Genomes and Genes
ROBERT C CULVERHOUSE
Affiliation: Washington University School of Medicine
- Uncovering hidden variance: pair-wise SNP analysis accounts for additional variance in nicotine dependenceROBERT C CULVERHOUSE
Division of General Medical Sciences, Department of Medicine, Washington University, Saint Louis, MO 63110, USA
Hum Genet 129:177-88. 2011..Methodologies that limit analyses of joint effects to variants that demonstrate association in single SNP analyses, or require a significant interaction term, will likely miss important joint effects...
- Protocol for a collaborative meta-analysis of 5-HTTLPR, stress, and depressionROBERT C CULVERHOUSE
Department of Medicine, Washington University School of Medicine, St, Louis, MO, USA
BMC Psychiatry 13:304. 2013..Meta-analyses of multiple studies have also reached differing conclusions...
- Identifying rare variants from exome scans: the GAW17 experienceSaurabh Ghosh
Human Genetics Unit, Indian Statistical Institute, Kolkata 700018, India
BMC Proc 5:S1. 2011....
- A comparison of methods sensitive to interactions with small main effectsROBERT C CULVERHOUSE
Department of Internal Medicine, Washington University in St Louis School of Medicine, St Louis, Missouri 63110, USA
Genet Epidemiol 36:303-11. 2012..The MDR outperformed the SVM when the true model had only a few, well-separated risk classes; while the SVM outperformed the MDR on more complicated models. Of these methods, only MDR has a well-developed user interface...
- Gene x gene and gene x environment interactions for complex disordersRobert Culverhouse
Department of Medicine, Washington University, 660 South Euclid, GMS Box 8005, St, Louis, Missouri 63110, USA
BMC Proc 1:S72. 2007....
- Power and false-positive rates for the restricted partition method (RPM) in a large candidate gene data setRobert Culverhouse
Department of Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St, Louis, Missouri 63110, USA
BMC Proc 3:S74. 2009..Power and false-positive rates were evaluated using the first 100 replicate datasets. This included an exploration of the utility of using of all genotyped family members compared with selecting one member per family...
- The restricted partition methodRobert Culverhouse
Washington University in St Louis School of Medicine, St Louis, Missouri, USA
Adv Genet 72:117-39. 2010..Because the algorithm and software lend themselves to distributed processing, larger analyses can easily be split among multiple computers...
- The use of the restricted partition method with case-control dataR Culverhouse
Department of Internal Medicine, Washington University in St Louis School of Medicine, St Louis, MO 63110, USA
Hum Hered 63:93-100. 2007..The aim of this study is to evaluate the performance of the RPM on case-control data...
- Smoking and genetic risk variation across populations of European, Asian, and African American ancestry--a meta-analysis of chromosome 15q25Li Shiun Chen
Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
Genet Epidemiol 36:340-51. 2012..Using the cross-population study paradigm provides valuable insights to narrow regions of interest and inform future biological experiments...
- The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-AmericansNancy L Saccone
Department of Genetics, Washington University, St Louis, Missouri 63110, UA
Cancer Res 69:6848-56. 2009..The nonsynonymous SNP rs16969968, a known risk variant in populations of European-descent, is also significantly associated with risk in African-Americans. Additional SNPs contribute to risk in distinct ways in these two populations...
- Multiple independent loci at chromosome 15q25.1 affect smoking quantity: a meta-analysis and comparison with lung cancer and COPDNancy L Saccone
Department of Genetics, Washington University School of Medicine, St Louis, Missouri, USA
PLoS Genet 6:. 2010..This study is also the first report of association between rs588765 (and correlates) and smoking that achieves genome-wide significance; these SNPs have previously been associated with mRNA levels of CHRNA5 in brain and lung tissue...
- Multiple distinct CHRNB3-CHRNA6 variants are genetic risk factors for nicotine dependence in African Americans and European AmericansROBERT C CULVERHOUSE
Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA Division of Biostatistics, Washington University School of Medicine, Saint Louis, MO, USA
Addiction 109:814-22. 2014..We investigate whether this generalizes to African Americans, whether the association is specific to nicotine dependence and whether this region contains additional genetic contributors to nicotine dependence...
- Association of the OPRM1 Variant rs1799971 (A118G) with Non-Specific Liability to Substance Dependence in a Collaborative de novo Meta-Analysis of European-Ancestry CohortsTae Hwi Schwantes-An
Department of Genetics, Washington University School of Medicine, 4523 Clayton Avenue, Campus Box 8232, St Louis, MO, 63110, USA
Behav Genet 46:151-69. 2016..This project highlights the benefits of examining addictive behaviors collectively and the power of collaborative data sharing and meta-analyses...
- Stratify or adjust? Dealing with multiple populations when evaluating rare variantsROBERT C CULVERHOUSE
Department of Medicine, Washington University School of Medicine, 660 South Euclid Avenue, Saint Louis, MO 63110, USA
BMC Proc 5:S101. 2011..However, including population as a covariate was not an effective substitute for analyzing the subpopulations separately when only one subpopulation contained a rare variant linked to the phenotype...
- Linkage analysis merging replicate phenotypes: an application to three quantitative phenotypes in two African samplesAnthony L Hinrichs
Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Ave, Campus Box 8134, St, Louis, MO 63110, USA
BMC Proc 5:S81. 2011..Using both methods, we found numerous significant linkage signals for Q1, although population colocalization was absent for most of these signals. The linkage analysis of Q2 and Q4 failed to reveal any strong linkage signals...
- A genome-wide association study of alcohol dependenceLaura J Bierut
Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 107:5082-7. 2010..11 and 1.16. Further dissection of the alcoholism phenotype, to disentangle the influence of comorbid substance-use disorders, will be a next step in identifying genetic variants associated with alcohol dependence...
- Gene by environment interactionsROBERT C CULVERHOUSE
Department of Medicine, Washington University School of Medicine, 600 South Euclid, St Louis, MO 63110, USA
Genet Epidemiol 31:S68-74. 2007..A related but distinct goal is to characterize an interaction (e.g. to determine if the interaction is significant)...
- Exploiting linkage disequilibrium in population isolatesR Culverhouse
Department of Psychiatry, Washington University School of Medicine, Box 8134, Dept. of Psychiatry, 660 South Euclid, St. Louis, MO 63110, USA
Genet Epidemiol 21:S429-34. 2001..We describe two statistical methods to utilize D: a method appropriate for a single moderately sized sample and a sequential approach appropriate for multiple small independent samples...