D A Leib
Affiliation: Washington University School of Medicine
- Interferons regulate the phenotype of wild-type and mutant herpes simplex viruses in vivoD A Leib
Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Exp Med 189:663-72. 1999..The phenotypes of mutant viruses therefore cannot be interpreted based solely upon studies in cell culture but must be considered carefully in the context of host factors that may define the in vivo phenotype...
- Role of cis-acting sequences of the ICPO promoter of herpes simplex virus type 1 in viral pathogenesis, latency and reactivationD J Davido
Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
J Gen Virol 77:1853-63. 1996..This indicates that elements which regulate ICPO expression and virulence during acute infection may be distinct from those involved in reactivation...
- Specific phenotypic restoration of an attenuated virus by knockout of a host resistance geneD A Leib
Department of Ophthalmology, Washington University School of Medicine, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 97:6097-101. 2000..The use of recombinant viruses to infect animals with null mutations in host defense genes provides a formal genetic test for identifying in vivo mechanisms and targets of microbial virulence genes...
- Herpes simplex virus type 1 corneal infection results in periocular disease by zosteriform spreadB C Summers
Department of Ophthalmology, Washington University School of Medicine, St. Louis, Missouri 63110, USA
J Virol 75:5069-75. 2001..Furthermore, clinical evidence is discussed suggesting that a similar mode of spreading and disease occurs in humans following primary ocular infection...
- Counteraction of interferon-induced antiviral responses by herpes simplex virusesD A Leib
Departments of Ophthalmology and Visual Sciences and Molecular Microbiology, Washington University School of Medicine, Box 8096, 660 South Euclid Avenue, St Louis, MO 63110, USA
Curr Top Microbiol Immunol 269:171-85. 2002..In particular, the roles of specific viral genes in resistance to the antiviral effects of PKR and RNaseL are described, along with other HSV genes and loci associated with resistance to IFN for which mechanisms have yet to be described...