David S Gierada

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. doi request reprint Interval lung cancer after a negative CT screening examination: CT findings and outcomes in National Lung Screening Trial participants
    David S Gierada
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, Box 8131, 510 S Kingshighway Blvd, St Louis, MO, 63110, USA
    Eur Radiol . 2017
  2. pmc Projected outcomes using different nodule sizes to define a positive CT lung cancer screening examination
    David S Gierada
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO DSG Division of Cancer Prevention, National Cancer Institute, Bethesda, MD PP University of Alabama at Birmingham, Birmingham, AL HN Wake Forest University Health Science Center, Winston Salem, NC CC Center for Statistical Sciences and Department of Biostatistics, Brown University School of Public Health, Providence, RI FD Radiological Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA DRA
    J Natl Cancer Inst 106:. 2014
  3. pmc Quantitative CT assessment of emphysema and airways in relation to lung cancer risk
    David S Gierada
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 S Kingshighway Blvd, Box 8131, St Louis, MO 63110, USA
    Radiology 261:950-9. 2011
  4. ncbi request reprint Comparison of standard- and low-radiation-dose CT for quantification of emphysema
    David S Gierada
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 S Kingshighway Blvd, St Louis, MO 63110, USA
    AJR Am J Roentgenol 188:42-7. 2007
  5. pmc CT quality assurance in the lung screening study component of the National Lung Screening Trial: implications for multicenter imaging trials
    David S Gierada
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 S Kingshighway Blvd, Campus Box 8131, St Louis, MO 63105, USA
    AJR Am J Roentgenol 193:419-24. 2009
  6. ncbi request reprint Lung cancer: interobserver agreement on interpretation of pulmonary findings at low-dose CT screening
    David S Gierada
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 S Kingshighway Blvd, St Louis, MO 63105, USA
    Radiology 246:265-72. 2008
  7. pmc Effects of diffusion time on short-range hyperpolarized (3)He diffusivity measurements in emphysema
    David S Gierada
    Mallinckrodt Institute of Radiology, Washington University, St Louis, Missouri 63105, USA
    J Magn Reson Imaging 30:801-8. 2009
  8. pmc Effects of CT section thickness and reconstruction kernel on emphysema quantification relationship to the magnitude of the CT emphysema index
    David S Gierada
    Mallinckrodt Institute of Radiology, 510 S Kingshighway Blvd, Washington University, St Louis, MO 63105, USA
    Acad Radiol 17:146-56. 2010
  9. pmc Emphysema quantification in inflation-fixed lungs using low-dose computed tomography and 3He magnetic resonance imaging
    David S Gierada
    Mallinckrodt Institute of Radiology, Washington University, St Louis, MO 63105, USA
    J Comput Assist Tomogr 34:773-9. 2010
  10. pmc Quantification of lung microstructure with hyperpolarized 3He diffusion MRI
    Dmitriy A Yablonskiy
    Mallinckrodt Inst of Radiology, 4525 Scott Ave, Rm 2302, St Louis, MO 63110, USA
    J Appl Physiol (1985) 107:1258-65. 2009

Detail Information

Publications50

  1. doi request reprint Interval lung cancer after a negative CT screening examination: CT findings and outcomes in National Lung Screening Trial participants
    David S Gierada
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, Box 8131, 510 S Kingshighway Blvd, St Louis, MO, 63110, USA
    Eur Radiol . 2017
    ....
  2. pmc Projected outcomes using different nodule sizes to define a positive CT lung cancer screening examination
    David S Gierada
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO DSG Division of Cancer Prevention, National Cancer Institute, Bethesda, MD PP University of Alabama at Birmingham, Birmingham, AL HN Wake Forest University Health Science Center, Winston Salem, NC CC Center for Statistical Sciences and Department of Biostatistics, Brown University School of Public Health, Providence, RI FD Radiological Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA DRA
    J Natl Cancer Inst 106:. 2014
    ..The acceptability of reducing false-positive rates and diagnostic evaluations by increasing the nodule size threshold for a positive screen depends on the projected balance between benefits and risks...
  3. pmc Quantitative CT assessment of emphysema and airways in relation to lung cancer risk
    David S Gierada
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 S Kingshighway Blvd, Box 8131, St Louis, MO 63110, USA
    Radiology 261:950-9. 2011
    ..To determine whether quantitative computed tomographic (CT) measurements of emphysema and airway dimensions are associated with lung cancer risk in a screening population...
  4. ncbi request reprint Comparison of standard- and low-radiation-dose CT for quantification of emphysema
    David S Gierada
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 S Kingshighway Blvd, St Louis, MO 63110, USA
    AJR Am J Roentgenol 188:42-7. 2007
    ..This study was performed to compare standard- and low-radiation-dose techniques in the CT quantification of emphysema...
  5. pmc CT quality assurance in the lung screening study component of the National Lung Screening Trial: implications for multicenter imaging trials
    David S Gierada
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 S Kingshighway Blvd, Campus Box 8131, St Louis, MO 63105, USA
    AJR Am J Roentgenol 193:419-24. 2009
    ..The purpose of this study was to describe the effect of implementing an imaging quality assurance program on CT image quality in the Lung Screening Study component of the National Lung Screening Trial...
  6. ncbi request reprint Lung cancer: interobserver agreement on interpretation of pulmonary findings at low-dose CT screening
    David S Gierada
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 S Kingshighway Blvd, St Louis, MO 63105, USA
    Radiology 246:265-72. 2008
    ..To evaluate agreement among radiologists on the interpretation of pulmonary findings at low-dose computed tomographic (CT) screening examinations for lung cancer...
  7. pmc Effects of diffusion time on short-range hyperpolarized (3)He diffusivity measurements in emphysema
    David S Gierada
    Mallinckrodt Institute of Radiology, Washington University, St Louis, Missouri 63105, USA
    J Magn Reson Imaging 30:801-8. 2009
    ..To characterize the effect of diffusion time on short-range hyperpolarized (3)He magnetic resonance imaging (MRI) diffusion measurements across a wide range of emphysema severity...
  8. pmc Effects of CT section thickness and reconstruction kernel on emphysema quantification relationship to the magnitude of the CT emphysema index
    David S Gierada
    Mallinckrodt Institute of Radiology, 510 S Kingshighway Blvd, Washington University, St Louis, MO 63105, USA
    Acad Radiol 17:146-56. 2010
    ..Computed tomography (CT) section thickness and reconstruction kernel each influence CT measurements of emphysema. This study was performed to assess whether their effects are related to the magnitude of the measurement...
  9. pmc Emphysema quantification in inflation-fixed lungs using low-dose computed tomography and 3He magnetic resonance imaging
    David S Gierada
    Mallinckrodt Institute of Radiology, Washington University, St Louis, MO 63105, USA
    J Comput Assist Tomogr 34:773-9. 2010
    ..To evaluate the use of inflation-fixed lung tissue for emphysema quantification with computed tomography (CT) and He magnetic resonance (MR) diffusion imaging...
  10. pmc Quantification of lung microstructure with hyperpolarized 3He diffusion MRI
    Dmitriy A Yablonskiy
    Mallinckrodt Inst of Radiology, 4525 Scott Ave, Rm 2302, St Louis, MO 63110, USA
    J Appl Physiol (1985) 107:1258-65. 2009
    ....
  11. pmc The role of collateral paths in long-range diffusion of 3He in lungs
    Mark S Conradi
    Department of Physics, Washington University, Saint Louis, MO 63130, USA
    Acad Radiol 15:675-82. 2008
    ..However, no clear understanding of LRDC in healthy lungs has emerged. Here we compare LRDC measured in healthy lungs with computer simulations of diffusion along the airway tree with no collateral connections...
  12. pmc Accuracy of emphysema quantification performed with reduced numbers of CT sections
    Thomas K Pilgram
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 S Kingshighway Blvd, Campus Box 8131, St Louis, MO 63110, USA
    AJR Am J Roentgenol 194:585-91. 2010
    ..The purpose of this study was to assess the accuracy of emphysema measurements obtained from systematic samples of evenly spaced CT images compared with measurements obtained from the entire scan...
  13. pmc In vivo detection of acinar microstructural changes in early emphysema with (3)He lung morphometry
    James D Quirk
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, 4525 Scott Ave, Campus Box 8227, St Louis, MO 63110, USA
    Radiology 260:866-74. 2011
    ....
  14. pmc Results of the two incidence screenings in the National Lung Screening Trial
    Denise R Aberle
    Department of Radiological Sciences, David Geffen School of Medicine at the University of California at Los Angeles UCLA, Los Angeles, CA 90024, USA
    N Engl J Med 369:920-31. 2013
    ..We present detailed findings from the first two incidence screenings (rounds T1 and T2)...
  15. pmc Accurate measurement of small airways on low-dose thoracic CT scans in smokers
    Barbara A Lutey
    Division of Medical Education, Washington University School of Medicine, Campus Box 8121, 660 S Euclid Ave, St Louis, MO 63110, USA
    Chest 143:1321-9. 2013
    ..The purpose of this study was to assess the effect of partial volume averaging and tilt corrections on airway wall thickness measurement accuracy and on relationships between airway wall thickening and clinical status in COPD...
  16. pmc Cigarette smoke induces nucleic-acid oxidation in lung fibroblasts
    Gaetan Deslee
    Division of Pulmonary and Critical Care Medicine, School of Medicine, Washington University, St Louis, Missouri 63110, USA
    Am J Respir Cell Mol Biol 43:576-84. 2010
    ..Together, our results demonstrate ROS-dependent, cigarette smoke-induced nucleic-acid oxidation in alveolar fibroblasts, which may play a role in the pathogenesis of emphysema...
  17. pmc In vivo lung morphometry with hyperpolarized 3He diffusion MRI in canines with induced emphysema: disease progression and comparison with computed tomography
    Tariq S K Tanoli
    Departments of Radiology, Washington University in St Louis, St Louis, Missouri, USA
    J Appl Physiol 102:477-84. 2007
    ..The observed sensitivity of our method to emphysema progression suggests that this technique has potential for the diagnosis of emphysema and tracking of disease progression or improvement via a pharmaceutical intervention...
  18. pmc 3He diffusion MRI of the lung
    Mark S Conradi
    Department of Physics, Washington University, Saint Louis, MO 63130, USA
    Acad Radiol 12:1406-13. 2005
    ..MR imaging of the restricted diffusion of laser-polarized 3He gas provides unique insights into the changes in lung microstructure in emphysema...
  19. pmc The National Lung Screening Trial: overview and study design
    Denise R Aberle
    Center for Statistical Sciences, Brown University, Box G S121, 121 S Main St, 7th Floor, Providence, RI 02912, USA
    Radiology 258:243-53. 2011
    ..The NLST is such a trial. The rationale for and design of the NLST are presented...
  20. ncbi request reprint 19F MR imaging of ventilation and diffusion in excised lungs
    Richard E Jacob
    Department of Physics, Washington University in St Louis, St Louis, MO 63130 4899, USA
    Magn Reson Med 54:577-85. 2005
    ..033 cm2/s) places it in a regime where the ADC measurement allows the surface-to-volume ratio to be determined in each voxel, a potentially valuable quantitative characterization of regional lung tissue destruction in emphysema...
  21. pmc Role of collateral paths in long-range diffusion in lungs
    Seth Emil T Bartel
    Department of Physics 1105, Washington University, One Brookings Drive, St Louis, MO 63130, USA
    J Appl Physiol (1985) 104:1495-503. 2008
    ..The role of collateral paths is supported by measurements of smaller LRADC in pigs, where collateral ventilation is known to be smaller...
  22. pmc Hyperpolarized 3He MR imaging: physiologic monitoring observations and safety considerations in 100 consecutive subjects
    Barbara A Lutey
    Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, 510 S Kingshighway Blvd, St Louis, MO 63110, USA
    Radiology 248:655-61. 2008
    ..To evaluate the safety of hyperpolarized helium 3 ((3)He) magnetic resonance (MR) imaging...
  23. pmc Experimental evidence of age-related adaptive changes in human acinar airways
    James D Quirk
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri
    J Appl Physiol (1985) 120:159-65. 2016
    ....
  24. pmc Collecting 48,000 CT exams for the lung screening study of the National Lung Screening Trial
    Kenneth W Clark
    Mallinckrodt Institute of Radiology, Washington University, 510 South Kingshighway, Saint Louis, MO 63110, USA
    J Digit Imaging 22:667-80. 2009
    ..The approach to large scale, multi-center trial CT image collection detailed here may serve as a useful model, while the experience reported should be valuable in the planning and execution of future equivalent endeavors...
  25. pmc National lung screening trial: variability in nodule detection rates in chest CT studies
    Paul F Pinsky
    Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, 6130 Executive Blvd, Bethesda, MD 20892, USA
    Radiology 268:865-73. 2013
    ....
  26. pmc The role of matrix metalloproteinase-9 in cigarette smoke-induced emphysema
    Jeffrey J Atkinson
    Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Respir Crit Care Med 183:876-84. 2011
    ..Mouse models have demonstrated that excess MMP-9 production can result in permanent alveolar destruction...
  27. pmc Reader variability in identifying pulmonary nodules on chest radiographs from the national lung screening trial
    Satinder P Singh
    Department of Radiology, University of Alabama Hospitals in Birmingham, 619 South 19th Street, Birmingham, AL 35233, USA
    J Thorac Imaging 27:249-54. 2012
    ..To measure reader variability related to the evaluation of screening chest radiographs (CXRs) for findings of primary lung cancer...
  28. pmc Quantitative Computed Tomography Classification of Lung Nodules: Initial Comparison of 2- and 3-Dimensional Analysis
    David S Gierada
    From the Mallinckrodt Institute of Radiology, The Department of Biostatistics, and the Division of Cardiothoracic Surgery, Washington University School of Medicine, Saint Louis, MO
    J Comput Assist Tomogr 40:589-95. 2016
    ..The aim of this study was to compare the performance of 2- (2D) and 3-dimensional (3D) quantitative computed tomography (CT) methods for classifying lung nodules as lung cancer, metastases, or benign...
  29. pmc Equating quantitative emphysema measurements on different CT image reconstructions
    Seth T Bartel
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Med Phys 38:4894-902. 2011
    ....
  30. pmc Evaluation of reader variability in the interpretation of follow-up CT scans at lung cancer screening
    Satinder Singh
    Department of Radiology, University of Alabama Hospitals, 619 19th St South, Birmingham, AL 35249, USA
    Radiology 259:263-70. 2011
    ....
  31. pmc Baseline characteristics of participants in the randomized national lung screening trial
    Denise R Aberle
    Department of Radiological Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    J Natl Cancer Inst 102:1771-9. 2010
    ..In this article, we present characteristics of the study population...
  32. pmc Measuring small airways in transverse CT images correction for partial volume averaging and airway tilt
    Susan H Conradi
    Department of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Acad Radiol 17:1525-34. 2010
    ..This phantom study was performed to derive and test corrections to the measurements on the basis of consideration of partial volume averaging and tilt effects...
  33. ncbi request reprint Gadolinium-enhanced computed tomography angiography in multi-detector row computed tomography: initial observations
    Kyongtae T Bae
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 S Kingshighway Boulevard, St Louis, MO 63110, USA
    Acad Radiol 11:61-8. 2004
    ..The feasibility of using gadolinium contrast medium for computed tomography angiography (CTA) in multi-detector row computed tomography and the effect of contrast medium dilution was investigated...
  34. doi request reprint What makes a good pediatric transplant lung: Insights from in vivo lung morphometry with hyperpolarized 3 He magnetic resonance imaging
    Emily F Fishman
    Department of Pediatrics, Washington University, St Louis, MO, USA
    Pediatr Transplant . 2017
    ..In vivo lung morphometry uniquely provides previously unavailable information on lung microstructure that may be predictive of a negative outcome and has a potential to aid in lung selection for transplantation...
  35. pmc Does the method of radiologic surveillance affect survival after resection of stage I non-small cell lung cancer?
    Traves D Crabtree
    Division of Cardiothoracic Surgery, Department of Surgery, Washington University School of Medicine, St Louis, Mo Electronic address
    J Thorac Cardiovasc Surg 149:45-52, 53.e1-3. 2015
    ..We compared the impact of surveillance computed tomography scan versus chest radiography in patients who underwent resection for stage I lung cancer...
  36. ncbi request reprint Variation in diaphragm position and shape in adults with normal pulmonary function
    Thitiporn Suwatanapongched
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Chest 123:2019-27. 2003
    ..However, previous population studies of normal diaphragm position and shape frequently lack objective radiographic measurements and documentation of pulmonary function, and do not account for the observed variability...
  37. doi request reprint A thoracic surgery clinic dedicated to indeterminate pulmonary nodules: too many scans and too little pathology?
    Nirmal K Veeramachaneni
    Division of Thoracic Surgery, Washington University School of Medicine, St Louis, Mo 63110 1013, USA
    J Thorac Cardiovasc Surg 137:30-5. 2009
    ..Widespread application of computed tomographic scans has increased detection of asymptomatic pulmonary nodules. A dedicated clinic was established to encourage referral and manage large numbers of patients with such nodules...
  38. ncbi request reprint Performance of a computer-aided program for automated matching of metastatic pulmonary nodules detected on follow-up chest CT
    Kyung Won Lee
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO, USA
    AJR Am J Roentgenol 189:1077-81. 2007
    ..The purpose of this study was to evaluate the performance of a computer-aided program that allows automated matching of metastatic pulmonary nodules imaged with two serial clinical chest CT studies...
  39. pmc Image quality assurance in the prostate, lung, colorectal, and ovarian cancer screening trial network of the National Lung Screening Trial
    Stephen M Moore
    Mallinckrodt Institute of Radiology, Washington University, St Louis, MO, USA
    J Digit Imaging 18:242-50. 2005
    ....
  40. ncbi request reprint A prospective evaluation of lung volume reduction surgery in 200 consecutive patients
    Roger D Yusen
    Division of Pulmonary, Washington University School of Medicine, St Louis, MO 63110, USA
    Chest 123:1026-37. 2003
    ..The primary objectives of this study were to assess long-term health-related quality of life, satisfaction, physiologic status, and survival of patients following LVRS...
  41. pmc Oxidative damage to nucleic acids in severe emphysema
    Gaetan Deslee
    Washington University School of Medicine, Division of Pulmonary and Critical Care Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Chest 135:965-74. 2009
    ..Oxidative stress is a key element in the pathogenesis of emphysema, but oxidation of nucleic acids has been largely overlooked. The aim of this study was to investigate oxidative damage to nucleic acids in severe emphysematous lungs...
  42. ncbi request reprint MRI of piriformis syndrome
    Edward Y Lee
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 S Kingshighway Blvd, Box 8131, St Louis, MO 63110, USA
    AJR Am J Roentgenol 183:63-4. 2004
  43. pmc Using imaging as a biomarker for asthma
    Abhaya Trivedi
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO
    J Allergy Clin Immunol 139:1-10. 2017
    ..Furthermore, imaging techniques can serve as a potential biomarker and be used to assess response to therapies, including newer biological treatments and bronchial thermoplasty...
  44. pmc Effect of Reducing Field of View on Multidetector Quantitative Computed Tomography Parameters of Airway Wall Thickness in Asthma
    Ajay Sheshadri
    From the Division of Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine, St Louis, MI Department of Medical Physics, University of Wisconsin Madison, Madison, WI Department of Surgery, University of Louisville School of Medicine, Louisville, KY Division of Biostatistics, Washington University School of Medicine, St Louis, MI Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pa Department of Radiology, University of Iowa College of Medicine, Iowa City, IA and Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MI
    J Comput Assist Tomogr 39:584-90. 2015
    ....
  45. ncbi request reprint Radiologic assessment of emphysema for lung volume reduction surgery
    David S Gierada
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, Barnes Jewish Hospital, St Louis, MO 63110, USA
    Semin Thorac Cardiovasc Surg 14:381-90. 2002
    ....
  46. pmc Lung imaging in asthmatic patients: the picture is clearer
    Mario Castro
    Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    J Allergy Clin Immunol 128:467-78. 2011
    ....
  47. ncbi request reprint CT depiction of pulmonary emboli: display window settings
    Kyongtae T Bae
    1 Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 S Kingshighway Blvd, St Louis, MO 63110, USA
    Radiology 236:677-84. 2005
    ..To compare computed tomographic (CT) window settings selected by radiologists with those determined by using two alternative approaches for depiction of pulmonary emboli (PE)...
  48. pmc Longitudinal changes in airway remodeling and air trapping in severe asthma
    Chad A Witt
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine, Campus Box 8052, 660 S Euclid Ave, St Louis, MO 63110 1093
    Acad Radiol 21:986-93. 2014
    ..This study aimed to evaluate predictors of airway wall remodeling and change in lung function and lung density over time in severe asthma...
  49. pmc Quantitative in vivo assessment of lung microstructure at the alveolar level with hyperpolarized 3He diffusion MRI
    Dmitriy A Yablonskiy
    Department of Radiology, Washington University School of Medicine, 4525 Scott Avenue, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 99:3111-6. 2002
    ..The technique offers promise as a clinical tool for early diagnosis of emphysema...
  50. pmc Volumetric measurements of lung nodules with multi-detector row CT: effect of changes in lung volume
    Jin Mo Goo
    Department of Radiology, Seoul National University College of Medicine, and the Institute of Radiation Medicine, SNUMRC, Jongno gu, Seoul, Korea
    Korean J Radiol 7:243-8. 2006
    ..To evaluate how changes in lung volume affect volumetric measurements of lung nodules using a multi-detector row CT...