P W Grigsby

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. doi request reprint In vitro chemoresponse to cisplatin and outcomes in cervical cancer
    Perry W Grigsby
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, MO 63110, USA
    Gynecol Oncol 130:188-91. 2013
  2. ncbi request reprint Preparation of patients with thyroid cancer for 131I scintigraphy or therapy by 1-3 weeks of thyroxine discontinuation
    Perry W Grigsby
    Department of Radiation Oncology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri, USA
    J Nucl Med 45:567-70. 2004
  3. ncbi request reprint Lack of benefit of concurrent chemotherapy in patients with cervical cancer and negative lymph nodes by FDG-PET
    Perry W Grigsby
    Department of Radiation Oncology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Int J Radiat Oncol Biol Phys 61:444-9. 2005
  4. doi request reprint PET/CT imaging to guide cervical cancer therapy
    Perry W Grigsby
    Mallinckrodt Institute of Radiology, Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
    Future Oncol 5:953-8. 2009
  5. doi request reprint FDG-PET/CT: new horizons in anal cancer
    P W Grigsby
    Division of Nuclear Medicine, Mallinckrodt Institute of Radiology, Washington University Medical Center, Saint Louis, Missouri, USA
    Gastroenterol Clin Biol 33:456-8. 2009
  6. ncbi request reprint 4th International Cervical Cancer Conference: update on PET and cervical cancer
    Perry W Grigsby
    Radiation Oncology Department, Washington University School of Medicine, Mallinckrodt Institute of Radiology, 4921 Parkview Place, Lower Level St Louis, MO 63110, USA
    Gynecol Oncol 99:S173-5. 2005
  7. ncbi request reprint Prospective phase I/II study of irradiation and concurrent chemotherapy for recurrent cervical cancer after radical hysterectomy
    P W Grigsby
    Department of Radiation Oncology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Int J Gynecol Cancer 14:860-4. 2004
  8. doi request reprint Role of PET in gynecologic malignancy
    Perry W Grigsby
    Department of Radiation Oncology, Mallinckrodt Institute of Radiology, Division of Nuclear Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Curr Opin Oncol 21:420-4. 2009
  9. ncbi request reprint Comparison of molecular markers of hypoxia and imaging with (60)Cu-ATSM in cancer of the uterine cervix
    Perry W Grigsby
    Department of Radiation Oncology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Imaging Biol 9:278-83. 2007
  10. ncbi request reprint The role of FDG-PET/CT imaging after radiation therapy
    Perry W Grigsby
    Department of Radiation Oncology and Division of Nuclear Medicine, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO, USA
    Gynecol Oncol 107:S27-9. 2007

Collaborators

Detail Information

Publications97

  1. doi request reprint In vitro chemoresponse to cisplatin and outcomes in cervical cancer
    Perry W Grigsby
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, MO 63110, USA
    Gynecol Oncol 130:188-91. 2013
    ..The aim of this study was to report clinical outcomes of cervical cancer patients treated with weekly cisplatin chemo-radiation therapy (chemoRT) stratified by pre-treatment cisplatin in vitro chemosensitivity...
  2. ncbi request reprint Preparation of patients with thyroid cancer for 131I scintigraphy or therapy by 1-3 weeks of thyroxine discontinuation
    Perry W Grigsby
    Department of Radiation Oncology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri, USA
    J Nucl Med 45:567-70. 2004
    ....
  3. ncbi request reprint Lack of benefit of concurrent chemotherapy in patients with cervical cancer and negative lymph nodes by FDG-PET
    Perry W Grigsby
    Department of Radiation Oncology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Int J Radiat Oncol Biol Phys 61:444-9. 2005
    ..To compare the outcome of patients with cervical cancer and negative lymph nodes by fluorodeoxyglucose-positron emission tomography (FDG-PET) treated with irradiation (RT) and concurrent chemotherapy or RT alone...
  4. doi request reprint PET/CT imaging to guide cervical cancer therapy
    Perry W Grigsby
    Mallinckrodt Institute of Radiology, Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
    Future Oncol 5:953-8. 2009
    ..Surveillance after completion of therapy and evaluation of clinically suspected recurrent disease are also uses of FDG-PET in patients with cervical cancer...
  5. doi request reprint FDG-PET/CT: new horizons in anal cancer
    P W Grigsby
    Division of Nuclear Medicine, Mallinckrodt Institute of Radiology, Washington University Medical Center, Saint Louis, Missouri, USA
    Gastroenterol Clin Biol 33:456-8. 2009
    ..This imaging modality can also be used to evaluate sites of recurrent disease. FDG-PET/CT is an imaging modality which greatly affects the management of patients with anal cancer...
  6. ncbi request reprint 4th International Cervical Cancer Conference: update on PET and cervical cancer
    Perry W Grigsby
    Radiation Oncology Department, Washington University School of Medicine, Mallinckrodt Institute of Radiology, 4921 Parkview Place, Lower Level St Louis, MO 63110, USA
    Gynecol Oncol 99:S173-5. 2005
  7. ncbi request reprint Prospective phase I/II study of irradiation and concurrent chemotherapy for recurrent cervical cancer after radical hysterectomy
    P W Grigsby
    Department of Radiation Oncology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Int J Gynecol Cancer 14:860-4. 2004
    ..By logistic regression, the only significant factor for survival was total irradiation dose (P = 0.04). In conclusion, long-term survival with this treatment regimen is possible but is accompanied by significant late toxicity...
  8. doi request reprint Role of PET in gynecologic malignancy
    Perry W Grigsby
    Department of Radiation Oncology, Mallinckrodt Institute of Radiology, Division of Nuclear Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Curr Opin Oncol 21:420-4. 2009
    ..The purpose of this review is to outline the current state-of-the-art use of PET imaging for patients with gynecologic malignancies...
  9. ncbi request reprint Comparison of molecular markers of hypoxia and imaging with (60)Cu-ATSM in cancer of the uterine cervix
    Perry W Grigsby
    Department of Radiation Oncology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Imaging Biol 9:278-83. 2007
    ..To determine if hypoxia-related molecular markers are associated with (60)Cu labeled diacetyl-bis (N4 -methylthiosemicarbazone); ((60)Cu-ATSM) imaging of tumor hypoxia in cervical cancer...
  10. ncbi request reprint The role of FDG-PET/CT imaging after radiation therapy
    Perry W Grigsby
    Department of Radiation Oncology and Division of Nuclear Medicine, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO, USA
    Gynecol Oncol 107:S27-9. 2007
  11. ncbi request reprint The contribution of new imaging techniques in staging cervical cancer
    Perry W Grigsby
    Department of Radiation Oncology and Division of Nuclear Medicine, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO, USA
    Gynecol Oncol 107:S10-2. 2007
  12. ncbi request reprint Nuclear imaging and cervical cancer
    P W Grigsby
    Department of Radiation Oncology, Division of Nuclear Medicine, Mallinckrodt Institute of Radiology, Department of Obstetrics and Gynecology, Alvin J Siteman Cancer Center, Washington University Medical Center, St Louis, MO 63110, USA
    Minerva Ginecol 61:45-51. 2009
    ....
  13. ncbi request reprint Posttherapy [18F] fluorodeoxyglucose positron emission tomography in carcinoma of the cervix: response and outcome
    Perry W Grigsby
    Department of Radiation Oncology, Box 8224, Washington University School of Medicine, 4921 Parkview Pl, Lower Level, St Louis, MO 63110, USA
    J Clin Oncol 22:2167-71. 2004
    ..The aim of this study was to evaluate response to therapy using posttherapy molecular imaging with [(18)F] fluorodeoxyglucose (FDG), and to compare the response with patient outcome...
  14. pmc The prognostic value of PET and PET/CT in cervical cancer
    Perry W Grigsby
    Department of Radiation Oncology and Division of Nuclear Medicine, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO, USA
    Cancer Imaging 8:146-55. 2008
    ..PET is superior to conventional imaging modalities for evaluating patients with cervical cancer...
  15. ncbi request reprint Lack of effect of tumor size on the prognosis of carcinoma of the uterine cervix Stage IB and IIA treated with preoperative irradiation and surgery
    P W Grigsby
    Radiation Oncology Center, Mallinckrodt Institute of Radiology, St Louis, MO 63110, USA
    Int J Radiat Oncol Biol Phys 45:645-51. 1999
    ..The purpose of this analysis was to evaluate the prognostic significance of cervical tumor size in patients with Stages Ib and IIa carcinoma of the cervix treated with preoperative irradiation and radical or conservative hysterectomy...
  16. ncbi request reprint Pelvic irradiation with concurrent chemotherapy versus pelvic and para-aortic irradiation for high-risk cervical cancer: an update of radiation therapy oncology group trial (RTOG) 90-01
    Patricia J Eifel
    Department of Radiation Oncology, Unit 97, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    J Clin Oncol 22:872-80. 2004
    ....
  17. ncbi request reprint FDG-PET in carcinoma of the uterine cervix with endometrial extension
    Andrew J Hope
    Department of Radiation Oncology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer 106:196-200. 2006
    ....
  18. ncbi request reprint Long-term follow-up of RTOG 92-10: cervical cancer with positive para-aortic lymph nodes
    P W Grigsby
    Radiation Oncology Center, Washington University Medical Center, St. Louis, MO 63110, USA
    Int J Radiat Oncol Biol Phys 51:982-7. 2001
    ..One patient died of acute complications of therapy. The survival estimates seem no better than standard fractionation irradiation without chemotherapy...
  19. ncbi request reprint Posttherapy surveillance monitoring of cervical cancer by FDG-PET
    Perry W Grigsby
    Department of Radiation Oncology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Int J Radiat Oncol Biol Phys 55:907-13. 2003
    ....
  20. ncbi request reprint Factors affecting long-term outcome of irradiation in carcinoma of the vagina
    C A Perez
    Radiation Oncology Center, Mallinckrodt Institute of Radiology, Washington University Medical Center, St Louis, MO, USA
    Int J Radiat Oncol Biol Phys 44:37-45. 1999
    ..This report evaluates prognostic and technical factors affecting outcome of patients with primary carcinoma of the vagina treated with definitive radiation therapy...
  21. ncbi request reprint Radiation therapy for carcinoma of the cervix with biopsy-proven positive para-aortic lymph nodes
    P W Grigsby
    Radiation Oncology Center, Mallinckrodt Institute of Radiology, St Louis, MO 63110, USA
    Int J Radiat Oncol Biol Phys 49:733-8. 2001
    ..To evaluate local tumor control, cause-specific survival, patterns of relapse, and toxicity in patients with cervical cancer and positive para-aortic lymph nodes treated with radiation therapy alone...
  22. ncbi request reprint FDG-PET lymph node staging and survival of patients with FIGO stage IIIb cervical carcinoma
    Anurag K Singh
    Department of Radiation Oncology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Int J Radiat Oncol Biol Phys 56:489-93. 2003
    ....
  23. doi request reprint Clinical outcomes of definitive intensity-modulated radiation therapy with fluorodeoxyglucose-positron emission tomography simulation in patients with locally advanced cervical cancer
    Elizabeth A Kidd
    Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
    Int J Radiat Oncol Biol Phys 77:1085-91. 2010
    ..This study aimed to evaluate the toxicity and clinical outcomes for cervical cancer patients treated definitively with intensity-modulated radiation therapy (IMRT) compared with non-IMRT treatment...
  24. ncbi request reprint Tumor response and survival predicted by post-therapy FDG-PET/CT in anal cancer
    Julie K Schwarz
    Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
    Int J Radiat Oncol Biol Phys 71:180-6. 2008
    ..To evaluate the response to therapy for anal carcinoma using post-therapy imaging with positron emission tomography (PET)/computed tomography and F-18 fluorodeoxyglucose (FDG) and to compare the metabolic response with patient outcome...
  25. doi request reprint 18F-fluorodeoxyglucose-positron emission tomography and pathologic tumor size in early-stage invasive cervical cancer
    Timothy N Showalter
    Department of Radiation Oncology, Thomas Jefferson University, St Louis, MO, USA
    Int J Gynecol Cancer 19:1412-4. 2009
    ..The purpose of this study was to evaluate the relationship between preoperative FDG-PET tumor size and pathologic tumor diameter in patients with early-stage cervical cancer who were undergoing radical hysterectomy...
  26. ncbi request reprint Are increased tumor aneuploidy and heightened cell proliferation along with heterogeneity associated with patient outcome for carcinomas of the uterine cervix? A combined analysis of subjects treated in RTOG 9001 and a single-institution trial
    Aaron H Wolfson
    Department of Radiation Oncology, University of Miami Miller School of Medicine, 1475 NW 12th Avenue, D 31, Miami, FL 33136, USA
    Int J Radiat Oncol Biol Phys 70:111-7. 2008
    ....
  27. ncbi request reprint FDG-PET evaluation of vaginal carcinoma
    Wayne T Lamoreaux
    Department of Radiation Oncology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Int J Radiat Oncol Biol Phys 62:733-7. 2005
    ..To compare the results of CT and positron emission tomography (PET) and F-18 fluorodeoxyglucose (FDG) in the detection of the primary tumor and lymph node metastases in carcinoma of the vagina...
  28. doi request reprint Lymph node staging by positron emission tomography in cervical cancer: relationship to prognosis
    Elizabeth A Kidd
    Department of Radiation Oncology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, 4921 Parkview Place, Box 8224, St Louis, MO 63110, USA
    J Clin Oncol 28:2108-13. 2010
    ..27 (95% CI 16.56 to 55.34). CONCLUSION Nodal involvement detected by FDG-PET in cervical cancer relates to clinical stage, is comparable to historical data, and stratifies patient recurrence and survival outcomes...
  29. ncbi request reprint FDG-PET imaging for the assessment of physiologic volume response during radiotherapy in cervix cancer
    Lilie L Lin
    Department of Radiation Oncology, Department of Radiology, Mallinckrodt Institute of Radiology, St Louis, MO, USA
    Int J Radiat Oncol Biol Phys 65:177-81. 2006
    ..To evaluate the physiologic tumor volume response during treatment in cervical cancer using 18F-fluorodeoxyglucose positron emission tomography (FDG-PET)...
  30. ncbi request reprint Current management of patients with invasive cervical carcinoma
    P W Grigsby
    Mallinckrodt Institute of Radiology, Box 8224, Washington University Medical Center, 4939 Children s Place, Suite 5500, St Louis, MO 63110, USA
    Clin Obstet Gynecol 44:531-7. 2001
    ..Further refinement of treatment for those patients who require combined chemo/radiation versus those with comorbidities such that combination chemotherapy is actually too toxic must be defined...
  31. ncbi request reprint Gene expression patterns in advanced human cervical cancer
    P W Grigsby
    Department of Radiation Oncology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri, USA
    Int J Gynecol Cancer 16:562-7. 2006
    ..Both overall and cause-specific survivals were different between these two patient groups (P= 0.006). This limited data set identified candidate biomarkers of extent of lymph node metastases that correlated with poor survival outcome...
  32. ncbi request reprint Cervical tumor control evaluated with ICRU 38 reference volumes and integrated reference air kerma
    P W Grigsby
    Radiation Oncology Center, Mallinckrodt Institute of Radiology, Washington University School of Medicine, MO, St. Louis, USA
    Radiother Oncol 58:19-23. 2001
    ..001). CONCLUSION: Analysis of the 60-160 Gy reference volumes and IRAK failed to demonstrate a consistent positive increasing correlation of these values to primary cervical tumor control...
  33. ncbi request reprint Irradiation with or without misonidazole for patients with stages IIIB and IVA carcinoma of the cervix: final results of RTOG 80-05. Radiation Therapy Oncology Group
    P W Grigsby
    Washington University Medical Center, St Louis, MO 63110, USA
    Int J Radiat Oncol Biol Phys 44:513-7. 1999
    ..This is a report of the final results of the study...
  34. ncbi request reprint FDG-PET/CT in the evaluation of anal carcinoma
    Shane E Cotter
    Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO, USA
    Int J Radiat Oncol Biol Phys 65:720-5. 2006
    ....
  35. ncbi request reprint Prospective evaluation of FDG-PET for detecting pelvic and para-aortic lymph node metastasis in uterine corpus cancer
    Neil S Horowitz
    Division of Gynecologic Oncology, Departments of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, MO 63110, USA
    Gynecol Oncol 95:546-51. 2004
    ....
  36. ncbi request reprint Association of posttherapy positron emission tomography with tumor response and survival in cervical carcinoma
    Julie K Schwarz
    Department of Radiation Oncology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    JAMA 298:2289-95. 2007
    ..Retrospective studies have demonstrated that the use of positron emission tomography (PET) with F-18 fluorodeoxyglucose (FDG) in the posttherapy evaluation of patients with cervical carcinoma is predictive of survival outcome...
  37. ncbi request reprint Adaptive brachytherapy treatment planning for cervical cancer using FDG-PET
    Lilie L Lin
    Radiation Oncology Department, Mallinckrodt Institute of Radiology, St Louis, MO 63110, USA
    Int J Radiat Oncol Biol Phys 67:91-6. 2007
    ..A dosimetric study was conducted to compare intracavitary brachytherapy using both a conventional and a custom loading intended to cover a positron emission tomography (PET)-defined tumor volume in patients with cervix cancer...
  38. ncbi request reprint Lymph node staging by positron emission tomography in patients with carcinoma of the cervix
    P W Grigsby
    Mallinckrodt Institute of Radiology and the Siteman Cancer Center, Washington University School of Medicine, St Louis, MO, USA
    J Clin Oncol 19:3745-9. 2001
    ....
  39. ncbi request reprint Cervical cancer: combined modality therapy
    P W Grigsby
    Mallinckrodt Institute of Radiology, Washington University Medical Center, St Louis, Missouri 63110, USA
    Cancer J 7:S47-50. 2001
    ..These findings are summarized with respect to their implications fortreatment of patients with advanced cervical cancer...
  40. doi request reprint Pelvic lymph node F-18 fluorodeoxyglucose uptake as a prognostic biomarker in newly diagnosed patients with locally advanced cervical cancer
    Elizabeth A Kidd
    Department of Radiation Oncology, Box 8224, Mallinckrodt Institute of Radiology, Washington University School of Medicine, 4921 Parkview Place, St Louis, MO 63110, USA
    Cancer 116:1469-75. 2010
    ....
  41. doi request reprint Intratumoral metabolic heterogeneity of cervical cancer
    Elizabeth A Kidd
    Department of Radiation Oncology, Mallinckrodt Institute of Radiology, Washington University Medical Center, St Louis, Missouri, USA
    Clin Cancer Res 14:5236-41. 2008
    ..The purpose of this study was to evaluate the pretreatment intratumoral metabolic heterogeneity of FDG...
  42. ncbi request reprint Occult supraclavicular lymph node metastasis identified by FDG-PET in patients with carcinoma of the uterine cervix
    Binh N Tran
    Department of Radiation Oncology, Mallinckrodt Institute of Radiology, St Louis, MO, USA
    Gynecol Oncol 90:572-6. 2003
    ....
  43. doi request reprint Surveillance FDG-PET detection of asymptomatic recurrences in patients with cervical cancer
    Rebecca A Brooks
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
    Gynecol Oncol 112:104-9. 2009
    ..To evaluate survival after detection of recurrent cervical cancer by FDG-PET in symptomatic versus asymptomatic patients...
  44. ncbi request reprint The standardized uptake value for F-18 fluorodeoxyglucose is a sensitive predictive biomarker for cervical cancer treatment response and survival
    Elizabeth A Kidd
    Department of Radiation Oncology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer 110:1738-44. 2007
    ....
  45. ncbi request reprint Outcome analysis for stage IE and IIE thyroid lymphoma
    Steven J DiBiase
    Department of Radiation Oncology, University of Maryland, Baltimore, Maryland, USA
    Am J Clin Oncol 27:178-84. 2004
    ..Because of the risk of both local-regional and distant failure, combined modality approaches that use chemotherapy with radiotherapy are warranted for intermediate- and high grade thyroid lymphoma...
  46. ncbi request reprint Contralateral papillary thyroid cancer at completion thyroidectomy has no impact on recurrence or survival after radioiodine treatment
    Perry W Grigsby
    Department of Radiation Oncology, Washington University School of Medicine, Saint Louis, MO 63110, USA
    Surgery 140:1043-7; discussion 1047-9. 2006
    ..The study sought predictors of contralateral disease and examined the impact of contralateral disease in RAI-treated patients...
  47. ncbi request reprint External radiotherapy versus vaginal brachytherapy for patients with intermediate risk endometrial cancer
    Lilie L Lin
    Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
    Gynecol Oncol 106:215-20. 2007
    ..To determine if brachytherapy alone is adequate adjuvant local therapy in patients classified as intermediate risk after complete surgical staging for endometrioid adenocarcinoma...
  48. doi request reprint Combined intensity-modulated radiation therapy and brachytherapy in the treatment of cervical cancer
    Dusten M Macdonald
    Department of Radiation Oncology, Mallinckrodt Institute of Radiology, St Louis, MO 63110, USA
    Int J Radiat Oncol Biol Phys 71:618-24. 2008
    ....
  49. ncbi request reprint Combined [18F]Fluorodeoxyglucose positron emission tomography and computed tomography (FDG-PET/CT) for detection of recurrent, 131I-negative thyroid cancer
    Steven E Finkelstein
    Department of Surgery, Washington University School of Medicine, St Louis, MO, USA
    Ann Surg Oncol 15:286-92. 2008
    ..Limited data are available regarding the performance of combined FDG-PET/computed tomography (FDG-PET/CT) for detecting recurrent thyroid cancer in WBS-neg patients...
  50. doi request reprint 18-F-fluorodeoxyglucose-positron emission tomography evaluation of early metabolic response during radiation therapy for cervical cancer
    Julie K Schwarz
    Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO, USA
    Int J Radiat Oncol Biol Phys 72:1502-7. 2008
    ..To document changes in cervical tumor (18)-F-fluorodeoxyglocose (FDG) uptake during radiation therapy and to correlate those changes with post-treatment tumor response and survival outcome...
  51. ncbi request reprint Anaplastic thyroid carcinoma: comparison of conventional radiotherapy and hyperfractionation chemoradiotherapy in two groups
    Dwight E Heron
    Department of Radiation Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15232, USA
    Am J Clin Oncol 25:442-6. 2002
    ..Among patients with ATC surgery, hyperfractionated radiotherapy in conjunction with chemotherapy is associated with better survival but not PFS compared to conventional radiotherapy...
  52. doi request reprint Prognostic factors in patients with well-differentiated thyroid cancer presenting with pulmonary metastasis
    Timothy N Showalter
    Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA, USA
    Cancer Biother Radiopharm 23:655-9. 2008
    ..Survival outcomes in patients presenting with well-differentiated thyroid cancer with pulmonary metastasis are variable. The aim of this study was to evaluate prognostic factors for outcome in this patient population...
  53. doi request reprint A new method of anatomically conformal vaginal cuff HDR brachytherapy
    Douglas A Miller
    Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
    Gynecol Oncol 116:413-8. 2010
    ..This study describes the use and dosimetry of a new method of anatomically conformal post-operative vaginal cuff HDR brachytherapy using an intra-vaginal balloon applicator...
  54. ncbi request reprint Rethinking the use of radiation and chemotherapy after radical hysterectomy: a clinical-pathologic analysis of a Gynecologic Oncology Group/Southwest Oncology Group/Radiation Therapy Oncology Group trial
    Bradley J Monk
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Chao Family Comprehensive Cancer Center, University of California, Irvine Medical Center, 101 The City Drive, Building 23, Room 107, Orange, CA 92868, USA
    Gynecol Oncol 96:721-8. 2005
    ....
  55. ncbi request reprint F-18 fluorodeoxyglucose uptake in primary cervical cancer as an indicator of prognosis after radiation therapy
    Feiyu Xue
    Division of Nuclear Medicine, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Gynecol Oncol 101:147-51. 2006
    ....
  56. ncbi request reprint Postoperative irradiation in cervical cancer: prognostic factors and outcome
    Perry W Grigsby
    Mallinckrodt Institute of Radiology, Department of Radiation Oncology Box 8224, Washington University School of Medicine, 4921 Parkview Place, Lower Level, St Louis, MO 63110, USA
    Radiat Med 22:106-10. 2004
    ..The aim of this study was to evaluate prognostic factors and outcomes in patients with cervical cancer who underwent hysterectomy followed by pelvic irradiation...
  57. ncbi request reprint Utility of parametrectomy for early stage cervical cancer treated with radical hysterectomy
    Jason D Wright
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Cancer 110:1281-6. 2007
    ..Parametrectomy results in significant morbidity. The objective of the study was to determine factors predictive of parametrial tumor spread and to define a subset of patients at low risk for parametrial disease...
  58. ncbi request reprint Immunohistochemistry as a predictor of clinical outcome in patients given postoperative radiation for subtotally resected pituitary adenomas
    J J Kovalic
    Radiation Oncology Center, University School of Medicine, St Louis, Missouri 63110
    J Neurooncol 16:227-32. 1993
    ..We conclude that additional prognostic information can be obtained in this subset of patients (by performing IHC analysis) that is not known by the clinical presentation or appearance on H&E stain...
  59. ncbi request reprint Radiation exposure from outpatient radioactive iodine (131I) therapy for thyroid carcinoma
    P W Grigsby
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO, USA
    JAMA 283:2272-4. 2000
    ..In May 1997, the US Nuclear Regulatory Commission (NRC) revised its patient release regulations, allowing for outpatient administration of larger activities of sodium iodide 131I than previously permitted...
  60. ncbi request reprint Comparison of clinical outcome in black and white women treated with radiotherapy for cervical carcinoma
    P W Grigsby
    Radiation Oncology Center, Mallinckrodt Institute of Radiology, St Louis, Missouri 63110, USA
    Gynecol Oncol 79:357-61. 2000
    ..The purpose of this investigation was to evaluate the significance of race on the cancer-specific survival outcome of women treated with radiotherapy for advanced-stage cancer of the uterine cervix...
  61. doi request reprint Cervical cancer histology and tumor differentiation affect 18F-fluorodeoxyglucose uptake
    Elizabeth A Kidd
    Department of Radiation Oncology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer 115:3548-54. 2009
    ..This study aimed to evaluate the variation in cervical cancer glucose metabolism for different tumor histologies and levels of differentiation, as measured by the uptake of 18F-fluorodeoxyglucose (FDG) by positron emission tomography (PET)...
  62. doi request reprint Use of serial CT imaging for the quality assurance of MammoSite therapy
    Jacqueline Esthappan
    Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
    Brachytherapy 8:379-84. 2009
    ..This report presents the use of serial computed tomography (CT) imaging, in addition to planar or ultrasound imaging, for the quality assurance of an APBI treatment using the elliptical MammoSite...
  63. doi request reprint Assessing tumor hypoxia in cervical cancer by PET with 60Cu-labeled diacetyl-bis(N4-methylthiosemicarbazone)
    Farrokh Dehdashti
    Division of Nuclear Medicine, Edward Mallinckrodt Institute of Radiology, St Louis, Missouri 63110, USA
    J Nucl Med 49:201-5. 2008
    ..9). Pretherapy (60)Cu-ATSM PET provides clinically relevant information about tumor oxygenation that is predictive of outcome in patients with cervical cancer...
  64. doi request reprint Estimation of setup uncertainty using planar and MVCT imaging for gynecologic malignancies
    Lakshmi Santanam
    Department of Radiation Oncology, Washington University School of Medicine, 4921 Parkview Place, St Louis, MO 63110 1093, USA
    Int J Radiat Oncol Biol Phys 71:1511-7. 2008
    ..This prospective study investigates gynecologic malignancy online treatment setup error corrections using planar kilovoltage/megavoltage (KV/MV) imaging and helical MV computed tomography (MVCT) imaging...
  65. pmc A microRNA expression signature for cervical cancer prognosis
    Xiaoxia Hu
    Departments of Radiation Oncology, Pathology and Immunology, and Obstetrics and Gynecology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 70:1441-8. 2010
    ..In particular, miR-200a is likely to affect the metastatic potential of cervical cancer cells by coordinate suppression of multiple genes controlling cell motility...
  66. doi request reprint An imaging comparison of 64Cu-ATSM and 60Cu-ATSM in cancer of the uterine cervix
    Jason S Lewis
    Division of Radiological Sciences, Mallinckrodt Institute of Radiology, St Louis, Missouri, USA
    J Nucl Med 49:1177-82. 2008
    ....
  67. doi request reprint Dosimetric effects of air pockets around high-dose rate brachytherapy vaginal cylinders
    Susan Richardson
    Department of Radiation Oncology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Int J Radiat Oncol Biol Phys 78:276-9. 2010
    ..Recent published data have identified air pockets between the vaginal cylinders and the vaginal mucosa. The purpose of this research was to evaluate the incidence, size, and dosimetric effects of these air pockets...
  68. doi request reprint Radiotherapy for epidermoid carcinoma of the anus: thirty years' experience
    Robert J Myerson
    Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
    Int J Radiat Oncol Biol Phys 75:428-35. 2009
    ..To evaluate the factors associated with disease control and morbidity after radiotherapy for anal carcinoma...
  69. ncbi request reprint Acute toxicity of postoperative IMRT and chemotherapy for endometrial cancer
    Ryan M Tierney
    Department of Radiation Oncology, Box 8224, Mallinckrodt Institute of Radiology, Washington University School of Medicine, 4921 Parkview Place, Lower Level, St Louis, MO 63110, USA
    Radiat Med 25:439-45. 2007
    ..The aim of this study was to determine the acute toxicity of postoperative intensity-modulated radiotherapy (IMRT) with and without chemotherapy in patients with endometrial cancer...
  70. ncbi request reprint Sequential FDG-PET brachytherapy treatment planning in carcinoma of the cervix
    Lilie L Lin
    Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
    Int J Radiat Oncol Biol Phys 63:1494-501. 2005
    ..To evaluate the utility of sequential (18)F-fluorodeoxyglucose positron emission tomography (FDG-PET) imaging for brachytherapy treatment planning in patients with carcinoma of the cervix...
  71. ncbi request reprint Cervix carcinoma, concurrent chemoradiotherapy, and salvage of isolated paraaortic lymph node recurrence
    Anurag K Singh
    Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
    Int J Radiat Oncol Biol Phys 61:450-5. 2005
    ..To determine the effect of concurrent chemoradiotherapy on the outcome of invasive cervical carcinoma patients with disease recurrence isolated to the paraaortic lymph nodes...
  72. ncbi request reprint Lymph node control in cervical cancer
    Perry W Grigsby
    Department of Radiation Oncology, and Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, MO 63110, USA
    Int J Radiat Oncol Biol Phys 59:706-12. 2004
    ..The aim was to evaluate pretreatment lymph node size, irradiation dose, and failure patterns...
  73. ncbi request reprint A treatment planning study comparing HDR and AGIMRT for cervical cancer
    Sasha H Wahab
    Department of Radiation Oncology, Mallinckrodt Institute, Washington University School of Medicine, Box 8224, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Med Phys 31:734-43. 2004
    ..This investigation is being expanded using sequential PET images to model tumor regression and compare brachytherapy and AGIMRT throughout the course of therapy...
  74. ncbi request reprint Assessing tumor hypoxia in cervical cancer by positron emission tomography with 60Cu-ATSM: relationship to therapeutic response-a preliminary report
    Farrokh Dehdashti
    Division of Nuclear Medicine, Edward Mallinckrodt Institute of Radiology, St Louis, MO 63110, USA
    Int J Radiat Oncol Biol Phys 55:1233-8. 2003
    ..We have investigated whether pretreatment tumor hypoxia assessed by positron emission tomography (PET) with Cu-60 diacetyl-bis(N(4)-methylthiosemicarbazone) ((60)Cu-ATSM) predicts responsiveness to subsequent therapy in cervical cancer...
  75. ncbi request reprint PET-guided IMRT for cervical carcinoma with positive para-aortic lymph nodes-a dose-escalation treatment planning study
    Sasa Mutic
    Department of Radiation Oncology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Int J Radiat Oncol Biol Phys 55:28-35. 2003
    ..One goal of this process was not to modify the traditional treatment of the pelvic region...
  76. ncbi request reprint Childhood and adolescent thyroid carcinoma
    Perry W Grigsby
    Department of Radiation Oncology, Mallinckrodt Institute of Radiology, Washington University Medical Center, St Louis, Missouri 63110, USA
    Cancer 95:724-9. 2002
    ..This analysis was performed to evaluate the influence of clinical and treatment factors on local tumor control, control of distant metastasis, survival, and complications in children and adolescents with thyroid carcinoma...
  77. ncbi request reprint Applicator-guided intensity-modulated radiation therapy
    Daniel A Low
    Department of Radiation Oncology, Mallinckrodt Institute, St Louis, MO 63110, USA
    Int J Radiat Oncol Biol Phys 52:1400-6. 2002
    ..The flexibility of IMRT will enable customized dose distributions that have the potential to reduce complications and improve local control, especially for locally advanced disease...
  78. ncbi request reprint Preoperative lymph node staging of early-stage cervical carcinoma by [18F]-fluoro-2-deoxy-D-glucose-positron emission tomography
    Jason D Wright
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine and Alvin J Siteman Cancer Center, St Louis, Missouri 63110, USA
    Cancer 104:2484-91. 2005
    ..The objective of this study was to determine the sensitivity and specificity of PET in detecting lymph node metastasis in women with early-stage cervical carcinoma...
  79. ncbi request reprint Cervical carcinoma in the elderly: an analysis of patterns of care and outcome
    Jason D Wright
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer 103:85-91. 2005
    ..Advanced age often is considered a poor prognostic factor for cervical carcinoma. The authors investigated the patterns of care and treatment outcomes of elderly women with cervical carcinoma...
  80. doi request reprint Prospective clinical trial of positron emission tomography/computed tomography image-guided intensity-modulated radiation therapy for cervical carcinoma with positive para-aortic lymph nodes
    Jacqueline Esthappan
    Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
    Int J Radiat Oncol Biol Phys 72:1134-9. 2008
    ..Here, we describe methods for simulation and planning of these treatments and provide objectives for target coverage as well as normal tissue sparing to guide treatment plan evaluation...
  81. ncbi request reprint PET-guided three-dimensional treatment planning of intracavitary gynecologic implants
    Sasa Mutic
    Department of Radiation Oncology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Int J Radiat Oncol Biol Phys 52:1104-10. 2002
    ..This study evaluates the feasibility of using PET as the sole source of target, normal structure, and applicator delineation for intracavitary GYN implant treatment planning...
  82. ncbi request reprint CD83 gene polymorphisms increase susceptibility to human invasive cervical cancer
    Zhengyan Zhang
    Department of Obstetrics and Gynecology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8064, St Louis, MO 63110, USA
    Cancer Res 67:11202-8. 2007
    ..None of seven nearby genes was differentially expressed in cervical cancer. The importance of CD83 in epithelial versus dendritic cells needs to be determined, as does its role in promoting cervical cancer...
  83. ncbi request reprint Improved prognostic value of 18F-FDG PET using a simple visual analysis of tumor characteristics in patients with cervical cancer
    Tom R Miller
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Nucl Med 44:192-7. 2003
    ..This study using PET with (18)F-FDG was undertaken to determine whether a simple and fast visual analysis of characteristics of the primary tumor before initiation of treatment could achieve this goal...
  84. ncbi request reprint Treatment planning guidelines regarding the use of CT/PET-guided IMRT for cervical carcinoma with positive paraaortic lymph nodes
    Jacqueline Esthappan
    Department of Radiation Oncology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Int J Radiat Oncol Biol Phys 58:1289-97. 2004
    ..g., number of beams, beam geometry) and organ-specific parameters (e.g., importance weighting and tolerance dose) for intensity-modulated radiotherapy planning for the PALNs...
  85. ncbi request reprint Functional imaging in treatment planning in radiation therapy: a review
    Carlos A Perez
    Department of Radiation Oncology, Washington University Medical Center, St Louis, MO, USA
    Rays 27:157-73. 2002
    ..The recent introduction of a combined CT and PET scanner will substantially simplify image acquisition and treatment planning...
  86. pmc Notch-deficient skin induces a lethal systemic B-lymphoproliferative disorder by secreting TSLP, a sentinel for epidermal integrity
    Shadmehr Demehri
    Department of Developmental Biology, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS Biol 6:e123. 2008
    ..These observations demonstrate that local skin perturbations can drive a lethal systemic disease and have important implications for a wide range of humoral and autoimmune diseases with skin manifestations...
  87. ncbi request reprint Outcomes in 24 selected patients with stage IVB cervical cancer and excellent performance status treated with radiotherapy and chemotherapy
    Israel Zighelboim
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Washington University School of Medicine, Alvin J Siteman Cancer Center, St Louis, MO, USA
    Radiat Med 24:625-30. 2006
    ..We sought to review outcomes in patients with stage IVB carcinoma of the cervix treated with irradiation in combination with chemotherapy...
  88. ncbi request reprint Postoperative radiation therapy for grade II and III intracranial ependymoma
    David B Mansur
    Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
    Int J Radiat Oncol Biol Phys 61:387-91. 2005
    ..To retrospectively determine the long-term outcome of intracranial ependymoma patients treated with surgery and postoperative radiation therapy...
  89. ncbi request reprint Bevacizumab combination therapy in heavily pretreated, recurrent cervical cancer
    Jason D Wright
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, MO 63110, USA
    Gynecol Oncol 103:489-93. 2006
    ..To report the utility of the monoclonal, anti-vascular endothelial growth factor antibody bevacizumab in combination with cytotoxic chemotherapy for women with recurrent cervical cancer...
  90. ncbi request reprint Measurement of tumor volume by PET to evaluate prognosis in patients with advanced cervical cancer treated by radiation therapy
    Tom R Miller
    Mallinckrodt Institute of Radiology, St Louis, MO 63110, USA
    Int J Radiat Oncol Biol Phys 53:353-9. 2002
    ..This study evaluated the usefulness of tumor volume measurement with positron emission tomography (PET) in patients with advanced cervical cancer treated by radiation therapy...
  91. ncbi request reprint Intensity-modulated radiation therapy (IMRT) reduces small bowel, rectum, and bladder doses in patients with cervical cancer receiving pelvic and para-aortic irradiation
    L Portelance
    Department of Radiology, Radiation Oncology Center, Mallinckrodt Institute of Radiology, Washington University Medical Center, St. Louis, MO 63110, USA
    Int J Radiat Oncol Biol Phys 51:261-6. 2001
    ..48 +/- 31.80%) techniques (p < 0.05). CONCLUSION: In this dosimetric study, we demonstrated that with similar target coverage, normal tissue sparing is superior with IMRT in the treatment of cervical cancer...
  92. ncbi request reprint Prognostic factors and results of radiotherapy alone in the management of pituitary adenomas
    P W Grigsby
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110
    Int J Radiat Oncol Biol Phys 15:1103-10. 1988
    ..2 years, with the last failure occurring at 12 years following the completion of radiotherapy. Severe complications were apparent in 5 patients (7.1%), including one death from central nervous system radionecrosis...
  93. ncbi request reprint Update on radiation therapy for endometrial cancer
    Perry W Grigsby
    Radiation Oncology Center, Mallinckrodt Institute of Radiology, St Louis, Missouri, USA
    Oncology (Williston Park) 16:777-86, 790; discussion 791, 794-5. 2002
    ..Also described is the use of irradiation in recurrent endometrial cancer after surgery alone, as well as palliative radiation. In addition, ongoing prospective randomized trials are described...
  94. ncbi request reprint Effect of a T0 radical hysterectomy specimen on survival for early stage cervical cancer
    Jason D Wright
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Columbia University College of Physicians and Surgeons, 161 Fort Washington Ave, 8th Floor, New York, NY 10032, USA
    Gynecol Oncol 107:280-4. 2007
    ..The goal of this study was to evaluate the outcome of patients with no residual tumor (T0) in their hysterectomy specimens...
  95. ncbi request reprint Lymph node metastases in differentiated thyroid cancer under 2 cm
    Rishindra M Reddy
    Department of Surgery, Washington University School of Medicine, Saint Louis, MO 63110, USA
    Surgery 140:1050-4; discussion 1054-5. 2006
    ..The goal of this study was to evaluate the presence of lymph node metastasis in patients with T1 differentiated thyroid cancer (DTC) and determine prognostic significance for tumor recurrence and cancer-related death...
  96. ncbi request reprint Comparison of high-dose-rate and low-dose-rate brachytherapy in the treatment of endometrial carcinoma
    Alaa Fayed
    Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
    Int J Radiat Oncol Biol Phys 67:480-4. 2007
    ..To compare the outcomes for endometrial carcinoma patients treated with either high-dose-rate (HDR) or low-dose-rate (LDR) brachytherapy...
  97. doi request reprint Tumor hypoxia detected by positron emission tomography with 60Cu-ATSM as a predictor of response and survival in patients undergoing Neoadjuvant chemoradiotherapy for rectal carcinoma: a pilot study
    David W Dietz
    Department of Colorectal Surgery, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Dis Colon Rectum 51:1641-8. 2008
    ....