Alex Brown

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. doi Vitamin D analogs: therapeutic applications and mechanisms for selectivity
    Alex J Brown
    Renal Division, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Aspects Med 29:433-52. 2008
  2. ncbi Vitamin D analogs for secondary hyperparathyroidism: what does the future hold?
    Alex J Brown
    Renal Division, Washington University School of Medicine, Box 8126, 660 S Euclid, St Louis, MO 63110, USA
    J Steroid Biochem Mol Biol 103:578-83. 2007
  3. ncbi Drug insight: vitamin D analogs in the treatment of secondary hyperparathyroidism in patients with chronic kidney disease
    Alex J Brown
    Renal Division, Washington University School of Medicine, St Louis, MO, USA
    Nat Clin Pract Endocrinol Metab 3:134-44. 2007
  4. ncbi Calcium, phosphorus and vitamin D disorders in uremia
    Eduardo Slatopolsky
    Washington University School of Medicine, Department of Medicine, Renal Division, St Louis, MO 63110, USA
    Contrib Nephrol 149:261-71. 2005
  5. ncbi New vitamin D analogs
    Eduardo Slatopolsky
    Renal Division, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Kidney Int Suppl . 2003
  6. ncbi Vitamin D analogues for secondary hyperparathyroidism
    Alex J Brown
    Renal Division, Washington University School of Medicine, St Louis, Missouri, USA
    Nephrol Dial Transplant 17:10-9. 2002
  7. ncbi Isolation and identification of 1alpha-hydroxy-3-epi-vitamin D3, a potent suppressor of parathyroid hormone secretion
    Alex J Brown
    Washington University School of Medicine, 660S Euclid Avenue, Box 8126, St Louis, Missouri 63110, USA
    J Cell Biochem 96:569-78. 2005
  8. ncbi The vitamin D prodrugs 1alpha(OH)D2, 1alpha(OH)D3 and BCI-210 suppress PTH secretion by bovine parathyroid cells
    Alex J Brown
    Renal Division, Washington University School of Medicine, St Louis, MO 63110, USA
    Nephrol Dial Transplant 21:644-50. 2006
  9. ncbi Oral feeding acutely down-regulates serum PTH in hemodialysis patients
    Alex J Brown
    Renal Division, Department of Internal Medicine, Chromalloy American Kidney Center at Washington University School of Medicine, St Louis, MO, USA
    Nephron Clin Pract 103:c106-13. 2006
  10. pmc FGF-23 and sFRP-4 in chronic kidney disease and post-renal transplantation
    Sangeeta Pande
    Renal Division, Washington University School of Medicine, St Louis, MO 63110, USA
    Nephron Physiol 104:p23-32. 2006

Research Grants

Collaborators

Detail Information

Publications24

  1. doi Vitamin D analogs: therapeutic applications and mechanisms for selectivity
    Alex J Brown
    Renal Division, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Aspects Med 29:433-52. 2008
    ..Although many new analogs show tremendous promise in cell-based models, this article will limit it focus on the development of analogs currently in use and those that have demonstrated efficacy in animal models or in clinical trials...
  2. ncbi Vitamin D analogs for secondary hyperparathyroidism: what does the future hold?
    Alex J Brown
    Renal Division, Washington University School of Medicine, Box 8126, 660 S Euclid, St Louis, MO 63110, USA
    J Steroid Biochem Mol Biol 103:578-83. 2007
    ..Combining these agents with higher doses of vitamin D compounds may achieve greater suppression of PTH and possibly enhance survival in patients with chronic kidney disease...
  3. ncbi Drug insight: vitamin D analogs in the treatment of secondary hyperparathyroidism in patients with chronic kidney disease
    Alex J Brown
    Renal Division, Washington University School of Medicine, St Louis, MO, USA
    Nat Clin Pract Endocrinol Metab 3:134-44. 2007
    ....
  4. ncbi Calcium, phosphorus and vitamin D disorders in uremia
    Eduardo Slatopolsky
    Washington University School of Medicine, Department of Medicine, Renal Division, St Louis, MO 63110, USA
    Contrib Nephrol 149:261-71. 2005
    ..Alterations in calcium, phosphate (P) and vitamin D metabolism play a critical role in the development of secondary hyperparathyroidism (SH), parathyroid hyperplasia and soft tissue and vascular calcification...
  5. ncbi New vitamin D analogs
    Eduardo Slatopolsky
    Renal Division, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Kidney Int Suppl . 2003
    ..However, the potent effect of 1,25-(OH)2D3 on intestinal calcium and phosphorus absorption and bone mineral mobilization often leads to the development of hypercalcemia and hyperphosphatemia precluding 1,25-(OH)2D3 therapy...
  6. ncbi Vitamin D analogues for secondary hyperparathyroidism
    Alex J Brown
    Renal Division, Washington University School of Medicine, St Louis, Missouri, USA
    Nephrol Dial Transplant 17:10-9. 2002
    ..A clear understanding of the molecular basis for the selectivity of vitamin D analogues on parathyroid function may allow the design of even more effective analogues...
  7. ncbi Isolation and identification of 1alpha-hydroxy-3-epi-vitamin D3, a potent suppressor of parathyroid hormone secretion
    Alex J Brown
    Washington University School of Medicine, 660S Euclid Avenue, Box 8126, St Louis, Missouri 63110, USA
    J Cell Biochem 96:569-78. 2005
    ..5 mg/dl) was nearly 80 times higher. These findings indicate that 1alphaOH-3-epi-D3 is a highly selective vitamin D analog with tremendous potential for treatment of secondary hyperparathyroidism in chronic renal failure patients...
  8. ncbi The vitamin D prodrugs 1alpha(OH)D2, 1alpha(OH)D3 and BCI-210 suppress PTH secretion by bovine parathyroid cells
    Alex J Brown
    Renal Division, Washington University School of Medicine, St Louis, MO 63110, USA
    Nephrol Dial Transplant 21:644-50. 2006
    ..In previous studies, 1alpha(OH)D3, a vitamin D prodrug, inhibited PTH secretion in cultured bovine parathyroid cells, but it was unclear whether 1alpha(OH)D3 itself or an active metabolite produced this inhibition...
  9. ncbi Oral feeding acutely down-regulates serum PTH in hemodialysis patients
    Alex J Brown
    Renal Division, Department of Internal Medicine, Chromalloy American Kidney Center at Washington University School of Medicine, St Louis, MO, USA
    Nephron Clin Pract 103:c106-13. 2006
    ..Recent animal studies show ingestion of a low phosphorus meal can lower serum PTH within 15 min, before changes in serum ionized calcium or phosphorus occur, suggesting a rapid gastrointestinal signal may regulate PTH...
  10. pmc FGF-23 and sFRP-4 in chronic kidney disease and post-renal transplantation
    Sangeeta Pande
    Renal Division, Washington University School of Medicine, St Louis, MO 63110, USA
    Nephron Physiol 104:p23-32. 2006
    ....
  11. ncbi Hyperplasia of the parathyroid gland without secondary hyperparathyroidism
    Fumiaki Takahashi
    Renal Division, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Kidney Int 61:1332-8. 2002
    ..The present study explores the effects of P restriction on parathyroid hormone (PTH) synthesis and secretion and PT cell growth in rats with established SH and PTG hyperplasia...
  12. ncbi Effect of 2-methylene-19-nor-(20S)-1 alpha-hydroxy-bishomopregnacalciferol (2MbisP), an analog of vitamin D, on secondary hyperparathyroidism
    Eduardo Slatopolsky
    Renal Division, Washington University Medical School, St Louis, MO 63110, USA
    J Bone Miner Res 22:686-94. 2007
    ..We tested a new analog of vitamin D, 2MbisP, and found that it suppresses PTH at doses that do not affect serum Ca or P...
  13. ncbi Destabilization of parathyroid hormone mRNA by extracellular Ca2+ and the calcimimetic R-568 in parathyroid cells: role of cytosolic Ca and requirement for gene transcription
    Cynthia S Ritter
    Renal Division, Washington University Medical School, Box 8126, 660 S Euclid, St Louis, Missouri 63110, USA
    J Mol Endocrinol 40:13-21. 2008
    ..However, increasing cytosolic Ca with thapsigargin or the Ca ionophore A23187 decreased PTH mRNA levels. In summary, Ca-mediated destabilization of PTH mRNA requires gene transcription and involves increases in cytosolic Ca...
  14. ncbi Vitamin D
    Adriana S Dusso
    Renal Division, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Am J Physiol Renal Physiol 289:F8-28. 2005
    ..This local production of 1,25(OH)(2)D(3) is dependent on circulating precursor levels, providing a potential explanation for the association of vitamin D deficiency with various cancers and autoimmune diseases...
  15. ncbi Acute regulation of parathyroid hormone by dietary phosphate
    Daniel R Martin
    Renal Division, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Physiol Endocrinol Metab 289:E729-34. 2005
    ..These findings indicate that oral P(i) increases PTH release in vivo more rapidly than previously reported; this response may be from both plasma phosphate and an additional signal arising from the gastrointestinal tract...
  16. ncbi Vitamin D analogs for the treatment of secondary hyperparathyroidism
    Eduardo Slatopolsky
    Washington University School of Medicine, Renal Division, St Louis, MO 63110, USA
    Blood Purif 20:109-12. 2002
    ..The lower Ca x P product in 19-nor-1,25(OH)(2)D(2)-treated rats may be an important consideration in patient therapy. Further studies in patients are necessary to define these differences...
  17. ncbi Effect of age, vitamin D, and calcium on the regulation of rat intestinal epithelial calcium channels
    Alex J Brown
    Renal Division, Washington University School of Medicine, St Louis, MO 63110, USA
    Arch Biochem Biophys 437:51-8. 2005
    ..These findings suggest that the apical calcium channels, along with calbindin and the calcium pump, may play a role in intestinal calcium transport and its modulation by age, dietary calcium, and 1,25(OH)2D3...
  18. ncbi Vitamin D analogs: new therapeutic agents for secondary hyperparathyroidism
    Alex J Brown
    Renal Division, Washington University School of Medicine, St Louis, Missouri, USA
    Treat Endocrinol 1:313-27. 2002
    ..The selectivity of the other analogs is achieved by distinct mechanisms. Understanding how these compounds exert their selective actions on the parathyroid glands will aid in the design of safer, more effective analogs...
  19. ncbi Differential effects of 19-nor-1,25-dihydroxyvitamin D(2) and 1,25-dihydroxyvitamin D(3) on intestinal calcium and phosphate transport
    Alex J Brown
    Renal Division, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Lab Clin Med 139:279-84. 2002
    ..In summary, the reduced calcemic and phosphatemic activities of 19-norD(2) can be attributed to lower potency in stimulating intestinal calcium and phosphate absorption...
  20. ncbi Tissue distribution and activity studies of 1,24-dihydroxyvitamin D2, a metabolite of vitamin D2 with low calcemic activity in vivo
    Alex J Brown
    Renal Division, Washington University School of Medicine, St Louis, MO, USA
    Biochem Pharmacol 68:1289-96. 2004
    ..Further studies will be necessary to confirm these findings and to confirm the clinical utility of 1,24(OH)(2)D(2)...
  21. ncbi Parathyroid cells cultured in collagen matrix retain calcium responsiveness: importance of three-dimensional tissue architecture
    Cynthia S Ritter
    Renal Division, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Bone Miner Res 19:491-8. 2004
    ..These findings also illustrate the importance of 3-D cellular architecture in parathyroid gland function...
  22. ncbi Successful treatment of an adynamic bone disorder with bone morphogenetic protein-7 in a renal ablation model
    Richard J Lund
    Renal Division, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Am Soc Nephrol 15:359-69. 2004
    ..05). ABD produced in mice with CKD in the absence of hyperparathyroidism was successfully reversed with a bone anabolic, BMP-7, associated with a reduction in plasma phosphorus...
  23. ncbi Reversal of secondary hyperparathyroidism by phosphate restriction restores parathyroid calcium-sensing receptor expression and function
    Cynthia S Ritter
    Renal Division, Washington University School of Medicine, St Louis, Missouri, USA
    J Bone Miner Res 17:2206-13. 2002
    ..We conclude that although phosphate restriction restores CaR expression and function in parathyroid glands of uremic rats, it is a late event and not involved in the arrest of secondary HPT...
  24. ncbi 2,2-Disubstituted analogues of the natural hormone 1 alpha,25-dihydroxyvitamin D(3): chemistry and biology
    Gary H Posner
    Department of Chemistry, Krieger School of Arts and Sciences, The Johns Hopkins University, Baltimore, MD 21218, USA
    Bioorg Med Chem 10:2353-65. 2002
    ..Dimethylated analogue strongly suppresses parathyroid hormone (PTH) secretion...

Research Grants1

  1. CA2+ SENSING RECEPTOR EXPRESSION IN HYPERPARATHYROIDISM
    Alex Brown; Fiscal Year: 2002
    ..abstract_text> ..