Jeanne M Nerbonne

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. pmc Molecular basis of functional voltage-gated K+ channel diversity in the mammalian myocardium
    J M Nerbonne
    Department of Molecular Biology and Pharmacology, Washington University Medical School, St Louis, MO 63110, USA
    J Physiol 525:285-98. 2000
  2. ncbi request reprint Heterogeneous expression of voltage-gated potassium channels in the heart: roles in normal excitation and arrhythmias
    Jeanne M Nerbonne
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Cardiovasc Electrophysiol 13:406-9. 2002
  3. pmc The sodium channel accessory subunit Navβ1 regulates neuronal excitability through modulation of repolarizing voltage-gated K⁺ channels
    Celine Marionneau
    Department of Developmental Biology, Washington University Medical School, St Louis, Missouri 63110, USA
    J Neurosci 32:5716-27. 2012
  4. pmc PPARalpha-mediated remodeling of repolarizing voltage-gated K+ (Kv) channels in a mouse model of metabolic cardiomyopathy
    Celine Marionneau
    Department of Molecular Biology and Pharmacology, Washington University Medical School, St Louis, MO 63110, USA
    J Mol Cell Cardiol 44:1002-15. 2008
  5. ncbi request reprint The FGF14(F145S) mutation disrupts the interaction of FGF14 with voltage-gated Na+ channels and impairs neuronal excitability
    Fernanda Laezza
    Department of Molecular Biology and Pharmacology, Washington University Medical School, St Louis, Missouri 63110, USA
    J Neurosci 27:12033-44. 2007
  6. pmc Interdependent roles for accessory KChIP2, KChIP3, and KChIP4 subunits in the generation of Kv4-encoded IA channels in cortical pyramidal neurons
    Aaron J Norris
    Department of Developmental Biology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 30:13644-55. 2010
  7. ncbi request reprint Accessory Kvbeta1 subunits differentially modulate the functional expression of voltage-gated K+ channels in mouse ventricular myocytes
    Franck Aimond
    Department of Molecular Biology and Pharmacology, Washington University Medical School, St Louis, MO 63110 1093, USA
    Circ Res 96:451-8. 2005
  8. pmc FGF14 N-terminal splice variants differentially modulate Nav1.2 and Nav1.6-encoded sodium channels
    Fernanda Laezza
    Department of Developmental Biology, Washington University School of Medicine, Saint Louis, MO 63110, USA
    Mol Cell Neurosci 42:90-101. 2009
  9. ncbi request reprint The kv4.2 potassium channel subunit is required for pain plasticity
    Hui Juan Hu
    Washington University Pain Center and Department of Anesthesiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Neuron 50:89-100. 2006
  10. ncbi request reprint Transgenic expression of fatty acid transport protein 1 in the heart causes lipotoxic cardiomyopathy
    Hsiu Chiang Chiu
    Center for Cardiovascular Research, Washington University School of Medicine, St Louis, MO 63110, USA
    Circ Res 96:225-33. 2005

Collaborators

Detail Information

Publications68

  1. pmc Molecular basis of functional voltage-gated K+ channel diversity in the mammalian myocardium
    J M Nerbonne
    Department of Molecular Biology and Pharmacology, Washington University Medical School, St Louis, MO 63110, USA
    J Physiol 525:285-98. 2000
    ..e. Ito,f, Ito,s, IKr, IKs, IKur, IK,slow, etc.) in myocyardial cells...
  2. ncbi request reprint Heterogeneous expression of voltage-gated potassium channels in the heart: roles in normal excitation and arrhythmias
    Jeanne M Nerbonne
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Cardiovasc Electrophysiol 13:406-9. 2002
    ..Targeting the K+ channels that function to maintain the normal dispersion of ventricular repolarization could be effective in treating cardiac arrhythmias...
  3. pmc The sodium channel accessory subunit Navβ1 regulates neuronal excitability through modulation of repolarizing voltage-gated K⁺ channels
    Celine Marionneau
    Department of Developmental Biology, Washington University Medical School, St Louis, Missouri 63110, USA
    J Neurosci 32:5716-27. 2012
    ..2-encoded current densities. Together, the results presented here identify Navβ1 as a component of native neuronal Kv4.2-encoded I(A) channel complexes and a novel regulator of I(A) channel densities and neuronal excitability...
  4. pmc PPARalpha-mediated remodeling of repolarizing voltage-gated K+ (Kv) channels in a mouse model of metabolic cardiomyopathy
    Celine Marionneau
    Department of Molecular Biology and Pharmacology, Washington University Medical School, St Louis, MO 63110, USA
    J Mol Cell Cardiol 44:1002-15. 2008
    ..The molecular mechanisms underlying I(to,f) and I(ss) remodeling in MHC-PPARalpha ventricular myocytes, therefore, are distinct...
  5. ncbi request reprint The FGF14(F145S) mutation disrupts the interaction of FGF14 with voltage-gated Na+ channels and impairs neuronal excitability
    Fernanda Laezza
    Department of Molecular Biology and Pharmacology, Washington University Medical School, St Louis, Missouri 63110, USA
    J Neurosci 27:12033-44. 2007
    ....
  6. pmc Interdependent roles for accessory KChIP2, KChIP3, and KChIP4 subunits in the generation of Kv4-encoded IA channels in cortical pyramidal neurons
    Aaron J Norris
    Department of Developmental Biology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 30:13644-55. 2010
    ..In neurons expressing constructs to mediate simultaneous RNA interference-induced reductions in the expression of KChIP2, 3, and 4, I(A) densities were markedly reduced and Kv current remodeling was evident...
  7. ncbi request reprint Accessory Kvbeta1 subunits differentially modulate the functional expression of voltage-gated K+ channels in mouse ventricular myocytes
    Franck Aimond
    Department of Molecular Biology and Pharmacology, Washington University Medical School, St Louis, MO 63110 1093, USA
    Circ Res 96:451-8. 2005
    ..1 expression is increased in Kvbeta1-/- ventricles. Taken together, these results demonstrate that Kvbeta1 differentially regulates the functional cell surface expression of myocardial I(to,f) and I(K,slow2) channels...
  8. pmc FGF14 N-terminal splice variants differentially modulate Nav1.2 and Nav1.6-encoded sodium channels
    Fernanda Laezza
    Department of Developmental Biology, Washington University School of Medicine, Saint Louis, MO 63110, USA
    Mol Cell Neurosci 42:90-101. 2009
    ..Thus, the FGF14 N-terminus is required for targeting and functional regulation of Nav channels, suggesting an important function for FGF14 alternative splicing in regulating neuronal excitability...
  9. ncbi request reprint The kv4.2 potassium channel subunit is required for pain plasticity
    Hui Juan Hu
    Washington University Pain Center and Department of Anesthesiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Neuron 50:89-100. 2006
    ..2-mediated currents in neurons. These results show that Kv4.2 is a downstream target of ERK in spinal cord and plays a crucial role in pain plasticity...
  10. ncbi request reprint Transgenic expression of fatty acid transport protein 1 in the heart causes lipotoxic cardiomyopathy
    Hsiu Chiang Chiu
    Center for Cardiovascular Research, Washington University School of Medicine, St Louis, MO 63110, USA
    Circ Res 96:225-33. 2005
    ..Moreover, the MHC-FATP model supports a role for FATPs in FFA import into the heart in vivo...
  11. doi request reprint Ca2+-independent alterations in diastolic sarcomere length and relaxation kinetics in a mouse model of lipotoxic diabetic cardiomyopathy
    Thomas P Flagg
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA
    Circ Res 104:95-103. 2009
    ....
  12. pmc Deep RNA sequencing reveals dynamic regulation of myocardial noncoding RNAs in failing human heart and remodeling with mechanical circulatory support
    Kai Chien Yang
    Department of Developmental Biology K C Y, J M N and Center for Cardiovascular Research, Division of Cardiology, Department of Internal Medicine K A Y, A Y P, V K T, G A E, D L M, Washington University Medical School, St Louis, MO Division of Cardiothoracic Surgery, New York Presbyterian Hospital, Columbia University College of Physicians and Surgeons, New York, NY I G and Department of Surgery, University of Maryland School of Medicine, Baltimore F H C Dr Yang s current affiliation is the Department of Pharmacology, National Taiwan University School of Medicine, Taipei, Taiwan
    Circulation 129:1009-21. 2014
    ....
  13. pmc Molecular dissection of I(A) in cortical pyramidal neurons reveals three distinct components encoded by Kv4.2, Kv4.3, and Kv1.4 alpha-subunits
    Aaron J Norris
    Department of Developmental Biology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 30:5092-101. 2010
    ..4-encoded component. The experimental findings also demonstrate that the targeted deletion of the individual Kv alpha-subunits encoding components of I(A) results in electrical remodeling that is Kv alpha-subunit specific...
  14. ncbi request reprint Functional role of the fast transient outward K+ current IA in pyramidal neurons in (rat) primary visual cortex
    Weilong Yuan
    Department of Molecular Biology and Pharmacology, Washington University Medical School, St Louis, Missouri 63110, USA
    J Neurosci 25:9185-94. 2005
    ....
  15. pmc I(A) channels encoded by Kv1.4 and Kv4.2 regulate neuronal firing in the suprachiasmatic nucleus and circadian rhythms in locomotor activity
    Daniel Granados-Fuentes
    Department of Biology, School of Medicine, Washington University, St Louis, Missouri 63130 4899, USA
    J Neurosci 32:10045-52. 2012
    ..4- and Kv4.2-encoded I(A) channels regulate the intrinsic excitability of SCN neurons during the day and night and determine the period and amplitude of circadian rhythms in SCN neuron firing and locomotor behavior...
  16. pmc Kv4.3 is not required for the generation of functional Ito,f channels in adult mouse ventricles
    Noriko Niwa
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, 660 South Euclid Avenue, Box 8103, St Louis, MO 63110 1093, USA
    J Mol Cell Cardiol 44:95-104. 2008
    ..3-/- ventricles. Taken together, the results presented here suggest that, in contrast with Kv4.2, Kv4.3 is not required for the generation of functional mouse ventricular I(to,f) channels...
  17. pmc Distinct cellular and molecular mechanisms underlie functional remodeling of repolarizing K+ currents with left ventricular hypertrophy
    Celine Marionneau
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA
    Circ Res 102:1406-15. 2008
    ..Functional changes in repolarizing K(+) currents with LVH, therefore, result from distinct cellular (cardiomyocyte enlargement) and molecular (alterations in the numbers of functional channels) mechanisms...
  18. pmc Heterogeneous expression of repolarizing, voltage-gated K+ currents in adult mouse ventricles
    Sylvain Brunet
    Department of Molecular Biology and Pharmacology, Washington University Medical School, 660 South Euclid Avenue, Box 8103, St Louis, MO 63110 1093, USA
    J Physiol 559:103-20. 2004
    ....
  19. pmc MicroRNA-133a protects against myocardial fibrosis and modulates electrical repolarization without affecting hypertrophy in pressure-overloaded adult hearts
    Scot J Matkovich
    Center for Pharmacogenomics, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Circ Res 106:166-75. 2010
    ..Because miR-133a levels decrease during reactive cardiac hypertrophy, some have considered that restoring miR-133a levels could suppress hypertrophic remodeling...
  20. ncbi request reprint Differential expression of I(A) channel subunits Kv4.2 and Kv4.3 in mouse visual cortical neurons and synapses
    Andreas Burkhalter
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 26:12274-82. 2006
    ..Thus, the synapse-specific distribution of Kv4 channels functions to optimize dendritic excitation and the association between presynaptic and postsynaptic activity...
  21. ncbi request reprint Targeted deletion of Kv4.2 eliminates I(to,f) and results in electrical and molecular remodeling, with no evidence of ventricular hypertrophy or myocardial dysfunction
    Weinong Guo
    Department of Molecular Biology and Pharmacology, Washington University Medical School, St Louis, MO 63110, USA
    Circ Res 97:1342-50. 2005
    ..Taken together, these findings demonstrate not only an essential role for Kv4.2 in the generation of mouse ventricular I(to,f) channels but also that the loss of I(to,f) per se does not have overt pathophysiological consequences...
  22. ncbi request reprint KChIP2 modulates the cell surface expression of Kv 1.5-encoded K(+) channels
    Huilin Li
    Department of Molecular Biology and Pharmacology, Washington University Medical School, 660 South Euclid Avenue, Saint Louis, MO 63110, USA
    J Mol Cell Cardiol 39:121-32. 2005
    ..5-encoded) I(K,slow1) channels as well, perhaps, as other Kv1.5-encoded K(+) currents, including I(Kur) (I(K,ultrarapid)), in human atria...
  23. pmc FGF14 regulates the intrinsic excitability of cerebellar Purkinje neurons
    Vikram G Shakkottai
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neurobiol Dis 33:81-8. 2009
    ..6 expression in Purkinje neurons, and that the loss of FGF14 impairs spontaneous and repetitive firing in Purkinje neurons by altering the expression of Nav1.6 channels...
  24. ncbi request reprint Studying cardiac arrhythmias in the mouse--a reasonable model for probing mechanisms?
    Jeanne M Nerbonne
    Department of Molecular Biology and Pharmacology, Washington University Medical School, St Louis, Missouri, USA
    Trends Cardiovasc Med 14:83-93. 2004
    ..The important issue is whether the mouse is an appropriate model system to explore arrhythmia mechanisms...
  25. pmc A-type K+ channels encoded by Kv4.2, Kv4.3 and Kv1.4 differentially regulate intrinsic excitability of cortical pyramidal neurons
    Yarimar Carrasquillo
    Department of Developmental Biology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8103, St Louis, MO 63110, USA
    J Physiol 590:3877-90. 2012
    ..4-encoded IA channels do contribute to controlling resting membrane potentials, the regulation of current thresholds for action potential generation and repetitive firing rates in mature CP neurons...
  26. pmc Electrical remodelling maintains firing properties in cortical pyramidal neurons lacking KCND2-encoded A-type K+ currents
    Jeanne M Nerbonne
    Department of Molecular Biology and Pharmacology, Box 8103, Washington University Medical School, 660 South Euclid Avenue, St Louis, MO 63110 1093, USA
    J Physiol 586:1565-79. 2008
    ..Repetitive firing is also maintained in Kv4.2-/- cortical pyramidal neurons, suggesting that the increased densities of I(K) and I(ss) compensate for the in vivo loss of I(A)...
  27. pmc Co-assembly of Kv4 {alpha} subunits with K+ channel-interacting protein 2 stabilizes protein expression and promotes surface retention of channel complexes
    Nicholas C Foeger
    Department of Developmental Biology, Washington University Medical School, St Louis, Missouri 63110, USA
    J Biol Chem 285:33413-22. 2010
    ..2 N terminus. Taken together, these observations demonstrate that KChIP2 differentially regulates total and cell surface Kv4.2 protein expression and Kv4 current densities...
  28. pmc Augmentation of Kv4.2-encoded currents by accessory dipeptidyl peptidase 6 and 10 subunits reflects selective cell surface Kv4.2 protein stabilization
    Nicholas C Foeger
    Department of Developmental Biology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 287:9640-50. 2012
    ..2...
  29. pmc FGF14 localization and organization of the axon initial segment
    Maolei Xiao
    Department of Developmental Biology, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Cell Neurosci 56:393-403. 2013
    ..1 and Nav1.6 α subunits are modestly, but significantly (p<0.005), reduced within sub-domains of the AIS, changes that may contribute to the reduced excitability of Fgf14(-/-) Purkinje neurons...
  30. pmc Exercise training and PI3Kα-induced electrical remodeling is independent of cellular hypertrophy and Akt signaling
    Kai Chien Yang
    Department of Developmental Biology, Washington University Medical School, St Louis, MO 63110 1093, USA
    J Mol Cell Cardiol 53:532-41. 2012
    ....
  31. pmc CD36 protein influences myocardial Ca2+ homeostasis and phospholipid metabolism: conduction anomalies in CD36-deficient mice during fasting
    Terri A Pietka
    Center for Human Nutrition, Washington University, St Louis, Missouri 63110, USA
    J Biol Chem 287:38901-12. 2012
    ..Potential relevance of the findings to CD36-deficient humans would need to be determined...
  32. pmc Combined deep microRNA and mRNA sequencing identifies protective transcriptomal signature of enhanced PI3Kα signaling in cardiac hypertrophy
    Kai Chien Yang
    Department of Developmental Biology, Washington University Medical School, St Louis, MO 63110 1093, USA
    J Mol Cell Cardiol 53:101-12. 2012
    ....
  33. ncbi request reprint Delayed rectifier K+ currents, IK, are encoded by Kv2 alpha-subunits and regulate tonic firing in mammalian sympathetic neurons
    Sacha A Malin
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 22:10094-105. 2002
    ..Expression of Kv2.2DN also results in membrane depolarization, suggesting that Kv2.1- and Kv2.2-encoded I(K) channels play distinct roles in regulating the excitability of SCG neurons...
  34. ncbi request reprint Selective elimination of I(K,slow1) in mouse ventricular myocytes expressing a dominant negative Kv1.5alpha subunit
    Huilin Li
    Department of Molecular Biology and Pharmacology, Washington University Medical School, 660 S Euclid Ave, St Louis, MO 63110, USA
    Am J Physiol Heart Circ Physiol 286:H319-28. 2004
    ..1 transgene; however, no electrical remodeling is evident in Kv1.5DN-expressing ventricular myocytes, and the (Kv1.5DN-induced) elimination of IK,slow1 does not result in spontaneous ventricular arrhythmias...
  35. pmc Distinct balance of excitation and inhibition in an interareal feedforward and feedback circuit of mouse visual cortex
    Weiguo Yang
    Department of Anatomy and Neurobiology and Department of Developmental Biology, Washington University School of Medicine, St Louis, Missouri 63110, and Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia 20147
    J Neurosci 33:17373-84. 2013
    ..The findings indicate that FFI in FF(V1→LM) and FB(LM→V1) circuits are organized in a pathway- and lamina-specific fashion...
  36. pmc Enhanced cardiac PI3Kα signalling mitigates arrhythmogenic electrical remodelling in pathological hypertrophy and heart failure
    Kai Chien Yang
    Department of Developmental Biology, Washington University Medical School, 660 South Euclid Avenue Box 8103, St Louis, MO 63110 1093, USA
    Cardiovasc Res 93:252-62. 2012
    ..The experiments here were undertaken to test the hypothesis that increased PI3Kα signalling will counteract the adverse electrophysiological remodelling associated with pathological hypertrophy and heart failure...
  37. ncbi request reprint Modulation of Kv4-encoded K(+) currents in the mammalian myocardium by neuronal calcium sensor-1
    Weinong Guo
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 277:26436-43. 2002
    ..Taken together, these results suggest that NCS-1 is an accessory subunit of Kv4-encoded I(to,f) channels that functions to regulate I(to,f) density in the mammalian myocardium...
  38. pmc Neuronal voltage-gated K+ (Kv) channels function in macromolecular complexes
    Aaron J Norris
    Department of Developmental Biology, Washington University School of Medicine, Campus Box 8103, 660 South Euclid Avenue, St Louis, MO 63110, United States
    Neurosci Lett 486:73-7. 2010
    ..With the increasing association of altered Kv channel functioning with neurological disorders, the potential impact of these efforts is clear...
  39. ncbi request reprint Role of heteromultimers in the generation of myocardial transient outward K+ currents
    Weinong Guo
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA
    Circ Res 90:586-93. 2002
    ..2/Kv4.3 alpha subunits and KChIP2. The results here also suggest that Kv4.2 is the primary determinant of the regional heterogeneity in I(to,f) expression in adult mouse ventricle...
  40. pmc Homeostatic regulation of electrical excitability in physiological cardiac hypertrophy
    Kai Chien Yang
    Department of Developmental Biology, Washington University Medical School, St Louis, MO 63110 1093, USA
    J Physiol 588:5015-32. 2010
    ....
  41. pmc IA Channels Encoded by Kv1.4 and Kv4.2 Regulate Circadian Period of PER2 Expression in the Suprachiasmatic Nucleus
    Daniel Granados-Fuentes
    Department of Biology, Washington University, St Louis, MO, USA
    J Biol Rhythms 30:396-407. 2015
    ..4- and Kv4.2-encoded IA channels in controlling the light-dependent responses of neurons within and/or outside of the SCN to regulate circadian phase of daily activity. ..
  42. pmc Stabilization of Kv4 protein by the accessory K(+) channel interacting protein 2 (KChIP2) subunit is required for the generation of native myocardial fast transient outward K(+) currents
    Nicholas C Foeger
    J M Nerbonne Department of Developmental Biology, Washington University School of Medicine, Campus Box 8103, 660 South Euclid Avenue, St Louis, MO 63110, USA
    J Physiol 591:4149-66. 2013
    ..Taken together, these results demonstrate that association with KChIP2 early in the biosynthetic pathway and KChIP2-mediated stabilization of Kv4 protein are critical determinants of native cardiac Ito,f channel expression...
  43. pmc Molecular determinants of cardiac transient outward potassium current (I(to)) expression and regulation
    Noriko Niwa
    Department of Developmental Biology, Washington University School of Medicine, 660 South Euclid Avenue, Box 8103, St Louis, MO 63110 1093, USA
    J Mol Cell Cardiol 48:12-25. 2010
    ....
  44. ncbi request reprint Differential depression of inhibitory synaptic responses in feedforward and feedback circuits between different areas of mouse visual cortex
    Hongwei Dong
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Comp Neurol 475:361-73. 2004
    ..This property was shown to be critically important in cortical circuits that modulate the gain of pyramidal cell firing (Chance et al. [2002] Neuron 35:773-782)...
  45. ncbi request reprint Molecular physiology of cardiac repolarization
    Jeanne M Nerbonne
    Dept of Molecular Biology and Pharmacology, Washington University Medical School, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Physiol Rev 85:1205-53. 2005
    ....
  46. pmc Proteomic analysis of native cerebellar iFGF14 complexes
    Marie K Bosch
    a Department of Developmental Biology, Washington University School of Medicine, St Louis, MO, USA
    Channels (Austin) 10:297-312. 2016
    ..Western blot and MS analyses revealed that the loss of iFGF14 does not measurably affect the protein composition or the relative abundance of Nav channel interacting proteins in native adult mouse cerebellar Nav channel complexes. ..
  47. pmc ER71 specifies Flk-1+ hemangiogenic mesoderm by inhibiting cardiac mesoderm and Wnt signaling
    Fang Liu
    Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Blood 119:3295-305. 2012
    ..We provide the molecular basis for the antagonistic relationship between hemangiogenic and cardiogenic mesoderm specification by ER71 and Wnt signaling...
  48. pmc Fibroblast growth factor 14 is an intracellular modulator of voltage-gated sodium channels
    Jun Yang Lou
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, Saint Louis, MO 63110, USA
    J Physiol 569:179-93. 2005
    ..Together, these findings implicate FGF14 as a unique modulator of Nav channel activity in the CNS and provide a possible mechanism to explain the neurological phenotypes observed in mice and humans with mutations in Fgf14...
  49. pmc Proteomic analyses of native brain K(V)4.2 channel complexes
    Celine Marionneau
    Department of Developmental Biology, Washington University, St Louis, MO, USA
    Channels (Austin) 3:284-94. 2009
    ..2 channel complexes. Additional biochemical and functional approaches will be required to elucidate the physiological roles of these newly identified K(V)4 interacting proteins...
  50. pmc A critical role for PPARalpha-mediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy: modulation by dietary fat content
    Brian N Finck
    Department of Medicine, Center for Cardiovascular Research, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 100:1226-31. 2003
    ..These results link dysregulation of the PPARalpha gene regulatory pathway to cardiac dysfunction in the diabetic and provide a rationale for serum lipid-lowering strategies in the treatment of diabetic cardiomyopathy...
  51. pmc Mesp1 coordinately regulates cardiovascular fate restriction and epithelial-mesenchymal transition in differentiating ESCs
    R Coleman Lindsley
    Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Cell Stem Cell 3:55-68. 2008
    ..Thus, in addition to its effects on EMT, Mesp1 may be capable of generating the recently identified multipotent cardiovascular progenitor from ESCs in vitro...
  52. pmc How to build an integrated biobank: the Washington University Translational Cardiovascular Biobank & Repository experience
    Kathryn A Yamada
    Cardiovascular Division, Department of Medicine, Washington University School of Medicine, St Louis, MO, USA
    Clin Transl Sci 6:226-31. 2013
    ..Labor and capital investments into growing biobanking resources will facilitate collaborative efforts aimed at limiting morbidity and mortality due to heart disease and improving overall cardiovascular health...
  53. pmc Mitofusin 2-containing mitochondrial-reticular microdomains direct rapid cardiomyocyte bioenergetic responses via interorganelle Ca(2+) crosstalk
    Yun Chen
    Center for Pharmacogenomics, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Circ Res 111:863-75. 2012
    ..Mitofusin (Mfn) 1 and 2 mediate mitochondrial outer membrane fusion, whereas Mfn2 but not Mfn1 tethers endoplasmic reticulum to mitochondria in noncardiac cells...
  54. ncbi request reprint Mechanisms linking short- and long-term electrical remodeling in the heart...is it a stretch?
    Scott B Marrus
    Department of Internal Medicine, Washington University Medical School, Saint Louis, Missouri, USA
    Channels (Austin) 2:117-24. 2008
    ..With time, altered gene transcription and protein synthesis lead to persistent changes in ion channel levels and activities, changes that can significantly impact normal cardiac function and increase arrhythmia susceptibility...
  55. pmc Notch-Mediated Epigenetic Regulation of Voltage-Gated Potassium Currents
    Aditi Khandekar
    From the Cardiovascular Division, Department of Medicine A K, S S, W W, S H, C W, J M N, S R and Department of Developmental Biology J M N, S R, Washington University School of Medicine, St Louis, MO and Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA R D T
    Circ Res 119:1324-1338. 2016
    ..Notch activation reprograms cardiac myocytes to an induced Purkinje-like state characterized by prolonged action potential duration and expression of Purkinje-enriched genes...
  56. doi request reprint Early remodeling of repolarizing K+ currents in the αMHC403/+ mouse model of familial hypertrophic cardiomyopathy
    Rocco Hueneke
    Department of Developmental Biology, Washington University Medical School, St Louis, MO 63110 1093, USA Department of Anesthesiology, Washington University Medical School, St Louis, MO 63110 1093, USA
    J Mol Cell Cardiol . 2017
    ....
  57. doi request reprint IA channels: diverse regulatory mechanisms
    Yarimar Carrasquillo
    1Department of Developmental Biology, Washington University School of Medicine, St Louis, MO, USA
    Neuroscientist 20:104-11. 2014
    ..Here, we review the diverse molecular mechanisms that have been shown or proposed to underlie the functional diversity of native neuronal IA channels. ..
  58. ncbi request reprint Regional upregulation of Kv2.1-encoded current, IK,slow2, in Kv1DN mice is abolished by crossbreeding with Kv2DN mice
    Jun Zhou
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Physiol Heart Circ Physiol 284:H491-500. 2003
    ..1 polypeptide (Kv2DN) eliminated I(K,slow2). In summary, our data indicate that the spatially restrictive upregulation of Kv2.1-encoded currents underlies the increased dispersion of the repolarization observed in Kv1DN mice...
  59. ncbi request reprint Microarray analysis reveals complex remodeling of cardiac ion channel expression with altered thyroid status: relation to cellular and integrated electrophysiology
    Sabrina Le Bouter
    INSERM U533, Physiopathologie et Pharmacologie Cellulaires et Moléculaires, Faculte de Medecine, Nantes, France
    Circ Res 92:234-42. 2003
    ..Our results also document the potential of cDNA microarray analysis for the simultaneous examination of ion channel transcript expression levels in the diseased/remodeled myocardium...
  60. ncbi request reprint Attenuation of I(K,slow1) and I(K,slow2) in Kv1/Kv2DN mice prolongs APD and QT intervals but does not suppress spontaneous or inducible arrhythmias
    Sodikdjon A Kodirov
    Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
    Am J Physiol Heart Circ Physiol 286:H368-74. 2004
    ..However, attenuation of Kv2.1-encoded currents in Kv1DN mice did not suppress the arrhythmias. Thus, the elimination of I(K,slow2) prolongs APD and the QT intervals, but does not have an antiarrhythmic effect...
  61. pmc Concordant expression of KChIP2 mRNA, protein and transient outward current throughout the canine ventricle
    Barbara Rosati
    Department of Physiology and Biophysics, Institute of Molecular Cardiology, State University of New York at Stony Brook, NY 11794, USA
    J Physiol 548:815-22. 2003
    ..It is concluded that transcriptional regulation of the KChIP2 gene is a primary determinant of Ito expression in heart...
  62. ncbi request reprint The perplexing complexity of cardiac arrhythmias: beyond electrical remodeling
    Philip B Adamson
    University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
    Heart Rhythm 2:650-9. 2005
    ..Approaches are recommended for future investigations focused on providing new mechanistic insights and therapeutic interventions...
  63. ncbi request reprint Calmodulin kinase II inhibition shortens action potential duration by upregulation of K+ currents
    Jingdong Li
    Department of Internal Medicine, University of Iowa, Carver College of Medicine, Iowa City, USA
    Circ Res 99:1092-9. 2006
    ..These findings provide novel in vivo and cellular evidence that CaMKII links Ca(2+)(i) to cardiac repolarization and suggest that PLN may be a critical CaMKII target for feedback regulation of APD in ventricular myocytes...
  64. pmc Dispersion of repolarization and refractoriness are determinants of arrhythmia phenotype in transgenic mice with long QT
    Barry London
    University of Pittsburgh, Cardiovascular Institute, Pittsburgh, PA 15213, USA
    J Physiol 578:115-29. 2007
    ..2DN mice. Thus, dispersion of repolarization (DR) appears to be an important determinant of arrhythmia vulnerability...
  65. pmc Mediation of neuronal apoptosis by Kv2.1-encoded potassium channels
    Sumon Pal
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 23:4798-802. 2003
    ..1. These results suggest that Kv2.1-encoded K+ channels are necessary for the apoptotic signaling cascade in mammalian cortical neurons in culture and are sufficient for increasing the susceptibility to apoptogens in a nonexcitable cell...
  66. ncbi request reprint Validation of a model for predicting drug-induced torsades de pointes: the risky business of assessing arrhythmogenic potential
    Kathryn A Yamada
    Heart Rhythm 3:957-8. 2006
  67. ncbi request reprint Inherited arrhythmias: a National Heart, Lung, and Blood Institute and Office of Rare Diseases workshop consensus report about the diagnosis, phenotyping, molecular mechanisms, and therapeutic approaches for primary cardiomyopathies of gene mutations affe
    Stephan E Lehnart
    Department of Physiology and Cellular Biophysics, Clyde and Helen Wu Center for Molecular Cardiology, College of Physicians and Surgeons of Columbia University, P and S 9 401 box 22, 630 W 168 St, New York, NY 10032, USA
    Circulation 116:2325-45. 2007
    ....
  68. ncbi request reprint Calmodulin kinase II inhibition enhances ischemic preconditioning by augmenting ATP-sensitive K+ current
    Jingdong Li
    Departments of Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242 1081, USA
    Channels (Austin) 1:387-94. 2007
    ..Our study results show CaMKII inhibition enhances beneficial effects of IP by increasing I(KATP)...