Li Shiun Chen

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. pmc Incorporating age at onset of smoking into genetic models for nicotine dependence: evidence for interaction with multiple genes
    Richard A Grucza
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Ave, St Louis, MO 63110, USA
    Addict Biol 15:346-57. 2010
  2. ncbi request reprint Smoking Cessation and Electronic Cigarettes in Community Mental Health Centers: Patient and Provider Perspectives
    Li Shiun Chen
    Department of Psychiatry, Washington University School of Medicine, 660 S Euclid Ave, Box 8134, St Louis, MO, 63110, USA
    Community Ment Health J . 2016
  3. pmc Genetic Risk Can Be Decreased: Quitting Smoking Decreases and Delays Lung Cancer for Smokers With High and Low CHRNA5 Risk Genotypes - A Meta-Analysis
    Li Shiun Chen
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA Siteman Cancer Center, Washington University, St Louis, MO, USA Electronic address
    EBioMedicine 11:219-226. 2016
  4. pmc Pathways to precision medicine in smoking cessation treatments
    Li Shiun Chen
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, United States Electronic address
    Neurosci Lett . 2016
  5. pmc Genetic variation (CHRNA5), medication (combination nicotine replacement therapy vs. varenicline), and smoking cessation
    Li Shiun Chen
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO, 63110, United States The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, MO, 63110, United States Electronic address
    Drug Alcohol Depend 154:278-82. 2015
  6. pmc Interplay of genetic risk (CHRNA5) and environmental risk (partner smoking) on cigarette smoking reduction
    Li Shiun Chen
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, United States Electronic address
    Drug Alcohol Depend 143:36-43. 2014
  7. pmc Interplay of genetic risk factors (CHRNA5-CHRNA3-CHRNB4) and cessation treatments in smoking cessation success
    Li Shiun Chen
    Department of Psychiatry and the Department of Genetics, Washington University School of Medicine, St Louis, MO, USA
    Am J Psychiatry 169:735-42. 2012
  8. pmc Nicotine dependence and comorbid psychiatric disorders: examination of specific genetic variants in the CHRNA5-A3-B4 nicotinic receptor genes
    Li Shiun Chen
    Department of Psychiatry, Washington University, St Louis, MO 63110, USA
    Drug Alcohol Depend 123:S42-51. 2012
  9. pmc Smoking and genetic risk variation across populations of European, Asian, and African American ancestry--a meta-analysis of chromosome 15q25
    Li Shiun Chen
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Genet Epidemiol 36:340-51. 2012
  10. pmc Dissection of the phenotypic and genotypic associations with nicotinic dependence
    Li Shiun Chen
    Department of Psychiatry Box 8134, Washington University School of Medicine, 660S Euclid Ave, St Louis, MO 63110, USA
    Nicotine Tob Res 14:425-33. 2012

Detail Information

Publications20

  1. pmc Incorporating age at onset of smoking into genetic models for nicotine dependence: evidence for interaction with multiple genes
    Richard A Grucza
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Ave, St Louis, MO 63110, USA
    Addict Biol 15:346-57. 2010
    ..Incorporation of logically chosen interaction parameters, such as AOS, into genetic models of substance use disorders may increase the degree of explained phenotypic variation and constitutes a promising avenue for gene discovery...
  2. ncbi request reprint Smoking Cessation and Electronic Cigarettes in Community Mental Health Centers: Patient and Provider Perspectives
    Li Shiun Chen
    Department of Psychiatry, Washington University School of Medicine, 660 S Euclid Ave, Box 8134, St Louis, MO, 63110, USA
    Community Ment Health J . 2016
    ..This study highlights the need for interventions targeting different phases of smoking cessation in these patients suffering disproportionately from tobacco dependence...
  3. pmc Genetic Risk Can Be Decreased: Quitting Smoking Decreases and Delays Lung Cancer for Smokers With High and Low CHRNA5 Risk Genotypes - A Meta-Analysis
    Li Shiun Chen
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA Siteman Cancer Center, Washington University, St Louis, MO, USA Electronic address
    EBioMedicine 11:219-226. 2016
    ..It is unclear whether smoking cessation confers the same benefits in terms of lung cancer risk reduction for those who possess CHRNA5 risk variants versus those who do not...
  4. pmc Pathways to precision medicine in smoking cessation treatments
    Li Shiun Chen
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, United States Electronic address
    Neurosci Lett . 2016
    ..These findings strengthen the case for the development and rigorous testing of treatments that target patients with different biological risk profiles...
  5. pmc Genetic variation (CHRNA5), medication (combination nicotine replacement therapy vs. varenicline), and smoking cessation
    Li Shiun Chen
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO, 63110, United States The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, MO, 63110, United States Electronic address
    Drug Alcohol Depend 154:278-82. 2015
    ..This study tests whether the coding variant rs16969968 in the CHRNA5 nicotinic receptor gene predicts the effects of combination nicotine replacement therapy (cNRT) and varenicline on treatment outcomes...
  6. pmc Interplay of genetic risk (CHRNA5) and environmental risk (partner smoking) on cigarette smoking reduction
    Li Shiun Chen
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, United States Electronic address
    Drug Alcohol Depend 143:36-43. 2014
    ..This study tests whether the genetic predictor (CHRNA5 nicotine receptor gene variants) and an environmental risk factor (partner smoking) interact in the prediction of smoking reduction...
  7. pmc Interplay of genetic risk factors (CHRNA5-CHRNA3-CHRNB4) and cessation treatments in smoking cessation success
    Li Shiun Chen
    Department of Psychiatry and the Department of Genetics, Washington University School of Medicine, St Louis, MO, USA
    Am J Psychiatry 169:735-42. 2012
    ..This study tested whether variants in the nicotinic receptor gene cluster CHRNA5-CHRNA3-CHRNB4 predict age at smoking cessation and relapse after an attempt to quit smoking...
  8. pmc Nicotine dependence and comorbid psychiatric disorders: examination of specific genetic variants in the CHRNA5-A3-B4 nicotinic receptor genes
    Li Shiun Chen
    Department of Psychiatry, Washington University, St Louis, MO 63110, USA
    Drug Alcohol Depend 123:S42-51. 2012
    ..We examined whether these genetic variants were associated with comorbid disorders and whether comorbid psychiatric disorders modified the genetic risk of nicotine dependence...
  9. pmc Smoking and genetic risk variation across populations of European, Asian, and African American ancestry--a meta-analysis of chromosome 15q25
    Li Shiun Chen
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Genet Epidemiol 36:340-51. 2012
    ..Using the cross-population study paradigm provides valuable insights to narrow regions of interest and inform future biological experiments...
  10. pmc Dissection of the phenotypic and genotypic associations with nicotinic dependence
    Li Shiun Chen
    Department of Psychiatry Box 8134, Washington University School of Medicine, 660S Euclid Ave, St Louis, MO 63110, USA
    Nicotine Tob Res 14:425-33. 2012
    ..We examined how these identified genetic variants relate to nicotine dependence defined by different categorical and dimensional measures...
  11. pmc Familial aggregation of clinical and neurocognitive features in sibling pairs with and without schizophrenia
    Li Shiun Chen
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Schizophr Res 111:159-66. 2009
    ....
  12. pmc Pharmacotherapy effects on smoking cessation vary with nicotine metabolism gene (CYP2A6)
    Li Shiun Chen
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA
    Addiction 109:128-37. 2014
    ..We examine the effect of CYP2A6 genotype on smoking cessation success and response to cessation pharmacotherapy, and combine these effects with those of CHRNA5 genotypes...
  13. pmc Variants in two adjacent genes, EGLN2 and CYP2A6, influence smoking behavior related to disease risk via different mechanisms
    A Joseph Bloom
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA
    Hum Mol Genet 23:555-61. 2014
    ..These results indicate a previously unappreciated novel mechanism behind genome-wide significant associations with cigarette consumption and disease risk unrelated to nicotine metabolism...
  14. pmc Association of the OPRM1 Variant rs1799971 (A118G) with Non-Specific Liability to Substance Dependence in a Collaborative de novo Meta-Analysis of European-Ancestry Cohorts
    Tae Hwi Schwantes-An
    Department of Genetics, Washington University School of Medicine, 4523 Clayton Avenue, Campus Box 8232, St Louis, MO, 63110, USA
    Behav Genet 46:151-69. 2016
    ..This project highlights the benefits of examining addictive behaviors collectively and the power of collaborative data sharing and meta-analyses...
  15. pmc When Does Choice of Accuracy Measure Alter Imputation Accuracy Assessments?
    Shelina Ramnarine
    Department of Genetics, Washington University, St Louis, Missouri, United States of America
    PLoS ONE 10:e0137601. 2015
    ..IQS is important to consider when evaluating imputation accuracy, particularly for rare and low frequency variants...
  16. pmc CYP2B6 non-coding variation associated with smoking cessation is also associated with differences in allelic expression, splicing, and nicotine metabolism independent of common amino-acid changes
    A Joseph Bloom
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS ONE 8:e79700. 2013
    ..These results indicate differences in mRNA expression and splicing as potential molecular mechanisms by which non-coding variation in CYP2B6 may affect enzymatic activity leading to differences in metabolism and smoking cessation. ..
  17. pmc Identification of Medically Actionable Secondary Findings in the 1000 Genomes
    Emily Olfson
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS ONE 10:e0135193. 2015
    ..Our results also confirm that understudied populations will not reap proportionate benefits of genomic medicine, highlighting the need for continued research efforts on genetic diseases in these populations. ..
  18. pmc Return of individual genetic results in a high-risk sample: enthusiasm and positive behavioral change
    Sarah M Hartz
    School of Medicine, Washington University in St Louis, St Louis, Missouri, USA
    Genet Med 17:374-9. 2015
    ..The goal of this study was to examine participant responses to disclosure of genetic results in a minority population at high risk for depression and anxiety...
  19. doi request reprint Task-related fMRI responses to a nicotinic acetylcholine receptor partial agonist in schizophrenia: A randomized trial
    Deanna M Barch
    Department of Psychology, Washington University, St Louis, MO, USA Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA Department of Radiology, Washington University School of Medicine, St Louis, MO, USA Electronic address
    Prog Neuropsychopharmacol Biol Psychiatry 71:66-75. 2016
    ..This study evaluated brain activation during performance of a working memory task (WMT) and an episodic memory task (EMT), and the effect of AQW051 on task-related brain activation and performance in subjects with schizophrenia...
  20. pmc CHRNA5 variant predicts smoking cessation in patients with acute myocardial infarction
    Li Shiun Chen
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO
    Nicotine Tob Res 16:1224-31. 2014
    ..This study investigates the association between CHRNA5 rs16969968 and smoking cessation in patients hospitalized with acute MI...