Joan L Luby

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi ThePreschool Feelings Checklist: a brief and sensitive screening measure for depression in young children
    Joan L Luby
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110
    J Am Acad Child Adolesc Psychiatry 43:708-17. 2004
  2. pmc Preschool depression: homotypic continuity and course over 24 months
    Joan L Luby
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Arch Gen Psychiatry 66:897-905. 2009
  3. pmc Structural-functional correlations between hippocampal volume and cortico-limbic emotional responses in depressed children
    Hideo Suzuki
    Department of Psychiatry, Washington University School of Medicine, Saint Louis, MO 63110, USA
    Cogn Affect Behav Neurosci 13:135-51. 2013
  4. pmc The clinical significance of preschool depression: impairment in functioning and clinical markers of the disorder
    Joan L Luby
    Washington University School of Medicine, Department of Psychiatry, Box 8134, 660 S Euclid, St Louis, MO 63110, United States
    J Affect Disord 112:111-9. 2009
  5. ncbi Characteristics of depressed preschoolers with and without anhedonia: evidence for a melancholic depressive subtype in young children
    Joan L Luby
    Department of Psychiatry, Washington University School of Medicine, 660 S Euclid Ave, Box 8134, St Louis, MO 63110, USA
    Am J Psychiatry 161:1998-2004. 2004
  6. pmc Clinical characteristics of bipolar vs. unipolar depression in preschool children: an empirical investigation
    Joan L Luby
    Washington University School of Medicine, Department of Psychiatry, 660 S Euclid Ave, Box 1834, St Louis, MO 63110, USA
    J Clin Psychiatry 69:1960-9. 2008
  7. ncbi Modification of DSM-IV criteria for depressed preschool children
    Joan L Luby
    Department of Psychiatry, Washington University School of Medicine, AMO 63110, USA
    Am J Psychiatry 160:1169-72. 2003
  8. ncbi Risk factors for preschool depression: the mediating role of early stressful life events
    Joan L Luby
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Child Psychol Psychiatry 47:1292-8. 2006
  9. ncbi Alterations in stress cortisol reactivity in depressed preschoolers relative to psychiatric and no-disorder comparison groups
    Joan L Luby
    Washington University School of Medicine, Department of Psychiatry, St Louis, MO 63110, USA
    Arch Gen Psychiatry 60:1248-55. 2003
  10. pmc Early childhood depression
    Joan L Luby
    Department of Psychiatry, Washington University School of Medicine, 660 S Euclid, Box 8134, St Louis, MO 63110, USA
    Am J Psychiatry 166:974-9. 2009

Detail Information

Publications51

  1. ncbi ThePreschool Feelings Checklist: a brief and sensitive screening measure for depression in young children
    Joan L Luby
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110
    J Am Acad Child Adolesc Psychiatry 43:708-17. 2004
    ..Based on the need for the earliest possible identification of depression, the development of a brief screening measure to capture young children with markers of depression from these community settings was developed and tested...
  2. pmc Preschool depression: homotypic continuity and course over 24 months
    Joan L Luby
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Arch Gen Psychiatry 66:897-905. 2009
    ....
  3. pmc Structural-functional correlations between hippocampal volume and cortico-limbic emotional responses in depressed children
    Hideo Suzuki
    Department of Psychiatry, Washington University School of Medicine, Saint Louis, MO 63110, USA
    Cogn Affect Behav Neurosci 13:135-51. 2013
    ..These findings suggest that there may be important interrelationships between reduced hippocampal volume and hyperactivation of brain responses in children, both those with and those without a history of PO-MDD...
  4. pmc The clinical significance of preschool depression: impairment in functioning and clinical markers of the disorder
    Joan L Luby
    Washington University School of Medicine, Department of Psychiatry, Box 8134, 660 S Euclid, St Louis, MO 63110, United States
    J Affect Disord 112:111-9. 2009
    ..other disorders, as well as depression severity between two depressed sub-groups and other diagnostic comparison groups...
  5. ncbi Characteristics of depressed preschoolers with and without anhedonia: evidence for a melancholic depressive subtype in young children
    Joan L Luby
    Department of Psychiatry, Washington University School of Medicine, 660 S Euclid Ave, Box 8134, St Louis, MO 63110, USA
    Am J Psychiatry 161:1998-2004. 2004
    ..This study investigated whether a melancholic subtype similar to that established in depressed adults can be identified in depressed preschool children...
  6. pmc Clinical characteristics of bipolar vs. unipolar depression in preschool children: an empirical investigation
    Joan L Luby
    Washington University School of Medicine, Department of Psychiatry, 660 S Euclid Ave, Box 1834, St Louis, MO 63110, USA
    J Clin Psychiatry 69:1960-9. 2008
    ..An investigation of the characteristics of depression among putative bipolar preschoolers may inform the controversial nosologic questions that surround the diagnosis in this young age group...
  7. ncbi Modification of DSM-IV criteria for depressed preschool children
    Joan L Luby
    Department of Psychiatry, Washington University School of Medicine, AMO 63110, USA
    Am J Psychiatry 160:1169-72. 2003
    ..This study compared the severity of depression in preschoolers diagnosed by standard versus modified DSM-IV criteria for major depression...
  8. ncbi Risk factors for preschool depression: the mediating role of early stressful life events
    Joan L Luby
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Child Psychol Psychiatry 47:1292-8. 2006
    ..The current study used regression analyses to examine the relationships between family history of mood disorders and stressful life events as risk factors for depression in a preschool sample...
  9. ncbi Alterations in stress cortisol reactivity in depressed preschoolers relative to psychiatric and no-disorder comparison groups
    Joan L Luby
    Washington University School of Medicine, Department of Psychiatry, St Louis, MO 63110, USA
    Arch Gen Psychiatry 60:1248-55. 2003
    ..The current study is, to our knowledge, the first investigation of HPA axis reactivity in very young children with a clinical depressive syndrome for which content validity has been established...
  10. pmc Early childhood depression
    Joan L Luby
    Department of Psychiatry, Washington University School of Medicine, 660 S Euclid, Box 8134, St Louis, MO 63110, USA
    Am J Psychiatry 166:974-9. 2009
    ..It also clarifies parameters for the rare situations in which antidepressants may be tried when psychotherapeutic options fail and depression is severe and impairing...
  11. pmc Gender differences in emotional reactivity of depressed and at-risk preschoolers: implications for gender specific manifestations of preschool depression
    Joan L Luby
    Department of Psychiatry, Washington University, St Louis, St Louis, MO 63110, USA
    J Clin Child Adolesc Psychol 38:525-37. 2009
    ..This finding was detected in depressed and "at risk for internalizing" boys who were not comorbid for externalizing problems...
  12. pmc Functional brain activation to emotionally valenced faces in school-aged children with a history of preschool-onset major depression
    Deanna M Barch
    Department of Psychiatry, Washington University School of Medicine, Saint Louis, MO, USA
    Biol Psychiatry 72:1035-42. 2012
    ..Recent research has demonstrated that clinical depression can emerge as early as the preschool period. Here, we examine brain function in children with a history of preschool-onset depression (PO-MDD) in comparison with healthy children...
  13. pmc Preschool bipolar disorder
    Joan L Luby
    Department of Psychiatry, Washington University School of Medicine in St Louis, 660 S Euclid, St Louis, MO 63110, USA
    Child Adolesc Psychiatr Clin N Am 18:391-403, ix. 2009
    ..Data elucidating this developmental trajectory could then inform the design of earlier potentially preventive interventions that may have implications for the disorder across the lifespan...
  14. pmc Disrupted amygdala reactivity in depressed 4- to 6-year-old children
    Michael S Gaffrey
    Washington University, School of Medicine, Department of Psychiatry, St Louis, MO 63110, USA
    J Am Acad Child Adolesc Psychiatry 52:737-46. 2013
    ..The current study addressed this question by examining functional brain activity and its relationships to emotion regulation in depressed 4- to 6-year-old children and their healthy peers...
  15. pmc Temper tantrums in healthy versus depressed and disruptive preschoolers: defining tantrum behaviors associated with clinical problems
    Andy C Belden
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Pediatr 152:117-22. 2008
    ..To investigate whether differences in the tantrum behaviors of healthy versus mood and disruptive disordered preschoolers can be detected...
  16. pmc Depressed and healthy preschoolers' internal representations of their mothers' caregiving: associations with observed caregiving behaviors one year later
    Andy C Belden
    Washington University School of Medicine, Department of Psychiatry, St Louis, MO 63110, USA
    Attach Hum Dev 9:239-54. 2007
    ..Results suggest that the MSSB may be a useful child-informant method for interpreting depressed children's internalization of caregiving relationships...
  17. pmc The 2-week duration criterion and severity and course of early childhood depression: implications for nosology
    Michael S Gaffrey
    Washington University School of Medicine, Department of Psychiatry, Saint Louis, Missouri 63110, USA
    J Affect Disord 133:537-45. 2011
    ..The current study aimed to begin addressing this question...
  18. ncbi An observational analysis of behavior in depressed preschoolers: further validation of early-onset depression
    Joan L Luby
    Department of Psychiatry, Washington University in St Louis School of Medicine, 660 S Euclid Avenue, Campus Box 8134, St Louis, MO 63110, USA
    J Am Acad Child Adolesc Psychiatry 45:203-12. 2006
    ..Support for the validity of preschool depression is now available; however, objective evidence of negative behaviors among depressed preschoolers is needed...
  19. pmc Early Childhood Depression and Alterations in the Trajectory of Gray Matter Maturation in Middle Childhood and Early Adolescence
    Joan L Luby
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri
    JAMA Psychiatry 73:31-8. 2016
    ..Synaptic pruning-based volume decline has been related to experience-dependent plasticity in animals. To date, there have been no data to inform whether and how childhood depression might be associated with this trajectory...
  20. pmc Association between depression severity and amygdala reactivity during sad face viewing in depressed preschoolers: an fMRI study
    Michael S Gaffrey
    Washington University School of Medicine, Department of Psychiatry, Saint Louis, MO 63110, United States
    J Affect Disord 129:364-70. 2011
    ..Previous research has indicated that symptom severity and amygdala reactivity during the viewing of facial expressions of emotion are related in depression. However, it remains unclear how early in development this can be detected...
  21. pmc Pediatric bipolar disorder: evidence for prodromal states and early markers
    Joan L Luby
    Washington University School of Medicine, St Louis, MO 63110, USA
    J Child Psychol Psychiatry 51:459-71. 2010
    ..Therefore, the search for prodromes or early markers of risk for later childhood bipolar disorder may be of great importance for prevention and/or early identification...
  22. ncbi The clinical picture of depression in preschool children
    Joan L Luby
    Washington University School of Medicine, Department of Psychiatry, St Louis, MO 63110, USA
    J Am Acad Child Adolesc Psychiatry 42:340-8. 2003
    ..To investigate the clinical characteristics of depression in preschool children...
  23. ncbi Preschoolers' contribution to their diagnosis of depression and anxiety: uses and limitations of young child self-report of symptoms
    Joan L Luby
    Department of Psychiatry, Washington University School of Medicine, 660 S Euclid, Campus Box 8134, St Louis, MO 63110, USA
    Child Psychiatry Hum Dev 38:321-38. 2007
    ..Based on the finding of a valid preschool depressive syndrome, methods to obtain self-report of symptoms of depression and related anxiety directly from the child are now needed...
  24. ncbi Psychotropic prescriptions in a sample including both healthy and mood and disruptive disordered preschoolers: relationships to diagnosis, impairment, prescriber type, and assessment methods
    Joan L Luby
    Washington University School of Medicine, Department of Psychiatry, St Louis, Missouri 63108, USA
    J Child Adolesc Psychopharmacol 17:205-15. 2007
    ....
  25. pmc Preschool is a sensitive period for the influence of maternal support on the trajectory of hippocampal development
    Joan L Luby
    Department of Psychiatry, Washington University in St Louis, St Louis, MO 63110
    Proc Natl Acad Sci U S A 113:5742-7. 2016
    ..They also show that this growth trajectory is associated with later emotion functioning...
  26. pmc Anterior insula volume and guilt: neurobehavioral markers of recurrence after early childhood major depressive disorder
    Andy C Belden
    Department of Psychiatry, Washington University in St Louis, St Louis, Missouri
    JAMA Psychiatry 72:40-8. 2015
    ..This is the first study to date to examine volumetric alterations in the anterior insula (AI) as a potential biomarker for the course of childhood major depressive disorder (MDD)...
  27. pmc Default mode network connectivity in children with a history of preschool onset depression
    Michael S Gaffrey
    Department of Psychiatry, Washington University in St Louis, Saint Louis, MO 63110, USA
    J Child Psychol Psychiatry 53:964-72. 2012
    ..The current case-control study examined the DMN in a unique prospective sample of school-age children with a previous history of preschool depression...
  28. pmc Towards the study of functional brain development in depression: an Interactive Specialization approach
    Michael S Gaffrey
    Department of Psychiatry, Washington University School of Medicine, Saint Louis, MO, USA
    Neurobiol Dis 52:38-48. 2013
    ..Future directions including longitudinal neuroimaging studies of early onset depression and groups at risk for this disorder are proposed...
  29. pmc Maternal support in early childhood predicts larger hippocampal volumes at school age
    Joan L Luby
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 109:2854-9. 2012
    ..These findings provide prospective evidence in humans of the positive effect of early supportive parenting on healthy hippocampal development, a brain region key to memory and stress modulation...
  30. ncbi Preschool depression
    Melissa Meade Stalets
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8134, St Louis, MO 63110, USA
    Child Adolesc Psychiatr Clin N Am 15:899-917, viii-ix. 2006
    ..This article reviews the relatively new body of evidence supporting the validity of preschool depression...
  31. pmc Subgenual cingulate connectivity in children with a history of preschool-depression
    Michael S Gaffrey
    Departments of Psychiatry, Washington University, St Louis, Missouri, USA
    Neuroreport 21:1182-8. 2010
    ..These findings demonstrate that atypical sgACC functional connections are evident as early as school age in children with a history of PO-MDD and suggest an association with a very early episode of depression...
  32. pmc Functional connectivity of the amygdala and subgenual cingulate during cognitive reappraisal of emotions in children with MDD history is associated with rumination
    Eric R Murphy
    Department of Psychiatry, Washington University in St Louis, 660 South Euclid Avenue, St Louis, MO 63110, USA Electronic address
    Dev Cogn Neurosci 18:89-100. 2016
    ..These differences in rumination may provide important insight into depressive risk and potential avenues for treatment. ..
  33. pmc Early Adversity, Psychopathology, and Latent Class Profiles of Global Physical Health From Preschool Through Early Adolescence
    Diana J Whalen
    From the Department of Psychiatry Whalen, Belden, Tillman, BArch, Luby, The Program in Neuroscience Barch, Department of Psychology Barch, and Department of Radiology Barch, Washington University School of Medicine, St Louis, Missouri
    Psychosom Med 78:1008-1018. 2016
    ....
  34. pmc Stimulus-Driven Attention, Threat Bias, and Sad Bias in Youth with a History of an Anxiety Disorder or Depression
    Chad M Sylvester
    Department of Psychiatry, Washington University School of Medicine, 4444 Forest Park Avenue, Campus Box 8511, St Louis, MO, 63110, USA
    J Abnorm Child Psychol 44:219-31. 2016
    ..These results inform the design of attention bias modification programs that aim to reverse threat biases and reduce symptoms associated with pediatric anxiety and depression...
  35. pmc Altered gray matter volume and school age anxiety in children born late preterm
    Cynthia E Rogers
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO Department of Pediatrics, Washington University School of Medicine, St Louis, Mo Electronic address
    J Pediatr 165:928-35. 2014
    ..To determine if late preterm (LP) children differ from full term (FT) children in volumes of the cortex, hippocampus, corpus callosum, or amygdala and whether these differences are associated with anxiety symptoms at school-age...
  36. pmc Blunted stress cortisol reactivity and failure to acclimate to familiar stress in depressed and sub-syndromal children
    Hideo Suzuki
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA Electronic address
    Psychiatry Res 210:575-83. 2013
    ..These results suggest that the hypothalamic-pituitary-adrenal (HPA) axis shows a blunted response to stress and failed to acclimate to familiar stressful situations in depressed and sub-syndromal depressed children. ..
  37. ncbi Preschoolers' depression severity and behaviors during dyadic interactions: the mediating role of parental support
    Andy C Belden
    Department of Psychiatry, Washington University in St Louis School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    J Am Acad Child Adolesc Psychiatry 45:213-22. 2006
    ..To investigate the relationship between preschool depression severity, observed behavior, and parental emotional support in a population of 3.0- to 5.6-year-olds and their mothers...
  38. ncbi Depressed preschoolers with bipolar family history: a group at high risk for later switching to mania?
    Joan L Luby
    Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Child Adolesc Psychopharmacol 13:187-97. 2003
    ..Future studies that directly investigate age-appropriate mania manifestations in preschool samples are now warranted...
  39. pmc Latent class profiles of depressive symptoms from early to middle childhood: predictors, outcomes, and gender effects
    Diana J Whalen
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA
    J Child Psychol Psychiatry 57:794-804. 2016
    ..Further, the extant literature in this domain has been limited by the use of parent report checklists of nonspecific 'internalizing' psychopathology rather than diagnostic interviews for depression...
  40. pmc Amygdala reactivity to sad faces in preschool children: An early neural marker of persistent negative affect
    Michael S Gaffrey
    Washington University in St Louis, Department of Psychiatry, Campus Box 8511, 660 South Euclid Avenue, Saint Louis, MO 63110, United States Electronic address
    Dev Cogn Neurosci 17:94-100. 2016
    ..The current study examined the relationship between amygdala activity and negative affect measured concurrently and approximately 12 months later in preschool-age children...
  41. pmc Neural activation associated with the cognitive emotion regulation of sadness in healthy children
    Andy C Belden
    Department of Psychiatry, Washington University in St Louis, 660 S Euclid Avenue, St Louis, MO 63110, USA Electronic address
    Dev Cogn Neurosci 9:136-47. 2014
    ....
  42. pmc Serotonin transporter-linked polymorphic region (5-HTTLPR) genotype and stressful life events interact to predict preschool-onset depression: a replication and developmental extension
    Ryan Bogdan
    Department of Psychology, Washington University in St Louis, St Louis, MO, USA Department of Psychiatry, Washington University in St Louis, St Louis, MO, USA
    J Child Psychol Psychiatry 55:448-57. 2014
    ....
  43. pmc Treatment of anxiety and depression in the preschool period
    Joan L Luby
    Washington University School of Medicine, Department of Psychiatry Child, St Louis, MO 63110, USA
    J Am Acad Child Adolesc Psychiatry 52:346-58. 2013
    ..0 years. Because empirical studies validating and characterizing these disorders in preschoolers are relatively recent, less work has been done on the development and testing of age-appropriate treatments...
  44. pmc A randomized controlled trial of risperidone, lithium, or divalproex sodium for initial treatment of bipolar I disorder, manic or mixed phase, in children and adolescents
    Barbara Geller
    Department of Psychiatry, Washington University in St Louis, 660 S Euclid, St Louis, MO 63110, USA
    Arch Gen Psychiatry 69:515-28. 2012
    ..There was a paucity of comparative pharmacological research for initial treatment of bipolar I disorder, manic or mixed phase, in children and adolescents...
  45. ncbi Differential performance of the macarthur HBQ and DISC-IV in identifying DSM-IV internalizing psychopathology in young children
    Joan L Luby
    Washington University School of Medicine, St Louis, MO 63110, USA
    J Am Acad Child Adolesc Psychiatry 41:458-66. 2002
    ....
  46. pmc Depression and social functioning in preschool children with chronic medical conditions
    Carmen E Curtis
    Washington University School of Medicine, St Louis, MO, USA
    J Pediatr 153:408-13. 2008
    ..To investigate the relations among depressive symptoms, social behavior, and chronic medical illness in preschool children...
  47. ncbi Preschool major depressive disorder: preliminary validation for developmentally modified DSM-IV criteria
    Joan L Luby
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    J Am Acad Child Adolesc Psychiatry 41:928-37. 2002
    ..To investigate the validity of developmentally modified DSM-IV criteria for preschool major depressive disorder (MDD)...
  48. doi Disruptive behavior in preschool children: distinguishing normal misbehavior from markers of current and later childhood conduct disorder
    Ji S Hong
    Department of Psychiatry, Washington University School of Medicine, St Louis, Mo Electronic address
    J Pediatr 166:723-30.e1. 2015
    ..To investigate which disruptive behaviors in preschool were normative and transient vs markers of conduct disorder, as well as which disruptive behaviors predicted the persistence of conduct disorder into school age...
  49. ncbi Psychopharmacology of psychiatric disorders in the preschool period
    Joan L Luby
    J Child Adolesc Psychopharmacol 17:149-51. 2007
  50. ncbi Psychopharmacological treatment for very young children: contexts and guidelines
    Mary Margaret Gleason
    Bradley Hasbro Research Center, Providence, RI 02903, USA
    J Am Acad Child Adolesc Psychiatry 46:1532-72. 2007
    ..The purpose of this effort is to promote responsible treatment of young children, recognizing that this will sometimes involve the use of medications...
  51. ncbi Adaptive strategies for treating childhood mania
    Ree Dawson
    Frontier Science Technology and Research Foundation, Boston, Massachusetts 02215, USA
    Biol Psychiatry 61:758-64. 2007
    ..Our exposition is developed in the specific clinical context of childhood mania to maximize accessibility of the ideas but applies more generally to other chronic mental and physical health disorders that are difficult to treat...