre syndrome: correlating the molecular, cellular, and clinical consequences of cathepsin C/dipeptidyl peptidase I deficiency in humans
    Christine T N Pham
    Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA
    J Immunol 173:7277-81. 2004
  5. ncbi request reprint Pathophysiology of abdominal aortic aneurysms: insights from the elastase-induced model in mice with different genetic backgrounds
    Robert W Thompson
    Department of Surgery Section of Vascular Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Ann N Y Acad Sci 1085:59-73. 2006
  6. ncbi request reprint Serine protease cathepsin G regulates adhesion-dependent neutrophil effector functions by modulating integrin clustering
    Sofia Z Raptis
    Division of Rheumatology, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    Immunity 22:679-91. 2005
  7. pmc Complement-dependent neutrophil recruitment is critical for the development of elastase-induced abdominal aortic aneurysm
    Monica B Pagano
    Department of Surgery, Section of Vascular Surgery, Washington University School of Medicine, St Louis, MO, USA
    Circulation 119:1805-13. 2009
  8. pmc Critical role of dipeptidyl peptidase I in neutrophil recruitment during the development of experimental abdominal aortic aneurysms
    Monica B Pagano
    Department of Surgery, Section of Vascular Surgery, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63124, USA
    Proc Natl Acad Sci U S A 104:2855-60. 2007
  9. ncbi request reprint Neutrophil-derived serine proteases in immune complex-mediated diseases
    Sofia Z Raptis
    Washington University School of Medicine, St Louis, MO 63110, USA
    Immunol Res 32:211-5. 2005
  10. pmc Dipeptidyl peptidase I-dependent neutrophil recruitment modulates the inflammatory response to Sendai virus infection
    Antonina M Akk
    Division of Rheumatology, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 180:3535-42. 2008

Research Grants

Collaborators

Detail Information

Publications14

  1. pmc Dipeptidyl peptidase I activates neutrophil-derived serine proteases and regulates the development of acute experimental arthritis
    April M Adkison
    Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    J Clin Invest 109:363-71. 2002
    ..These results implicate DPPI and polymorphonuclear neutrophil-derived serine proteases in the regulation of cytokine production at sites of inflammation...
  2. ncbi request reprint Neutrophil serine proteases: specific regulators of inflammation
    Christine T N Pham
    Division of Rheumatology, Department of Internal Medicine, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    Nat Rev Immunol 6:541-50. 2006
    ....
  3. pmc Neutrophil serine proteases fine-tune the inflammatory response
    Christine T N Pham
    Division of Rheumatology, Department of Internal Medicine, Washington University, 660 South Euclid Avenue, Box 8045, St Louis, MO 63110, USA
    Int J Biochem Cell Biol 40:1317-33. 2008
    ..In summary, these studies point to neutrophil serine proteases as versatile mediators that fine-tune the local immune response and identify them as potential targets for therapeutic interventions...
  4. ncbi request reprint Papillon-Lefèvre syndrome: correlating the molecular, cellular, and clinical consequences of cathepsin C/dipeptidyl peptidase I deficiency in humans
    Christine T N Pham
    Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA
    J Immunol 173:7277-81. 2004
    ....
  5. ncbi request reprint Pathophysiology of abdominal aortic aneurysms: insights from the elastase-induced model in mice with different genetic backgrounds
    Robert W Thompson
    Department of Surgery Section of Vascular Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Ann N Y Acad Sci 1085:59-73. 2006
    ..Investigations on mice from different genetic backgrounds are also beginning to offer a novel approach to evaluate the genetic basis for susceptibility to aneurysm development...
  6. ncbi request reprint Serine protease cathepsin G regulates adhesion-dependent neutrophil effector functions by modulating integrin clustering
    Sofia Z Raptis
    Division of Rheumatology, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    Immunity 22:679-91. 2005
    ..These findings identify an important role for CG in integrin-dependent PMN effector functions that are separate from and downstream of integrin-dependent adhesion...
  7. pmc Complement-dependent neutrophil recruitment is critical for the development of elastase-induced abdominal aortic aneurysm
    Monica B Pagano
    Department of Surgery, Section of Vascular Surgery, Washington University School of Medicine, St Louis, MO, USA
    Circulation 119:1805-13. 2009
    ..In this study, we tested the hypothesis that complement participates in the development of AAA by providing the necessary chemotactic signal that recruits neutrophils to the aortic wall...
  8. pmc Critical role of dipeptidyl peptidase I in neutrophil recruitment during the development of experimental abdominal aortic aneurysms
    Monica B Pagano
    Department of Surgery, Section of Vascular Surgery, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63124, USA
    Proc Natl Acad Sci U S A 104:2855-60. 2007
    ..These findings suggest that DPPI and/or granule-associated serine proteases are necessary for neutrophil recruitment into the diseased aorta and that these proteases act to amplify vascular wall inflammation that leads to AAAs...
  9. ncbi request reprint Neutrophil-derived serine proteases in immune complex-mediated diseases
    Sofia Z Raptis
    Washington University School of Medicine, St Louis, MO 63110, USA
    Immunol Res 32:211-5. 2005
    ..Loss-of-function mutations in serine proteases have provided critical insights into the significance of these serine proteases in initiating and amplifying immune complex-mediated diseases...
  10. pmc Dipeptidyl peptidase I-dependent neutrophil recruitment modulates the inflammatory response to Sendai virus infection
    Antonina M Akk
    Division of Rheumatology, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 180:3535-42. 2008
    ..These results indicate that DPPI and neutrophils play a critical role in Sendai virus-induced asthma phenotype as a result of a DPPI-dependent neutrophil recruitment and cytokine response...
  11. ncbi request reprint Characterization of murine cathepsin W and its role in cell-mediated cytotoxicity
    Jennifer K Ondr
    Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 279:27525-33. 2004
    ..In addition, mCtsW deficiency does not alter the susceptibility of cytotoxic lymphocytes to suicide or fratricide after degranulation. Thus, mCtsW does not have a unique role in target cell apoptosis or cytotoxic cell survival in vitro...
  12. ncbi request reprint Dipeptidyl peptidase I regulates the development of collagen-induced arthritis
    Ying Hu
    Washington University School of Medicine, St Louis, MO 63110, USA
    Arthritis Rheum 52:2553-8. 2005
    ..To examine the role of dipeptidyl peptidase I (DPPI), a widely expressed lysosomal cysteine protease, in the development of collagen-induced arthritis (CIA) in mice...
  13. pmc Alphavbeta3-targeted nanotherapy suppresses inflammatory arthritis in mice
    Hui Fang Zhou
    Division of Rheumatology, Washington University School of Medicine, St Louis, Missouri, USA
    FASEB J 23:2978-85. 2009
    ..Ligand-targeted nanotherapy to deliver antiangiogenic agents may represent an effective way to treat inflammatory arthritis...
  14. pmc Mast cell dipeptidyl peptidase I mediates survival from sepsis
    Jon Mallen-St Clair
    Department of Medicine and the Cardiovascular Research Institute, University of California, San Francisco, California 94143 0911, USA
    J Clin Invest 113:628-34. 2004
    ..These results indicate that mast cell DPPI harms the septic host and that DPPI is a novel potential therapeutic target for treatment of sepsis...

Research Grants1

  1. Role of DPPI & Serine Proteases in Inflammatory Diseases
    Christine Pham; Fiscal Year: 2007
    ..We also hypothesize that decreased expression of complement regulators in the kidney mav be a determinant that influences the severity of tissue damage in the target organ. ..