Ben Wen Li

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi request reprint Quantitative analysis of gender-regulated transcripts in the filarial nematode Brugia malayi by real-time RT-PCR
    Ben Wen Li
    Infectious Diseases Division, Washington University School of Medicine, Campus Box 8051, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Mol Biochem Parasitol 137:329-37. 2004
  2. pmc Transcription profiling reveals stage- and function-dependent expression patterns in the filarial nematode Brugia malayi
    Ben Wen Li
    Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, St, Louis, MO 63110, USA
    BMC Genomics 13:184. 2012
  3. pmc Transcriptomes and pathways associated with infectivity, survival and immunogenicity in Brugia malayi L3
    Ben Wen Li
    Department of Internal Medicine, Washington University School of Medicine, St, Louis, MO 63110, USA
    BMC Genomics 10:267. 2009
  4. ncbi request reprint Profiling of gender-regulated gene transcripts in the filarial nematode Brugia malayi by cDNA oligonucleotide array analysis
    Ben Wen Li
    Infectious Diseases Division, Washington University School of Medicine, Campus Box 8051, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Mol Biochem Parasitol 143:49-57. 2005
  5. ncbi request reprint Brugia malayi: effects of radiation and culture on gene expression in infective larvae
    Ben Wen Li
    Infectious Diseases Division, Campus Box 8051, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Mol Biochem Parasitol 149:201-7. 2006
  6. pmc Gender-associated genes in filarial nematodes are important for reproduction and potential intervention targets
    Ben Wen Li
    Infectious Diseases Division, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS Negl Trop Dis 5:e947. 2011
  7. pmc Gene expression analysis distinguishes tissue-specific and gender-related functions among adult Ascaris suum tissues
    Zhengyuan Wang
    The Genome Institute, Washington University School of Medicine, St Louis, MO 63108, USA
    Mol Genet Genomics 288:243-60. 2013
  8. ncbi request reprint Localization of gender-regulated gene expression in the filarial nematode Brugia malayi
    Daojun Jiang
    Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, Campus Box 8051, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Int J Parasitol 38:503-12. 2008
  9. pmc Targeting protein-protein interactions for parasite control
    Christina M Taylor
    Department of Genetics, The Genome Center, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS ONE 6:e18381. 2011
  10. pmc Conservation and diversification of the transcriptomes of adult Paragonimus westermani and P. skrjabini
    Ben Wen Li
    Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO, USA
    Parasit Vectors 9:497. 2016

Detail Information

Publications12

  1. ncbi request reprint Quantitative analysis of gender-regulated transcripts in the filarial nematode Brugia malayi by real-time RT-PCR
    Ben Wen Li
    Infectious Diseases Division, Washington University School of Medicine, Campus Box 8051, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Mol Biochem Parasitol 137:329-37. 2004
    ..Our results represent an important step toward improved understanding of the molecular biology of reproduction in filarial nematodes...
  2. pmc Transcription profiling reveals stage- and function-dependent expression patterns in the filarial nematode Brugia malayi
    Ben Wen Li
    Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, St, Louis, MO 63110, USA
    BMC Genomics 13:184. 2012
    ..Although a first draft genome sequence was released in 2007, very little is understood about transcription programs that govern developmental changes required for the parasite's development and survival in its mammalian and insect hosts...
  3. pmc Transcriptomes and pathways associated with infectivity, survival and immunogenicity in Brugia malayi L3
    Ben Wen Li
    Department of Internal Medicine, Washington University School of Medicine, St, Louis, MO 63110, USA
    BMC Genomics 10:267. 2009
    ..Radiation effects are especially interesting because irradiated L3 induce partial immunity to filarial infections. The underlying molecular mechanisms responsible for the efficacy of such vaccines are unkown...
  4. ncbi request reprint Profiling of gender-regulated gene transcripts in the filarial nematode Brugia malayi by cDNA oligonucleotide array analysis
    Ben Wen Li
    Infectious Diseases Division, Washington University School of Medicine, Campus Box 8051, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Mol Biochem Parasitol 143:49-57. 2005
    ..malayi; this should lead to improved understanding of reproduction in filarial nematodes. More generally, this approach holds great promise as a means of studying stage-specific or tissue-specific gene expression in parasitic nematodes...
  5. ncbi request reprint Brugia malayi: effects of radiation and culture on gene expression in infective larvae
    Ben Wen Li
    Infectious Diseases Division, Campus Box 8051, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Mol Biochem Parasitol 149:201-7. 2006
    ..This study provides an improved description of the adaptations that accompany the transition from L3i to L3c and the special ability of L3ir to induce protective immunity...
  6. pmc Gender-associated genes in filarial nematodes are important for reproduction and potential intervention targets
    Ben Wen Li
    Infectious Diseases Division, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS Negl Trop Dis 5:e947. 2011
    ..We have performed the first genome-wide analysis of gender-associated (GA) gene expression in a filarial nematode to improve understanding of key reproductive processes in these parasites...
  7. pmc Gene expression analysis distinguishes tissue-specific and gender-related functions among adult Ascaris suum tissues
    Zhengyuan Wang
    The Genome Institute, Washington University School of Medicine, St Louis, MO 63108, USA
    Mol Genet Genomics 288:243-60. 2013
    ..A notable finding was very high module similarity between adult reproductive tissues and intestine. Our results provide the most comprehensive assessment of gene expression among tissues of a parasitic nematode to date...
  8. ncbi request reprint Localization of gender-regulated gene expression in the filarial nematode Brugia malayi
    Daojun Jiang
    Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, Campus Box 8051, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Int J Parasitol 38:503-12. 2008
    ..Thus, ISH provides a means to independently confirm differential expression of genes identified by other methods. In addition, localization patterns provide insight regarding the function of known or novel genes in the parasite...
  9. pmc Targeting protein-protein interactions for parasite control
    Christina M Taylor
    Department of Genetics, The Genome Center, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS ONE 6:e18381. 2011
    ..malayi (H. sapiens parasite), which have extremely different modes of parasitism. As more genomes of pathogens are sequenced and PPI databases expanded, this methodology will become increasingly applicable...
  10. pmc Conservation and diversification of the transcriptomes of adult Paragonimus westermani and P. skrjabini
    Ben Wen Li
    Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO, USA
    Parasit Vectors 9:497. 2016
    ..skrjabini, are responsible for the bulk of human disease. Despite their medical and economic significance, there is limited information on the gene content and expression of Paragonimus lung flukes...
  11. pmc Antibody responses to Brugia malayi antigens induced by DNA vaccination
    Ben Wen Li
    Infectious Diseases Division, Campus Box 8051, Washington University School of Medicine, 660 S, Euclid Avenue, St, Louis, MO 63110, USA
    Filaria J 3:1. 2004
    ..The isotype bias of antibody responses following DNA vaccination can be affected by route of administration and by intrinsic characteristics of individual antigens...
  12. pmc Draft genome of the filarial nematode parasite Brugia malayi
    Elodie Ghedin
    Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Science 317:1756-60. 2007
    ..malayi to niches in its human and vector hosts and insights into the molecular basis of a mutualistic relationship with its Wolbachia endosymbiont. These findings offer a foundation for rational drug design...