Deborah E Dobson

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. pmc Two functionally divergent UDP-Gal nucleotide sugar transporters participate in phosphoglycan synthesis in Leishmania major
    Althea A Capul
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Biol Chem 282:14006-17. 2007
  2. ncbi request reprint Identification of genes encoding arabinosyltransferases (SCA) mediating developmental modifications of lipophosphoglycan required for sand fly transmission of leishmania major
    Deborah E Dobson
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 278:28840-8. 2003
  3. pmc Leishmania major survival in selective Phlebotomus papatasi sand fly vector requires a specific SCG-encoded lipophosphoglycan galactosylation pattern
    Deborah E Dobson
    Department of Molecular Microbiology, Washington University Medical School, St Louis, Missouri, United States of America
    PLoS Pathog 6:e1001185. 2010
  4. pmc Demonstration of genetic exchange during cyclical development of Leishmania in the sand fly vector
    Natalia S Akopyants
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Science 324:265-8. 2009
  5. ncbi request reprint Genomic organization and expression of the expanded SCG/L/R gene family of Leishmania major: internal clusters and telomeric localization of SCGs mediating species-specific LPG modifications
    Deborah E Dobson
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Biochem Parasitol 146:231-41. 2006
  6. ncbi request reprint Functional identification of galactosyltransferases (SCGs) required for species-specific modifications of the lipophosphoglycan adhesin controlling Leishmania major-sand fly interactions
    Deborah E Dobson
    Department of Molecular Microbiology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    J Biol Chem 278:15523-31. 2003
  7. pmc A Narnavirus in the Trypanosomatid Protist Plant Pathogen Phytomonas serpens
    Natalia S Akopyants
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, Missouri, USA
    Genome Announc 4:. 2016
  8. ncbi request reprint Flypaper for parasites
    Stephen M Beverley
    Department of Molecular Microbiology, Washington University Medical School, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Cell 119:311-2. 2004
  9. pmc A Novel Bunyavirus-Like Virus of Trypanosomatid Protist Parasites
    Natalia S Akopyants
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, Missouri, USA
    Genome Announc 4:. 2016
  10. pmc A Narnavirus-Like Element from the Trypanosomatid Protozoan Parasite Leptomonas seymouri
    Lon Fye Lye
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, Missouri, USA
    Genome Announc 4:. 2016

Collaborators

  • S M Beverley
  • Shaden Kamhawi
  • Natalia S Akopyants
  • Lon Fye Lye
  • Julius Lukes
  • Althea A Capul
  • Salvatore J Turco
  • Mamta Goswami
  • Alasdair C Ivens
  • Nicola Kimblin
  • David L Sacks
  • Phillip Lawyer
  • Nathan Peters
  • Rachel Patrick
  • Nagila Secundino
  • Tamara Barron
  • Katja Borzym
  • Natasha Larke
  • Silke Müller-Auer
  • Angela K Cruz
  • Ellen Sisk
  • Rita Aert
  • Martin Pentony
  • Angela Lord
  • Helmut Hilbert
  • Michael Rieger
  • Monika Fuchs
  • Jeremy C Mottram
  • David Saunders
  • Shulamit Michaeli
  • Richard M R Coulson
  • Sven Klages
  • Dhileep Sivam
  • Bart Barrell
  • Deborah F Smith
  • Gabriella Bianchettin
  • Heather Munden
  • Gautam Aggarwal
  • Richard Reinhardt
  • Arlette Goble
  • Elizabeth A Worthey
  • Andreas Duesterhoeft
  • Christine Clayton
  • John Woodward
  • Steve Squares
  • Javier De Gaudenzi
  • Andre Goffeau
  • Atashi Anupama
  • Michael A Quail
  • Christy Vogt
  • Heesun Shin
  • David C Schwartz
  • Audrey Fraser
  • Michael Kube
  • Guido Volckaert
  • Simon Rutter
  • Kenneth D Stuart
  • Marco Marra
  • Yiting Huang
  • Joel Rinta
  • Claire Price
  • Siri Nelson
  • Johan Robben
  • Jeronimo C Ruiz
  • Christiane Hertz-Fowler
  • Jenefer M Blackwell
  • Wolfgang Zimmermann
  • Gordana Bothe
  • Andrew Knights
  • Sarah Sharp
  • Lyudmila Litvin
  • Valentina Tosato
  • Thomas M Pohl
  • Melanie Schäfer
  • Gholam Fazelina
  • Lee Murphy
  • David Harris
  • Jacquie Schein
  • Claudia Gabel
  • Peter J Myler
  • Ellen Adlem
  • Kathy Seeger
  • Rob Squares
  • Rolf Wambutt
  • Ester Rabbinowitsch
  • David Horn
  • Holger Wedler
  • Amber Seyler
  • Zina Apostolou
  • Shiguo Zhou

Detail Information

Publications12

  1. pmc Two functionally divergent UDP-Gal nucleotide sugar transporters participate in phosphoglycan synthesis in Leishmania major
    Althea A Capul
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Biol Chem 282:14006-17. 2007
    ..Identification of these key NSTs in Leishmania will facilitate the dissection of glycoconjugate synthesis and its role(s) in the parasite life cycle and further our understanding of NSTs generally...
  2. ncbi request reprint Identification of genes encoding arabinosyltransferases (SCA) mediating developmental modifications of lipophosphoglycan required for sand fly transmission of leishmania major
    Deborah E Dobson
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 278:28840-8. 2003
    ..The SCA genes define a new family of eukaryotic betaAraTs and represent novel developmentally regulated LPG-modifying activities identified in Leishmania...
  3. pmc Leishmania major survival in selective Phlebotomus papatasi sand fly vector requires a specific SCG-encoded lipophosphoglycan galactosylation pattern
    Deborah E Dobson
    Department of Molecular Microbiology, Washington University Medical School, St Louis, Missouri, United States of America
    PLoS Pathog 6:e1001185. 2010
    ....
  4. pmc Demonstration of genetic exchange during cyclical development of Leishmania in the sand fly vector
    Natalia S Akopyants
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Science 324:265-8. 2009
    ....
  5. ncbi request reprint Genomic organization and expression of the expanded SCG/L/R gene family of Leishmania major: internal clusters and telomeric localization of SCGs mediating species-specific LPG modifications
    Deborah E Dobson
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Biochem Parasitol 146:231-41. 2006
    ..Potentially, telomeric localization of SCG genes may function primarily to facilitate gene conversion and the elaboration of functional evolutionary diversity in the degree of PG sc-galactosylation observed in other strains of L. major...
  6. ncbi request reprint Functional identification of galactosyltransferases (SCGs) required for species-specific modifications of the lipophosphoglycan adhesin controlling Leishmania major-sand fly interactions
    Deborah E Dobson
    Department of Molecular Microbiology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    J Biol Chem 278:15523-31. 2003
    ..Thus the L. major genome encodes a family of SCGs with varying specificity and activity, and we propose that strain-specific LPG galactosylation patterns reflect differences in their expression...
  7. pmc A Narnavirus in the Trypanosomatid Protist Plant Pathogen Phytomonas serpens
    Natalia S Akopyants
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, Missouri, USA
    Genome Announc 4:. 2016
    ..The properties of PserNV1 permit assignment to the genus Narnavirus (Narnaviridae), the first reported from a host other than fungi or oomycetes. ..
  8. ncbi request reprint Flypaper for parasites
    Stephen M Beverley
    Department of Molecular Microbiology, Washington University Medical School, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Cell 119:311-2. 2004
    ..This interaction is critical for parasite survival in the midgut of its sand fly vector. The results open new avenues for studies of insect immunity, transmission binding vaccines, and host-parasite coevolution...
  9. pmc A Novel Bunyavirus-Like Virus of Trypanosomatid Protist Parasites
    Natalia S Akopyants
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, Missouri, USA
    Genome Announc 4:. 2016
    ....
  10. pmc A Narnavirus-Like Element from the Trypanosomatid Protozoan Parasite Leptomonas seymouri
    Lon Fye Lye
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, Missouri, USA
    Genome Announc 4:. 2016
    ..A 2.9-kb segment encodes an RNA-dependent RNA polymerase (RdRp), while a smaller 1.5-kb segment showed no database search matches. This is the first report of bisegmented Narnaviridae from insect trypanosomatids. ..
  11. ncbi request reprint Demonstration by heterologous expression that the Leishmania SCA1 gene encodes an arabinopyranosyltransferase
    Mamta Goswami
    Department of Biochemistry, University of Kentucky Medical Center, Lexington, KY 40536, USA
    Glycobiology 16:230-6. 2006
    ..No activity was observed in the absence of LPG. These results demonstrate that SCA1 encodes a sc-D-ArapT and provide the first example of heterologous expression of a D-ArapT gene...
  12. pmc The genome of the kinetoplastid parasite, Leishmania major
    Alasdair C Ivens
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK
    Science 309:436-42. 2005
    ..Abundant RNA-binding proteins are encoded in the Tritryp genomes, consistent with active posttranscriptional regulation of gene expression...