Deborah H Schmiel
Affiliation: Walter Reed Army Medical Center
- Importance of antibodies to lipopolysaccharide in natural and vaccine-induced serum bactericidal activity against Neisseria meningitidis group BDeborah H Schmiel
Division of Bacterial and Rickettsial Diseases, Walter Reed Army Institute of Research, Silver Spring, MD 20910 7500, USA
Infect Immun 79:4146-56. 2011..Additionally, subsets of these bactericidal antibodies are cross-reactive, binding to several different LPS immunotypes, which is a useful characteristic for an effective group B meningococcal vaccine antigen...
- Design and evaluation in mice of a broadly protective meningococcal group B native outer membrane vesicle vaccineWendell D Zollinger
Division of Bacterial and Rickettsial Diseases, 503 Robert Grant Ave, Walter Reed Army Institute of Research WRAIR, Silver Spring, MD 20910, USA
Vaccine 28:5057-67. 2010..Analysis of the bactericidal activity indicated that antibodies to the LOS were responsible for a major portion of the bactericidal activity and that these antibodies may enhance the bactericidal activity of anti-protein antibodies...
- A phase 1 study of a group B meningococcal native outer membrane vesicle vaccine made from a strain with deleted lpxL2 and synX and stable expression of opcAPaul B Keiser
Walter Reed Army Institute of Research WRAIR, Silver Spring, MD, USA
Vaccine 28:6970-6. 2010..These results suggest that genetically modified NOMV vaccines can induce protection against group B meningococcus...
- Characterization of an antibody depletion assay for analysis of bactericidal antibody specificityWendell D Zollinger
Division of Bacterial and Rickettsial Diseases, Walter Reed Army Institute of Research, 503 Robert Grant Ave, Silver Spring, Maryland 20910 7500, USA
Clin Vaccine Immunol 16:1789-95. 2009..The bactericidal depletion assay can be an effective tool for studying the specificity of serum bactericidal antibodies...