Chris Todd Hittinger

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi request reprint Gene duplication and the adaptive evolution of a classic genetic switch
    Chris Todd Hittinger
    Howard Hughes Medical Institute, Laboratory of Genetics, University of Wisconsin Madison, 1525 Linden Drive, Madison, Wisconsin 53706, USA
    Nature 449:677-81. 2007
  2. pmc Evolution of an insect-specific GROUCHO-interaction motif in the ENGRAILED selector protein
    Chris Todd Hittinger
    Laboratory of Genetics, Howard Hughes Medical Institute, University of Wisconsin Madison, Madison, WI 53706 1534, USA
    Evol Dev 10:537-45. 2008
  3. doi request reprint Genomic analysis and D-xylose fermentation of three novel Spathaspora species: Spathaspora girioi sp. nov., Spathaspora hagerdaliae f. a., sp. nov. and Spathaspora gorwiae f. a., sp. nov
    Mariana R Lopes
    Departamento de Microbiologia, ICB, C P 486, Universidade Federal de Minas Gerais, Belo Horizonte, MG 31270 901, Brazil Laboratory of Genetics, Genome Center of Wisconsin, Wisconsin Energy Institute, J F Crow Institute for the Study of Evolution, University of Wisconsin Madison, Madison, WI 53706, USA
    FEMS Yeast Res 16:. 2016
  4. pmc Complex Ancestries of Lager-Brewing Hybrids Were Shaped by Standing Variation in the Wild Yeast Saccharomyces eubayanus
    David Peris
    Laboratory of Genetics, Genome Center of Wisconsin, Wisconsin Energy Institute, J F Crow Institute for the Study of Evolution, University of Wisconsin Madison, Madison, Wisconsin, United States of America
    PLoS Genet 12:e1006155. 2016
  5. pmc Genomics and the making of yeast biodiversity
    Chris Todd Hittinger
    Laboratory of Genetics, Genome Center of Wisconsin, Wisconsin Energy Institute, J F Crow Institute for the Study of Evolution, University of Wisconsin Madison, Madison, WI 53706, USA DOE Great Lakes Bioenergy Research Center, University of Wisconsin Madison, Madison, WI 53706, USA Electronic address
    Curr Opin Genet Dev 35:100-9. 2015
  6. pmc Horizontally acquired genes in early-diverging pathogenic fungi enable the use of host nucleosides and nucleotides
    William G Alexander
    Laboratory of Genetics, DOE Department of Energy Great Lakes Bioenergy Research Center, Wisconsin Energy Institute, Genome Center of Wisconsin, J F Crow Institute for the Study of Evolution, University of Wisconsin Madison, Madison, WI 53706
    Proc Natl Acad Sci U S A 113:4116-21. 2016
  7. pmc Efficient engineering of marker-free synthetic allotetraploids of Saccharomyces
    William G Alexander
    Laboratory of Genetics, Genome Center of Wisconsin, Wisconsin Energy Institute, J F Crow Institute for the Study of Evolution, University of Wisconsin Madison, Madison, WI 53706, United States DOE Great Lakes Bioenergy Research Center, University of Wisconsin Madison, Madison, WI 53706, United States
    Fungal Genet Biol 89:10-7. 2016
  8. pmc The Genome Sequence of Saccharomyces eubayanus and the Domestication of Lager-Brewing Yeasts
    EmilyClare Baker
    Laboratory of Genetics, Genome Center of Wisconsin, Wisconsin Energy Institute, J F Crow Institute for the Study of Evolution, University of Wisconsin Madison
    Mol Biol Evol 32:2818-31. 2015
  9. doi request reprint Population structure and reticulate evolution of Saccharomyces eubayanus and its lager-brewing hybrids
    David Peris
    Laboratory of Genetics, Genome Center of Wisconsin, Wisconsin Energy Institute, DOE Great Lakes Bioenergy Research Center, University of Wisconsin Madison, Madison, WI, 53706, USA
    Mol Ecol 23:2031-45. 2014
  10. ncbi request reprint Pleiotropic functions of a conserved insect-specific Hox peptide motif
    Chris Todd Hittinger
    Howard Hughes Medical Institute, University of Wisconsin Madison, Madison, WI 53706, USA
    Development 132:5261-70. 2005

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Gene duplication and the adaptive evolution of a classic genetic switch
    Chris Todd Hittinger
    Howard Hughes Medical Institute, Laboratory of Genetics, University of Wisconsin Madison, 1525 Linden Drive, Madison, Wisconsin 53706, USA
    Nature 449:677-81. 2007
    ....
  2. pmc Evolution of an insect-specific GROUCHO-interaction motif in the ENGRAILED selector protein
    Chris Todd Hittinger
    Laboratory of Genetics, Howard Hughes Medical Institute, University of Wisconsin Madison, Madison, WI 53706 1534, USA
    Evol Dev 10:537-45. 2008
    ..The acquisition and conservation of this auxiliary peptide motif shows how the number and activity of short peptide motifs can evolve in transcription factors while existing regulatory functions are maintained...
  3. doi request reprint Genomic analysis and D-xylose fermentation of three novel Spathaspora species: Spathaspora girioi sp. nov., Spathaspora hagerdaliae f. a., sp. nov. and Spathaspora gorwiae f. a., sp. nov
    Mariana R Lopes
    Departamento de Microbiologia, ICB, C P 486, Universidade Federal de Minas Gerais, Belo Horizonte, MG 31270 901, Brazil Laboratory of Genetics, Genome Center of Wisconsin, Wisconsin Energy Institute, J F Crow Institute for the Study of Evolution, University of Wisconsin Madison, Madison, WI 53706, USA
    FEMS Yeast Res 16:. 2016
    ..The type strains are Sp. girioi sp. nov. UFMG-CM-Y302(T) (=CBS 13476), Sp. hagerdaliae f.a., sp. nov. UFMG-CM-Y303(T) (=CBS 13475) and Sp. gorwiae f.a., sp. nov. UFMG-CM-Y312(T) (=CBS 13472). ..
  4. pmc Complex Ancestries of Lager-Brewing Hybrids Were Shaped by Standing Variation in the Wild Yeast Saccharomyces eubayanus
    David Peris
    Laboratory of Genetics, Genome Center of Wisconsin, Wisconsin Energy Institute, J F Crow Institute for the Study of Evolution, University of Wisconsin Madison, Madison, Wisconsin, United States of America
    PLoS Genet 12:e1006155. 2016
    ..We conclude that the relationships among wild strains of S. eubayanus and their domesticated hybrids reflect complex biogeographical and genetic processes. ..
  5. pmc Genomics and the making of yeast biodiversity
    Chris Todd Hittinger
    Laboratory of Genetics, Genome Center of Wisconsin, Wisconsin Energy Institute, J F Crow Institute for the Study of Evolution, University of Wisconsin Madison, Madison, WI 53706, USA DOE Great Lakes Bioenergy Research Center, University of Wisconsin Madison, Madison, WI 53706, USA Electronic address
    Curr Opin Genet Dev 35:100-9. 2015
    ..Expanding the taxonomic breadth of deep genomic investigations will further illuminate how genome function evolves to encode their diverse metabolisms and ecologies. ..
  6. pmc Horizontally acquired genes in early-diverging pathogenic fungi enable the use of host nucleosides and nucleotides
    William G Alexander
    Laboratory of Genetics, DOE Department of Energy Great Lakes Bioenergy Research Center, Wisconsin Energy Institute, Genome Center of Wisconsin, J F Crow Institute for the Study of Evolution, University of Wisconsin Madison, Madison, WI 53706
    Proc Natl Acad Sci U S A 113:4116-21. 2016
    ..We further argue that interfacial genes with well-understood activities, especially those horizontally transferred from bacteria or viruses, could provide medical treatments for microsporidian infections. ..
  7. pmc Efficient engineering of marker-free synthetic allotetraploids of Saccharomyces
    William G Alexander
    Laboratory of Genetics, Genome Center of Wisconsin, Wisconsin Energy Institute, J F Crow Institute for the Study of Evolution, University of Wisconsin Madison, Madison, WI 53706, United States DOE Great Lakes Bioenergy Research Center, University of Wisconsin Madison, Madison, WI 53706, United States
    Fungal Genet Biol 89:10-7. 2016
    ..This method provides an efficient means for producing novel synthetic hybrids for beverage and biofuel production, as well as for constructing tetraploids to be used for basic research in evolutionary genetics and genome stability. ..
  8. pmc The Genome Sequence of Saccharomyces eubayanus and the Domestication of Lager-Brewing Yeasts
    EmilyClare Baker
    Laboratory of Genetics, Genome Center of Wisconsin, Wisconsin Energy Institute, J F Crow Institute for the Study of Evolution, University of Wisconsin Madison
    Mol Biol Evol 32:2818-31. 2015
    ..cerevisiae × S. eubayanus hybrids that brew lager beers. Our findings demonstrate how this industrially important hybrid has been domesticated along similar evolutionary trajectories on multiple occasions. ..
  9. doi request reprint Population structure and reticulate evolution of Saccharomyces eubayanus and its lager-brewing hybrids
    David Peris
    Laboratory of Genetics, Genome Center of Wisconsin, Wisconsin Energy Institute, DOE Great Lakes Bioenergy Research Center, University of Wisconsin Madison, Madison, WI, 53706, USA
    Mol Ecol 23:2031-45. 2014
    ..These findings show how genetically diverse eukaryotic microbes can produce rare but economically important hybrids with low genetic diversity when they migrate from their natural ecological context...
  10. ncbi request reprint Pleiotropic functions of a conserved insect-specific Hox peptide motif
    Chris Todd Hittinger
    Howard Hughes Medical Institute, University of Wisconsin Madison, Madison, WI 53706, USA
    Development 132:5261-70. 2005
    ....
  11. pmc Parallel inactivation of multiple GAL pathway genes and ecological diversification in yeasts
    Chris Todd Hittinger
    Howard Hughes Medical Institute and Laboratories of Genetics and Molecular Biology, University of Wisconsin, 1525 Linden Drive, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 101:14144-9. 2004
    ..Inactivated genes may generally serve as markers of specific functions made dispensable by recent adaptive shifts...
  12. pmc High-efficiency genome editing and allele replacement in prototrophic and wild strains of Saccharomyces
    William G Alexander
    Laboratory of Genetics, Genome Center of Wisconsin, Wisconsin Energy Institute, J F Crow Institute for the Study of Evolution, University of Wisconsin, Madison, Wisconsin 53706 DOE Great Lakes Bioenergy Research Center, University of Wisconsin, Madison, Wisconsin 53706
    Genetics 198:859-66. 2014
    ..Using these new techniques, many of the most powerful yeast genetic manipulation strategies are now available in wild, industrial, and other prototrophic strains from across the diverse Saccharomyces genus. ..
  13. doi request reprint Saccharomyces diversity and evolution: a budding model genus
    Chris Todd Hittinger
    Laboratory of Genetics, Genome Center of Wisconsin, Wisconsin Bioenergy Initiative, DOE Great Lakes Bioenergy Research Center, University of Wisconsin Madison, Madison, WI 53706, USA
    Trends Genet 29:309-17. 2013
    ..Expanding strain collections, low-cost genome sequencing, and tools for precise genetic manipulation promise to usher in a golden era for this surprisingly diverse genus as an evolutionary model...
  14. ncbi request reprint Transcriptional rewiring: the proof is in the eating
    Antonis Rokas
    Vanderbilt University, Department of Biological Sciences, VU Station B 351634, Nashville, Tennessee 37235, USA
    Curr Biol 17:R626-8. 2007
    ..Analysis of the galactose genetic pathway in Candida albicans and comparison with the classical pathway in Saccharomyces cerevisiae have revealed remarkable differences in its regulation in the two yeasts...
  15. ncbi request reprint Evolutionarily conserved domains required for activation and repression functions of the Drosophila Hox protein Ultrabithorax
    Ella Tour
    Section in Cell and Developmental Biology, Division of Biology, University of California, San Diego, La Jolla, CA 92093, USA
    Development 132:5271-81. 2005
    ..These results suggest that the N-terminal region containing the SSYF motif has been conserved in many Hox proteins for its role in transcriptional activation...