Anne M Connolly

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi Congenital myasthenic syndrome: presentation, electrodiagnosis, and muscle biopsy
    Christina A Gurnett
    Department of Neurology, Washington University School of Medicine, Saint Louis, MO 63110, USA
    J Child Neurol 19:175-82. 2004
  2. ncbi Three mouse models of muscular dystrophy: the natural history of strength and fatigue in dystrophin-, dystrophin/utrophin-, and laminin alpha2-deficient mice
    A M Connolly
    Department of Neurology, Washington University School of Medicine, Box 8111 660 S Euclid, Saint Louis, MO 63110, USA
    Neuromuscul Disord 11:703-12. 2001
  3. ncbi Complement 3 deficiency and oral prednisolone improve strength and prolong survival of laminin alpha2-deficient mice
    Anne M Connolly
    Department of Neurology, Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO 63110, USA
    J Neuroimmunol 127:80-7. 2002
  4. ncbi High dose weekly oral prednisone improves strength in boys with Duchenne muscular dystrophy
    Anne M Connolly
    Department of Neurology, Saint Louis Children s Hospital, Washington University School of Medicine, Box 8111, 660 S Euclid Avenue, Saint Louis, MO 63110, USA
    Neuromuscul Disord 12:917-25. 2002
  5. ncbi Weekly oral prednisolone improves survival and strength in male mdx mice
    Richard M Keeling
    Department of Neurology, Box 8111, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Muscle Nerve 35:43-8. 2007
  6. ncbi Sensitive ultrasonic delineation of steroid treatment in living dystrophic mice with energy-based and entropy-based radio frequency signal processing
    Kirk D Wallace
    Washington University School of Medicine, Washington University, St Louis, MO, USA
    IEEE Trans Ultrason Ferroelectr Freq Control 54:2291-9. 2007
  7. ncbi RAG2 gene knockout in mice causes fatigue
    Paul T Golumbek
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Muscle Nerve 36:471-6. 2007
  8. ncbi Strength and corticosteroid responsiveness of mdx mice is unchanged by RAG2 gene knockout
    Paul T Golumbek
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuromuscul Disord 17:376-84. 2007
  9. doi Clinical trial readiness in non-ambulatory boys and men with duchenne muscular dystrophy: MDA-DMD network follow-up
    Anne M Connolly
    Department of Neurology, Washington University School of Medicine, Saint Louis, Missouri, USA
    Muscle Nerve 54:681-9. 2016
  10. pmc Outcome reliability in non-ambulatory boys/men with Duchenne muscular dystrophy
    Anne M Connolly
    Department of Neurology, Washington University School of Medicine in Saint Louis, St Louis, Missouri, 63110, USA Department of Pediatrics, Washington University School of Medicine in Saint Louis, St Louis, Missouri, USA
    Muscle Nerve 51:522-32. 2015

Collaborators

Detail Information

Publications27

  1. ncbi Congenital myasthenic syndrome: presentation, electrodiagnosis, and muscle biopsy
    Christina A Gurnett
    Department of Neurology, Washington University School of Medicine, Saint Louis, MO 63110, USA
    J Child Neurol 19:175-82. 2004
    ..Our experience suggests that many children with congenital myasthenic syndromes might be undiagnosed because of atypical presentation and because additional electrophysiologic studies are required...
  2. ncbi Three mouse models of muscular dystrophy: the natural history of strength and fatigue in dystrophin-, dystrophin/utrophin-, and laminin alpha2-deficient mice
    A M Connolly
    Department of Neurology, Washington University School of Medicine, Box 8111 660 S Euclid, Saint Louis, MO 63110, USA
    Neuromuscul Disord 11:703-12. 2001
    ..This work demonstrates a distinct pattern of disease progression in each model and provides a foundation for assessing strategies for improving strength in each model...
  3. ncbi Complement 3 deficiency and oral prednisolone improve strength and prolong survival of laminin alpha2-deficient mice
    Anne M Connolly
    Department of Neurology, Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO 63110, USA
    J Neuroimmunol 127:80-7. 2002
    ..Because complement activity may be modified pharmacologically, this work may have implications for treatment of children with congenital muscular dystrophy secondary to laminin alpha2 deficiency...
  4. ncbi High dose weekly oral prednisone improves strength in boys with Duchenne muscular dystrophy
    Anne M Connolly
    Department of Neurology, Saint Louis Children s Hospital, Washington University School of Medicine, Box 8111, 660 S Euclid Avenue, Saint Louis, MO 63110, USA
    Neuromuscul Disord 12:917-25. 2002
    ..Twice weekly prednisone improved strength over 6-12 months in the majority of boys, but did not slow contracture development. Sustained benefit beyond 12 months is possible with fewer side effects compared to daily prednisone...
  5. ncbi Weekly oral prednisolone improves survival and strength in male mdx mice
    Richard M Keeling
    Department of Neurology, Box 8111, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Muscle Nerve 35:43-8. 2007
    ..As corticosteroids remain the most validated long-term treatment of DMD, this work may allow for better prediction of synergistic treatments likely to translate to effective improvement for boys with this progressive muscular dystrophy...
  6. ncbi Sensitive ultrasonic delineation of steroid treatment in living dystrophic mice with energy-based and entropy-based radio frequency signal processing
    Kirk D Wallace
    Washington University School of Medicine, Washington University, St Louis, MO, USA
    IEEE Trans Ultrason Ferroelectr Freq Control 54:2291-9. 2007
    ..Successful differentiation among dystrophic, steroid-treated, and normal tissues suggests the potential for local noninvasive monitoring of disease severity and therapeutic effects...
  7. ncbi RAG2 gene knockout in mice causes fatigue
    Paul T Golumbek
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Muscle Nerve 36:471-6. 2007
    ..Whether these effects were centrally or peripherally mediated is unknown. This model may help to explain fatigue in human conditions in which the immune system is suppressed or absent...
  8. ncbi Strength and corticosteroid responsiveness of mdx mice is unchanged by RAG2 gene knockout
    Paul T Golumbek
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuromuscul Disord 17:376-84. 2007
    ..Prednisolone's therapeutic effect is through T-cell/B-cell independent mechanisms in mdx mice...
  9. doi Clinical trial readiness in non-ambulatory boys and men with duchenne muscular dystrophy: MDA-DMD network follow-up
    Anne M Connolly
    Department of Neurology, Washington University School of Medicine, Saint Louis, Missouri, USA
    Muscle Nerve 54:681-9. 2016
    ..Outcomes sensitive to change over time in non-ambulatory boys/men with Duchenne muscular dystrophy (DMD) are not well-established...
  10. pmc Outcome reliability in non-ambulatory boys/men with Duchenne muscular dystrophy
    Anne M Connolly
    Department of Neurology, Washington University School of Medicine in Saint Louis, St Louis, Missouri, 63110, USA Department of Pediatrics, Washington University School of Medicine in Saint Louis, St Louis, Missouri, USA
    Muscle Nerve 51:522-32. 2015
    ..Therapeutic trials in Duchenne muscular dystrophy (DMD) often exclude non-ambulatory individuals. Here we establish optimal and reliable assessments in a multicenter trial...
  11. pmc Motor and cognitive assessment of infants and young boys with Duchenne Muscular Dystrophy: results from the Muscular Dystrophy Association DMD Clinical Research Network
    Anne M Connolly
    Department of Neurology, Washington University School of Medicine, Saint Louis, MO 63110, USA
    Neuromuscul Disord 23:529-39. 2013
    ..NSAA (n = 18 boys; 2.2 ± 0.4 years) showed a mean score of 12 ± 5. Outcome assessments of young boys with DMD are feasible and in this multicenter study were best demonstrated using the Bayley III...
  12. pmc Rapamycin nanoparticles target defective autophagy in muscular dystrophy to enhance both strength and cardiac function
    Kristin P Bibee
    2Center for Translational Research in Advanced Imaging and Nanomedicine, Department of Medicine, Washington University School of Medicine, 660 South Euclid Ave, Saint Louis, MO 63110 USA
    FASEB J 28:2047-61. 2014
    ....
  13. pmc Sensitive ultrasonic detection of dystrophic skeletal muscle in patients with duchenne muscular dystrophy using an entropy-based signal receiver
    Michael S Hughes
    Washington University, School of Medicine, St Louis, MO 63108, USA
    Ultrasound Med Biol 33:1236-43. 2007
    ..005, student two-tailed paired t-test). Consequently, these imaging techniques may prove useful for longitudinal monitoring of disease progression and therapy...
  14. pmc One year outcome of boys with Duchenne muscular dystrophy using the Bayley-III scales of infant and toddler development
    Anne M Connolly
    Department of Neurology, Saint Louis Children s Hospital, Washington University School of Medicine in Saint Louis, Saint Louis, Missouri Department of Pediatrics, Saint Louis Children s Hospital, Washington University School of Medicine in Saint Louis, Saint Louis, Missouri Electronic address
    Pediatr Neurol 50:557-63. 2014
    ..Clinical evaluators at six centers were trained and certified to perform the Bayley-III. Here, we report 6- and 12-month follow-up of two subsets of these boys...
  15. pmc Skeletal muscle abnormalities and genetic factors related to vertical talus
    Laura J Merrill
    Departments of Orthopaedic Surgery, Washington University School of Medicine, 1 Children s Place, Suite 4S 60, St Louis, MO 63110, USA
    Clin Orthop Relat Res 469:1167-74. 2011
    ..Identifying the tissue abnormalities and genetic causes responsible for vertical talus has the potential to lead to improved treatment and preventive strategies...
  16. ncbi Brain-derived neurotrophic factor and autoantibodies to neural antigens in sera of children with autistic spectrum disorders, Landau-Kleffner syndrome, and epilepsy
    Anne M Connolly
    Department of Neurology and Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Biol Psychiatry 59:354-63. 2006
    ..Other autoantibodies (AAs) to endothelial cells (ECs) and myelin basic protein (MBP) are also elevated in some children. We tested relationships between BDNF, BDNF AAs, and other AAs in children with these disorders...
  17. doi Electrical impedance myography in Duchenne muscular dystrophy and healthy controls: A multicenter study of reliability and validity
    Craig M Zaidman
    Department of Neurology, Washington University School of Medicine, 660 South Euclid Avenue, Box 8111, St Louis, Missouri, 63110, USA
    Muscle Nerve 52:592-7. 2015
    ..Electrical impedance myography (EIM) is a non-invasive, painless, objective technique to quantify muscle pathology...
  18. doi Muscle ultrasound quantifies disease progression over time in infants and young boys with duchenne muscular dystrophy
    Craig M Zaidman
    Department of Neurology, Washington University School of Medicine, 660 South Euclid Avenue, Box 8111, St Louis, Missouri, 63110, USA
    Muscle Nerve 52:334-8. 2015
    ..Studies of quantitative ultrasound in infants/young boys with DMD over time have not been reported...
  19. pmc Myosin binding protein C1: a novel gene for autosomal dominant distal arthrogryposis type 1
    Christina A Gurnett
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Hum Mol Genet 19:1165-73. 2010
    ..These findings reveal that the MYBPC1 is a novel gene responsible for DA1, though the mechanism of disease may differ from how some cardiac MYBPC3 mutations cause hypertrophic cardiomyopathy...
  20. ncbi Compositional analysis of muscle in boys with Duchenne muscular dystrophy using MR imaging
    Franklin A Marden
    Mallinckrodt Institute of Radiology at Washington University Medical Center, 510 South Kingshighway Blvd, St Louis, MO 63110, USA
    Skeletal Radiol 34:140-8. 2005
    ..We used magnetic resonance (MR) imaging to study age-related changes in the composition and distribution of diseased muscles...
  21. doi Quantitative muscle ultrasound measures rapid declines over time in children with SMA type 1
    Kay W Ng
    Washington University School of Medicine, Department of Neurology, St Louis, MO 63110, United States
    J Neurol Sci 358:178-82. 2015
    ..In children with SMA type 1, muscle atrophies and becomes hyperechoic over time. Quantitative muscle ultrasound measures disease progression in SMA type 1 that warrants additional study in more children...
  22. ncbi Valproate may improve strength and function in patients with type III/IV spinal muscle atrophy
    Conrad C Weihl
    Department of Neurology, Washington University School of Medicine, 660 South Euclid Avenue, Box 8111, St Louis, MO 63110, USA
    Neurology 67:500-1. 2006
    ..The treated patients with SMA had increased quantitative muscle strength and subjective function. Further trials of valproate treatment for SMA type III/IV are warranted...
  23. pmc Quantitative ultrasound using backscatter analysis in Duchenne and Becker muscular dystrophy
    Craig M Zaidman
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuromuscul Disord 20:805-9. 2010
    ..Longitudinal studies are required to determine the sensitivity of this measure to changes in pathology over time...
  24. ncbi Occult cardiac contractile dysfunction in dystrophin-deficient children revealed by cardiac magnetic resonance strain imaging
    M W Ashford
    Department of Medicine, Washington University School of Medicine, St Louis, MO, USA
    Circulation 112:2462-7. 2005
    ..The purpose of this study was to apply the technique of cardiac magnetic resonance (CMR) tagging to detect occult cardiac dysfunction in young subjects with DMD by measuring myocardial strain and torsion...
  25. ncbi Longitudinal assessment of neuropsychologic and language function in children with benign rolandic epilepsy
    Ellen Northcott
    School of Women s and Children s Health, University of New South Wales, Sydney, NSW, Australia
    J Child Neurol 21:518-22. 2006
    ..It is important to recognize cognitive difficulties in children with benign rolandic epilepsy. Some difficulties can resolve; however, continued monitoring, particularly in areas of visual memory and phonologic awareness, is required...
  26. ncbi CINRG randomized controlled trial of creatine and glutamine in Duchenne muscular dystrophy
    Diana M Escolar
    Children s National Medical Center, George Washington University, Washington, DC, USA
    Ann Neurol 58:151-5. 2005
    ..Creatine and glutamine were well tolerated...
  27. ncbi Mental retardation and early onset of weakness in a girl with a dystrophinopathy and a large Xp21-23 deletion
    Raffaele Falsaperla
    Department of Pediatrics and Pediatric Neurology, Azienda Policlinico, University of Catania, Italy
    J Child Neurol 18:79-81. 2003
    ..To our knowledge, the combination of this dystrophinopathy in association with severe mental retardation has not been described in a girl...